{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:38:43Z","timestamp":1791520723500,"version":"4.3.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jpeds.2021.02.060","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T05:01:04Z","timestamp":1614315664000},"page":"156-162.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex"],"prefix":"10.1016","volume":"233","author":[{"given":"Hanna M.","family":"Hulshof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M.H.","family":"Slot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Breuillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Boddaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3350-6326","authenticated-orcid":false,"given":"Sergiusz","family":"Jozwiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kotulska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-3555","authenticated-orcid":false,"given":"Kate","family":"Riney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Feucht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-5636","authenticated-orcid":false,"given":"Sharon","family":"Samueli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-7328","authenticated-orcid":false,"given":"Theresa","family":"Scholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Krsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-2833","authenticated-orcid":false,"given":"Barbora","family":"Benova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees P.J.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floor E.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Nabbout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Curatolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Aronica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Weschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wojdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sijko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"G\u0142owacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Borkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Doma\u0144ska-Pakie\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Anink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Benvenuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blazejczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bongaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chmielewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dabrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Giannikou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hamieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Har\u0119za","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jaworski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaczorowska-Frontczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Leusman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ma\u0107kowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Muelebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Scheldeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sciuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Slowinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tempes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van Scheppingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Verhelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vervisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Urba\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2021.02.060_bib1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(08)61279-9","article-title":"Tuberous sclerosis","volume":"372","author":"Curatolo","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2021.02.060_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pediatrneurol.2017.05.014","article-title":"Early detection of tuberous sclerosis complex: an opportunity for improved neurodevelopmental outcome","volume":"76","author":"Riney","year":"2017","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejpn.2011.03.010","article-title":"Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex","volume":"15","author":"J\u00f3\u017awiak","year":"2011","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00247-007-0436-y","article-title":"Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma","volume":"37","author":"M\u00fchler","year":"2007","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/uog.6367","article-title":"Prenatal diagnosis of cardiac rhabdomyomas: incidence of associated cerebral lesions of tuberous sclerosis complex","volume":"34","author":"Saada","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib6","doi-asserted-by":"crossref","first-page":"16035","DOI":"10.1038\/nrdp.2016.35","article-title":"Tuberous sclerosis complex","volume":"2","author":"Henske","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jpeds.2021.02.060_bib7","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ejpn.2018.08.005","article-title":"Review article: Diagnosis of tuberous sclerosis complex in the fetus","volume":"22","author":"Dragoumi","year":"2018","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s002340050459","article-title":"Magnetization transfer in the investigation of patients with tuberous sclerosis","volume":"39","author":"Girard","year":"1997","journal-title":"Neuroradiology"},{"key":"10.1016\/j.jpeds.2021.02.060_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1053\/j.semperi.2009.04.009","article-title":"Normal Development of the Fetal Brain by MRI","volume":"33","author":"Glenn","year":"2009","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01403693","article-title":"Prenatal MRI diagnosis of fetal cerebral tuberous sclerosis","volume":"26","author":"Sonigo","year":"1996","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/ajmg.1320420527","article-title":"Incidence of tuberous sclerosis in patients with cardiac rhabdomyoma","volume":"42","author":"Webb","year":"1992","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jpeds.2021.02.060_bib12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"Kwan","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpeds.2021.02.060_bib13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/088307389701200203","article-title":"Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex","volume":"12","author":"Goodman","year":"1997","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib14","first-page":"149","article-title":"MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment","volume":"16","author":"Shepherd","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2021.02.060_bib15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/adc.2003.026815","article-title":"The relation of infantile spasms, tubers, and intelligence in tuberous sclerosis complex","volume":"89","author":"O\u2019Callaghan","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2021.02.060_bib16","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/01.wnl.0000280579.04974.c0","article-title":"Cognitive impairment in tuberous sclerosis complex is a multifactorial condition","volume":"70","author":"Jansen","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jpeds.2021.02.060_bib17","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(97)80012-8","article-title":"Association of tuberous sclerosis of temporal lobes with autism and atypical autism","volume":"349","author":"Bolton","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2021.02.060_bib18","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jfma.2014.02.008","article-title":"The relationship of neuroimaging findings and neuropsychiatric comorbidities in children with tuberous sclerosis complex","volume":"114","author":"Huang","year":"2015","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jpeds.2021.02.060_bib19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00787-017-1066-z","article-title":"Cortical dysplasia and autistic trait severity in children with tuberous sclerosis complex: a clinical epidemiological study","volume":"27","author":"Mous","year":"2018","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.jpeds.2021.02.060_bib20","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1528-1167.2009.02474.x","article-title":"The natural history of epilepsy in tuberous sclerosis complex","volume":"51","author":"Chu-Shore","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpeds.2021.02.060_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ajmg.c.31652","article-title":"Current concepts on epilepsy management in tuberous sclerosis complex","volume":"178","author":"Canevini","year":"2018","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jpeds.2021.02.060_bib22","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1177\/0883073815600870","article-title":"Cerebellar development and autism spectrum disorder in tuberous sclerosis complex","volume":"30","author":"Sundberg","year":"2015","journal-title":"J Child Neurol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347621001992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347621001992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:06:24Z","timestamp":1758359184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347621001992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":22,"alternative-id":["S0022347621001992"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2021.02.060","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2021.02.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}