{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:08:10Z","timestamp":1780092490100,"version":"3.54.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020258","name":"Department of Molecular Medicine, University of Pavia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020258","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jpeds.2021.07.007","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T01:34:52Z","timestamp":1626140092000},"page":"74-79.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Nasal Endoscopy in the Clinical Diagnosis of Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1016","volume":"238","author":[{"given":"Elina","family":"Matti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-9187","authenticated-orcid":false,"given":"Roberta","family":"Lizzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ugolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Maiorano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Zaccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-8441","authenticated-orcid":false,"given":"Annalisa","family":"De Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"De Sando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Marseglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Benazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pagella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5863","authenticated-orcid":false,"given":"Giuseppe","family":"Spinozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2021.07.007_bib1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/GIM.0b013e3182136d32","article-title":"Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis","volume":"13","author":"McDonald","year":"2011","journal-title":"Genet Med"},{"key":"10.1016\/j.jpeds.2021.07.007_bib2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ajmg.1320320302","article-title":"Age-related clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population","volume":"32","author":"Plauchu","year":"1989","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jpeds.2021.07.007_bib3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpeds.2013.02.009","article-title":"Hereditary hemorrhagic telangiectasia: arteriovenous malformations in children","volume":"163","author":"Giordano","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2021.07.007_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00405-005-0956-8","article-title":"Manifestations of hereditary hemorrhagic telangiectasia in children and adolescents","volume":"263","author":"Folz","year":"2006","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jpeds.2021.07.007_bib5","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.3390\/jcm9092714","article-title":"Genotype-phenotype correlations in children with HHT","volume":"9","author":"Kilian","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jpeds.2021.07.007_bib6","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/lary.27015","article-title":"Epistaxis in children and adolescents with hereditary hemorrhagic telangiectasia","volume":"128","author":"Gonzalez","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jpeds.2021.07.007_bib7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM199510053331407","article-title":"Hereditary hemorrhagic telangiectasia","volume":"333","author":"Guttmacher","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2021.07.007_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpeds.2018.01.079","article-title":"Applicability of the Cura\u00e7ao criteria for the diagnosis of hereditary hemorrhagic telangiectasia in the pediatric population","volume":"197","author":"Pahl","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2021.07.007_bib9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/archpedi.160.6.596","article-title":"Symptomatic children with hereditary hemorrhagic telangiectasia: a pediatric center experience","volume":"160","author":"Mei-Zahav","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.jpeds.2021.07.007_bib10","first-page":"407","article-title":"Mucocutaneous telangiectases of the head and neck in individuals with hereditary hemorrhagic telangiectasia\u2014analysis of distribution and symptoms","volume":"14","author":"Folz","year":"2004","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jpeds.2021.07.007_bib11","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaad.2018.11.014","article-title":"Localization and age distribution of telangiectases in children and adolescents with hereditary hemorrhagic telangiectasia: a retrospective cohort study","volume":"81","author":"Gonzalez","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jpeds.2021.07.007_bib12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.7326\/M20-1443","article-title":"Second international guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia","volume":"173","author":"Faughnan","year":"2020","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jpeds.2021.07.007_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/jmg.2009.069013","article-title":"International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia","volume":"48","author":"Faughnan","year":"2011","journal-title":"J Med Genet"},{"key":"10.1016\/j.jpeds.2021.07.007_bib14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1365-2222.2001.01057.x","article-title":"Nasal endoscopy in asthmatic children: assessment of rhinosinusitis and adenoiditis incidence, correlations with cytology and microbiology","volume":"31","author":"Tosca","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jpeds.2021.07.007_bib15","first-page":"516","article-title":"FID Score: an effective tool in hereditary haemorrhagic telangiectasia-related epistaxis","volume":"58","author":"Pagella","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jpeds.2021.07.007_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/alr.21867","article-title":"Epistaxis grading in Osler's disease: comparison of comprehensive scores with detailed bleeding diaries","volume":"7","author":"Parzefall","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jpeds.2021.07.007_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ajmg.a.35715","article-title":"Hereditary hemorrhagic telangiectasia: how accurate are the clinical criteria","volume":"161A","author":"van Gent","year":"2013","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jpeds.2021.07.007_bib18","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s10038-007-0187-5","article-title":"Analysis of ENG and ACVRL1 genes in 137 HHT Italian families identifies 76 different mutations (24 novel). Comparison with other European studies","volume":"52","author":"Olivieri","year":"2007","journal-title":"J Hum Genet"},{"key":"10.1016\/j.jpeds.2021.07.007_bib19","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1002\/ajmg.a.32243","article-title":"Genotype-phenotype relationship for localization and age distribution of telangiectases in hereditary hemorrhagic telangiectasia","volume":"146A","author":"Letteboer","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jpeds.2021.07.007_bib20","first-page":"83","article-title":"Epistaxis in childhood","volume":"17","author":"Petruson","year":"1979","journal-title":"Rhinology"},{"key":"10.1016\/j.jpeds.2021.07.007_bib21","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.otohns.2006.12.019","article-title":"Health-related quality of life in hereditary hemorrhagic telangiectasia","volume":"136","author":"Geisthoff","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jpeds.2021.07.007_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2500\/ajra.2009.23.3263","article-title":"Correlation of severity of epistaxis with nasal telangiectasias in hereditary hemorrhagic telangiectasia (HHT) patients","volume":"23","author":"Pagella","year":"2009","journal-title":"Am J Rhinol Allergy"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347621006727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347621006727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:10:22Z","timestamp":1758359422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347621006727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":22,"alternative-id":["S0022347621006727"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2021.07.007","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasal Endoscopy in the Clinical Diagnosis of Hereditary Hemorrhagic Telangiectasia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2021.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}