{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:01:24Z","timestamp":1783947684360,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["K23 DK120932"],"award-info":[{"award-number":["K23 DK120932"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jpeds.2022.05.044","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T11:18:04Z","timestamp":1654082284000},"page":"17-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road\u00a0Ahead"],"prefix":"10.1016","volume":"247","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-6370","authenticated-orcid":false,"given":"Shylaja","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2022.05.044_bib1","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1001\/jama.2014.3201","article-title":"Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009","volume":"311","author":"Dabelea","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2022.05.044_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJMc1706291","article-title":"Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012","volume":"377","author":"Mayer-Davis","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jpeds.2004.12.042","article-title":"The global spread of type 2 diabetes mellitus in children and adolescents","volume":"146","author":"Pinhas-Hamiel","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.05.044_bib4","doi-asserted-by":"crossref","first-page":"e20173459","DOI":"10.1542\/peds.2017-3459","article-title":"Prevalence of obesity and severe obesity in US children, 1999-2016","volume":"141","author":"Skinner","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2022.05.044_bib5","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1056\/NEJMoa1109333","article-title":"A clinical trial to maintain glycemic control in youth with type 2 diabetes","volume":"366","author":"Zeitler","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1399-5448.2011.00841.x","article-title":"Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study","volume":"13","author":"Bacha","year":"2012","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib7","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.mayocp.2014.01.009","article-title":"Youth-onset type 2 diabetes mellitus: lessons learned from the TODAY study","volume":"89","author":"Narasimhan","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jpeds.2022.05.044_bib8","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.2337\/dc12-2420","article-title":"Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib9","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.2337\/dc12-2388","article-title":"Lipid and inflammatory cardiovascular risk worsens over 3 years in youth with type 2 diabetes: the TODAY clinical trial","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib10","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.2337\/dc07-0450","article-title":"Higher prevalence of elevated albumin excretion in youth with type 2 than type 1 diabetes: the SEARCH for Diabetes in Youth study","volume":"30","author":"Maahs","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib11","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1464-5491.2012.03591.x","article-title":"Diabetic retinopathy in the SEARCH for Diabetes in Youth cohort: a pilot study","volume":"29","author":"Mayer-Davis","year":"2012","journal-title":"Diabet Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib12","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.2337\/dc12-2455","article-title":"Long-term complications and mortality in young-onset diabetes: type 2 diabetes is more hazardous and lethal than type 1 diabetes","volume":"36","author":"Constantino","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jama.2017.0686","article-title":"Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood","volume":"317","author":"Dabelea","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2022.05.044_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2019.02.024","article-title":"The genetic basis of metabolic disease","volume":"177","author":"Barroso","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jpeds.2022.05.044_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12916-017-0901-x","article-title":"Environmental\/lifestyle factors in the pathogenesis and prevention of type 2 diabetes","volume":"15","author":"Kolb","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00262007","article-title":"Diabetes in identical twins. A study of 200 pairs","volume":"20","author":"Barnett","year":"1981","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpeds.2022.05.044_bib17","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1017\/thg.2015.83","article-title":"The concordance and heritability of type 2 diabetes in 34,166 twin pairs from international twin registers: the Discordant Twin (DISCOTWIN) Consortium","volume":"18","author":"Willemsen","year":"2015","journal-title":"Twin Res Hum Genet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1210\/jc.2010-1642","article-title":"Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline","volume":"96","author":"Copeland","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2022.05.044_bib19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2337\/diacare.19.8.827","article-title":"Parental history of diabetes in a population-based study","volume":"19","author":"Klein","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000354219","article-title":"Diabetes mellitus in neonates and infants: genetic heterogeneity, clinical approach to diagnosis, and therapeutic options","volume":"80","author":"Rubio-Cabezas","year":"2013","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.jpeds.2022.05.044_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2337\/diab.24.1.44","article-title":"A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people","volume":"24","author":"Tattersall","year":"1975","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/(SICI)1096-9136(199801)15:1<15::AID-DIA562>3.0.CO;2-M","article-title":"Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity","volume":"15","author":"Hattersley","year":"1998","journal-title":"Diabet Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib23","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.2337\/db21-0844","article-title":"Evaluation of evidence for pathogenicity demonstrates that BLK, KLF11, and PAX4 should not be included in diagnostic testing for MODY","volume":"71","author":"Laver","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib24","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s00125-005-1738-y","article-title":"Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection","volume":"48","author":"Pearson","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpeds.2022.05.044_bib25","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(03)14571-0","article-title":"Genetic cause of hyperglycaemia and response to treatment in diabetes","volume":"362","author":"Pearson","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jama.2013.283980","article-title":"Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia","volume":"311","author":"Steele","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2022.05.044_bib27","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1210\/jc.2013-1279","article-title":"Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth","volume":"98","author":"Pihoker","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2022.05.044_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/gim.2017.150","article-title":"Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial","volume":"20","author":"Kleinberger","year":"2018","journal-title":"Genet Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib29","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.2337\/dc21-0491","article-title":"Monogenic diabetes in youth with presumed type 2 diabetes: results from the Progress in Diabetes Genetics in Youth (ProDiGY) collaboration","volume":"44","author":"Todd","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nrendo.2016.50","article-title":"Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes","volume":"12","author":"Flannick","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jpeds.2022.05.044_bib31","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2337\/db10-1575","article-title":"Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children","volume":"60","author":"Barker","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib32","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/db09-0374","article-title":"Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study","volume":"58","author":"Kelliny","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib33","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00125-010-1982-7","article-title":"Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth","volume":"54","author":"Dabelea","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpeds.2022.05.044_bib34","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/pedi.12497","article-title":"Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: a case-control and case-parent trio study","volume":"18","author":"Miranda-Lora","year":"2017","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2337\/dc19-0806","article-title":"Genetic susceptibility determines \u03b2-cell function and fasting glycemia trajectories throughout childhood: a 12-year cohort study (EarlyBird 76)","volume":"43","author":"Carayol","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib36","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2337\/dc13-1458","article-title":"Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes","volume":"37","author":"Giannini","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib37","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1210\/jc.2016-2432","article-title":"Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths","volume":"101","author":"Morandi","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpeds.2022.05.044_bib38","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00125-018-4640-0","article-title":"An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese","volume":"61","author":"Graae","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpeds.2022.05.044_bib39","doi-asserted-by":"crossref","first-page":"647864","DOI":"10.3389\/fendo.2021.647864","article-title":"A genetic risk score improves the prediction of type 2 diabetes mellitus in Mexican youths but has lower predictive utility compared with non-genetic factors","volume":"12","author":"Miranda-Lora","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jpeds.2022.05.044_bib40","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05616","article-title":"A genome-wide association study identifies novel risk loci for type 2 diabetes","volume":"445","author":"Sladek","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jpeds.2022.05.044_bib41","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41588-018-0241-6","article-title":"Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps","volume":"50","author":"Mahajan","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1399-5448.2007.00237.x","article-title":"Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes","volume":"8","author":"Zeitler","year":"2007","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cct.2004.08.002","article-title":"SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth","volume":"25","year":"2004","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jpeds.2022.05.044_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature18642","article-title":"The genetic architecture of type 2 diabetes","volume":"536","author":"Fuchsberger","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jpeds.2022.05.044_bib45","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2337\/db20-0443","article-title":"The first genome-wide association study for type 2 diabetes in youth: the Progress in Diabetes Genetics in Youth (ProDiGY) Consortium","volume":"70","author":"Srinivasan","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/ng.2897","article-title":"Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility","volume":"46","author":"Mahajan","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib47","doi-asserted-by":"crossref","first-page":"e1002654","DOI":"10.1371\/journal.pmed.1002654","article-title":"Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: a soft clustering analysis","volume":"15","author":"Udler","year":"2018","journal-title":"PLoS Med"},{"key":"10.1016\/j.jpeds.2022.05.044_bib48","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s41588-021-00948-2","article-title":"Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes","volume":"53","author":"Mansour Aly","year":"2021","journal-title":"Nat Genet"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2022.05.044_bib49","first-page":"S180","article-title":"13. Children and adolescents: standards of medical care in diabetes\u20142021","volume":"44","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00125-011-2353-8","article-title":"Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism","volume":"55","author":"Walford","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.jpeds.2022.05.044_bib51","article-title":"Validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations","author":"Ge","year":"2022","journal-title":"medRxiv"},{"key":"10.1016\/j.jpeds.2022.05.044_bib52","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ng.530","article-title":"A map of open chromatin in human pancreatic islets","volume":"42","author":"Gaulton","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib53","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.2337\/dc10-0004","article-title":"From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation","volume":"33","author":"Bacha","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.05.044_bib54","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1203\/01.pdr.0000246097.73031.27","article-title":"Longitudinal study of physiologic insulin resistance and metabolic changes of puberty","volume":"60","author":"Hannon","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2022.05.044_bib55","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.2337\/db13-1951","article-title":"\u03b2-cell function, incretin effect, and incretin hormones in obese youth along the span of glucose tolerance from normal to prediabetes to type 2 diabetes","volume":"63","author":"Michaliszyn","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib56","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2337\/db15-0950","article-title":"Lifestyle and metformin ameliorate insulin sensitivity independently of the genetic burden of established insulin resistance variants in diabetes prevention program participants","volume":"65","author":"Hivert","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib57","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S2213-8587(14)70050-6","article-title":"Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis","volume":"2","author":"Zhou","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jpeds.2022.05.044_bib58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng.735","article-title":"Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes","volume":"43","author":"Zhou","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib59","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.3632","article-title":"Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jpeds.2022.05.044_bib60","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2337\/db17-1164","article-title":"Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes","volume":"67","author":"Rotroff","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.05.044_bib61","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/clpt.2009.176","article-title":"Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study","volume":"87","author":"Zhou","year":"2010","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2022.05.044_bib62","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group","volume":"352","year":"1998","journal-title":"Lancet"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347622005145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347622005145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:12:45Z","timestamp":1758359565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347622005145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":62,"alternative-id":["S0022347622005145"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2022.05.044","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road\u00a0Ahead","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2022.05.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}