{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:12:02Z","timestamp":1784164322062,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007305","name":"Maternal and Child Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U01 HD062417"],"award-info":[{"award-number":["U01 HD062417"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015015","name":"Government of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC00001"],"award-info":[{"award-number":["U03 MC00001"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC00003"],"award-info":[{"award-number":["U03 MC00003"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC00006"],"award-info":[{"award-number":["U03 MC00006"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC00007"],"award-info":[{"award-number":["U03 MC00007"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC00008"],"award-info":[{"award-number":["U03 MC00008"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC22684"],"award-info":[{"award-number":["U03 MC22684"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["U03 MC22685"],"award-info":[{"award-number":["U03 MC22685"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jpeds.2022.07.033","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T19:07:36Z","timestamp":1659812856000},"page":"100-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis"],"prefix":"10.1016","volume":"250","author":[{"given":"Nicole S.","family":"Glaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly S.","family":"Quayle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"McManemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise E.","family":"Nigrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Tzimenatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Stoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arleta","family":"Rewers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff E.","family":"Schunk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sage R.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y.","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Charles","family":"Casper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody S.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Kuppermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2022.07.033_bib1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jpeds.2004.12.041","article-title":"Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis","volume":"146","author":"Lawrence","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.033_bib2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1056\/NEJM200101253440404","article-title":"Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics","volume":"344","author":"Glaser","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.07.033_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/adc.85.1.16","article-title":"The risk and outcome of cerebral oedema developing during diabetic ketoacidosis","volume":"85","author":"Edge","year":"2001","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2022.07.033_bib4","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0887-8994(99)00079-X","article-title":"Risk factors for developing brain herniation during diabetic ketoacidosis","volume":"21","author":"Mahoney","year":"1999","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2022.07.033_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2337\/diacare.14.1.78b","article-title":"Early onset of fatal cerebral edema in diabetic ketoacidosis","volume":"14","author":"Couch","year":"1991","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.07.033_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diacare.14.1.77","article-title":"Devastating cerebral edema in diabetic ketoacidosis before therapy","volume":"14","author":"Glasgow","year":"1991","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.07.033_bib7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2337\/diacare.27.7.1541","article-title":"Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings and early identification","volume":"27","author":"Muir","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpeds.2022.07.033_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1399-543X.2006.00143.x","article-title":"Conscious level in children with diabetic ketoacidosis is related to severity of acidosis and not to blood glucose concentration","volume":"7","author":"Edge","year":"2006","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2022.07.033_bib9","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1056\/NEJMoa1716816","article-title":"Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis","volume":"378","author":"Kuppermann","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.07.033_bib10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/pedi.12027","article-title":"Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial","volume":"14","author":"Glaser","year":"2013","journal-title":"Pediatr Diabetes"},{"issue":"1 Pt 1","key":"10.1016\/j.jpeds.2022.07.033_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0022-3476(88)80521-3","article-title":"Factors associated with brain herniation in the treatment of diabetic ketoacidosis","volume":"113","author":"Duck","year":"1988","journal-title":"J Pediatr"},{"issue":"1 Pt 1","key":"10.1016\/j.jpeds.2022.07.033_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-3476(88)80529-8","article-title":"Safe management of diabetic ketoacidemia","volume":"113","author":"Harris","year":"1988","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.033_bib13","doi-asserted-by":"crossref","first-page":"e001793","DOI":"10.1136\/bmjdrc-2020-001793","article-title":"Acute and chronic neuroinflammation is triggered by diabetic ketoacidosis in a rat model","volume":"8","author":"Glaser","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.jpeds.2022.07.033_bib14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/micc.12053","article-title":"Diabetic ketoacidosis elicits systemic inflammation associated with cerebrovascular endothelial cell dysfunction","volume":"20","author":"Close","year":"2013","journal-title":"Microcirculation"},{"key":"10.1016\/j.jpeds.2022.07.033_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1521-6616(03)00144-X","article-title":"Cytokine response to diabetic ketoacidosis and its treatment","volume":"108","author":"Hoffman","year":"2003","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jpeds.2022.07.033_bib16","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.2337\/diabetes.53.8.2079","article-title":"Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises","volume":"53","author":"Stentz","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.jpeds.2022.07.033_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/pedi.12359","article-title":"Circulating matrix metalloproteinases in children with diabetic ketoacidosis","volume":"18","author":"Garro","year":"2017","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2022.07.033_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/pr.2015.215","article-title":"Dynamic regulation of plasma matrix metalloproteinases in human diabetic ketoacidosis","volume":"79","author":"Woo","year":"2016","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2022.07.033_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/pedi.12251","article-title":"Diabetic ketoacidosis in juvenile rats is associated with reactive gliosis and activation of microglia in the hippocampus","volume":"17","author":"Lo","year":"2016","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.jpeds.2022.07.033_bib20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/pedi.12396","article-title":"Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain","volume":"18","author":"Glaser","year":"2017","journal-title":"Pediatr Diabetes"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347622006990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347622006990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:13:51Z","timestamp":1758359631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347622006990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":20,"alternative-id":["S0022347622006990"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2022.07.033","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2022.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}