{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:23:14Z","timestamp":1791296594466,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006327","name":"National Institute of Radiological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS107417"],"award-info":[{"award-number":["R01 NS107417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS113921"],"award-info":[{"award-number":["R01 NS113921"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jpeds.2022.07.046","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T01:21:14Z","timestamp":1659835274000},"page":"146-153.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Plasma Biomarkers of Evolving Encephalopathy and Brain Injury in Neonates with Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1016","volume":"252","author":[{"given":"Ruoying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathinaswamy B.","family":"Govindan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen D.","family":"Everett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Perin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Vezina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Tekes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May W.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Northington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlamaine","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"O'Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"McGowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Krein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Al-Shargabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-6165","authenticated-orcid":false,"given":"An N.","family":"Massaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2022.07.046_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib3","doi-asserted-by":"crossref","first-page":"F398","DOI":"10.1136\/archdischild-2011-301524","article-title":"Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy","volume":"97","author":"Shankaran","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2022.07.046_bib4","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00401-017-1707-9","article-title":"Roles of tau protein in health and disease","volume":"133","author":"Guo","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000047946","article-title":"Serum tau protein level as a marker of axonal damage in acute ischemic stroke","volume":"47","author":"Bitsch","year":"2002","journal-title":"Eur Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.jpeds.2022.07.046_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40120-017-0073-9","article-title":"A review of fluid biomarkers for Alzheimer's Disease: moving from CSF to blood","volume":"6","author":"Blennow","year":"2017","journal-title":"Neurol Ther"},{"key":"10.1016\/j.jpeds.2022.07.046_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3233\/JAD-2009-1177","article-title":"Cerebrospinal fluid biomarkers for Alzheimer's disease","volume":"18","author":"Blennow","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jpeds.2022.07.046_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpeds.2020.06.078","article-title":"Plasma and cerebrospinal fluid candidate biomarkers of neonatal encephalopathy severity and neurodevelopmental outcomes","volume":"226","author":"Dietrick","year":"2020","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.046_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jpeds.2017.10.060","article-title":"Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy","volume":"194","author":"Massaro","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.046_bib11","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41390-021-01405-w","article-title":"Serial plasma biomarkers of brain injury in infants with neonatal encephalopathy treated with therapeutic hypothermia","volume":"90","author":"McGowan","year":"2021","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2022.07.046_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"Middeldorp","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jpeds.2013.10.067","article-title":"Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy","volume":"164","author":"Chalak","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.046_bib14","doi-asserted-by":"crossref","first-page":"251.e1","DOI":"10.1016\/j.ajog.2011.06.025","article-title":"Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling","volume":"205","author":"Ennen","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/PCC.0b013e3182720642","article-title":"Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study","volume":"14","author":"Massaro","year":"2013","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib16","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/cne.20774","article-title":"RC3\/neurogranin is expressed in pyramidal neurons of motor and somatosensory cortex in normal and denervated monkeys","volume":"493","author":"Guadano-Ferraz","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib17","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1523\/JNEUROSCI.10-12-03782.1990","article-title":"Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate","volume":"10","author":"Represa","year":"1990","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib18","doi-asserted-by":"crossref","first-page":"105380","DOI":"10.1016\/j.clineuro.2019.105380","article-title":"NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries","volume":"183","author":"Cevik","year":"2019","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.jpeds.2022.07.046_bib19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.clinbiochem.2015.05.015","article-title":"Serum neurogranin measurement as a biomarker of acute traumatic brain injury","volume":"48","author":"Yang","year":"2015","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jpeds.2022.07.046_bib20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/pd.5474","article-title":"Noninvasive assessment of fetal central nervous system insult: Potential application to prenatal diagnosis","volume":"39","author":"Goetzl","year":"2019","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jpeds.2022.07.046_bib21","doi-asserted-by":"crossref","first-page":"8419","DOI":"10.1111\/jcmm.16802","article-title":"Evaluation of putative CSF biomarkers in paediatric spinal muscular atrophy (SMA) patients before and during treatment with nusinersen","volume":"25","author":"Johannsen","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib22","doi-asserted-by":"crossref","first-page":"e2100003","DOI":"10.1002\/prca.202100003","article-title":"Proteomic discovery in sickle cell disease: Elevated neurogranin levels in children with sickle cell disease","volume":"15","author":"Lance","year":"2021","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.jpeds.2022.07.046_bib23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.jpeds.2015.08.013","article-title":"Neonatal magnetic resonance imaging pattern of brain injury as a biomarker of childhood outcomes following a trial of hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"167","author":"Shankaran","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.046_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jneumeth.2018.09.003","article-title":"Ensuring signal quality of cerebral near infrared spectroscopy during continuous longterm monitoring","volume":"309","author":"Govindan","year":"2018","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.jpeds.2022.07.046_bib25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1542\/peds.106.4.625","article-title":"Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants","volume":"106","author":"Tsuji","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2022.07.046_bib26","first-page":"1","article-title":"Comparison of Frequency- and Time-Domain Autoregulation and Vasoreactivity Indices in a Piglet Model of Hypoxia-Ischemia and Hypothermia","author":"Govindan","year":"2019","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12028-020-01150-8","article-title":"Exploratory assessment of the relationship between hemoglobin volume phase index, magnetic resonance imaging, and functional outcome in neonates with hypoxic-ischemic encephalopathy","volume":"35","author":"Massaro","year":"2021","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.jpeds.2022.07.046_bib28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib29","doi-asserted-by":"crossref","DOI":"10.1159\/000522314","article-title":"The utility of cerebral autoregulation indices in detecting severe brain injury varies by cooling treatment phase in neonates with hypoxic-ischemic encephalopathy","author":"Chen","year":"2022","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib30","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/PCC.0b013e3181fe3ec7","article-title":"Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation","volume":"12","author":"Bembea","year":"2011","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000486820","article-title":"High-dose erythropoietin for asphyxia and encephalopathy (HEAL): A randomized controlled trial - background, aims, and study protocol","volume":"113","author":"Juul","year":"2018","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2022.07.046_bib32","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0191","article-title":"High-dose erythropoietin and hypothermia for hypoxic-ischemic encephalopathy: A Phase II Trial","volume":"137","author":"Wu","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2022.07.046_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-444-64029-1.00013-8","article-title":"Biomarkers in neonatal hypoxic-ischemic encephalopathy-Review of the literature to date and future directions for research","volume":"162","author":"Murray","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3892\/etm.2016.3911","article-title":"SBDPs and Tau proteins for diagnosis and hypothermia therapy in neonatal hypoxic ischemic encephalopathy","volume":"13","author":"Wu","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jpeds.2022.07.046_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-0037-1607212","article-title":"Evolution of amplitude-integrated electroencephalogram as a predictor of outcome in term encephalopathic neonates receiving therapeutic hypothermia","volume":"35","author":"Sewell","year":"2018","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib36","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2022.07.046_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pediatrneurol.2021.10.005","article-title":"Relationship between MRI scoring systems and neurodevelopmental outcome at two years in infants with neonatal encephalopathy","volume":"126","author":"Ni Bhroin","year":"2021","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib38","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1474-4422(11)70016-3","article-title":"Treatment advances in neonatal neuroprotection and neurointensive care","volume":"10","author":"Johnston","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib39","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1203\/00006450-199705000-00001","article-title":"Reperfusion injury as the mechanism of brain damage after perinatal asphyxia","volume":"41","author":"Fellman","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2022.07.046_bib40","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1523\/JNEUROSCI.21-06-01931.2001","article-title":"Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis","volume":"21","author":"Northington","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000496602","article-title":"Hypoxia-ischemia and hypothermia independently and interactively affect neuronal pathology in neonatal piglets with short-term recovery","volume":"41","author":"O'Brien","year":"2019","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib42","doi-asserted-by":"crossref","first-page":"e0208453","DOI":"10.1371\/journal.pone.0208453","article-title":"Effects of cold on murine brain mitochondrial function","volume":"13","author":"Pamenter","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jpeds.2022.07.046_bib43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1177\/0271678X15607881","article-title":"The effects of therapeutic hypothermia on cerebral metabolism in neonates with hypoxic-ischemic encephalopathy: An in\u00a0vivo 1H-MR spectroscopy study","volume":"36","author":"Wisnowski","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jpeds.2022.07.046_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520943770","article-title":"Efficacy of different treatment times of mild cerebral hypothermia on oxidative factors and neuroprotective effects in neonatal patients with moderate\/severe hypoxic-ischemic encephalopathy","volume":"48","author":"Yang","year":"2020","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jpeds.2022.07.046_bib45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41390-019-0475-8","article-title":"Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep","volume":"88","author":"Zhou","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2022.07.046_bib46","doi-asserted-by":"crossref","first-page":"F149","DOI":"10.1136\/archdischild-2015-308733","article-title":"Hypoglycaemia and hyperglycaemia are associated with unfavourable outcome in infants with hypoxic ischaemic encephalopathy: a post hoc analysis of the CoolCap Study","volume":"101","author":"Basu","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2022.07.046_bib47","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1089\/neu.2020.7290","article-title":"Autoregulatory or fixed cerebral perfusion pressure targets in traumatic brain injury: determining which is better in an energy metabolic perspective","volume":"38","author":"Svedung Wettervik","year":"2021","journal-title":"J Neurotrauma"},{"issue":"2 Pt 2","key":"10.1016\/j.jpeds.2022.07.046_bib48","first-page":"H871","article-title":"Hypoglycemia selectively abolishes hypoxic reactivity of pial arterioles in piglets: role of adenosine","volume":"268","author":"Park","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib49","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.earlhumdev.2014.06.013","article-title":"The \u201cneurovascular unit approach\u201d to evaluate mechanisms of dysfunctional autoregulation in asphyxiated newborns in the era of hypothermia therapy","volume":"90","author":"Chalak","year":"2014","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpeds.2022.07.046_bib50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12883-015-0464-4","article-title":"A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia","volume":"15","author":"Burton","year":"2015","journal-title":"BMC Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/pr.2013.132","article-title":"Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy","volume":"74","author":"Howlett","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpeds.2022.07.046_bib52","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3389\/fnhum.2014.00266","article-title":"Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia","volume":"8","author":"Govindan","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib53","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1750-3639.1992.tb00695.x","article-title":"Effect of cerebral blood flow and cerebrovascular autoregulation on the distribution, type and extent of cerebral injury","volume":"2","author":"Greisen","year":"1992","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib54","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.resuscitation.2014.07.006","article-title":"A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest","volume":"85","author":"Lee","year":"2014","journal-title":"Resuscitation"},{"key":"10.1016\/j.jpeds.2022.07.046_bib55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000452833","article-title":"Optimizing cerebral autoregulation may decrease neonatal regional hypoxic-ischemic brain injury","volume":"39","author":"Lee","year":"2017","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.jpeds.2022.07.046_bib56","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1152\/jn.00353.2015","article-title":"Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"114","author":"Massaro","year":"2015","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib57","doi-asserted-by":"crossref","first-page":"F110","DOI":"10.1136\/fn.81.2.F110","article-title":"Abnormal cerebral haemodynamics in perinatally asphyxiated neonates related to outcome","volume":"81","author":"Meek","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2022.07.046_bib58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-3476(05)72459-8","article-title":"Vasoparalysis associated with brain damage in asphyxiated term infants","volume":"117","author":"Pryds","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2022.07.046_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3174\/ajnr.A4083","article-title":"Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury","volume":"36","author":"Tekes","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib60","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1542\/peds.92.3.365","article-title":"Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia","volume":"92","author":"van Bel","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2022.07.046_bib61","doi-asserted-by":"crossref","first-page":"662839","DOI":"10.3389\/fneur.2021.662839","article-title":"Wavelet Autoregulation Monitoring Identifies Blood Pressures Associated With Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy","volume":"12","author":"Liu","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.jpeds.2022.07.046_bib62","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nicl.2016.01.020","article-title":"Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy","volume":"11","author":"Tian","year":"2016","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.jpeds.2022.07.046_bib63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jpeds.2017.09.043","article-title":"A novel magnetic resonance imaging score predicts neurodevelopmental outcome after perinatal asphyxia and therapeutic hypothermia","volume":"192","author":"Weeke","year":"2018","journal-title":"J Pediatr"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347622006758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347622006758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:14:47Z","timestamp":1758359687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347622006758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":63,"alternative-id":["S0022347622006758"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2022.07.046","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma Biomarkers of Evolving Encephalopathy and Brain Injury in Neonates with Hypoxic-Ischemic Encephalopathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2022.07.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}