{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:39:11Z","timestamp":1791859151819,"version":"4.3.4"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","jpeds.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jpeds.2024.114220","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T06:59:07Z","timestamp":1722581947000},"page":"114220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Prolonged Beta-Lactam Infusions in Children: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"275","author":[{"given":"Annabelle","family":"Briand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Pincivy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Roumeliotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Autmizguine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Marsot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c9laine","family":"M\u00e9tras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7612-2934","authenticated-orcid":false,"given":"Celine","family":"Thibault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2024.114220_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1164\/rccm.201412-2323OC","article-title":"Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study","volume":"191","author":"Weiss","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib3","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/PCC.0000000000000225","article-title":"Pediatric severe sepsis in U.S. children's hospitals","volume":"15","author":"Balamuth","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib4","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and trends of sepsis in US hospitals using clinical vs Claims data, 2009-2014","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2024.114220_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global Incidence and mortality of hospital-treated sepsis. Current Estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib6","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Fleischmann-Struzek","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13054-020-02950-2","article-title":"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis","volume":"24","author":"Bauer","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.jpeds.2024.114220_bib8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/jamapediatrics.2018.4839","article-title":"Global case-Fatality rates in pediatric severe sepsis and septic shock: a systematic review and meta-analysis","volume":"173","author":"Tan","year":"2019","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jpeds.2024.114220_bib9","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/CCM.0000000000000509","article-title":"Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis","volume":"42","author":"Weiss","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib10","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/PCC.0000000000000254","article-title":"Pediatric severe sepsis: current trends and outcomes from the pediatric health information systems database","volume":"15","author":"Ruth","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib11","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jpeds.2024.114220_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.833189","article-title":"Pharmacodynamic thresholds for beta-lactam antibiotics: a story of Mouse versus man","volume":"13","author":"Berry","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpeds.2024.114220_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13054-019-2378-9","volume":"23","author":"Guilhaumou","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.jpeds.2024.114220_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.777854","article-title":"Beta-lactams therapeutic monitoring in septic children-what target are We Aiming for? A scoping review","volume":"10","author":"Morales Junior","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jpeds.2024.114220_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s40560-020-00504-w","article-title":"The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome","volume":"8","author":"Scharf","year":"2020","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jpeds.2024.114220_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bjae.2018.09.006","article-title":"Pharmacokinetics in sepsis","volume":"19","author":"Charlton","year":"2019","journal-title":"BJA Educ"},{"key":"10.1016\/j.jpeds.2024.114220_bib17","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1007\/s00134-014-3403-8","article-title":"Risk factors for target non-attainment during empirical treatment with beta-lactam antibiotics in critically ill patients","volume":"40","author":"De Waele","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/cid\/ciu027","article-title":"DALI: defining antibiotic levels in intensive care unit patients: are current beta-lactam antibiotic doses sufficient for critically ill patients?","volume":"58","author":"Roberts","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-0034-1398490","article-title":"Applying pharmacokinetic\/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development","volume":"36","author":"Abdul-Aziz","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib20","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1097\/CCM.0b013e318180fe62","article-title":"Antibiotic resistance--what's dosing got to do with it?","volume":"36","author":"Roberts","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib21","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1128\/AAC.02089-15","article-title":"Population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children","volume":"60","author":"Nichols","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jpeds.2024.114220_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/AAC.01260-19","article-title":"Population pharmacokinetics and safety of piperacillin-tazobactam extended infusions in infants and children","volume":"63","author":"Thibault","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jpeds.2024.114220_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/INF.0b013e31820ef3e5","article-title":"Prolonged beta-lactam infusion for gram-negative infections","volume":"30","author":"Tamma","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jpeds.2024.114220_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1473-3099(17)30615-1","article-title":"Prolonged versus short-term intravenous infusion of antipseudomonal beta-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials","volume":"18","author":"Vardakas","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/cid\/cis857","article-title":"Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin\/tazobactam: a systematic review and meta-analysis","volume":"56","author":"Falagas","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib26","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving sepsis Campaign: International guidelines for management of sepsis and septic shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3947\/ic.2016.48.2.81","article-title":"Prolonged versus intermittent infusion of beta-lactams for the treatment of Nosocomial pneumonia: a meta-analysis","volume":"48","author":"Lal","year":"2016","journal-title":"Infect Chemother"},{"key":"10.1016\/j.jpeds.2024.114220_bib28","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1128\/AAC.00174-09","article-title":"Continuous versus intermittent infusions of ceftazidime for treating exacerbation of cystic fibrosis","volume":"53","author":"Hubert","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jpeds.2024.114220_bib29","first-page":"723","article-title":"Continuous-infusion antipseudomonal Beta-lactam therapy in patients with cystic fibrosis","volume":"36","author":"Prescott","year":"2011","journal-title":"P T"},{"key":"10.1016\/j.jpeds.2024.114220_bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/phar.2617","article-title":"Scoping review of augmented renal clearance in critically ill pediatric patients","volume":"41","author":"Rhoney","year":"2021","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jpeds.2024.114220_bib31","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00467-019-04205-x","article-title":"Augmented renal clearance: a common condition in critically ill children","volume":"34","author":"Van Der Heggen","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jpeds.2024.114220_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00467-018-4120-2","article-title":"Augmented renal clearance in pediatric intensive care: are we undertreating our sickest patients?","volume":"35","author":"Dhont","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jpeds.2024.114220_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11102575","article-title":"Antimicrobial Multidrug resistance: clinical implications for infection management in critically ill patients","volume":"11","author":"Kalin","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.jpeds.2024.114220_bib34","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/1060028014566447","article-title":"Implementing extended-infusion cefepime as standard of care in a children's hospital: a prospective descriptive study","volume":"49","author":"Nichols","year":"2015","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jpeds.2024.114220_bib35","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.clinthera.2012.05.005","article-title":"System-wide implementation of the use of an extended-infusion piperacillin\/tazobactam dosing strategy: feasibility of utilization from a children's hospital perspective","volume":"34","author":"Nichols","year":"2012","journal-title":"Clin Ther"},{"key":"10.1016\/j.jpeds.2024.114220_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jac\/dkv289","article-title":"Population pharmacokinetics of meropenem administered as a prolonged infusion in children with cystic fibrosis","volume":"71","author":"Pettit","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jpeds.2024.114220_bib37","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/PCC.0000000000002198","article-title":"Surviving sepsis Campaign International guidelines for the management of septic shock and sepsis-associated organ dysfunction in children","volume":"21","author":"Weiss","year":"2020","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib38","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.recesp.2021.06.016","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"74","author":"Page","year":"2021","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.jpeds.2024.114220_bib39","series-title":"Prolonged beta-lactams in pediatrics","author":"Pincivy","year":"2023"},{"key":"10.1016\/j.jpeds.2024.114220_bib40","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jpeds.2024.114220_bib41","series-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of Nonrandomised studies in meta-Analyses","year":"2014"},{"key":"10.1016\/j.jpeds.2024.114220_bib42","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bja.2019.08.015","article-title":"Use of the GRADE approach in systematic reviews and guidelines","volume":"123","author":"Granholm","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jpeds.2024.114220_bib43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jclinepi.2019.10.013","article-title":"Meta-analyses frequently pooled different study types together: a meta-epidemiological study","volume":"118","author":"Bun","year":"2020","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jpeds.2024.114220_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-14-25","article-title":"The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method","volume":"14","author":"IntHout","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jpeds.2024.114220_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12874-015-0091-1","article-title":"Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies","volume":"15","author":"Rover","year":"2015","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jpeds.2024.114220_bib46","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1002\/sim.7411","article-title":"The Hartung-Knapp modification for random-effects meta-analysis: a useful refinement but are there any residual concerns?","volume":"36","author":"Jackson","year":"2017","journal-title":"Stat Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"key":"10.1016\/j.jpeds.2024.114220_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Software"},{"key":"10.1016\/j.jpeds.2024.114220_bib49","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijid.2021.05.044","article-title":"Comparison of piperacillin plasma concentrations in a prospective randomized trial of extended infusion versus intermittent bolus of piperacillin\/tazobactam in paediatric patients","volume":"108","author":"Chongcharoenyanon","year":"2021","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib50","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S1473-3099(11)70055-X","article-title":"Slow initial \u03b2-lactam infusion and oral paracemol to treat childhood bacterial meningitis: a randomised, controlled trial","volume":"11","author":"Pelkonen","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib51","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/cid\/ciaa341","article-title":"Extended continuous \u03b2-lactam infusion with oral Acetaminophen in childhood bacterial meningitis: a randomized, Double-blind clinical trial","volume":"72","author":"Savonius","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib52","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/INF.0000000000001445","article-title":"Conventional versus prolonged infusion of meropenem in neonates with gram-negative late-onset sepsis: a randomized controlled trial","volume":"36","author":"Shabaan","year":"2017","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jpeds.2024.114220_bib53","first-page":"283","article-title":"Piperacillin\/Tazobactam in continuous INFUSION versus Intermittent Infusion in children with febrile neutropenia","volume":"71","author":"Sol\u00f3rzano-Santos","year":"2019","journal-title":"Rev Invest Clin"},{"key":"10.1016\/j.jpeds.2024.114220_bib54","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/IPC.0000000000000767","article-title":"Outcomes of extended infusion cefepime in pediatric patients","volume":"27","author":"Beauchamp","year":"2019","journal-title":"Infect Dis Clin Pract"},{"key":"10.1016\/j.jpeds.2024.114220_bib55","article-title":"Extended infusion of meropenem in neonatal sepsis: a Historical cohort study","volume":"11","author":"Cao","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jpeds.2024.114220_bib56","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/ppul.25817","article-title":"Evaluation of the safety of cefepime prolonged infusions in pediatric patients with cystic fibrosis","volume":"57","author":"Imburgia","year":"2022","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpeds.2024.114220_bib57","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/ppul.26299","article-title":"Evaluation of the safety of piperacillin-tazobactam extended infusion in pediatric cystic fibrosis patients","volume":"58","author":"Riggsbee","year":"2023","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpeds.2024.114220_bib58","first-page":"677","article-title":"Extended infusion \u03b2-lactams for the treatment of gram-negative bacteremia in children","volume":"27","author":"Zembles","year":"2022","journal-title":"J Pediatr Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2024.114220_bib59","first-page":"187","article-title":"Extended infusion of beta-lactams is associated with improved outcomes in pediatric patients","volume":"26","author":"Zembles","year":"2021","journal-title":"J Pediatr Pharmacol Ther"},{"key":"10.1016\/j.jpeds.2024.114220_bib60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijid.2022.04.052","article-title":"Therapeutic drug monitoring of meropenem and pharmacokinetic-pharmacodynamic target assessment in critically ill pediatric patients from a prospective observational study","volume":"120","author":"Maimongkol","year":"2022","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib61","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1128\/AAC.00655-12","article-title":"Short versus long infusion of meropenem in very-low-birth-weight neonates","volume":"56","author":"Padari","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jpeds.2024.114220_bib62","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1164\/rccm.201601-0024OC","article-title":"Continuous versus intermittent beta-lactam infusion in severe sepsis. A meta-analysis of individual patient data from randomized trials","volume":"194","author":"Roberts","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib63","first-page":"1","article-title":"Comparing prolonged infusion to intermittent infusion strategies for beta-lactam antibiotics in patients with gram-negative bacterial infections: a systematic review and meta-analysis","author":"Lin","year":"2024","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jpeds.2024.114220_bib64","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13613-024-01263-9","article-title":"Prolonged versus intermittent beta-lactam infusion in sepsis: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Zhao","year":"2024","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jpeds.2024.114220_bib65","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1097\/CCM.0000000000003342","article-title":"Epidemiology and Costs of sepsis in the United States-an analysis based on timing of diagnosis and severity level","volume":"46","author":"Paoli","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib66","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1875041901104010004","article-title":"Pediatric Sepsis - Part I: \"Children are not small adults!\"","volume":"4","author":"Wheeler","year":"2011","journal-title":"Open Inflamm J"},{"key":"10.1016\/j.jpeds.2024.114220_bib67","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/CCM.0000000000002817","article-title":"Beta-lactam therapeutic drug management in the PICU","volume":"46","author":"Cies","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpeds.2024.114220_bib68","article-title":"Pharmacokinetics of drugs: newborn perspective","volume":"7","author":"Bansal","year":"2023","journal-title":"Pediatric Medicine"},{"key":"10.1016\/j.jpeds.2024.114220_bib69","doi-asserted-by":"crossref","DOI":"10.7573\/dic.212608","article-title":"Neonatal pharmacology and clinical implications","volume":"8","author":"Ruggiero","year":"2019","journal-title":"Drugs Context"},{"key":"10.1016\/j.jpeds.2024.114220_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102293","article-title":"Extended infusion of beta-lactams significantly reduces mortality and enhances microbiological eradication in paediatric patients: a systematic review and meta-analysis","volume":"65","author":"Budai","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jpeds.2024.114220_bib71","article-title":"Extended infusion of beta-lactams and Glycopeptides: a new Era in pediatric care? A systematic review and meta-analysis","volume":"13","author":"Burch","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jpeds.2024.114220_bib72","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/PL00008370","article-title":"Continuous infusion of ceftazidime with a portable pump is as effective as thrice-a-day bolus in cystic fibrosis children","volume":"159","author":"Rappaz","year":"2000","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2024.114220_bib73","author":"Fuentes"},{"key":"10.1016\/j.jpeds.2024.114220_bib74","first-page":"S214","article-title":"Extended INFUSION OF beta-lactams IN the TREATMENT OF acute pulmonary exacerbations IN cystic fibrosis: a PILOT evaluation OF safety and efficacy outcomes","volume":"52","author":"Repholz","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpeds.2024.114220_bib75","first-page":"372","article-title":"Efficacy of prolonged intravenous infusion duration of meropenem on neonatal late-onset sepsis","volume":"40","author":"Li","year":"2018","journal-title":"Guangxi Med J"},{"key":"10.1016\/j.jpeds.2024.114220_bib76","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00431-022-04716-0","article-title":"Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study","volume":"182","author":"Debray","year":"2023","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jpeds.2024.114220_bib77","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.therap.2020.04.007","article-title":"Are beta-lactam concentrations adequate in severe sepsis and septic shock in children?","volume":"75","author":"Chosidow","year":"2020","journal-title":"Therapie"},{"key":"10.1016\/j.jpeds.2024.114220_bib78","series-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.4 (updated August 2023)","article-title":"Chapter 24: including non-randomized studies on intervention effects","author":"Reeves","year":"2023"},{"key":"10.1016\/j.jpeds.2024.114220_bib79","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.drup.2011.02.005","article-title":"Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective","volume":"14","author":"Mouton","year":"2011","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.jpeds.2024.114220_bib80","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciad428","article-title":"Infectious diseases Society of America 2023 guidance on the treatment of antimicrobial resistant gram-negative infections","author":"Tamma","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib81","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrmicro862","article-title":"Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'","volume":"2","author":"Drusano","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jpeds.2024.114220_bib82","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1093\/infdis\/jiaa118","article-title":"Optimizing pharmacokinetics-pharmacodynamics of antimicrobial management in patients with sepsis: a review","volume":"222","author":"Phe","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jpeds.2024.114220_bib83","article-title":"Prolonged administration of beta-lactam antibiotics - a comprehensive review and critical appraisal","volume":"146","author":"Osthoff","year":"2016","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.jpeds.2024.114220_bib84","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/17425255.2021.1836157","article-title":"The pharmacokinetics of antibiotics in cystic fibrosis","volume":"17","author":"Akkerman-Nijland","year":"2021","journal-title":"Expert Opin Drug Metab Toxicol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347624003238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347624003238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T02:57:07Z","timestamp":1731121027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347624003238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":84,"alternative-id":["S0022347624003238"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2024.114220","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged Beta-Lactam Infusions in Children: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2024.114220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114220"}}