{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:43:41Z","timestamp":1793313821977,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jpeds.2026.115044","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:12:03Z","timestamp":1771546323000},"page":"115044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Initial Hemodynamic Phenotypes and Clinical Trajectory in Congenital Diaphragmatic Hernia: A Pilot Study"],"prefix":"10.1016","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-6449","authenticated-orcid":false,"suffix":"Jr.","given":"John T.","family":"Wren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael M.","family":"Hyland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-8872","authenticated-orcid":false,"given":"Patrick J.","family":"Mcnamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2026.115044_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/wjps-2024-000835","article-title":"Fetal therapy for congenital diaphragmatic hernia: past, present and future","volume":"7","author":"Abbasi","year":"2024","journal-title":"World J Pediatr Surg"},{"key":"10.1016\/j.jpeds.2026.115044_bib2","first-page":"2112","article-title":"Fetal surgery for severe left diaphragmatic hernia","volume":"385","author":"Deprest","year":"2021","journal-title":"Reply N Engl J Med"},{"key":"10.1016\/j.jpeds.2026.115044_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpeds.2019.09.052","article-title":"Inhaled nitric oxide is associated with improved oxygenation in a subpopulation of infants with congenital diaphragmatic hernia and pulmonary hypertension","volume":"219","author":"Lawrence","year":"2020","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2026.115044_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.890422","article-title":"The heart in congenital diaphragmatic hernia: knowns, unknowns, and future priorities","volume":"10","author":"Patel","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jpeds.2026.115044_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/wjps-2024-000789","article-title":"Lung-protective ventilation in the management of congenital diaphragmatic hernia","volume":"7","author":"Traynor","year":"2024","journal-title":"World J Pediatr Surg"},{"key":"10.1016\/j.jpeds.2026.115044_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2022.101383","article-title":"Diagnosis & management of pulmonary hypertension in congenital diaphragmatic hernia","volume":"27","author":"Bhombal","year":"2022","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.jpeds.2026.115044_bib7","doi-asserted-by":"crossref","first-page":"e720","DOI":"10.1542\/neo.24-11-e720","article-title":"Unique cardiopulmonary interactions in congenital diaphragmatic hernia: physiology and therapeutic implications","volume":"24","author":"Johng","year":"2023","journal-title":"Neoreviews"},{"key":"10.1016\/j.jpeds.2026.115044_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/wjps-2024-000790","article-title":"Hemodynamic management of congenital diaphragmatic hernia: the role of targeted neonatal echocardiography","volume":"7","author":"Surak","year":"2024","journal-title":"World J Pediatr Surg"},{"key":"10.1016\/j.jpeds.2026.115044_bib9","first-page":"54","article-title":"Hemodynamic phenotypes in congenital diaphragmatic hernia and their association with morbidity and mortality","volume":"82","author":"Ibarra-Rios","year":"2025","journal-title":"Bol Med Hosp Infant Mex"},{"key":"10.1016\/j.jpeds.2026.115044_bib10","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1542\/peds.99.6.838","article-title":"Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. The Neonatal Inhaled Nitric Oxide Study Group (NINOS)","volume":"99","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2026.115044_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41372-023-01807-0","article-title":"The impact of a care bundle with an emphasis on hemodynamic assessment on the short-term outcomes in neonates with congenital diaphragmatic hernia","volume":"44","author":"Kuan","year":"2024","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2026.115044_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/echo.70189","article-title":"Safety and feasibility of early targeted neonatal echocardiography and a focused assessment protocol in neonates with congenital diaphragmatic hernia","volume":"42","author":"Wren","year":"2025","journal-title":"Echocardiography"},{"key":"10.1016\/j.jpeds.2026.115044_bib13","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/s41372-025-02362-6","article-title":"Clinical outcomes after implementation of a physiologic pre-operative management strategy in neonates with congenital diaphragmatic hernia","volume":"45","author":"Byrd","year":"2025","journal-title":"J Perinatol"},{"key":"10.1016\/j.jpeds.2026.115044_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.echo.2023.11.016","article-title":"Guidelines and recommendations for targeted neonatal echocardiography and cardiac point-of-care ultrasound in the neonatal intensive care unit: an update from the American society of echocardiography","volume":"37","author":"McNamara","year":"2024","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jpeds.2026.115044_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.sempedsurg.2024.151438","article-title":"Cardiac function in congenital diaphragmatic hernia","volume":"33","author":"Altit","year":"2024","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpeds.2026.115044_bib30","doi-asserted-by":"crossref","first-page":"F304","DOI":"10.1136\/adc.2009.175109","article-title":"Assessment of myocardial function in neonates using tissue Doppler imaging","volume":"97","author":"Negrine","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2026.115044_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000322006","article-title":"Systolic right ventricular function in preterm and term neonates: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 258 patients and calculation of Z-score values","volume":"100","author":"Koestenberger","year":"2011","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2026.115044_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpeds.2019.12.037","article-title":"Implications of atrial-level shunting by echocardiography in newborns with congenital diaphragmatic hernia","volume":"219","author":"Wehrmann","year":"2020","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2026.115044_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2024.114061","article-title":"Congenital diaphragmatic hernia patients with left heart hypoplasia and left ventricular dysfunction have highest odds of mortality","volume":"271","author":"Fraga","year":"2024","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2026.115044_bib18","article-title":"Longitudinal changes of left ventricular hypoplasia and ventricular disproportion in congenital diaphragmatic hernia neonates","author":"Pugnaloni","year":"2025","journal-title":"J Perinat Med"},{"key":"10.1016\/j.jpeds.2026.115044_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpedsurg.2025.162423","article-title":"Revisiting inhaled nitric oxide utilization in congenital diaphragmatic hernia: a national cohort study of major children's hospitals in the United States","volume":"60","author":"Sescleifer","year":"2025","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpeds.2026.115044_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jss.2019.05.007","article-title":"Toward standardized management of congenital diaphragmatic hernia: an analysis of practice guidelines","volume":"243","author":"Jancelewicz","year":"2019","journal-title":"J Surg Res"},{"key":"10.1016\/j.jpeds.2026.115044_bib21","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.3390\/ijms22094937","article-title":"Traditional and emerging biomarkers in asymptomatic left ventricular dysfunction-promising non-coding RNAs and exosomes as biomarkers in early phases of cardiac damage","volume":"22","author":"Janjusevic","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jpeds.2026.115044_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2024.101535","article-title":"microRNAs in congenital diaphragmatic hernia: insights into prenatal and perinatal biomarkers and altered molecular pathways","volume":"6","author":"Bardill","year":"2024","journal-title":"Am J Obstet Gynecol MFM"},{"key":"10.1016\/j.jpeds.2026.115044_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/archdischild-2023-325865","article-title":"Diagnosis and management of congenital diaphragmatic hernia: a 2023 update from the Canadian Congenital Diaphragmatic Hernia Collaborative","volume":"109","author":"Puligandla","year":"2024","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.jpeds.2026.115044_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000444210","article-title":"Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO consortium consensus - 2015 update","volume":"110","author":"Snoek","year":"2016","journal-title":"Neonatology"},{"key":"10.1016\/j.jpeds.2026.115044_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2025.114510","article-title":"Are early, frequent echocardiograms necessary to improve outcomes of neonates with congenital diaphragmatic hernia?","volume":"280","author":"Yang","year":"2025","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2026.115044_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2023.113490","article-title":"Failure to normalize biventricular function is associated with extracorporeal membrane oxygenation use in neonates with congenital diaphragmatic hernia","volume":"260","author":"Le","year":"2023","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpeds.2026.115044_bib27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/PCC.0000000000002318","article-title":"Early left ventricular dysfunction and severe pulmonary hypertension predict adverse outcomes in \"Low-Risk\" congenital diaphragmatic hernia","volume":"21","author":"Dao","year":"2020","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jpeds.2026.115044_bib28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/archdischild-2024-326906","article-title":"Disease severity impacts perceived quality of life in congenital diaphragmatic hernia: a prospective observational study","volume":"109","author":"Dimmer","year":"2024","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2026.115044_bib29","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41372-025-02265-6","article-title":"Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review","volume":"45","author":"Wren","year":"2025","journal-title":"J Perinatol"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347626000727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347626000727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T20:22:54Z","timestamp":1779481374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347626000727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"alternative-id":["S0022347626000727"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2026.115044","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Initial Hemodynamic Phenotypes and Clinical Trajectory in Congenital Diaphragmatic Hernia: A Pilot Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2026.115044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115044"}}