{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:35:09Z","timestamp":1793028909684,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpeds.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pediatrics"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jpeds.2026.115361","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:33Z","timestamp":1791330033000},"page":"115361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characterizing Pediatric Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Symptom Burden, Functional Impairment, and Comparison with Adults in the Multisite Clinical Assessment of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome Study"],"prefix":"10.1016","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-6004","authenticated-orcid":false,"given":"Stephanie Sargent","family":"Weaver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-6694","authenticated-orcid":false,"given":"Joanna J.","family":"Regan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindita","family":"Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-1056","authenticated-orcid":false,"given":"Elizabeth A.","family":"Fall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2853-9959","authenticated-orcid":false,"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-6593","authenticated-orcid":false,"given":"Jin-Mann S.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-5635","authenticated-orcid":false,"given":"Elizabeth R.","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpeds.2026.115361_bib1","series-title":"Beyond myalgic encephalomyelitis\/chronic fatigue syndrome: redefining an illness","year":"2015"},{"key":"10.1016\/j.jpeds.2026.115361_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fped.2017.00121","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome diagnosis and management in young people: a primer","volume":"5","author":"Rowe","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jpeds.2026.115361_bib3","series-title":"Myalgic encephalomyelitis (or encephalopathy)\/chronic fatigue syndrome: diagnosis and management. NICE guideline NG206","year":"2021"},{"key":"10.1016\/j.jpeds.2026.115361_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1542\/peds.2008-1879","article-title":"Chronic fatigue syndrome following infectious mononucleosis in adolescents","volume":"124","author":"Katz","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2026.115361_bib5","doi-asserted-by":"crossref","first-page":"e1169","DOI":"10.1542\/peds.2010-1147","article-title":"Adolescent chronic fatigue syndrome: prevalence, incidence, and morbidity","volume":"127","author":"Nijhof","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpeds.2026.115361_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/jamapediatrics.2013.4647","article-title":"Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial","volume":"168","author":"Sulheim","year":"2014","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jpeds.2026.115361_bib7","first-page":"536","article-title":"The impact of CFS\/ME on employment and productivity in youth and young adults","volume":"96","author":"Collin","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpeds.2026.115361_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fped.2018.00302","article-title":"School functioning in adolescents with chronic fatigue syndrome","volume":"6","author":"Knight","year":"2018","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jpeds.2026.115361_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fped.2019.00026","article-title":"Health-related quality of life in adolescents with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"7","author":"Roma","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jpeds.2026.115361_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/aje\/kwx029","article-title":"Multi-site clinical assessment of myalgic encephalomyelitis\/chronic fatigue syndrome (MCAM): design and implementation of a prospective\/retrospective rolling cohort study","volume":"185","author":"Unger","year":"2017","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jpeds.2026.115361_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-7954-3-8","article-title":"Psychometric properties of the CDC Symptom Inventory for assessment of chronic fatigue syndrome","volume":"3","author":"Wagner","year":"2005","journal-title":"Popul Health Metr"},{"key":"10.1016\/j.jpeds.2026.115361_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item Short-Form Health Survey (SF-36): I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"10.1016\/j.jpeds.2026.115361_bib13","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1097\/00007632-200012150-00008","article-title":"SF-36 health survey update","volume":"25","author":"Ware","year":"2000","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jpeds.2026.115361_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","article-title":"The Multidimensional Fatigue Inventory (MFI): psychometric qualities of an instrument to assess fatigue","volume":"39","author":"Smets","year":"1995","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.jpeds.2026.115361_bib15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1478-7954-7-18","article-title":"Further validation of the multidimensional fatigue inventory in a US adult population sample","volume":"7","author":"Lin","year":"2009","journal-title":"Popul Health Metr"},{"key":"10.1016\/j.jpeds.2026.115361_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1300\/J092v13n02_01","article-title":"A pediatric case definition for myalgic encephalomyelitis and chronic fatigue syndrome","volume":"13","author":"Jason","year":"2006","journal-title":"J Chronic Fatigue Syndr"},{"key":"10.1016\/j.jpeds.2026.115361_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4137\/CMPed.S978","article-title":"A case definition for children with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"1","author":"Jason","year":"2008","journal-title":"Clin Med Pediatr"},{"key":"10.1016\/j.jpeds.2026.115361_bib18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7175\/rhc.v3i4.280","article-title":"Pediatric myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"3","author":"Jason","year":"2012","journal-title":"Rev Health Care"},{"key":"10.1016\/j.jpeds.2026.115361_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3844\/ajbbsp.2010.120.135","article-title":"The development of a revised Canadian myalgic encephalomyelitis chronic fatigue syndrome case definition","volume":"6","author":"Jason","year":"2010","journal-title":"Am J Biochem Biotechnol"},{"key":"10.1016\/j.jpeds.2026.115361_bib20","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.23555","article-title":"Myalgic encephalomyelitis\/Chronic fatigue syndrome after SARS-CoV-2 infection","volume":"7","author":"Unger","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jpeds.2026.115361_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3102\/10769986006002107","article-title":"Distribution theory for Glass's estimator of effect size and related estimators","volume":"6","author":"Hedges","year":"1981","journal-title":"J Educ Stat"},{"key":"10.1016\/j.jpeds.2026.115361_bib22","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.jpeds.2026.115361_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1266738","article-title":"One-year follow-up of young people with ME\/CFS following infectious mononucleosis by Epstein-Barr virus","volume":"11","author":"Pricoco","year":"2024","journal-title":"Front Pediatr"},{"key":"10.1016\/j.jpeds.2026.115361_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-089038","article-title":"Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (SPOT-ME): protocol for a prospective pediatric cohort study","volume":"14","author":"Thomas","year":"2024","journal-title":"BMJ Open"}],"container-title":["The Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347626003896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022347626003896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:54:17Z","timestamp":1793026457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022347626003896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":24,"alternative-id":["S0022347626003896"],"URL":"https:\/\/doi.org\/10.1016\/j.jpeds.2026.115361","relation":{},"ISSN":["0022-3476"],"issn-type":[{"value":"0022-3476","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterizing Pediatric Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Symptom Burden, Functional Impairment, and Comparison with Adults in the Multisite Clinical Assessment of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpeds.2026.115361","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115361"}}