{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:37:36Z","timestamp":1781951856896,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.jpedsurg.2007.05.015","type":"journal-article","created":{"date-parts":[[2007,9,11]],"date-time":"2007-09-11T11:08:46Z","timestamp":1189508926000},"page":"1623-1626","source":"Crossref","is-referenced-by-count":26,"title":["Medullary thyroid carcinoma in a 2-month-old male with multiple endocrine neoplasia 2B and symptoms of pseudo-Hirschsprung disease: a case report"],"prefix":"10.1016","volume":"42","author":[{"given":"Annika","family":"Unruh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Fitze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"J\u00e4nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bielack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Lochb\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiltrud","family":"Coerdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2007.05.015_bib1","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1038\/sj.onc.1209669","article-title":"Evaluation of potential mechanisms underlying genotype-phenotype correlations in multiple endocrine neoplasia type 2","volume":"25","author":"Mise","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/00000658-200205000-00006","article-title":"Gastrointestinal manifestations of multiple endocrine neoplasia type 2","volume":"235","author":"Cohen","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/hmg\/7.1.129","article-title":"Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation","volume":"7","author":"Decker","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib4","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1093\/hmg\/3.12.2163","article-title":"Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene","volume":"3","author":"Mulligan","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0039-6060(05)80057-1","article-title":"Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease","volume":"117","author":"Borst","year":"1995","journal-title":"Surgery"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1046\/j.1365-2796.1998.00332.x","article-title":"Association of multiple endocrine neoplasia type 2 and Hirschsprung disease","volume":"243","author":"Romeo","year":"1998","journal-title":"J Intern Med"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2214\/ajr.140.1.73","article-title":"Multiple endocrine neoplasia (MEN) syndrome type IIB: gastrointestinal manifestations","volume":"140","author":"Demos","year":"1983","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-3468(96)90343-7","article-title":"Medullary thyroid carcinoma in children with multiple endocrine neoplasia types 2A and 2B","volume":"31","author":"Skinner","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cncr.10205","article-title":"Medullary thyroid carcinoma as part of a multiple endocrine neoplasia type 2B syndrome: influence of the stage on the clinical course","volume":"94","author":"Leboulleux","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/0009922806289625","article-title":"Metastatic medullary thyroid cancer in a pediatric patient with MEN 2B: emphasis on the need for early recognition of extrathyroidal clinical findings associated with MEN 2B","volume":"45","author":"Barrows","year":"2006","journal-title":"Clin Pediatr"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jpedsurg.2005.11.023","article-title":"An association of multiple endocrine neoplasia 2B, a RET mutation; constipation; and low substance P-nerve fiber density in colonic circular muscle","volume":"41","author":"King","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/gut.45.1.143","article-title":"Intestinal ganglioneuromatosis and multiple endocrine neoplasia type 2B: implications for treatment","volume":"45","author":"Smith","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib13","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/1097-0142(19911015)68:8<1832::AID-CNCR2820680832>3.0.CO;2-Z","article-title":"Multiple endocrine syndrome type IIb in early childhood","volume":"68","author":"Samaan","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/archsurg.138.4.409","article-title":"Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship","volume":"138","author":"Yip","year":"2003","journal-title":"Arch Surg"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cncr.10228","article-title":"Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of c-cell malignant disease in asymptomatic carriers","volume":"94","author":"Sanso","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0022-3468(99)90075-1","article-title":"Predictive DNA testing for multiple endocrine neoplasia 2: a therapeutic challenge of prophylactic thyroidectomy in very young children","volume":"34","author":"van Heurn","year":"1999","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib17","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00268-004-7637-4","article-title":"Multiple endocrine neoplasia 2B syndrome due to codon 918 mutation: clinical manifestation and course in early and late onset disease","volume":"28","author":"Brauckhoff","year":"2004","journal-title":"World J Surg"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2350\/06-05-0072.1","article-title":"Multiple endocrine neoplasia type 2B diagnosed on suction rectal biopsy in infancy: a report of 2 cases","volume":"9","author":"Yin","year":"2006","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00383-002-0824-1","article-title":"Diagnostic and therapeutic approach to multiple endocrine neoplasia type 2B in pediatric patients","volume":"18","author":"Torre","year":"2002","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib20","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jc.86.12.5658","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib21","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJM197612022952304","article-title":"Alimentary-tract ganglioneuromatosis. A major component of the syndrome of multiple endocrine neoplasia, type 2b","volume":"295","author":"Carney","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00004836-198302000-00018","article-title":"Gastrointestinal manifestations of multiple endocrine neoplasia, type IIB","volume":"5","author":"Barwick","year":"1983","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib23","first-page":"783","article-title":"Multiple endocrine neoplasia 2B presenting with pseudo-Hirschsprung's disease","volume":"98","author":"Erdogan","year":"2006","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.jpedsurg.2007.05.015_bib24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jpedsurg.2006.10.005","article-title":"Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2","volume":"42","author":"Moore","year":"2007","journal-title":"J Pediatr Surg"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346807003533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346807003533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T05:56:43Z","timestamp":1546581403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346807003533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0022346807003533"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.05.015","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}