{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:50:29Z","timestamp":1760982629365},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.jpedsurg.2008.01.005","type":"journal-article","created":{"date-parts":[[2008,6,15]],"date-time":"2008-06-15T19:08:23Z","timestamp":1213556903000},"page":"1191-1195","source":"Crossref","is-referenced-by-count":63,"title":["Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids)"],"prefix":"10.1016","volume":"43","author":[{"given":"George","family":"Ekema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Falchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Boroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rita","family":"Tanca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Altana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Righetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Ridella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gambarotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Berchich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2008.01.005_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1542\/peds.2005-2662","article-title":"Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management","volume":"118","author":"Gura","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.clnu.2005.05.020","article-title":"Use of a fish oil\u2013based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutrition","volume":"24","author":"Gura","year":"2005","journal-title":"Clin Nutr"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-3476(71)80289-5","article-title":"Total parenteral nutrition","volume":"78","author":"Peden","year":"1971","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0022-3468(75)90098-6","article-title":"Hepatic secretory obstruction with total parenteral nutrition in the infant","volume":"10","author":"Touloukian","year":"1975","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1542\/peds.63.1.110","article-title":"Liver disease in infants receiving total perenteral nutrition","volume":"63","author":"Postuma","year":"1979","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0022-3468(85)80236-0","article-title":"TPN-associated hyperbilirubinemia: a common problem in newborn surgical patients","volume":"20","author":"Ginn Pease","year":"1985","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib7","first-page":"256","article-title":"Total parenteral nutrition related cholestasis in infants","volume":"10","author":"Bell","year":"1986","journal-title":"JPEN J Parenter Enter Nut"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib8","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/archpedi.1981.02130330052017","article-title":"Hyperalimentation-induced cholestasis, increased incidence and severity of premature infants","volume":"135","author":"Pereira","year":"1981","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1053\/jpsu.2000.7769","article-title":"Total parenteral nutrition-associated intrahepatic cholestasis in infants: 25 years' experience","volume":"35","author":"Kubota","year":"2000","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1542\/peds.62.6.984","article-title":"Cholestatic tendencies in premature infants on and off parenteral nutrition","volume":"62","author":"Sondheimer","year":"1978","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1542\/peds.64.3.342","article-title":"Intrahepatic cholestasis associated with parenteral nutrition in premature infants","volume":"64","author":"Beale","year":"1979","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1177\/0148607188012006602","article-title":"Hyperbilurubinemia in neonates associated with total parenteral nutrition","volume":"12","author":"Kubota","year":"1996","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0022-3468(96)90507-2","article-title":"Parenteral nutrition-related cholestasis in postsurgical neonates: multivariate analysis of risk factors","volume":"31","author":"Beath","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0022-3476(75)80486-0","article-title":"Cholestasis in immature infants: is parenteral alimentation responsible","volume":"86","author":"Ragar","year":"1975","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/ajcp\/76.3.276","article-title":"Hepatobiliary dysfunction in infants and children associated with long-term total parenteral nutrition. A clinico-pathological study","volume":"76","author":"Benjamin","year":"1981","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/gut.24.3.241","article-title":"Total parenteral nutrition in infancy: effects on the liver and suggested pathogenesis","volume":"24","author":"Hughes","year":"1983","journal-title":"Gut"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00005176-198601000-00004","article-title":"Cholestasis associated with total parenteral nutrition","volume":"5","author":"Merritt","year":"1986","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00000658-198501000-00013","article-title":"Multiple systems organ failure. Modulation of hepatocyte protein synthesis by endotoxin activated Kupffer cells","volume":"201","author":"Keller","year":"1985","journal-title":"Ann Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib19","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/hep.1840100523","article-title":"Intestinal endotoxins as mediators of hepatic injury\u2014an idea whose time has come again","volume":"10","author":"Nolan","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00005176-198904000-00006","article-title":"Bacterial infection: the main cause of acute cholestasis in newborn infants receiving short-term parenteral nutrition","volume":"8","author":"Wolf","year":"1989","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0022-3468(82)80090-0","article-title":"Hepatic failure in infants on total parenteral nutrition (TPN) clinical and histopathologic observations","volume":"17","author":"Hodes","year":"1982","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/adc.84.4.295","article-title":"Nutritional support at home and in the community","volume":"84","author":"Puntis","year":"2001","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib23","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI105432","article-title":"Production of bile duct hyperplasia and gallstones by lithocholic acid","volume":"45","author":"Palmer","year":"1964","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib24","first-page":"292","article-title":"Bile acid metabolism in mammals. Ultrastructural studies on the intrahepatic cholestasis induced by lithocholic and chenodeoxycholic acids in the rat","volume":"24","author":"Miyai","year":"1971","journal-title":"Lab Invest"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib25","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0022-3476(80)80573-7","article-title":"Prospective controlled study of parenteral nutrition-associated cholestatic jaundice: effect of protein intake","volume":"96","author":"Vileisis","year":"1980","journal-title":"Pediatics"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib26","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0022-4804(79)90012-X","article-title":"Abnormal liver function during parenteral nutrition: relation to infusion excess","volume":"26","author":"Lowry","year":"1979","journal-title":"J Surg Res"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0022-3468(84)80276-6","article-title":"Taurine deficiency in the severe hepatic dysfunction complicating total parenteral nutrition","volume":"19","author":"Cooper","year":"1984","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib28","first-page":"641","article-title":"Cholestasis caused by lipid emulsions","volume":"154","author":"Allardyce","year":"1982","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0899-9007(97)00233-5","article-title":"The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition","volume":"14","author":"Clayton","year":"1998","journal-title":"Nutrition"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0016-5085(81)90663-6","article-title":"Serial liver biopsies in parenteral nutrition associated cholestasis in early infancy","volume":"81","author":"Dahms","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0095-5108(18)30847-9","article-title":"Parenteral nutrition and hepatobiliary dysfunction","volume":"13","author":"Farrel","year":"1986","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0022-3468(95)90758-0","article-title":"Total parenteral nutrition-associated cholestasis in surgical neonates may be reversed by intravenous cholecystokinin: a preliminary report","volume":"30","author":"Rintala","year":"1995","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib33","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/0022-3468(90)90347-C","article-title":"The effect of metronidazole on TPN-associated liver dysfunction in neonates","volume":"25","author":"Kubota","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib34","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1023\/A:1010611920750","article-title":"Combination therapy with Bifidobacterium breve, Lactobacillus casei and galacto-oligosacharidis dramatically improved the intestinal function in a girl with short-bowel syndrome: a novel symbiotic therapy for intestinal failure","volume":"46","author":"Kanamori","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib35","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0022-3468(85)80042-7","article-title":"Resolution of intractable cholestasis associated with total parenteral nutrition following biliary irrigation","volume":"20","author":"Cooper","year":"1985","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib36","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/0022-3468(93)90040-R","article-title":"Surgical treatment of intractable cholestasis associated with total parenteral nutrition in premature infants","volume":"28","author":"Rintala","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib37","first-page":"2699","article-title":"Rapid development of hyperbilirubinemia in infants with the short bowel syndrome as a correlate to mortality: possible indication for early small bowel transplantation","volume":"26","author":"Teitelbaum","year":"1996","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0899-9007(97)00233-5","article-title":"The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition","volume":"14","author":"Clayton","year":"1998","journal-title":"Nutrition"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib39","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00005176-200005000-00014","article-title":"Effect of intravenous lipid emulsions on hepatic cholesterol metabolism","volume":"30","author":"Whitfield","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib40","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/hep.21626","article-title":"Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines","volume":"45","author":"Schm\u00f6cker","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib41","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/hep.21625","article-title":"Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids","volume":"45","author":"El-Badry","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib42","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1096\/fj.06-6250fje","article-title":"Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective liver mediators: protectin D1 and 17S-hydroxy-DHA","volume":"20","author":"Gonzalez-Periz","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jpedsurg.2008.01.005_bib43","first-page":"1014","article-title":"The role of enteral nutrition in the reversal of parenteral nutrition\u2014associated liver dysfunction in infants","volume":"49","author":"Javid","year":"2005","journal-title":"J Pediatr Surg"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346808000110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346808000110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:32:30Z","timestamp":1684441950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346808000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0022346808000110"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2008.01.005","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}