{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:34:43Z","timestamp":1762979683857},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jpedsurg.2008.08.005","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T04:41:11Z","timestamp":1239165671000},"page":"773-782","source":"Crossref","is-referenced-by-count":6,"title":["Mucosal nerve deficiency in chronic childhood constipation: a postmigration defect?"],"prefix":"10.1016","volume":"44","author":[{"given":"Gwen","family":"Wendelschafer-Crabb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishala","family":"Neppalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Jessurun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Vance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Saltzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Acton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2008.08.005_bib1","first-page":"105","article-title":"Biofeedback treatment for chronic constipation and encopresis in childhood: long-term outcome","volume":"96","author":"Loening-Baucke","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0016-5085(85)80128-1","article-title":"Severe idiopathic constipation is associated with a distinctive abnormality of the colonic myenteric plexus","volume":"88","author":"Krishnamurthy","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib3","first-page":"41","article-title":"Substance P in rectal mucosa of children with chronic constipation","volume":"31","author":"Granot","year":"2001","journal-title":"Acta Gastroenterol Latinoam"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0022-3468(96)90501-1","article-title":"Intractable constipation with a decrease in substance P-immunoreactive fibres: is it a variant of intestinal neuronal dysplasia","volume":"31","author":"Hutson","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s003830100687","article-title":"Colonic mucosal vasoactive intestinal peptide receptors in malformations of the enteric nervous system are reduced compared with morphologically normal innervated colon","volume":"18","author":"Schmittenbecher","year":"2002","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jpedsurg.2003.09.007","article-title":"Is there a role for surgery beyond colonic aganglionosis and anorectal malformations in children with intractable constipation","volume":"39","author":"Youssef","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib7","series-title":"The enteric nervous system and its extrinsic connections","author":"Furness","year":"1999"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib8","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1097\/01.mcg.0000156403.37240.30","article-title":"Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome","volume":"39","author":"Gershon","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/216173a0","article-title":"Fixation of ejaculated spermatozoa for electron microscopy","volume":"216","author":"Stefanini","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ana.410150114","article-title":"Collateral reinnervation of sweat glands","volume":"15","author":"Kennedy","year":"1984","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00005176-199008000-00006","article-title":"Visceral neuropathies responsible for chronic intestinal pseudo-obstruction syndrome in pediatric practice: analysis of 26 cases","volume":"11","author":"Navarro","year":"1990","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00214576","article-title":"Ultrastructure of enterochromaffin cells and associated neural and vascular elements in the mouse duodenum","volume":"241","author":"Wade","year":"1985","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib13","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1523\/JNEUROSCI.08-07-02582.1988","article-title":"Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype (5-HT1P) with a selective agonist, 3H-5-hydroxyindalpine","volume":"8","author":"Branchek","year":"1988","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib14","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1073\/pnas.83.24.9799","article-title":"Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists","volume":"83","author":"Mawe","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib15","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1523\/JNEUROSCI.20-09-03295.2000","article-title":"Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine","volume":"20","author":"Pan","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib16","first-page":"G346","article-title":"Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion","volume":"269","author":"Sidhu","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2982.1997.d01-41.x","article-title":"5-HT activates neural reflexes regulating secretion in the guinea-pig colon","volume":"9","author":"Cooke","year":"1997","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib18","first-page":"G1139","article-title":"CGRP as a transmitter in the sensory pathway mediating peristaltic reflex","volume":"266","author":"Grider","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1124\/jpet.103.053512","article-title":"Neurotransmitters mediating the intestinal peristaltic reflex in the mouse","volume":"307","author":"Grider","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib20","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/107710497174723","article-title":"Comparison of neuropeptide Y, protein gene product 9.5, and acetylcholinesterase in the diagnosis of Hirschsprung's disease","volume":"17","author":"Galvis","year":"1997","journal-title":"Pediatr Pathol Lab Med"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s003830050744","article-title":"The innervation of human bowel mucosa and its alterations in Hirschsprung's disease using a whole-mount preparation technique","volume":"16","author":"Nemeth","year":"2000","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0016-5085(03)00888-6","article-title":"Childhood constipation: longitudinal follow-up beyond puberty","volume":"125","author":"van Ginkel","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib23","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00005176-200111000-00014","article-title":"Colonic diversion for intractable constipation in children: colonic manometry helps guide clinical decisions","volume":"33","author":"Villarreal","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00005176-200401000-00017","article-title":"Colostomy for treatment of functional constipation in children: a preliminary report","volume":"38","author":"Woodward","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jpedsurg.2008.08.005_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00005176-199002000-00001","article-title":"Chronic intestinal pseudo-obstruction: progress and problems","volume":"10","author":"Schuffler","year":"1990","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346808006581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346808006581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T06:56:02Z","timestamp":1558248962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346808006581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0022346808006581"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2008.08.005","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}