{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:41:01Z","timestamp":1792147261680,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jpedsurg.2008.11.006","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T08:41:11Z","timestamp":1239180071000},"page":"831-835","source":"Crossref","is-referenced-by-count":3,"title":["A case of a choledochal cyst associated with a lymphatic infiltration of a hyperplastic gallbladder epithelium"],"prefix":"10.1016","volume":"44","author":[{"given":"Yutaka","family":"Hirayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ohtaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Nishikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Ajioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2008.11.006_bib1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/1097-0142(197909)44:3<1134::AID-CNCR2820440350>3.0.CO;2-T","article-title":"Carcinoma arising in the wall of congenital bile duct cyst","volume":"44","author":"Todani","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1440-1827.1996.tb03607.x","article-title":"Increased cell proliferation and transforming growth factor-alpha (TGF alpha) in the gall-bladder epithelium of patients with pancreaticobiliary maljunction","volume":"46","author":"Kaneko","year":"1996","journal-title":"Pathol Int"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s005340050176","article-title":"Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction","volume":"7","author":"Masuhara","year":"2000","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib4","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1111\/j.1572-0241.1999.01155.x","article-title":"Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct","volume":"94","author":"Hanada","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s005340200035","article-title":"K-ras and p53 gene mutation in cancerous biliary lesions of patients with pancreaticobiliary maljunction","volume":"9","author":"Matsubara","year":"2002","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib6","first-page":"378","article-title":"A case of carcinoma arising in the intrapancreatic terminal choledochus 12 years after primary excision of a giant choledochal cyst","volume":"81","author":"Yoshikawa","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib7","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.jpedsurg.2005.10.066","article-title":"An 11-year-old male patient demonstrating cholangiocarcinoma associated with congenital biliary dilatation","volume":"41","author":"Tanaka","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib8","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1053\/gast.1996.v110.pm8613069","article-title":"Early mucosal changes of the gallbladder in patients with anomalous arrangement of the pancreaticobiliary duct","volume":"110","author":"Tokiwa","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib9","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0022-3468(99)90769-8","article-title":"Cellular activity in the gallbladder of children with anomalous arrangement of the pancreaticobiliary duct","volume":"34","author":"Ono","year":"1999","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s00534-002-0733-7","article-title":"Classification of congenital biliary cystic disease: special reference to type Ic and IVA cysts with primary ductal stricture","volume":"10","author":"Todani","year":"2003","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib11","first-page":"37","article-title":"Anomalous arrangement of the pancreaticobiliary system in choledochal cyst","volume":"23","author":"Komi","year":"1976","journal-title":"Tokushima J Exp"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0016-5085(90)91036-6","article-title":"Increased secondary bile acids in a choledochal cyst. Possible role in biliary metaplasia and carcinoma","volume":"99","author":"Reveille","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2302\/kjm.40.118","article-title":"Bile acids and biliary carcinoma in pancreaticobiliary maljunction","volume":"40","author":"Funabiki","year":"1991","journal-title":"Keio J Med"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2302\/kjm.46.169","article-title":"Surgical strategy for patients with pancreaticobiliary maljunction without choledochal dilatation","volume":"46","author":"Funabiki","year":"1997","journal-title":"Keio J Med"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s005340050111","article-title":"Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of the pancreaticobiliary duct","volume":"6","author":"Hanada","year":"1999","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00423-003-0370-x","article-title":"Pancreaticobiliary maljunction: pathophysiological and clinical aspects and the impact on biliary carcinogenesis","volume":"388","author":"Matsumoto","year":"2003","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF02936958","article-title":"Carcinoma of the gallbladder and anomalous arrangement of the pancreaticobiliary ductal system: cell kinetic studies of gallbladder epithelial cells","volume":"32","author":"Yang","year":"1997","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1097-0142(19980715)83:2<267::AID-CNCR10>3.0.CO;2-R","article-title":"Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union","volume":"83","author":"Tanno","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib19","first-page":"3068","article-title":"Epithelial hyperplasia of the gallbladder in children with anomalous pancreaticobiliary ductal union","volume":"46","author":"Tanno","year":"1999","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00534-004-0966-8","article-title":"Clinicopathology of pancreaticobiliary maljunction: relationship between alterations in background biliary epithelium and neoplastic development","volume":"12","author":"Seki","year":"2005","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00004836-199707000-00023","article-title":"Malignancy in Peutz-Jeghers syndrome? The pitfall of pseudo-invasion","volume":"25","author":"Westerman","year":"1997","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib22","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1200\/JCO.2005.04.6631","article-title":"Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome","volume":"24","author":"Jarnagin","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib23","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3748\/wjg.v11.i5.744","article-title":"Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma","volume":"11","author":"Ma","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib24","first-page":"59","article-title":"An immunohistochemical study of the expression of cell-cycle\u2013regulated proteins p53, cyclin D1, RB, p27, Ki67 and MSH2 in gallbladder carcinoma and its precursor lesions","volume":"20","author":"Xuan","year":"2005","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib25","first-page":"4272","article-title":"Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma","volume":"6","author":"Hui","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s005350050027","article-title":"Nuclear cyclin D1 overexpression is a critical event associated with cell proliferation and invasive growth in gallbladder carcinogenesis","volume":"35","author":"Itoi","year":"2000","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib27","first-page":"4765","article-title":"Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation","volume":"57","author":"Lee","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/path.1711700111","article-title":"p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder","volume":"170","author":"Kamel","year":"1993","journal-title":"J Pathol"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/(SICI)1097-0142(19960201)77:3<452::AID-CNCR5>3.0.CO;2-M","article-title":"K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct","volume":"77","author":"Hanada","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib30","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1966::AID-CNCR13>3.0.CO;2-M","article-title":"Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis","volume":"86","author":"Takao","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.jpedsurg.2008.11.006_bib31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0344-0338(11)80778-8","article-title":"Mucosal changes of the gallbladder in anomalous union with the pancreatico-biliary duct system","volume":"187","author":"Yamamoto","year":"1991","journal-title":"Pathol Res Pract"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346808010178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346808010178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T10:54:54Z","timestamp":1589712894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346808010178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0022346808010178"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2008.11.006","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}