{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:58:54Z","timestamp":1784548734683,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.jpedsurg.2010.02.005","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T02:19:52Z","timestamp":1272853192000},"page":"859-864","source":"Crossref","is-referenced-by-count":40,"title":["Esophagus tissue engineering: in situ generation of rudimentary tubular vascularized esophageal conduit using the ovine model"],"prefix":"10.1016","volume":"45","author":[{"given":"Amulya K.","family":"Saxena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinrich","family":"Baumgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Komann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herwig","family":"Ainoedhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Soltysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Kofler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"H\u00f6llwarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2010.02.005_bib1","first-page":"910","article-title":"Esophageal atresia and tracheoesophageal fistula","volume":"59","author":"Clark","year":"1999","journal-title":"Am Fam Phycisian"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S1055-8586(98)70028-9","article-title":"Esophageal substitution","volume":"7","author":"Spitz","year":"1998","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/0022-3468(93)90499-B","article-title":"Development of a technique for jejunal interposition in long-gap esophageal atresia","volume":"28","author":"Cusick","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0022-3468(96)90316-4","article-title":"Intestinal bypass of the esophagus","volume":"31","author":"Raffensperger","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib5","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.jpedsurg.2006.07.004","article-title":"Esophageal atresia\u2014lessons I have learned in a 40-year experience","volume":"41","author":"Spitz","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00383-006-1770-0","article-title":"Oesophageal substitution with free and pedicled jejunum: short- and long-term outcomes","volume":"23","author":"Cauchi","year":"2007","journal-title":"Pediatr Surg Intl"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1308\/003588408X242222","article-title":"Oesophageal replacement in children","volume":"90","author":"Arul","year":"2008","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/0971-9261.16069","article-title":"Tissue engineering. Present concepts and strategies","volume":"10","author":"Saxena","year":"2005","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib9","doi-asserted-by":"crossref","first-page":"M389","DOI":"10.1097\/00002480-199407000-00028","article-title":"An artificial esophagus consisting of cultured human esophageal epithelial cells, polyglycolic acid mesh, and collagen","volume":"40","author":"Sato","year":"1994","journal-title":"ASAIO J"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00002480-199909000-00025","article-title":"An artificial esophagus constructed of cultured human esophageal epithelial cells, fibroblasts, polyglycolic acid mesh, and collagen","volume":"45","author":"Miki","year":"1999","journal-title":"ASAIO J"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib11","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jpedsurg.2009.01.019","article-title":"Esophagus tissue engineering: in vitro generation of esophageal epithelial sheets and viability on scaffold","volume":"44","author":"Saxena","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib12","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s11605-009-0836-4","article-title":"Esophagus tissue engineering: hybrid approach with esophageal epithelium and unidirectional smooth muscle tissue component generation in vitro","volume":"13","author":"Saxena","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/term.171","article-title":"Smooth muscle tissue engineering for hybrid tubular organs: scanning electron microscopic investigations of cell interactions with collagen scaffolds","volume":"3","author":"Kofler","year":"2009","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib14","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00002480-200107000-00009","article-title":"Successful repair of esophageal injury using an elastin based biomaterial patch","volume":"47","author":"Kajitani","year":"2001","journal-title":"ASAIO J"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1053\/jpsu.2001.20685","article-title":"Patch esophagoplasty using AlloDerm as a tissue scaffold","volume":"36","author":"Isch","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0022-5223(98)70247-8","article-title":"The experimental replacement of a cervical esophageal segment with an artificial prosthesis with the use of collagen matrix and a silicone stent","volume":"116","author":"Takimoto","year":"1998","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1053\/jpsu.2000.7834","article-title":"Resorbable bioscaffold for esophageal repair in a dog model","volume":"35","author":"Badylak","year":"2000","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-5223(03)00032-1","article-title":"Tissue-engineered esophagus: experimental substitution by onlay patch or interposition","volume":"126","author":"Grikscheit","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1525-1594.2009.00727.x","article-title":"Unsuccessful alloplastic esophageal replacement with porcine small intestinal submucosa","volume":"33","author":"Doede","year":"2009","journal-title":"Artif Organs"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib20","article-title":"Culture of ovine esophageal epithelial cells and in-vitro esophagus tissue engineering","author":"Saxena","year":"2009","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1089\/ten.2005.11.674","article-title":"Optimization of dynamic culture conditions: effects on biosynthetic activities of chondrocytes grown in collagen sponges","volume":"11","author":"Freyria","year":"2005","journal-title":"Tissue Eng"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3181\/0901-RM-5","article-title":"Grafts of porcine small intestinal submucosa with cultured autologous oral mucosal epithelial cells for esophageal repair in a canine model","volume":"234","author":"Wei","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib23","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jtcvs.2008.05.027","article-title":"Intrathoracic esophageal replacement by in situ tissue-engineered esophagus","volume":"136","author":"Nakase","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0963-6897(96)00025-5","article-title":"Fabrication of pliable biodegradable polymer foams to engineer soft tissues","volume":"5","author":"Wake","year":"1996","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib25","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.biomaterials.2005.07.012","article-title":"Fabricating tubular scaffolds with a radial pore size gradient by a spinning technique","volume":"27","author":"Harley","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib26","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.athoracsur.2004.05.085","article-title":"Seeding of human endothelial cells on valve containing aortic mini-roots: development of a seeding device and procedure","volume":"79","author":"Gulbins","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib27","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1016\/j.biomaterials.2006.04.042","article-title":"A seeding device for tissue engineered tubular structures","volume":"27","author":"Soletti","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib28","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1016\/j.biomaterials.2005.04.010","article-title":"Esophageal epithelial cell interaction with synthetic and natural scaffolds for tissue engineering","volume":"26","author":"Beckstead","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1115\/1.2354206","article-title":"3D mechanical properties of the layered esophagus: experiment and constitutive model","volume":"128","author":"Yang","year":"2006","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib30","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1115\/1.2372473","article-title":"Viscoelasticity of esophageal tissue and application of a QLV model","volume":"128","author":"Yang","year":"2006","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/ten.teb.2009.0085","article-title":"Vascularization strategies for tissue engineering","volume":"15","author":"Lovett","year":"2009","journal-title":"Tissue Eng Part B Rev"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib32","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1089\/ten.2006.12.2093","article-title":"Angiogenesis in tissue engineering. Breathing life into constructed tissue substitutes","volume":"12","author":"Laschke","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/teb.2007.0299","article-title":"Engineering the microcirculation","volume":"14","author":"Lokmic","year":"2008","journal-title":"Tissue Eng Part B Rev"},{"key":"10.1016\/j.jpedsurg.2010.02.005_bib34","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/term.202","article-title":"Micro computed tomography for implantation site imaging during in-situ esophagus tissue engineering in live small animal model","volume":"3","author":"Soltysiak","year":"2009","journal-title":"J Tissue Eng Regen Med"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346810000977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346810000977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T06:50:35Z","timestamp":1544511035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346810000977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0022346810000977"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2010.02.005","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}