{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:47:02Z","timestamp":1790725622019,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.jpedsurg.2010.02.007","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T02:19:52Z","timestamp":1272853192000},"page":"943-947","source":"Crossref","is-referenced-by-count":10,"title":["The effect of in vitro tracheal occlusion on branching morphogenesis in fetal lung explants from the rat nitrofen model of congenital diaphragmatic hernia"],"prefix":"10.1016","volume":"45","author":[{"given":"Jeremy R.","family":"Grushka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Al-Abbad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Baird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Puligandla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feige","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Martin","family":"Laberge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2010.02.007_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF00175643","article-title":"Natural history of congenital diaphragmatic hernia: implications for management","volume":"2","author":"Puri","year":"1987","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.semperi.2005.05.007","article-title":"Evidence-based management of infants with congenital diaphragmatic hernia","volume":"29","author":"Moya","year":"2005","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib3","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jpedsurg.2009.01.023","article-title":"Effect of hospital case volume on outcome in congenital diaphragmatic hernia: the experience of the Canadian Pediatric Surgery Network","volume":"44","author":"Grushka","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0022-3468(98)90522-X","article-title":"Current surgical management of congenital diaphragmatic hernia: a report from the Congenital Diaphragmatic Hernia Study Group","volume":"33","author":"Clark","year":"1998","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0095-5108(18)30201-X","article-title":"Congenital diaphragmatic hernia. Epidemiology and outcome","volume":"23","author":"Langham","year":"1996","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1542\/peds.112.3.532","article-title":"Nihilism in the 1990s: the true mortality of congenital diaphragmatic hernia","volume":"112","author":"Stege","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0378-3782(92)90195-M","article-title":"Prenatal diagnosis of congenital diaphragmatic hernia and perinatal care: assessment of lung hypoplasia","volume":"29","author":"Kamata","year":"1992","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0022-3476(85)80534-5","article-title":"Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair","volume":"107","author":"Geggel","year":"1985","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1203\/01.PDR.0000084344.42409.C6","article-title":"Pulmonary surfactant disaturated-phosphatidylcholine (DSPC) turnover and pool size in newborn infants with congenital diaphragmatic hernia (CDH)","volume":"54","author":"Cogo","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3476(81)80524-0","article-title":"Growth and development of the lung","volume":"98","author":"Inselman","year":"1981","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib11","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/0022-3468(93)90426-L","article-title":"Experimental fetal tracheal ligation prevents the pulmonary hypoplasia associated with fetal nephrectomy: possible application for congenital diaphragmatic hernia","volume":"28","author":"Wilson","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib12","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/0022-3468(95)90015-2","article-title":"Reversible tracheal obstruction in the fetal sheep: effects on tracheal fluid pressure and lung growth","volume":"30","author":"Hashim","year":"1995","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1053\/jpsu.2001.22950","article-title":"Pulmonary structural maturation and pulmonary artery remodeling after reversible fetal ovine tracheal occlusion in diaphragmatic hernia","volume":"36","author":"Bratu","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/jpsu.2002.29418","article-title":"Pulmonary effects of in utero tracheal occlusion are dependent on gestational age in a rabbit model of diaphragmatic hernia","volume":"37","author":"Wu","year":"2002","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib15","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jpedsurg.2004.03.049","article-title":"Pulmonary vascular morphology in a fetal rabbit model for congenital diaphragmatic hernia","volume":"39","author":"Roubliova","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib16","first-page":"569","article-title":"Growth and structrual development after reversible fetal tracheal occlusion in diaphragmatic hernia","volume":"50","author":"Bratu","year":"1999","journal-title":"Surg Forum"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/jpsu.2001.20027","article-title":"Surfactant levels after reversible tracheal occlusion and prenatal steroids in experimental diaphragmatic hernia","volume":"36","author":"Bratu","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib18","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jpedsurg.2004.06.024","article-title":"Lung function in lambs with diaphragmatic hernia after reversible fetal tracheal occlusion","volume":"39","author":"Bratu","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib19","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1056\/NEJMoa035005","article-title":"A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia","volume":"349","author":"Harrison","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpedsurg.2004.09.037","article-title":"Survival of severe congenital diaphragmatic hernia has morbid consequences","volume":"40","author":"Cortes","year":"2005","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib21","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0022-3468(90)90190-K","article-title":"Nitrofen-induced diaphragmatic hernias in rats: an animal model","volume":"25","author":"Kluth","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib22","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0022-3468(03)00183-0","article-title":"Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats","volume":"38","author":"Teramoto","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib23","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0002-9440(10)63848-5","article-title":"Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia","volume":"162","author":"Unger","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0022-3468(97)90588-1","article-title":"Pulmonary expression of vascular endothelial growth factor and myosin isoforms in rats with congenital diaphragmatic hernia","volume":"32","author":"Okazaki","year":"1997","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib25","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1203\/01.PDR.0000062660.12769.E6","article-title":"Etiology of congenital diaphragmatic hernia: the retinoid hypothesis","volume":"53","author":"Greer","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jss.2007.07.019","article-title":"The effect of tracheal occlusion on lung branching in the rat nitrofen CDH model","volume":"148","author":"Baird","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.mod.2007.10.013","article-title":"Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway","volume":"125","author":"Unbekandt","year":"2008","journal-title":"Mech Dev"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ppul.1950150205","article-title":"In vitro branching morphogenesis of the fetal rat lung","volume":"15","author":"Massoud","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib29","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0022-3468(99)90150-1","article-title":"Effects of dexamethasone, growth factors, and tracheal ligation on the development of nitrofen-exposed hypoplastic murine fetal lungs in organ culture","volume":"24","author":"Zgleszewski","year":"1999","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ar.1091990110","article-title":"Comparative morphometry of the upper bronchial tree in six mammalian species","volume":"199","author":"Schlesinger","year":"1981","journal-title":"Anat Rec"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0034-5687(95)00056-9","article-title":"Diameter-based analysis of the branching geometry of four mammalian bronchial trees","volume":"102","author":"Phillips","year":"1995","journal-title":"Respir Physiol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib32","first-page":"S1","article-title":"Tracheobronchial airway structure as revealed by casting techniques","volume":"128","author":"Phalen","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/ar.1091780405","article-title":"The postnatal growth of the rat lung. I. Morphometry","volume":"178","author":"Burri","year":"1974","journal-title":"Anat Rec"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib34","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00462.2000","article-title":"Nitric oxide modulates branching morphogenesis in fetal rat lung explants","volume":"282","author":"Young","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib35","first-page":"L362","article-title":"Nitrofen dose\u2013dependent gestational day-specific murine lung hypoplasia and left-sided diaphragmatic hernia","volume":"272","author":"Cilley","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0022-3468(90)90386-N","article-title":"Experimentally induced congenital diaphragmatic hernia in rats","volume":"25","author":"Tenbrinck","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib37","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0002-9440(10)65000-6","article-title":"Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia","volume":"156","author":"Keijzer","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/bjs.1800580507","article-title":"Lung hypoplasia in congenital diaphragmatic hernia. A quantitative study of airway, artery, and alveolar development","volume":"58","author":"Kitagawa","year":"1971","journal-title":"Br J Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib39","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.1.5325.230","article-title":"Hypoplasia of lung with congenital diaphragmatic hernia","volume":"1","author":"Areechon","year":"1963","journal-title":"Br Med J"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib40","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0022-3468(96)90824-6","article-title":"Correction of congenital diaphragmatic hernia in utero VIII: response of the hypoplastic lung to tracheal occlusion","volume":"31","author":"Harrison","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib41","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0022-3468(98)90524-3","article-title":"Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis (liver herniation and low lung-to-head ratio) can be saved by fetoscopic temporary tracheal occlusion","volume":"33","author":"Harrison","year":"1998","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib42","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.clp.2009.03.004","article-title":"Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe","volume":"36","author":"Deprest","year":"2009","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.gco.0000193000.12416.80","article-title":"Prenatal intervention for isolated congenital diaphragmatic hernia","volume":"18","author":"Deprest","year":"2006","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/uog.1711","article-title":"Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: evolution of a technique and preliminary results","volume":"24","author":"Deprest","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib45","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-2007-989275","article-title":"Impact of fetal intervention on postnatal management of congenital diaphragmatic hernia","volume":"17","author":"Saura","year":"2007","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib46","article-title":"Altered LGL-1 expression suggests diaphragmatic hernia contributes to pulmonary hypoplasia in nitrofen-fed rats","author":"Baird","year":"2006"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jpedsurg.2004.02.015","article-title":"VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia","volume":"39","author":"Chang","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.007_bib48","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jpedsurg.2008.06.020","article-title":"Gene expression analysis after prenatal tracheal ligation in fetal rat as a model of stimulated lung growth","volume":"44","author":"Mesas-Burgos","year":"2009","journal-title":"J Pediatr Surg"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346810000990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346810000990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:39:26Z","timestamp":1559068766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346810000990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0022346810000990"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2010.02.007","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}