{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:27:31Z","timestamp":1756682851350},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.jpedsurg.2010.02.018","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T06:19:52Z","timestamp":1272867592000},"page":"948-952","source":"Crossref","is-referenced-by-count":8,"title":["Insulin receptor is downregulated in the nitrofen-induced hypoplastic lung"],"prefix":"10.1016","volume":"45","author":[{"given":"Elke","family":"Ruttenstock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Dingemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2010.02.018_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1542\/peds.112.3.532","article-title":"Nihilism in the 1990s: the true mortality of congenital diaphragmatic hernia","volume":"112","author":"Stage","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1165\/rcmb.2006-0349OC","article-title":"Embryonic essential myosin light chain regulates fetal lung development in rats","volume":"37","author":"Santos","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1152\/ajplung.00286.2007","article-title":"Mechanisms of the congenital diaphragmatic hernia-inducing teratogen nitrofen","volume":"293","author":"Noble","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00383-008-2140-x","article-title":"Congenital diaphragmatic hernia and retinoids: searching for an etiology","volume":"24","author":"Montedonico","year":"2008","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1677\/jme.0.0140349","article-title":"IGF, type I IGF receptor and IGF-binding protein mRNA expression in the developing mouse lung","volume":"14","author":"Schuller","year":"1995","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib6","first-page":"56","article-title":"Expression of insulin-like growth factor receptors 1 and 2 in the developing lung and their relation to epithelial cell differentiation","volume":"12","author":"Maitre","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib7","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0167-4889(93)90106-Y","article-title":"Mutational analysis of insulin-receptor function: consensus and controversy","volume":"1178","author":"Tavare","year":"1993","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib9","first-page":"375","article-title":"Diverse signaling pathways in the cellular actions of insulin","volume":"270","author":"Saltiel","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib10","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/00004032-196412000-00016","article-title":"Biochemistry of the lung","volume":"10","author":"Felts","year":"1964","journal-title":"Health Phys"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib11","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/0024-3205(82)90069-8","article-title":"Insulin receptors in developing fetal lung","volume":"31","author":"Ulane","year":"1982","journal-title":"Life Sci"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib12","series-title":"Endocrinology of the lung development and surfactant synthesis","first-page":"181","article-title":"Insulin and lung development","author":"Snyder","year":"2000"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1006\/bbrc.1994.1986","article-title":"High glucose and insulin decrease fetal lung insulin receptor mRNA and tyrosine kinase activity in vitro","volume":"202","author":"Gewolb","year":"1994","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/01902149209031683","article-title":"Effects of insulin and glucose on pulmonary insulin receptors in late gestation fetal rats","volume":"18","author":"Zmora","year":"1992","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nprot.2006.83","article-title":"The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on","volume":"1","author":"Chomczynski","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib16","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0022-3468(92)90865-5","article-title":"Pathophysiology of congenital diaphragmatic hernia II: the fetal lamb CDH model is surfactant deficient","volume":"27","author":"Glick","year":"1992","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1203\/00006450-199705000-00014","article-title":"Contributions by individual lungs to the surfactant status in congenital diaphragmatic hernia","volume":"41","author":"Wilcox","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0022-3468(93)90250-O","article-title":"Biochemical immaturity of the lung in congenital diaphragmatic hernia","volume":"28","author":"Suen","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib19","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/0022-3468(94)90271-2","article-title":"Amniotic fluid phospholipids analysis in the fetus with congenital diaphragmatic hernia","volume":"29","author":"Sullivan","year":"1994","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00003246-199803000-00035","article-title":"Prospective evaluation of surfactant composition in bronchioalveolar lavage fluid in infants with congenital diaphragmatic hernia and of age matched controls","volume":"26","author":"Ijsselstijn","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib21","doi-asserted-by":"crossref","first-page":"L1159","DOI":"10.1152\/ajplung.2000.279.6.L1159","article-title":"Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development","volume":"279","author":"Guilbert","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib22","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0002-9440(10)65000-6","article-title":"Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia","volume":"156","author":"Keijzer","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2008-1063498","article-title":"Lung growth and maturation in the rat model of experimentally induced congenital diaphragmatic hernia","volume":"3","author":"Alfonso","year":"1993","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00303142","article-title":"Experimental study on embryogenesis of congenital diaphragmatic hernia","volume":"169","author":"Iritani","year":"1984","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.jpedsurg.2010.02.018_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/1043-2760(89)90025-8","article-title":"Regulation of pulmonary surfactant protein synthesis in fetal lung: a major role of glucocorticoids and cyclic AMP","volume":"1","author":"Mendelson","year":"1989","journal-title":"Trends Endocrinol Metab"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346810001107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346810001107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:39:27Z","timestamp":1559083167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346810001107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0022346810001107"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2010.02.018","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}