{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:43:21Z","timestamp":1760204601613},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.jpedsurg.2011.11.026","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T19:17:27Z","timestamp":1328728647000},"page":"336-340","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal retinoic acid upregulates connexin 43 (Cx43) gene expression in pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia rat model"],"prefix":"10.1016","volume":"47","author":[{"given":"Elke Maria","family":"Ruttenstock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Dingemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0005","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1651-2227.2008.01212.x","article-title":"Congenital diaphragmatic hernia: an overview of the etiology and current management","volume":"98","author":"Gaxiola","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0010","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/j.sempedsurg.2010.03.001","article-title":"Congenital diaphragmatic hernia","volume":"19","author":"Keijzer","year":"2010","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0015","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1542\/peds.112.3.532","article-title":"Nihilism in the 1990s: the true mortality of congenital diaphragmatic hernia","volume":"112","author":"Stege","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0020","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.amjsurg.2005.05.035","article-title":"Congenital diaphragmatic hernia: searching for answers","volume":"190","author":"Gosche","year":"2005","journal-title":"Am J Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0025","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/bdra.20151","article-title":"Congenital diaphragmatic hernia: a retinoid-signaling pathway disruption during lung development?","volume":"73","author":"Gallot","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0030","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1152\/ajplung.00286.2007","article-title":"Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen","volume":"293","author":"Noble","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0035","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0022-3468(90)90190-K","article-title":"Nitrofen-induced diaphragmatic hernias in rats: an animal model","volume":"25","author":"Kluth","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0040","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0022-3468(90)90386-N","article-title":"Experimentally induced congenital diaphragmatic hernia in rats","volume":"25","author":"Tenbrick","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0045","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jpedsurg.2009.10.075","article-title":"Spatiotemporal alteration in phosphatidylinositide 3-kinase-serine\/threonine protein kinase B signaling in the nitrofen-induced hypoplastic lung","volume":"45","author":"Doi","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0050","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jpedsurg.2010.02.111","article-title":"Insulinlike growth factor receptor type 1 and type 2 are downregulated in the nitrofen-induced hypoplastic lung","volume":"45","author":"Ruttenstock","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0055","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jpedsurg.2010.02.018","article-title":"Insulin receptor is downregulated in the nitrofen-induced hypoplastic lung","volume":"45","author":"Ruttenstock","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0060","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/physrev.2000.80.3.1021","article-title":"Retinoids in embryonal development","volume":"80","author":"Ross","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0070-2153(04)61007-6","article-title":"Retinoids in lung development and regeneration","volume":"61","author":"Maden","year":"2004","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00383-006-1848-8","article-title":"Altered regulation of retinoic acid synthesis in nitrofen-induced hypoplastic lung","volume":"23","author":"Nakazawa","year":"2007","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0075","first-page":"423","article-title":"Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats","volume":"277","author":"Thebaud","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00383-005-1571-x","article-title":"Retinoic acid rescues lung hypoplasia in nitrofen-induced hypoplastic foetal rat lung explants","volume":"22","author":"Montedonico","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0085","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jpedsurg.2007.10.030","article-title":"Prenatal treatment with retinoic acid promotes pulmonary alveologenesis in the nitrofen model of congenital diaphragmatic hernia","volume":"43","author":"Montedonico","year":"2008","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0090","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.jpedsurg.2009.04.027","article-title":"Prenatal retinoic acid up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia","volume":"44","author":"Doi","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0095","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.2741\/2029","article-title":"Connexin 43 gene expression in mice with cardiopulmonary developmental defects","volume":"11","author":"Le","year":"2006","journal-title":"Front Biosci"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0100","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.jpedsurg.2009.07.070","article-title":"Connexin 43 plays an important role in lung development","volume":"44","author":"Nagata","year":"2009","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/cbf.290130112","article-title":"Retinoic acid enhances connexin 43 expression at the post-transcriptional level in rat liver epithelial cells","volume":"13","author":"Bex","year":"1995","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0110","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1210\/jc.2004-0663","article-title":"Up-regulation of gap junctional intercellular communication and connexin 43 expression by retinoic acid in human endometrial stromal cells","volume":"90","author":"Tanmahasamut","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00383-005-1583-6","article-title":"Expression of connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it","volume":"22","author":"Gonzalez-Reyes","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0120","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/bdrb.20293","article-title":"Prenatal administration of retinoic acid upregulates insulin-like growth factor receptors in the nitrofen-induced hypoplastic lung","volume":"92","author":"Ruttenstock","year":"2011","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0125","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1203\/00006450-199405000-00002","article-title":"Antenatal glucocorticoid corrects pulmonary immaturity in experimentally induced congenital diaphragmatic hernia in rats","volume":"35","author":"Suen","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0130","first-page":"1184","article-title":"Effects of maternal vitamin A status on fetal heart and lung: changes in expression of key developmental genes","volume":"275","author":"Antipatis","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0135","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1152\/ajplung.2000.278.5.L955","article-title":"Retinoic acid treatment partially rescues failed septation in rats and in mice","volume":"278","author":"Massaro","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jpedsurg.2006.10.028","article-title":"Disturbance of retinol transportation causes nitrofen-induced hypoplastic lung","volume":"42","author":"Nakazawa","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0145","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s003830050399","article-title":"Retinol status of newborn infants with congenital diaphragmatic hernia","volume":"13","author":"Major","year":"1998","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0150","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.2010-0521","article-title":"Retinol status of newborn infants is associated with congenital diaphragmatic hernia","volume":"126","author":"Beurskens","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0155","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/ajplung.2001.280.6.L1083","article-title":"Gap junction communication in alveolar epithelial cells","volume":"280","author":"Rannels","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ppul.1099","article-title":"Down-regulation of regulatory proteins for differentiation and proliferation in murine fetal hypoplastic lungs: altered mesenchymal-epithelial interactions","volume":"32","author":"Chinoy","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jpedsurg.2011.11.026_bb0165","first-page":"971","article-title":"Mutations of connexin 43 in fetuses with congenital heart malformations","volume":"118","author":"Chen","year":"2005","journal-title":"Chin Med J (Engl)"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346811010062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346811010062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T10:28:09Z","timestamp":1561285689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346811010062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0022346811010062"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2011.11.026","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}