{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:00:43Z","timestamp":1786993243317,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.jpedsurg.2013.03.047","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T15:32:11Z","timestamp":1380814331000},"page":"2047-2053","source":"Crossref","is-referenced-by-count":23,"title":["Dysregulation of upstream and downstream transforming growth factor-\u03b2 transcripts in livers of children with biliary atresia and fibrogenic gene signatures"],"prefix":"10.1016","volume":"48","author":[{"given":"Tatiana","family":"Iordanskaia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica J.","family":"Hubal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Koeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan P.","family":"Nadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jss.2008.05.023","article-title":"Integrin alphavbeta6 and mediators of extracellular matrix deposition are up-regulated in experimental biliary atresia","volume":"154","author":"Nadler","year":"2009","journal-title":"J Surg Res"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/gm154","article-title":"Staging of biliary atresia at diagnosis by molecular profiling of the liver","volume":"2","author":"Moyer","year":"2010","journal-title":"Genome Med"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0020","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0025","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jss.2009.10.038","article-title":"Differential expression of hepatic fibrosis mediators in sick and spontaneously recovered mice with experimental biliary atresia","volume":"159","author":"Nadler","year":"2010","journal-title":"J Surg Res"},{"issue":"9","key":"10.1016\/j.jpedsurg.2013.03.047_bb0030","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.jpedsurg.2010.04.007","article-title":"Serum and tissue transforming [corrected] growth factor \u03b21 in children with biliary atresia","volume":"45","author":"de Oliveira","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0035","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1083\/jcb.133.4.921","article-title":"Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin","volume":"133","author":"Huang","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","article-title":"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0045","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2007.11.021","article-title":"Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies","volume":"48","author":"Popov","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/gad.14.2.163","article-title":"Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis","volume":"14","author":"Yu","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0055","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1074\/jbc.R400029200","article-title":"Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability","volume":"280","author":"Rifkin","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj20020809","article-title":"The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3","volume":"369","author":"Ludbrook","year":"2003","journal-title":"Biochem J"},{"issue":"5","key":"10.1016\/j.jpedsurg.2013.03.047_bb0065","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/hep.21849","article-title":"Role of alphavbeta6 integrin in acute biliary fibrosis","volume":"46","author":"Wang","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0070","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0092-8674(00)81618-9","article-title":"Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins","volume":"95","author":"Bader","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0075","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.jid.5700331","article-title":"Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma","volume":"126","author":"Asano","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0080","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.200109100","article-title":"The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1","volume":"157","author":"Mu","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0085","doi-asserted-by":"crossref","first-page":"36864","DOI":"10.1074\/jbc.M111.276790","article-title":"Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture","volume":"286","author":"Markovics","year":"2011","journal-title":"J Biol Chem"},{"issue":"22","key":"10.1016\/j.jpedsurg.2013.03.047_bb0090","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v13.i22.3056","article-title":"Transforming growth factor-beta and fibrosis","volume":"13","author":"Verrecchia","year":"2007","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.jpedsurg.2013.03.047_bb0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1523-1747.2002.01641.x","article-title":"Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation","volume":"118","author":"Verrecchia","year":"2002","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0100","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","author":"Massague","year":"1998","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"10.1016\/j.jpedsurg.2013.03.047_bb0105","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.1478-3231.2009.02011.x","article-title":"Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice","volume":"29","author":"Latella","year":"2009","journal-title":"Liver Int"},{"issue":"5","key":"10.1016\/j.jpedsurg.2013.03.047_bb0110","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.biomaterials.2010.10.023","article-title":"The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-\u03b2\/Smad signaling pathway","volume":"32","author":"Lee","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0115","doi-asserted-by":"crossref","first-page":"20489","DOI":"10.1074\/jbc.274.29.20489","article-title":"SIP1, a novel zinc finger\/homeodomain repressor, interacts with Smad proteins and binds to 50-CACCT sequences in candidate target genes","volume":"274","author":"Verschueren","year":"1999","journal-title":"J Biol Chem"},{"issue":"5\u20136","key":"10.1016\/j.jpedsurg.2013.03.047_bb0120","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cytogfr.2011.11.006","article-title":"Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGF-\u03b2\/BMP signaling in vivo","volume":"22","author":"Conidi","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0125","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1164\/rccm.201001-0028OC","article-title":"Expression of matrix metalloproteases by fibrocytes: possible role in migration and homing","volume":"182","author":"Garcia-de-Alba","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jpedsurg.2013.03.047_bb0130","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.cb.09.110193.002545","article-title":"Tumor cell interactions with the extracellular matrix during invasion and metastasis","volume":"9","author":"Stetler-Stevenson","year":"1993","journal-title":"Annu Rev Cell Biol"},{"issue":"8","key":"10.1016\/j.jpedsurg.2013.03.047_bb0135","doi-asserted-by":"crossref","first-page":"L746","DOI":"10.1152\/ajplung.00319.2011","article-title":"Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis","volume":"302","author":"Richards","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"10","key":"10.1016\/j.jpedsurg.2013.03.047_bb0140","doi-asserted-by":"crossref","first-page":"CR 598","DOI":"10.12659\/MSM.881987","article-title":"The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis","volume":"17","author":"Piotrowski","year":"2011","journal-title":"Med Sci Monit"},{"issue":"9","key":"10.1016\/j.jpedsurg.2013.03.047_bb0145","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1600-0625.2011.01321.x","article-title":"Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement","volume":"20","author":"Moinzadeh","year":"2011","journal-title":"Exp Dermatol"},{"issue":"6","key":"10.1016\/j.jpedsurg.2013.03.047_bb0150","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1053\/j.gastro.2005.09.010","article-title":"Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C","volume":"129","author":"Asselah","year":"2005","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jpedsurg.2013.03.047_bb0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.virol.2004.11.009","article-title":"Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection","volume":"332","author":"Bi\u00e8che","year":"2005","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.jpedsurg.2013.03.047_bb0160","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2353\/ajpath.2010.100011","article-title":"Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis","volume":"177","author":"Qin","year":"2010","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.jpedsurg.2013.03.047_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/ebm.2011.011255","article-title":"Alcoholic liver disease and the potential role of plasminogen activator inhibitor-1 and fibrin metabolism","volume":"237","author":"Beier","year":"2012","journal-title":"Exp Biol Med (Maywood)"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346813003096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346813003096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T16:18:47Z","timestamp":1646669927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346813003096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0022346813003096"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2013.03.047","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}