{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:50:09Z","timestamp":1756572609759},"reference-count":25,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.jpedsurg.2013.08.013","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T10:38:13Z","timestamp":1386067093000},"page":"2416-2424","source":"Crossref","is-referenced-by-count":1,"title":["Effects of rapamycin on granulation formation in response to centrally doubled coiled stents as a tracheal substitute"],"prefix":"10.1016","volume":"48","author":[{"given":"Masayuki","family":"Kubota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Fujimaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Wakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0005","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.jpedsurg.2012.09.012","article-title":"Tracheoplasty using a metallic fusiform centrally-doubled coiled stent for a major tracheal defect in rabbits","volume":"47","author":"Kubota","year":"2012","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0010","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0022-3468(98)90452-3","article-title":"Tracheobronchial stenting for the treatment of airway obstruction","volume":"33","author":"Filler","year":"1998","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0015","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/000348940211100401","article-title":"Metallic tracheal stents: complications associated with long-term use in the upper airway","volume":"111","author":"Burningham","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0020","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0025","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ceb.2011.09.003","article-title":"mTOR signaling in disease","volume":"3","author":"Dazert","year":"2011","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0030","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJMoa012843","article-title":"A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization","volume":"346","author":"Morice","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0130","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1111\/j.1476-5381.1993.tb13973.x","article-title":"Inhibition by rapamycin of leukocyte migration and bronchial hyperreactivity induced by injection of Sephadex beads to guinea-pigs","volume":"110","author":"Nogueira de Francischi","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0040","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1172\/JCI119038","article-title":"Rapamycin inhibits vascular smooth muscle cell migration","volume":"98","author":"Poon","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1148\/radiol.09090670","article-title":"IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model","volume":"255","author":"Kim","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the role of mTOR in cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0055","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1038\/onc.2011.165","article-title":"Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2\/mTOR","volume":"30","author":"Rosner","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0060","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7164\/antibiotics.28.721","article-title":"Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle","volume":"28","author":"Vezina","year":"1975","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1139\/y77-007","article-title":"Inhibition of the immune response by rapamycin, a new antifungal antibiotic","volume":"55","author":"Martel","year":"1977","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0070","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.7164\/antibiotics.40.1249","article-title":"FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics","volume":"40","author":"Kino","year":"1987","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0075","first-page":"544","article-title":"Inhibition of T and B lymphocyte proliferation by rapamycin","volume":"72","author":"Kay","year":"1991","journal-title":"Immunology"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0080","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08155","article-title":"mTOR regulates memory CD8 T-cell differentiation","volume":"460","author":"Araki","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0085","doi-asserted-by":"crossref","first-page":"e36589","DOI":"10.1371\/journal.pone.0036589","article-title":"Low dose rapamycin exacerbates autoimmune experimental uveitis","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0090","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1093\/ndt\/gfm420","article-title":"Pneumonitis associated with sirolimus: clinical characteristics, risk factors and outcome\u2013a single-centre experience and review of the literature","volume":"22","author":"Weiner","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0095","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/01.TP.0000118413.92211.B6","article-title":"Sirolimus-associated pulmonary toxicity","volume":"77","author":"Pham","year":"2004","journal-title":"Transplantation"},{"issue":"166","key":"10.1016\/j.jpedsurg.2013.08.013_bb0100","first-page":"168","article-title":"Interstitial pneumonitis in the transplant patient: consider sirolimus-associated pulmonary toxicity","volume":"161","author":"Feagans","year":"2009","journal-title":"J La State Med Soc"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00007890-200109150-00008","article-title":"Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients","volume":"72","author":"Morelon","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000327972","article-title":"Rapamycin-induced impaired wound healing is associated with compromised tissue lactate accumulation and extracellular matrix remodeling","volume":"47","author":"Weinreich","year":"2011","journal-title":"Eur Surg Res"},{"issue":"Suppl 17","key":"10.1016\/j.jpedsurg.2013.08.013_bb0115","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1399-0012.2006.00608.x","article-title":"Wound complications following kidney and liver transplantation","volume":"20","author":"Mehrabi","year":"2006","journal-title":"Clin Transplant"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0120","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1600-6143.2006.01282.x","article-title":"Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients","volume":"6","author":"Kuppahally","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jpedsurg.2013.08.013_bb0125","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1053-2498(03)00309-7","article-title":"Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression","volume":"23","author":"Groetzner","year":"2004","journal-title":"J Heart Lung Transplant"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234681300674X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234681300674X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T15:21:35Z","timestamp":1539012095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234681300674X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S002234681300674X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2013.08.013","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}