{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:18:28Z","timestamp":1790443108491,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jpedsurg.2016.02.018","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T19:01:30Z","timestamp":1455390090000},"page":"762-769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease"],"prefix":"10.1016","volume":"51","author":[{"given":"David","family":"Coyle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gillick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0005","series-title":"Hirschsprung's disease and allied disorders","author":"Holschneider","year":"2008"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.sempedsurg.2010.03.004","article-title":"Hirschsprung's disease","volume":"19","author":"Kenny","year":"2010","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0015","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1067\/j.cpsurg.2004.09.004","article-title":"Hirschsprung disease","volume":"41","author":"Dasgupta","year":"2004","journal-title":"Curr Probl Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.sempedsurg.2012.07.006","article-title":"The pathogenesis of Hirschsprung's disease-associated enterocolitis","volume":"21","author":"Austin","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0025","doi-asserted-by":"crossref","first-page":"426","DOI":"10.5056\/jnm.2013.19.4.426","article-title":"Ionic conductance(s) in response to post-junctional potentials","volume":"19","author":"Koh","year":"2013","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0030","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1023\/A:1015085923245","article-title":"Widespread changes in neurotransmitter expression and number of enteric neurons and interstitial cells of Cajal in lethal spotted mice: an explanation for persisting dysmotility after operation for Hirschsprung's disease?","volume":"47","author":"Sandgren","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0035","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1111\/nmo.12083","article-title":"Altered neuronal density and neurotransmitter expression in the ganglionated region of Ednrb null mice: implications for Hirschsprung's disease","volume":"25","author":"Zaitoun","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0040","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00383-006-1783-8","article-title":"Long-term results of bowel function after treatment for Hirschsprung's disease: a 29-year review","volume":"22","author":"Menezes","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0045","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jpedsurg.2004.06.008","article-title":"Persistent obstructive symptoms after surgery for Hirschsprung's disease: development of a diagnostic and therapeutic algorithm","volume":"39","author":"Langer","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0050","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jpedsurg.2010.11.014","article-title":"Redo pull-through in Hirschsprung's [corrected] disease for obstructive symptoms due to residual aganglionosis and transition zone bowel","volume":"46","author":"Lawal","year":"2011","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1053\/j.sempedsurg.2012.07.009","article-title":"The Hirschsprungs patient who is soiling after what was considered a \u201csuccessful\u201d pull-through","volume":"21","author":"Levitt","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0060","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.jpedsurg.2015.02.006","article-title":"A population-based, complete follow-up of 146 consecutive patients after transanal mucosectomy for Hirschsprung's disease","volume":"50","author":"Neuvonen","year":"2015","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0065","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/nmo.12142","article-title":"Choices choices: regulation of precursor differentiation during enteric nervous system development","volume":"25","author":"Harrison","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0022-3468(94)90335-2","article-title":"Abnormalities of nitric-oxide-producing neurons in Hirschsprung's disease: morphology and implications","volume":"29","author":"O'Kelly","year":"1994","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0075","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0022-3468(97)90398-5","article-title":"Altered mRNA expression of the neuronal nitric oxide synthase gene in Hirschsprung's disease","volume":"32","author":"Kusafuka","year":"1997","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0080","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01008017","article-title":"The distribution and co-localization of nitric oxide synthase and vasoactive intestinal polypeptide in nerves of the colons with Hirschsprung's disease","volume":"430","author":"Guo","year":"1997","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00383-007-2044-1","article-title":"Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung's disease","volume":"24","author":"O\u2019 Donnell","year":"2008","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0090","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1136\/gut.31.9.1046","article-title":"Characteristics of cholinergic neuroeffector transmission of ganglionic and aganglionic colon in Hirschsprung's disease","volume":"31","author":"Vizi","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0095","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1015-9584(08)60035-4","article-title":"Does abnormal expression of acetylcholine receptors in Hirschsprung's disease induce acetylcholine esterase positive nerve fibres?","volume":"30","author":"Kusafuka","year":"2007","journal-title":"Asian J Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0100","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sj.bjp.0706111","article-title":"Nitric oxide relaxes circular smooth muscle of rat distal colon through RhoA\/Rho-kinase independent Ca2+ desensitisation","volume":"144","author":"Colpaert","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s003830100687","article-title":"Colonic mucosal vasoactive intestinal peptide receptors in malformations of the enteric nervous system are reduced compared with morphologically normal innervated colon","volume":"18","author":"Schmittenbecher","year":"2002","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0110","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.peptides.2007.05.006","article-title":"Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease","volume":"28","author":"Lelievre","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0115","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1055\/s-2008-1066132","article-title":"Peptidergic nerves in Hirschsprung's disease and its allied disorders","volume":"4","author":"Tomita","year":"1994","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0120","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0022-3468(99)90496-7","article-title":"Morphological investigation of the enteric nervous system in Hirschsprung's disease and hypoganglionosis using whole-mount colon preparation","volume":"34","author":"Watanabe","year":"1999","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2016.02.018_bb0125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"O'Connor","year":"2004","journal-title":"J Cell Physiol"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346816000816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346816000816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T08:54:23Z","timestamp":1537001663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346816000816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0022346816000816"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.02.018","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}