{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:05:21Z","timestamp":1793642721330,"version":"4.5.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jpedsurg.2016.02.091","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T07:05:27Z","timestamp":1457939127000},"page":"1355-1361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combined low miR-34s are associated with unfavorable prognosis in children with hepatoblastoma: A Chinese population-based study"],"prefix":"10.1016","volume":"51","author":[{"given":"Chenwei","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzhi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/pbc.10376","article-title":"Liver transplantation for hepatoblastoma: Results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience","volume":"42","author":"Otte","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jpeds.2004.09.011","article-title":"The current management of hepatoblastoma: A combination of chemotherapy, conventional resection, and liver transplantation","volume":"146","author":"Tiao","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0015","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00383-009-2349-3","article-title":"Survival trends in children with hepatoblastoma","volume":"25","author":"Horton","year":"2009","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0025","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"microRNAs as oncogenes and tumor suppressors","volume":"302","author":"Zhang","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0035","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cub.2007.06.068","article-title":"p53-mediated activation of miRNA34 candidate tumor-suppressor genes","volume":"17","author":"Bommer","year":"2007","journal-title":"Curr Biol"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0040","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0045","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00428-010-1030-5","article-title":"Frequent concomitant inactivation of miR-34a and miR-34b\/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas","volume":"458","author":"Vogt","year":"2011","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.canlet.2008.09.035","article-title":"miR-34a inhibits migration and invasion by down-regulation of c-met expression in human hepatocellular carcinoma cells","volume":"275","author":"Li","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0055","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/mc.20484","article-title":"Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet","volume":"48","author":"Tryndyak","year":"2009","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0060","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/gcc.20662","article-title":"Reduced levels of miR-34a in neuroblastoma are not caused by mutations in the TP53 binding site","volume":"48","author":"Feinberg-Gorenshtein","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1261\/rna.1442309","article-title":"Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6","volume":"15","author":"Wang","year":"2009","journal-title":"RNA"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0070","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/leu.2008.377","article-title":"miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities","volume":"23","author":"Mraz","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002797","article-title":"Intact p53-dependent responses in miR-34-deficient mice","volume":"8","author":"Concepcion","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0080","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/ijc.26171","article-title":"CpG island methylation status of miRNAs in esophageal squamous cell carcinoma","volume":"130","author":"Chen","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0085","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12032-012-0413-7","article-title":"Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis","volume":"30","author":"Javeri","year":"2013","journal-title":"Med Oncol"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0090","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.lungcan.2011.10.002","article-title":"Frequent methylation and oncogenic role of microRNA-34b\/c in small-cell lung cancer","volume":"76","author":"Tanaka","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0095","first-page":"307","article-title":"Receiver operating characteristic (ROC) methodology: The state of the art","volume":"29","author":"Hanley","year":"1989","journal-title":"Crit Rev Diagn Imaging"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0100","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimations from incomplete observations","volume":"53","author":"ELK","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"DRC","year":"1972","journal-title":"J R Stat Soc B"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0110","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/pbc.22088","article-title":"Predictive power of pretreatment prognostic factors in children with hepatoblastoma: A report from the Children's Oncology Group","volume":"53","author":"Meyers","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0115","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0959-8049(97)00095-6","article-title":"Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma. Study Committee of the Cooperative Paediatric Liver Tumour Study HB89 of the German Society for Paediatric Oncology and Haematology","volume":"33","author":"von Schweinitz","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0120","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.ejso.2014.07.033","article-title":"Predictors of survival after resection of children with hepatoblastoma: A single Asian center experience","volume":"40","author":"Qiao","year":"2014","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0125","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1158\/0008-5472.CAN-05-0137","article-title":"MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells","volume":"65","author":"Chan","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0130","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1248\/bpb.29.903","article-title":"Naoe T: let-7 microRNA functions as a potential growth suppressor in human colon cancer cells","volume":"29","author":"Akao","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0135","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S1470-2045(13)70491-1","article-title":"Prognostic and predictive value of a microRNA signature in stage II colon cancer: A microRNA expression analysis","volume":"14","author":"Zhang","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0140","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1158\/1078-0432.CCR-14-1096","article-title":"A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma","volume":"20","author":"Saito","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0145","first-page":"113","article-title":"High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma","volume":"23","author":"Chung","year":"2010","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0150","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/hep.22806","article-title":"MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma","volume":"49","author":"Tsai","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0155","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.23380","article-title":"Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma","volume":"51","author":"Xiong","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0160","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2006.10.040","article-title":"Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans","volume":"127","author":"Ruby","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0165","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrc3318","article-title":"MicroRNAs in the p53 network: Micromanagement of tumour suppression","volume":"12","author":"Hermeking","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0170","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/cdd.2009.56","article-title":"The miR-34 family in cancer and apoptosis","volume":"17","author":"Hermeking","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jpedsurg.2016.02.091_bb0175","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbrc.2009.07.101","article-title":"Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples","volume":"388","author":"He","year":"2009","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346816002050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346816002050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T19:33:41Z","timestamp":1748806421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346816002050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0022346816002050"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.02.091","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined low miR-34s are associated with unfavorable prognosis in children with hepatoblastoma: A Chinese population-based study","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.02.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}