{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:55:41Z","timestamp":1787601341903,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["25462777"],"award-info":[{"award-number":["25462777"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institute of Laboratory Animal Sciences, Kagoshima University (Frontier Science Research Center)"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jpedsurg.2016.09.035","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T19:02:53Z","timestamp":1474138973000},"page":"2039-2043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ghrelin improves intestinal mucosal atrophy during parenteral nutrition: An experimental study"],"prefix":"10.1016","volume":"51","author":[{"given":"Waka","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuru","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoi","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Souda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ieiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jpedsurg.2016.09.035_bb0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/cs0590317","article-title":"Speed of onset of adaptive mucosal hypoplasia and hypofunction in the intestine of parenterally fed rats","volume":"59","author":"Hughes","year":"1980","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"10.1016\/j.jpedsurg.2016.09.035_bb0010","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/0148607195019006453","article-title":"Parenteral nutrition is associated with intestinal morphologic and functional changes in humans","volume":"19","author":"Buchman","year":"1995","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"2","key":"10.1016\/j.jpedsurg.2016.09.035_bb0015","first-page":"185","article-title":"Total parenteral nutrition promotes bacterial translocation from the gut","volume":"104","author":"Alverdy","year":"1988","journal-title":"Surgery"},{"issue":"5","key":"10.1016\/j.jpedsurg.2016.09.035_bb0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00000658-199205000-00013","article-title":"Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma","volume":"215","author":"Kudsk","year":"1992","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.jpedsurg.2016.09.035_bb0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/jpsu.2003.50018","article-title":"Keratinocyte growth factor decreases total parenteral nutrition-induced apoptosis in mouse intestinal epithelium via Bcl-2","volume":"38","author":"Wildhaber","year":"2003","journal-title":"J Pediatr Surg"},{"issue":"2","key":"10.1016\/j.jpedsurg.2016.09.035_bb0030","doi-asserted-by":"crossref","first-page":"G236","DOI":"10.1152\/ajpgi.00142.2011","article-title":"Epidermal growth factor\/TNF-alpha transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition","volume":"302","author":"Feng","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2 Pt 1","key":"10.1016\/j.jpedsurg.2016.09.035_bb0035","first-page":"G559","article-title":"Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2","volume":"273","author":"Chance","year":"1997","journal-title":"Am J Phys"},{"issue":"1\u20133","key":"10.1016\/j.jpedsurg.2016.09.035_bb0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejphar.2008.07.070","article-title":"The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat","volume":"596","author":"Kaji","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpedsurg.2016.09.035_bb0045","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/jn\/132.7.2010","article-title":"Alterations in enterocyte proliferation and apoptosis accompany TPN-induced mucosal hypoplasia and IGF-I-induced hyperplasia in rats","volume":"132","author":"Dahly","year":"2002","journal-title":"J Nutr"},{"issue":"3","key":"10.1016\/j.jpedsurg.2016.09.035_bb0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00005176-199903000-00019","article-title":"Growth hormone stimulates, through tyrosine kinase, ion transport and proliferation in human intestinal cells","volume":"28","author":"Canani","year":"1999","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6762","key":"10.1016\/j.jpedsurg.2016.09.035_bb0055","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"issue":"6 Suppl.","key":"10.1016\/j.jpedsurg.2016.09.035_bb0060","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1177\/014860719902300603","article-title":"Effects of insulin-like growth factor-I and growth hormone in models of parenteral nutrition","volume":"23","author":"Ney","year":"1999","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.jpedsurg.2016.09.035_bb0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: structure and function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.jpedsurg.2016.09.035_bb0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.biopha.2013.01.007","article-title":"The effect of ghrelin on cell proliferation in small intestinal IEC-6 cells","volume":"67","author":"Yu","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpedsurg.2016.09.035_bb0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.peptides.2013.11.021","article-title":"Ghrelin promotes intestinal epithelial cell proliferation through PI3K\/Akt pathway and EGFR trans-activation both converging to ERK 1\/2 phosphorylation","volume":"52","author":"Waseem","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.jpedsurg.2016.09.035_bb0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01852185","article-title":"Three-dimensional structure and cell kinetics at different sites of rat intestinal remnants during the early adaptive response to resection","volume":"181","author":"Menge","year":"1982","journal-title":"Res Exp Med"},{"issue":"9","key":"10.1016\/j.jpedsurg.2016.09.035_bb0085","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.5858\/arpa.2012-0354-OA","article-title":"Mechanism of villous atrophy in celiac disease: role of apoptosis and epithelial regeneration","volume":"137","author":"Shalimar","year":"2013","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"10.1016\/j.jpedsurg.2016.09.035_bb0090","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1053\/j.gastro.2009.12.058","article-title":"Effects of ghrelin adminisitration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study","volume":"138","author":"Adachi","year":"2010","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jpedsurg.2016.09.035_bb0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3181\/0706-RM-169","article-title":"Suppression of intestinal mucosal apoptosis by ghrelin in fasting rats","volume":"233","author":"Park","year":"2008","journal-title":"Exp Biol Med"},{"issue":"1\u20133","key":"10.1016\/j.jpedsurg.2016.09.035_bb0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.regpep.2011.11.007","article-title":"The effects of enteral ghrelin administration on the remodeling of the small intestinal mucosa in neonatal piglets","volume":"174","author":"S\u0142upecka","year":"2012","journal-title":"Regul Pept"},{"issue":"4","key":"10.1016\/j.jpedsurg.2016.09.035_bb0105","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1258\/ebm.2009.009247","article-title":"Exogenous ghrelin regulates proliferation and apoptosis in the hypotrophic gut mucosa of the rat","volume":"235","author":"de Segura","year":"2010","journal-title":"Exp Biol Med"},{"issue":"11","key":"10.1016\/j.jpedsurg.2016.09.035_bb0110","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1093\/jn\/135.11.2553","article-title":"Insulin-like growth factor-I (IGF-I) attenuates jejunal atrophy in association with increased expression of IGF-I binding protein-5 in parenterally fed mice","volume":"135","author":"Murali","year":"2005","journal-title":"J Nutr"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234681630358X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002234681630358X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T14:01:59Z","timestamp":1568383319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002234681630358X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S002234681630358X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.09.035","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin improves intestinal mucosal atrophy during parenteral nutrition: An experimental study","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.09.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}