{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:43:28Z","timestamp":1789980208342,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81402301"],"award-info":[{"award-number":["81402301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81401982"],"award-info":[{"award-number":["81401982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270481"],"award-info":[{"award-number":["81270481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272779"],"award-info":[{"award-number":["81272779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jpedsurg.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T08:45:56Z","timestamp":1485161156000},"page":"1182-1187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neuregulin 1 is involved in enteric nervous system development in zebrafish"],"prefix":"10.1016","volume":"52","author":[{"given":"Jiarui","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaotao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangsong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0005","first-page":"113","article-title":"Hirschsprung disease: a developmental disorder of the enteric nervous system","volume":"2","author":"McKeown","year":"2013","journal-title":"Rev Dev Biol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0010","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.earlhumdev.2014.09.016","article-title":"Hirschsprung disease and anorectal malformation","volume":"90","author":"Wetherill","year":"2014","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0015","first-page":"64","article-title":"Burns, A","volume":"366","author":"Sasselli","year":"2012","journal-title":"The enteric nervous system. Dev Biol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0020","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/dvg.20429","article-title":"Differentiation of the zebrafish enteric nervous system and intestinal smooth muscle","volume":"46","author":"Olden","year":"2008","journal-title":"Genesis"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0025","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/cne.21705","article-title":"Development of enteric and vagal innervation of the zebrafish (Danio rerio) gut","volume":"508","author":"Olsson","year":"2008","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/B978-0-12-387036-0.00006-2","article-title":"Development of the zebrafish enteric nervous system","volume":"101","author":"Shepherd","year":"2011","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00383-015-3731-y","article-title":"RET gene is a major risk factor for Hirschsprung's disease: a meta-analysis","volume":"31","author":"Tomuschat","year":"2015","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0040","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1073\/pnas.0809630105","article-title":"Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease","volume":"106","author":"Garcia-Barcelo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00439-011-1035-4","article-title":"Mutations in the NRG1 gene are associated with Hirschsprung disease","volume":"131","author":"Tang","year":"2012","journal-title":"Hum Genet"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2014.06.007","article-title":"Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases","volume":"83","author":"Mei","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0055","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/1471-2164-11-392","article-title":"Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0060","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mod.2004.10.009","article-title":"Intestinal growth and differentiation in zebrafish","volume":"122","author":"Wallace","year":"2005","journal-title":"Mech Dev"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0065","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1523\/JNEUROSCI.20-23-08762.2000","article-title":"The agrin\/MuSK signaling pathway is spatially segregated from the Neuregulin\/ErbB receptor signaling pathway at the neuromuscular junction","volume":"20","author":"Trinidad","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn2392","article-title":"Neuregulin 1 in neural development, synaptic plasticity and schizophrenia","volume":"9","author":"Mei","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0075","first-page":"1","article-title":"The neuregulin-I\/ErbB signaling system in development and disease","volume":"190","author":"Britsch","year":"2007","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0080","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.semcdb.2010.08.008","article-title":"Nrg1\/ErbB signaling networks in Schwann cell development and myelination","volume":"21","author":"Newbern","year":"2010","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0085","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1002\/cne.22449","article-title":"Neuregulin-1 at synapses on phrenic motoneurons","volume":"518","author":"Issa","year":"2010","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0090","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1242\/dev.022178","article-title":"Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons","volume":"135","author":"Honjo","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0095","doi-asserted-by":"crossref","first-page":"e36524","DOI":"10.1371\/journal.pone.0036524","article-title":"Comprehensive analysis of NRG1 common and rare variants in Hirschsprung patients","volume":"7","author":"Luz\u00f3n-Toro","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0100","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/jhg.2012.18","article-title":"Association of genetic polymorphisms in the RET-protooncogene and NRG1 with Hirschsprung disease in Thai patients","volume":"57","author":"Phusantisampan","year":"2012","journal-title":"J Hum Genet"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0105","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/hmg\/ddv051","article-title":"Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms","volume":"24","author":"Kapoor","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0110","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jpedsurg.2014.04.011","article-title":"Effects of RET and NRG1 polymorphisms in Indonesian patients with Hirschsprung disease","volume":"49","author":"Gunadi","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0115","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00439-013-1272-9","article-title":"RET and NRG1 interplay in Hirschsprung disease","volume":"132","author":"Gui","year":"2013","journal-title":"Hum Genet"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0120","doi-asserted-by":"crossref","first-page":"e16181","DOI":"10.1371\/journal.pone.0016181","article-title":"Fine mapping of the NRG1 Hirschsprung's disease locus","volume":"6","author":"Tang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0125","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cub.2005.02.030","article-title":"erbb3 and erbb2 are essential for Schwann cell migration and myelination in zebrafish","volume":"15","author":"Lyons","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics: a review","volume":"45","author":"Amiel","year":"2008","journal-title":"J Med Genet"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0135","first-page":"1117","article-title":"Hirschsprung's disease as a model of complex genetic etiology","volume":"28","author":"Borrego","year":"2013","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0140","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.3748\/wjg.v17.i45.4937","article-title":"Genetic interactions and modifier genes in Hirschsprung's disease","volume":"17","author":"Wallace","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0145","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.mod.2008.04.006","article-title":"Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species","volume":"125","author":"Heanue","year":"2008","journal-title":"Mech Dev"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1469-7580.2010.01254.x","article-title":"Distribution of glial cell line-derived neurotrophic factor receptor alpha-1 in the brain of adult zebrafish","volume":"217","author":"Lucini","year":"2010","journal-title":"J Anat"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0155","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neures.2013.08.012","article-title":"GDNF induces synaptic vesicle markers in enteric neurons","volume":"77","author":"B\u00f6ttner","year":"2013","journal-title":"Neurosci Res"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0160","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.onc.1201048","article-title":"The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis","volume":"14","author":"Marcos-Guti\u00e9rrez","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0165","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1242\/dev.128.21.4113","article-title":"Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates","volume":"128","author":"Dutton","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0170","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.jpedsurg.2012.03.061","article-title":"Aberrant high expression of NRG1 gene in Hirschsprung disease","volume":"47","author":"Tang","year":"2012","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0175","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.mod.2004.12.008","article-title":"Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent","volume":"122","author":"Elworthy","year":"2005","journal-title":"Mech Dev"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0180","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ydbio.2008.02.061","article-title":"Endoderm-derived sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish","volume":"318","author":"Reichenbach","year":"2008","journal-title":"Dev Biol"},{"issue":"5","key":"10.1016\/j.jpedsurg.2017.01.005_bb0185","doi-asserted-by":"crossref","first-page":"e1002687","DOI":"10.1371\/journal.pgen.1002687","article-title":"Genome-wide copy number analysis uncovers a new HSCR gene: NRG3","volume":"8","author":"Tang","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jpedsurg.2017.01.005_bb0190","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s12035-012-8392-4","article-title":"Exome sequencing identified NRG3 as a novel susceptible gene of Hirschsprung's disease in a Chinese population","volume":"47","author":"Yang","year":"2013","journal-title":"Mol Neurobiol"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346817300374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346817300374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:14:44Z","timestamp":1719015284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346817300374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0022346817300374"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.01.005","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuregulin 1 is involved in enteric nervous system development in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}