{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:50:24Z","timestamp":1789563024701,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jpedsurg.2017.01.046","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T20:20:47Z","timestamp":1485807647000},"page":"772-777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease"],"prefix":"10.1016","volume":"52","author":[{"given":"Christian","family":"Tomuschat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Coyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolas","family":"Dreher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0005","series-title":"Hirschsprung's disease and allied disorders","author":"Holschneider","year":"2008"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0010","series-title":"Surgical treatment of colorectal problems in children","author":"Pen\u00e3","year":"2015"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0015","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S1055-8586(98)70009-5","article-title":"Hirschsprung's disease: a search for etiology","volume":"7","author":"Puri","year":"1998","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0020","series-title":"Hirschsprung's disease and allied disorders","first-page":"107","article-title":"Hirschsprung's disease: clinical features","author":"Puri","year":"2008"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0025","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00383-013-3353-1","article-title":"Hirschsprung-associated enterocolitis: pathogenesis, treatment and prevention","volume":"29","author":"Demehri","year":"2013","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0030","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1053\/j.sempedsurg.2012.07.006","article-title":"The pathogenesis of Hirschsprung's disease-associated enterocolitis","volume":"21","author":"Austin","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0035","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jpedsurg.2015.10.006","article-title":"Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis","volume":"51","author":"Grishin","year":"2016","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0040","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1096\/fj.00-0078com","article-title":"Nosip, a novel modulator of endothelial nitric oxide synthase activity","volume":"15","author":"J\u00e4","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0045","doi-asserted-by":"publisher","first-page":"10454","DOI":"10.1523\/JNEUROSCI.2265-04.2004","article-title":"Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity","volume":"24","author":"Dreyer","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0050","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00383-016-3862-9","article-title":"Established and emerging concepts in Hirschsprung's-associated enterocolitis","volume":"32","author":"Gosain","year":"2016","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0055","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1053\/gast.2002.34212","article-title":"Distribution of the novel eNOS-interacting protein NOSIP in the liver, pancreas, and gastrointestinal tract of the rat","volume":"123","author":"Kummer","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0060","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/j.semperi.2008.01.002","article-title":"The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis","volume":"32","author":"Chokshi","year":"2008","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0065","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0092-8674(94)90266-6","article-title":"Nitric oxide synthases: roles, tolls, and controls","volume":"78","author":"Nathan","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0070","doi-asserted-by":"publisher","first-page":"8288","DOI":"10.1021\/bi062130b","article-title":"Differential binding of calmodulin domains to constitutive and inducible nitric oxide synthase enzymes","volume":"46","author":"Spratt","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0075","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0080","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","article-title":"Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle","volume":"113","author":"Kolios","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0090","first-page":"G1138","article-title":"Nitric oxide modulates epithelial permeability in the feline small intestine","volume":"262","author":"Kubes","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0095","first-page":"G418","article-title":"Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells","volume":"265","author":"Brown","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0100","first-page":"G225","article-title":"A critical role for nitric oxide in intestinal barrier function and dysfunction","volume":"270","author":"Inci","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0105","first-page":"G865","article-title":"Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity","volume":"287","author":"Vallance","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0110","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/(SICI)1097-4652(199707)172:1<12::AID-JCP2>3.0.CO;2-G","article-title":"Nitric oxide inhibits neutrophil \u00ce22 integrin function by inhibiting membrane-ssociated cyclic GMP synthesis","volume":"172","author":"Banick","year":"1997","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jpedsurg.2017.01.046_bb0115","doi-asserted-by":"publisher","first-page":"10826","DOI":"10.1074\/jbc.275.15.10826","article-title":"Reactive nitrogen and oxygen species attenuate interleukin-8-induced neutrophil chemotactic activity in vitro","volume":"275","author":"Sato","year":"2000","journal-title":"J Biol Chem"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346817300799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346817300799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T19:25:37Z","timestamp":1536089137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346817300799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0022346817300799"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.01.046","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}