{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:17:05Z","timestamp":1782519425492,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jpedsurg.2017.04.003","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T01:02:32Z","timestamp":1491613352000},"page":"1782-1786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of nitroglycerine ointment in the treatment of pediatric anal fissure"],"prefix":"10.1016","volume":"52","author":[{"given":"Ali E.","family":"Joda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali F.","family":"Al-Mayoof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0005","series-title":"Pediatric surgery","first-page":"1311","article-title":"Other disorders of the anus and rectum, anorectal function","author":"Rintala","year":"2012"},{"issue":"1","key":"10.1016\/j.jpedsurg.2017.04.003_bb0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.18773\/austprescr.2016.007","article-title":"Anal fissure","volume":"39","author":"Schlichtemeier","year":"2016","journal-title":"Austr Prescriber"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0015","series-title":"The ASCRS textbook of colon and rectal surgery","first-page":"178","article-title":"Benign anorectal: Anal fissure","author":"Dykes","year":"2007"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0020","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/adc.85.5.404","article-title":"Double blind randomised control trial of topical glyceryl trinitrate in anal fissure","volume":"85","author":"Kenny","year":"2001","journal-title":"Arch Dis Child"},{"issue":"3","key":"10.1016\/j.jpedsurg.2017.04.003_bb0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2165\/00003088-200342030-00001","article-title":"Clinical pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its metabolites","volume":"42","author":"Hashimoto","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0030","first-page":"474838","article-title":"Pain in children: assessment and non-pharmacological management","author":"Srouji","year":"2010","journal-title":"Int J Pediatr"},{"issue":"6","key":"10.1016\/j.jpedsurg.2017.04.003_bb0035","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1526-4610.1990.hed3006366.x","article-title":"Migraine headache in the infant and young child","volume":"30","author":"Elser","year":"1990","journal-title":"Headache"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00384-011-1286-5","article-title":"Botulinum toxin and anal fissure: efficacy and safety systematic review","volume":"27","author":"Yiannakopoulou","year":"2012","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0045","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2165\/00003495-200666030-00006","article-title":"0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain","volume":"66","author":"Fenton","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0050","series-title":"Chronic anal fissure: 0.2% topical glyceryl trinitrate ointment","year":"2013"},{"issue":"9","key":"10.1016\/j.jpedsurg.2017.04.003_bb0055","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1053\/jpsu.2002.34997","article-title":"Randomized placebo controlled treatment of anal fissure by lidocaine, EMLA and GTN in children","volume":"37","author":"Sonmez","year":"2002","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10151-011-0683-7","article-title":"The management of patients with primary chronic anal fissure: a position paper","volume":"15","author":"Altomare","year":"2011","journal-title":"Tech Coloproctol"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0065","first-page":"51","article-title":"Glyceryl trinitrate treatment in chronic fissure in ano","volume":"62","author":"Zghair","year":"2016","journal-title":"Iraqi Med J"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0070","series-title":"Advances in biomedical research","first-page":"498","article-title":"Current understanding of anal fissure pathophysiology","author":"Madalinski","year":"2010"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0075","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/ped.12282","article-title":"Clinical, psychological and maternal characteristics in early functional constipation","volume":"56","author":"Kilincaslan","year":"2014","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0080","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s10350-004-0785-7","article-title":"Practical parameters for the management of anal fissures","volume":"47","author":"Orsay","year":"2007","journal-title":"Dis Colon rectum"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0085","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s10350-005-0025-9","article-title":"Prospective manometric assessment of botulinum toxin and its correlation with healing of chronic anal fissure","volume":"48","author":"Thornton","year":"2005","journal-title":"Dis Colon rectum"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0090","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00384-010-0885-x","article-title":"Screening for the effectiveness of conservative treatment in chronic anal fissure patients using anorectal manometry","volume":"25","author":"Gil","year":"2010","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0100","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1179\/146532805X45737","article-title":"Long-term results of topical glyceryl trinitrate ointment in children with anal fissure","volume":"25","author":"Demirbag","year":"2005","journal-title":"Ann Trop Paediatr"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s13126-016-0278-x","article-title":"Comparative evaluation of 0.2% glyceryl trinitrate vs. 2% diltiazem ointment in treatment of chronic anal fissure: a case trial","volume":"88","author":"Bansal","year":"2016","journal-title":"Hell J Surg"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0110","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/DCR.0b013e31825a9f1f","article-title":"Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized control trial. Is this the solution to the headaches?","volume":"55","author":"P\u00e9rez-Legaz","year":"2012","journal-title":"Dis Colon rectum"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3393\/ac.2014.30.3.132","article-title":"Sphincter-preserving therapy for treating a chronic anal fissure: long-term outcomes","volume":"30","author":"Farouk","year":"2014","journal-title":"Ann Coloproctol"},{"key":"10.1016\/j.jpedsurg.2017.04.003_bb0120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1463-1318.2001.00248.x","article-title":"The dose response of the internal anal sphincter to topical application of glyceryl trinitrate ointment","volume":"3","author":"Cundall","year":"2001","journal-title":"Colorectal Dis"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346817302191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346817302191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T17:53:33Z","timestamp":1535910813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346817302191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0022346817302191"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.04.003","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of nitroglycerine ointment in the treatment of pediatric anal fissure","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}