{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:51:12Z","timestamp":1792615872655,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jpedsurg.2019.06.019","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T22:26:53Z","timestamp":1561760813000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Heritable spina bifida in sheep: A potential model for fetal repair of myelomeningocele"],"prefix":"10.1016","volume":"55","author":[{"given":"John W.","family":"Steele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Bayliss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bayliss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Linda","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan J.","family":"Wlodarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes G.","family":"Asfaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Finnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.jpedsurg.2019.06.019_bb0005","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/bdr2.1366","article-title":"A 2017 global update on folic acid-preventable spina bifida and anencephaly","volume":"110","author":"Kancherla","year":"2018","journal-title":"Birth Defects Res"},{"issue":"2","key":"10.1016\/j.jpedsurg.2019.06.019_bb0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1017\/S0007114508149200","article-title":"Not all cases of neural tube-defect can be prevented by increasing the uptake of folic acid","volume":"102","author":"Heseker","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0015","doi-asserted-by":"crossref","unstructured":"Joyeux L, Danzer E, Flake AW, Deprest J. Fetal surgery for spina bifida aperta. Arch Dis Child Fetal Neonatal Ed 2018; pii: fetalneonatal-2018-315143. https:\/\/doi.org\/10.1136\/archdischild-2018-315143","DOI":"10.1136\/archdischild-2018-315143"},{"issue":"4","key":"10.1016\/j.jpedsurg.2019.06.019_bb0020","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm0495-342","article-title":"In utero surgery rescues neurological function at birth in sheep with spina bifida","volume":"1","author":"Meuli","year":"1995","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jpedsurg.2019.06.019_bb0025","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/0022-3468(95)90335-6","article-title":"Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep","volume":"30","author":"Meuli","year":"1995","journal-title":"J Pediatr Surg"},{"issue":"3","key":"10.1016\/j.jpedsurg.2019.06.019_bb0030","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-3468(96)90746-0","article-title":"In utero repair of experimental myelomeningocele saves neurological function at birth","volume":"31","author":"Meuli","year":"1996","journal-title":"J Pediatr Surg"},{"issue":"7","key":"10.1016\/j.jpedsurg.2019.06.019_bb0035","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jpedsurg.2014.10.021","article-title":"Innate healing in the fetal sheep model of myelomeningocele: a standardized defect grading system","volume":"50","author":"Brown","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"3","key":"10.1016\/j.jpedsurg.2019.06.019_bb0040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/jpsu.2003.50078","article-title":"Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep","volume":"38","author":"Bouchard","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0045","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jpedsurg.2010.11.028","article-title":"Maldevelopment of the cerebral cortex in the surgically induced model of myelomeningocele: implications for fetal neurosurgery","volume":"46","author":"Encinas","year":"2011","journal-title":"J Pediatr Surg"},{"issue":"8","key":"10.1016\/j.jpedsurg.2019.06.019_bb0050","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s00381-014-2426-3","article-title":"Limits of the surgically induced model of myelomeningocele in the fetal sheep","volume":"30","author":"Guilbaud","year":"2014","journal-title":"Childs Nerv Syst"},{"issue":"4","key":"10.1016\/j.jpedsurg.2019.06.019_bb0055","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0378-1135(90)90001-C","article-title":"Evidence that cache valley virus induces congenital malformations in sheep","volume":"21","author":"Chung","year":"1990","journal-title":"Vet Microbiol"},{"issue":"9","key":"10.1016\/j.jpedsurg.2019.06.019_bb0060","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/hmg\/9.6.993","article-title":"Mouse models for neural tube closure defects","volume":"12","author":"Juriloff","year":"2000","journal-title":"Human Mol Genet"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0065","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s00464-002-9184-0","article-title":"Percutaneous fetoscopic patch coverage of experimental lumbosacral full-thickness skin lesions in sheep","volume":"17","author":"Kohl","year":"2003","journal-title":"Surg Endosc"},{"issue":"2","key":"10.1016\/j.jpedsurg.2019.06.019_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000089301","article-title":"Percutaneous fetoscopic patch coverage of spina bifida aperta in the human\u2014early clinical experience and potential","volume":"21","author":"Kohl","year":"2006","journal-title":"Fetal Diagn Ther"},{"issue":"3","key":"10.1016\/j.jpedsurg.2019.06.019_bb0075","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1590\/S0102-86502009000300014","article-title":"Sanchez e Oliveira Rde C, Saldiva PH, Pedreira DA. Simplified correction of a meningomyelocele-like defect in the ovine fetus","volume":"24","author":"Abou-Jamra","year":"2009","journal-title":"Acta Cir Bras"},{"issue":"4","key":"10.1016\/j.jpedsurg.2019.06.019_bb0080","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1590\/S1679-45082012000400011","article-title":"Comparison between two surgical techniques for prenatal correction of meningomyelocele in sheep","volume":"10","author":"Herrera","year":"2012","journal-title":"Einstein (Sao Paulo)"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0085","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1007\/s00464-013-2984-6","article-title":"Single-access fetal endoscopy (SAFE) for myelomeningocele in sheep model I: amniotic carbon dioxide gas approach","volume":"27","author":"Peiro","year":"2013","journal-title":"Surg Endosc"},{"issue":"1","key":"10.1016\/j.jpedsurg.2019.06.019_bb0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jpedsurg.2013.09.043","article-title":"In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model","volume":"49","author":"Brown","year":"2013","journal-title":"J Pediatr Surg"},{"issue":"3","key":"10.1016\/j.jpedsurg.2019.06.019_bb0095","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.1055\/s-0036-1592316","article-title":"Neurological outcomes after human umbilical cord patch for in utero spina bifida repair in a sheep model","volume":"6","author":"Papanna","year":"2016","journal-title":"AJP Rep"},{"issue":"6","key":"10.1016\/j.jpedsurg.2019.06.019_bb0100","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jpedsurg.2018.02.067","article-title":"Donor mesenchymal stem cell linetics after transamniotic stem cell therapy (TRASCET) for experimental spina bifida","volume":"53","author":"Shieh","year":"2018","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biomaterials.2015.10.051","article-title":"Complete tissue coverage achieved by scaffold-based tissue engineering in the fetal sheep model of myelomeningocele","volume":"76","author":"Watanabe","year":"2016","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jpedsurg.2019.06.019_bb0110","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.expneurol.2005.03.011","article-title":"Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathological analysis and magnetic resonance imaging","volume":"194","author":"Danzer","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0115","doi-asserted-by":"crossref","unstructured":"Bertram S, Ter Haar G, and De Decker S. Congenital malformations of the lumbosacral vertebral column are common in neurologically normal French bulldogs, English bulldogs, and pugs, with breed-specific differences. Vet Radiol Ultrasound 2019; Epub ahead of print. https:\/\/doi.org\/10.1111\/vru.12753","DOI":"10.1111\/vru.12753"},{"issue":"6","key":"10.1016\/j.jpedsurg.2019.06.019_bb0120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5326\/JAAHA-MS-6090","article-title":"Surgical correction of a sacral meningomyelocele in a dog","volume":"50","author":"Song","year":"2014","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0125","author":"Finney"},{"issue":"4","key":"10.1016\/j.jpedsurg.2019.06.019_bb0130","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jpedsurg.2015.01.002","article-title":"Development of a locomotor rating scale for testing motor function in sheep","volume":"50","author":"Brown","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"5","key":"10.1016\/j.jpedsurg.2019.06.019_bb0135","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/oxfordjournals.jhered.a109960","article-title":"Inheritance of spina bifida in Icelandic lambs","volume":"75","author":"Adalsteinsson","year":"1984","journal-title":"J Hered"},{"issue":"6","key":"10.1016\/j.jpedsurg.2019.06.019_bb0140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/00480169.2010.69763","article-title":"Spina bifida with associated malformations of the central nervous system in a Dorper-cross sheep","volume":"58","author":"Potter","year":"2010","journal-title":"N Z Vet J"},{"issue":"1","key":"10.1016\/j.jpedsurg.2019.06.019_bb0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.17236\/sat00004","article-title":"Spina bifida aperta in a sheep lamb","volume":"157","author":"Gutzwiller","year":"2015","journal-title":"Schweiz Arch Tierheilkd"},{"key":"10.1016\/j.jpedsurg.2019.06.019_bb0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000071319","article-title":"Review of surgically induced animal models of spinal neural tube defects: implications for fetal surgery","volume":"39","author":"George","year":"2003","journal-title":"Pediatr Neurosurg"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346819304464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346819304464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:34:35Z","timestamp":1758357275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346819304464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0022346819304464"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.06.019","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heritable spina bifida in sheep: A potential model for fetal repair of myelomeningocele","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}