{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:40:57Z","timestamp":1790674857898,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jpedsurg.2020.03.006","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T02:33:00Z","timestamp":1585103580000},"page":"2791-2796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Human skin-derived precursor cells xenografted in aganglionic bowel"],"prefix":"10.1016","volume":"55","author":[{"given":"Anne-Laure","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.Y.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0005","unstructured":"Holcomb GW, Murphy JP, Ostlie DJ. Ashcraft's pediatric surgery. n.d."},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0010","first-page":"72","article-title":"Intraoperative histochemical diagnosis of Hirschsprung disease","volume":"5","author":"Dodero","year":"1992","journal-title":"Cir Pediatr"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0015","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-3468(83)80368-6","article-title":"Anorectal manometry: experience with strain gauge pressure transducers for the diagnosis of Hirschsprung's disease","volume":"18","author":"Loening-Baucke","year":"1983","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF01194793","article-title":"Hirschsprung's disease as a neurochristopathy","volume":"12","author":"Martucciello","year":"1997","journal-title":"Pediatr Surg Int"},{"issue":"80","key":"10.1016\/j.jpedsurg.2020.03.006_bb0025","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.1085649","article-title":"Hirschsprung disease is linked to defects in neural crest stem cell function","volume":"301","author":"Iwashita","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0030","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0140-6736(17)32284-5","article-title":"Advances in paediatric gastroenterology","volume":"390","author":"Tam","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jcmgh.2015.09.007","article-title":"Enteric neural cells from Hirschsprung disease patients form ganglia in autologous aneuronal colon","volume":"2","author":"Rollo","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0040","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/cr.2012.11","article-title":"Neural crest stem cells: discovery, properties and potential for therapy","volume":"22","author":"Achilleos","year":"2012","journal-title":"Cell Res"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jss.2010.12.016","article-title":"Transplantation of enteric cells expressing p75 in the rodent stomach","volume":"174","author":"Geisbauer","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0050","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-2007-964952","article-title":"Neural crest neuroblasts can colonise aganglionic and ganglionic gut in vivo","volume":"17","author":"Gl","year":"2007","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147989","article-title":"In vivo transplantation of enteric neural crest cells into mouse gut; engraftment, Functional Integration and Long-Term Safety","volume":"11","author":"Cooper","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0060","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.12900","article-title":"In vivo transplantation of fetal human gut-derived enteric neural crest cells","volume":"29","author":"Cooper","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0065","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jdermsci.2012.10.007","article-title":"A novel niche for skin derived precursors in non-follicular skin","volume":"69","author":"Ruetze","year":"2013","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0070","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ncb0901-778","article-title":"Isolation of multipotent adult stem cells from the dermis of mammalian skin","volume":"3","author":"Toma","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0075","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1634\/stemcells.2007-0281","article-title":"A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin","volume":"26","author":"Hunt","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/978-1-60761-380-0_28","article-title":"Isolation and culture of hair follicle pluripotent stem (hfPS) cells and their use for nerve and spinal cord regeneration","volume":"585","author":"Amoh","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.copbio.2009.10.004","article-title":"Multipotent skin-derived precursors: from biology to clinical translation","volume":"20","author":"Hunt","year":"2009","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0090","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1038\/jid.2009.148","article-title":"Nestin in human skin: exclusive expression in intramesenchymal skin compartments and regulation by leptin","volume":"129","author":"Tiede","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0095","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1634\/stemcells.2004-0134","article-title":"Isolation and characterization of multipotent skin-derived precursors from human skin","volume":"23","author":"Toma","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0100","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/ncb1181","article-title":"A dermal niche for multipotent adult skin-derived precursor cells","volume":"6","author":"Fernandes","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0105","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1083\/jcb.200606062","article-title":"Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin","volume":"175","author":"Wong","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0110","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2353\/ajpath.2006.051170","article-title":"Isolation of a novel population of multipotent adult stem cells from human hair follicles","volume":"168","author":"Yu","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0115","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4161\/cc.10.5.14969","article-title":"The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla","volume":"10","author":"Liu","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0120","first-page":"1","article-title":"Delivery of epidermal neural crest stem cells (EPI-NCSC) to hippocamp in Alzheimer's disease rat model","volume":"16","author":"Esmaeilzade","year":"2012","journal-title":"Iran Biomed J"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0125","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jpedsurg.2012.08.026","article-title":"Potential use of skin-derived precursors (SKPs) in establishing a cell-based treatment model for Hirschsprung's disease","volume":"48","author":"Kwok","year":"2013","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.46582\/jsrm.0801006","article-title":"Morphological and electrophysiological features of mature neurons in differentiated skin-derived precursor cells","volume":"8","author":"Liebmann","year":"2012","journal-title":"J Stem Cells Regen Med"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0135","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.expneurol.2006.03.018","article-title":"Analysis of the neurogenic potential of multipotent skin-derived precursors","volume":"201","author":"Fernandes","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0140","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jpedsurg.2014.09.023","article-title":"Skin-derived precursors generate enteric-type neurons in aganglionic jejunum","volume":"49","author":"Wagner","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0145","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.jpedsurg.2014.01.061","article-title":"Transplanted skin-derived precursor stem cells generate enteric ganglion-like structures in vivo","volume":"49","author":"Wagner","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0150","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/BF01953222","article-title":"Selective destruction of intestinal nervous elements by local application of benzalkonium solution in the rat","volume":"35","author":"Sakata","year":"1979","journal-title":"Experientia"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0155","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s003830100681","article-title":"Selective chemical ablation of the enteric plexus in mice","volume":"18","author":"Yoneda","year":"2002","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0160","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1365-2982.2007.00981.x","article-title":"Neuroepithelial stem cells differentiate into neuronal phenotypes and improve intestinal motility recovery after transplantation in the aganglionic colon of the rat","volume":"19","author":"Liu","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0165","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12035-013-8430-x","article-title":"Treatment of aganglionic megacolon mice via neural stem cell transplantation","volume":"48","author":"Shu","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0170","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0304-3940(02)00832-7","article-title":"No reduction with ageing of the number of myenteric neurons in benzalkonium chloride treated rats","volume":"331","author":"Garcia","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0175","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.jpedsurg.2010.08.045","article-title":"Benzalkonium chloride-treated anorectums mimicked endothelin-3-deficient aganglionic anorectums on manometry","volume":"45","author":"Qin","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0180","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0022-3565(25)24834-0","article-title":"Pharmacological characterization of rat jejunal contractility after chronic ablation of the myenteric plexus","volume":"238","author":"Fox","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0185","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1023\/A:1026603327807","article-title":"Changes in muscularis externa of rat small intestine after myenteric ablation with benzalkonium chloride: electron microscopic and morphometric study","volume":"43","author":"Holle","year":"1998","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0190","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1038\/nprot.2006.422","article-title":"Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny","volume":"1","author":"Biernaskie","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0195","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0140-6736(04)16630-0","article-title":"Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells","volume":"364","author":"Joannides","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0200","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jpedsurg.2019.09.075","article-title":"Autologous transplantation of skin-derived precursor cells in a porcine model","volume":"55","author":"Thomas","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0205","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1600-0625.2006.00471.x","article-title":"Towards the development of a pragmatic technique for isolating and differentiating nestin-positive cells from human scalp skin into neuronal and glial cell populations: generating neurons from human skin?","volume":"15","author":"Kruse","year":"2006","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0210","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1523\/JNEUROSCI.1007-06.2006","article-title":"Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system","volume":"26","author":"McKenzie","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0215","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jcp.20889","article-title":"Differentiation of human adult skin-derived neuronal precursors into mature neurons","volume":"210","author":"Gingras","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0220","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejcb.2007.07.004","article-title":"Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells","volume":"87","author":"Kajahn","year":"2008","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0225","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1600-0625.2008.00724.x","article-title":"Multilineage differentiation potential of human dermal skin-derived fibroblasts","volume":"17","author":"Lorenz","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0230","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1073\/pnas.1406376111","article-title":"Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency","volume":"111","author":"Lee","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpedsurg.2020.03.006_bb0235","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00384-012-1411-0","article-title":"The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth","volume":"27","author":"Hagl","year":"2012","journal-title":"Int J Colorectal Dis"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346820302025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346820302025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:38:07Z","timestamp":1758357487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346820302025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0022346820302025"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2020.03.006","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human skin-derived precursor cells xenografted in aganglionic bowel","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2020.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}