{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:06:35Z","timestamp":1785168395960,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jpedsurg.2020.06.032","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T19:15:21Z","timestamp":1593285321000},"page":"352-359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deletion of interleukin enhancer binding factor 2 (ILF2) resulted in defective biliary development and bile flow blockage"],"prefix":"10.1016","volume":"56","author":[{"given":"Yim","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongluan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Mercedes","family":"Garcia-Barcelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Kwong Hang","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin Chung Hang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chi Hang","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpedsurg.2020.06.032_bb0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ebiom.2018.08.024","article-title":"Cholangiopathies \u2014 towards a molecular understanding","volume":"35","author":"Tam","year":"2018","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.yapd.2017.03.012","article-title":"Biliary atresia: epidemiology, genetics, clinical update, and public health perspective","volume":"64","author":"Sanchez-Valle","year":"2017","journal-title":"Adv Pediatr"},{"issue":"9702","key":"10.1016\/j.jpedsurg.2020.06.032_bb0015","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","article-title":"Biliary atresia","volume":"374","author":"Hartley","year":"2009","journal-title":"Lancet"},{"issue":"10099","key":"10.1016\/j.jpedsurg.2020.06.032_bb0020","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0140-6736(17)32284-5","article-title":"Advances in paediatric gastroenterology","volume":"390","author":"Tam","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jpedsurg.2020.06.032_bb0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jpedsurg.2014.11.015","article-title":"Predictors for failure after Kasai operation","volume":"50","author":"Chung","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"5","key":"10.1016\/j.jpedsurg.2020.06.032_bb0030","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1067\/mpd.2003.195","article-title":"Cholangitis after hepatic portoenterostomy for biliary atresia: a multivariate analysis of risk factors","volume":"142","author":"Ernest van Heurn","year":"2003","journal-title":"J Pediatr"},{"issue":"6","key":"10.1016\/j.jpedsurg.2020.06.032_bb0035","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1053\/jpsu.2002.32892","article-title":"Portal venous velocity in the follow-up of patients with biliary atresia after Kasai portoenterostomy","volume":"37","author":"Khong","year":"2002","journal-title":"J Pediatr Surg"},{"issue":"12","key":"10.1016\/j.jpedsurg.2020.06.032_bb0040","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.jpedsurg.2004.08.027","article-title":"Effective antibiotic regime for postoperative acute cholangitis in biliary atresia\u2014an evolving scene","volume":"39","author":"Wong","year":"2004","journal-title":"J Pediatr Surg"},{"issue":"4","key":"10.1016\/j.jpedsurg.2020.06.032_bb0045","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/MPG.0000000000002450","article-title":"Biliary atresia as a disease starting in utero: implications for treatment, diagnosis, and pathogenesis","volume":"69","author":"Mysore","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.jpedsurg.2020.06.032_bb0050","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jhep.2013.07.021","article-title":"Common genetic variants regulating ADD3 gene expression alter biliary atresia risk","volume":"59","author":"Cheng","year":"2013","journal-title":"J Hepatol"},{"issue":"14","key":"10.1016\/j.jpedsurg.2020.06.032_bb0055","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1093\/hmg\/ddq196","article-title":"Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2","volume":"19","author":"Garcia-Barcelo","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12920-017-0259-0","article-title":"Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis","volume":"10","author":"Cheng","year":"2017","journal-title":"BMC Med Genomics"},{"issue":"4862","key":"10.1016\/j.jpedsurg.2020.06.032_bb0065","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.3260404","article-title":"Identification of a putative regulator of early T cell activation genes","volume":"241","author":"Shaw","year":"1988","journal-title":"Science"},{"issue":"32","key":"10.1016\/j.jpedsurg.2020.06.032_bb0070","doi-asserted-by":"crossref","first-page":"20691","DOI":"10.1016\/S0021-9258(17)32048-3","article-title":"Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90","volume":"269","author":"Kao","year":"1994","journal-title":"J Biol Chem"},{"issue":"32","key":"10.1016\/j.jpedsurg.2020.06.032_bb0075","doi-asserted-by":"crossref","first-page":"20682","DOI":"10.1016\/S0021-9258(17)32047-1","article-title":"Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter","volume":"269","author":"Corthesy","year":"1994","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.jpedsurg.2020.06.032_bb0080","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S1097-2765(02)00730-X","article-title":"J RY, et al. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization","volume":"10","author":"Shim","year":"2002","journal-title":"Mol Cell"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0085","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4161\/rna.6.1.7565","article-title":"The NFAR's (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family","volume":"6","author":"Barber","year":"2009","journal-title":"RNA Biol"},{"issue":"14","key":"10.1016\/j.jpedsurg.2020.06.032_bb0090","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1128\/JVI.00243-06","article-title":"The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site","volume":"80","author":"Merrill","year":"2006","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0095","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/nar\/gkp861","article-title":"NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif","volume":"38","author":"Kuwano","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.jpedsurg.2020.06.032_bb0100","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/cdd.2009.164","article-title":"NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response","volume":"17","author":"Graber","year":"2010","journal-title":"Cell Death Differ"},{"issue":"23","key":"10.1016\/j.jpedsurg.2020.06.032_bb0105","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1128\/MCB.05849-11","article-title":"The NF90\/NF45 complex participates in DNA break repair via nonhomologous end joining","volume":"31","author":"Shamanna","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ccell.2017.05.011","article-title":"ILF2 is a regulator of RNA splicing and DNA damage response in 1q21-amplified multiple myeloma","volume":"32","author":"Marchesini","year":"2017","journal-title":"Cancer Cell"},{"issue":"13","key":"10.1016\/j.jpedsurg.2020.06.032_bb0115","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1128\/MCB.01836-08","article-title":"The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway","volume":"29","author":"Sakamoto","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"13","key":"10.1016\/j.jpedsurg.2020.06.032_bb0120","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1128\/MCB.01297-14","article-title":"Overexpression of NF90-NF45 represses myogenic microRNA biogenesis, resulting in development of skeletal muscle atrophy and centronuclear muscle fibers","volume":"35","author":"Todaka","year":"2015","journal-title":"Mol Cell Biol"},{"issue":"19","key":"10.1016\/j.jpedsurg.2020.06.032_bb0125","doi-asserted-by":"crossref","first-page":"18981","DOI":"10.1074\/jbc.M411034200","article-title":"NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3\u2032-untranslated region of MyoD and p21WAF1\/CIP1 mRNAs","volume":"280","author":"Shi","year":"2005","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.jpedsurg.2020.06.032_bb0130","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1261\/rna.061499.117","article-title":"NF45 and NF90\/NF110 coordinately regulate ESC pluripotency and differentiation","volume":"23","author":"Ye","year":"2017","journal-title":"RNA"},{"issue":"2","key":"10.1016\/j.jpedsurg.2020.06.032_bb0135","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.yexcr.2004.12.030","article-title":"NF45\/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function","volume":"305","author":"Zhao","year":"2005","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ydbio.2011.10.004","article-title":"Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b","volume":"361","author":"Cheung","year":"2012","journal-title":"Dev Biol"},{"issue":"2","key":"10.1016\/j.jpedsurg.2020.06.032_bb0145","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ydbio.2012.09.001","article-title":"Rargb regulates organ laterality in a zebrafish model of right atrial isomerism","volume":"372","author":"Garnaas","year":"2012","journal-title":"Dev Biol"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2011.12.025","article-title":"Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic biliary network","volume":"363","author":"Schaub","year":"2012","journal-title":"Dev Biol"},{"issue":"2","key":"10.1016\/j.jpedsurg.2020.06.032_bb0155","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.gep.2013.12.002","article-title":"A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts from zebrafish liver","volume":"14","author":"Wilkins","year":"2014","journal-title":"Gene Expr Patterns"},{"key":"10.1016\/j.jpedsurg.2020.06.032_bb0160","series-title":"The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio)","author":"Westerfield","year":"2000"},{"issue":"10","key":"10.1016\/j.jpedsurg.2020.06.032_bb0165","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nmeth.3543","article-title":"CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo","volume":"12","author":"Moreno-Mateos","year":"2015","journal-title":"Nat Methods"},{"issue":"34","key":"10.1016\/j.jpedsurg.2020.06.032_bb0170","doi-asserted-by":"crossref","first-page":"13904","DOI":"10.1073\/pnas.1308335110","article-title":"Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system","volume":"110","author":"Jao","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.jpedsurg.2020.06.032_bb0175","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/dev.119.4.1203","article-title":"Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos","volume":"119","author":"Thisse","year":"1993","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.jpedsurg.2020.06.032_bb0180","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0925-4773(02)00334-9","article-title":"Development of the biliary tract","volume":"120","author":"Lemaigre","year":"2003","journal-title":"Mech Dev"},{"issue":"3","key":"10.1016\/j.jpedsurg.2020.06.032_bb0185","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s007050200001","article-title":"Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA","volume":"147","author":"Shin","year":"2002","journal-title":"Arch Virol"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346820304553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346820304553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:37:08Z","timestamp":1758357428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346820304553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0022346820304553"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2020.06.032","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of interleukin enhancer binding factor 2 (ILF2) resulted in defective biliary development and bile flow blockage","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2020.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}