{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:59:02Z","timestamp":1785387542117,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001860"],"award-info":[{"award-number":["UL1 TR001860"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["CLIN1\\u201311404"],"award-info":[{"award-number":["CLIN1\\u201311404"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007557","name":"California Institute of Regenerative Medicine","doi-asserted-by":"publisher","award":["11404"],"award-info":[{"award-number":["11404"]}],"id":[{"id":"10.13039\/100007557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["01A1"],"award-info":[{"award-number":["01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS100761\\u201302"],"award-info":[{"award-number":["5R01NS100761\\u201302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS115860\\u201301A1"],"award-info":[{"award-number":["1R01NS115860\\u201301A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","award":["85135-NCA-21"],"award-info":[{"award-number":["85135-NCA-21"]}],"id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","award":["85108-NCA-19"],"award-info":[{"award-number":["85108-NCA-19"]}],"id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpedsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Surgery"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jpedsurg.2021.09.021","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T20:15:06Z","timestamp":1632168906000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long-term safety evaluation of placental mesenchymal stromal cells for in utero repair of myelomeningocele in a novel ovine model"],"prefix":"10.1016","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-1326","authenticated-orcid":false,"given":"Sarah C","family":"Stokes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M","family":"Theodorou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Pivetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarsini","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-5616","authenticated-orcid":false,"given":"Kaeli J","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-779X","authenticated-orcid":false,"given":"Zachary J","family":"Paxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizette","family":"Reynaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-9366","authenticated-orcid":false,"given":"Alicia","family":"Hyllen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0001","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.siny.2009.05.002","article-title":"Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention","volume":"15","author":"Adzick","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0002","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.sempedsurg.2012.10.003","article-title":"Fetal surgery for Spina bifida: past, present, future","volume":"22","author":"Adzick","year":"2013","journal-title":"Semin Pediatr Surg"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0003","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-3782(97)00090-X","article-title":"Perinatal motor behavior and neurological outcome in Spina bifida aperta","volume":"50","author":"Sival","year":"1997","journal-title":"Early Hum Dev"},{"issue":"8486","key":"10.1016\/j.jpedsurg.2021.09.021_bib0004","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0140-6736(86)91022-6","article-title":"Early fetal leg movements in myelomeningocele","volume":"1","author":"Korenromp","year":"1986","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jpedsurg.2021.09.021_bib0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm0495-342","article-title":"In utero surgery rescues neurological function at birth in sheep with spina bifida","volume":"1","author":"Meuli","year":"1995","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jpedsurg.2021.09.021_bib0006","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-3468(96)90746-0","article-title":"In utero repair of experimental myelomeningocele saves neurological function at birth","volume":"31","author":"Meuli","year":"1996","journal-title":"J Pediatr Surg"},{"issue":"5","key":"10.1016\/j.jpedsurg.2021.09.021_bib0007","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1067\/mob.2000.108867","article-title":"Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs","volume":"183","author":"Paek","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.jpedsurg.2021.09.021_bib0008","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/jpsu.2003.50078","article-title":"Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep","volume":"38","author":"Bouchard","year":"2003","journal-title":"J Pediatr Surg"},{"issue":"11","key":"10.1016\/j.jpedsurg.2021.09.021_bib0009","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick","year":"2011","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jpedsurg.2021.09.021_bib0010","doi-asserted-by":"crossref","first-page":"256.e1","DOI":"10.1016\/j.ajog.2017.12.001","article-title":"The management of myelomeningocele study: full cohort 30-month pediatric outcomes","volume":"218","author":"Farmer","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.jpedsurg.2021.09.021_bib0011","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1096\/fj.201800972R","article-title":"Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes","volume":"33","author":"Kumar","year":"2019","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0012","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jpedsurg.2018.10.032","article-title":"High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele","volume":"54","author":"Vanover","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0013","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5966\/sctm.2014-0296","article-title":"Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele","volume":"4","author":"Wang","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0014","article-title":"Placental mesenchymal stromal cells seeded on clinical grade extracellular matrix improve ambulation in ovine myelomeningocele","author":"Kabagambe","year":"2017","journal-title":"J Pediatr Surg"},{"issue":"6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0015","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000496201","article-title":"Spinal angulation: a limitation of the fetal lamb model of myelomeningocele","volume":"46","author":"Vanover","year":"2019","journal-title":"Fetal Diagn Ther"},{"issue":"12","key":"10.1016\/j.jpedsurg.2021.09.021_bib0016","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1159\/000510813","article-title":"Surviving lambs with myelomeningocele repaired in utero with placental mesenchymal stromal cells for 6 months: a pilot study","volume":"47","author":"Yamashiro","year":"2020","journal-title":"Fetal Diagn Ther"},{"issue":"11","key":"10.1016\/j.jpedsurg.2021.09.021_bib0017","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.3390\/ijms20112698","article-title":"Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy","volume":"20","author":"Cofano","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jpedsurg.2021.09.021_bib0018","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3109\/14653240903253857","article-title":"Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury\/paraplegia: a pilot clinical study","volume":"11","author":"Pal","year":"2009","journal-title":"Cytotherapy"},{"issue":"5\u20136","key":"10.1016\/j.jpedsurg.2021.09.021_bib0019","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/ten.2005.11.913","article-title":"Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor","volume":"11","author":"Park","year":"2005","journal-title":"Tissue Eng"},{"issue":"12","key":"10.1016\/j.jpedsurg.2021.09.021_bib0020","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3727\/096368908787648074","article-title":"Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies","volume":"17","author":"Geffner","year":"2008","journal-title":"Cell Transpl"},{"issue":"5","key":"10.1016\/j.jpedsurg.2021.09.021_bib0021","first-page":"397","article-title":"Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: electrophysiological changes and long-term efficacy","volume":"8","author":"Yao","year":"2013","journal-title":"Neural Regen Res"},{"issue":"11","key":"10.1016\/j.jpedsurg.2021.09.021_bib0022","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.3727\/096368916X691411","article-title":"Phase I-II clinical trial assessing safety and efficacy of umbilical cord blood mononuclear cell transplant therapy of chronic complete spinal cord injury","volume":"25","author":"Zhu","year":"2016","journal-title":"Cell Transpl"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0023","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4252\/wjsc.v7.i1.195","article-title":"Early gestation chorionic villi-derived stromal cells for fetal tissue engineering","volume":"7","author":"Lankford","year":"2015","journal-title":"World J Stem Cells"},{"issue":"2","key":"10.1016\/j.jpedsurg.2021.09.021_bib0024","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.intimp.2012.03.024","article-title":"Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells","volume":"13","author":"Lee","year":"2012","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"10.1016\/j.jpedsurg.2021.09.021_bib0025","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/14653240802419310","article-title":"Characterization and expansion of mesenchymal progenitor cells from first-trimester chorionic villi of human placenta","volume":"10","author":"Poloni","year":"2008","journal-title":"Cytotherapy"},{"issue":"9","key":"10.1016\/j.jpedsurg.2021.09.021_bib0026","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.jpedsurg.2019.09.029","article-title":"In utero treatment of myelomeningocele with placental mesenchymal stromal cells - Selection of an optimal cell line in preparation for clinical trials","volume":"55","author":"Galganski","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0027","article-title":"Efficacy of clinical-grade human placental mesenchymal stromal cells in fetal ovine myelomeningocele repair","author":"Theodorou","year":"2021","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0028","series-title":"International Society for Stem Cell Research","article-title":"Manufacture of Clinical Grade Placenta-Derived Mesenchymal Stem\/Stromal Cells for in utero Fetal Repair of Myelomeningocele","author":"Kumar","year":"2020"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0029","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/164_2019_292","article-title":"Good research practice: lessons from animal care and use","volume":"257","author":"Guill\u00e9n","year":"2020","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0030","unstructured":"UC Davis Office of Research Editor: UC Davis Office of Research Location: Davis, CA UC Davis Office of Research. Humane Endpoints for Laboratory Animals, https:\/\/research.ucdavis.edu\/policiescompliance\/animal-care-use\/iacuc\/humane-endpoints-for-laboratory-animals\/; 2017 [accessed 06\/17\/21]."},{"issue":"6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0031","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1159\/000516542","article-title":"A novel model of fetal spinal cord exposure allowing for long-term postnatal survival","volume":"48","author":"Stokes","year":"2021","journal-title":"Fetal Diagn Ther"},{"issue":"2","key":"10.1016\/j.jpedsurg.2021.09.021_bib0032","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-0934(00)00244-5","article-title":"A quantification of human cells using an ERV-3 real time PCR assay","volume":"91","author":"Yuan","year":"2001","journal-title":"J Virol Methods"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0033","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00580-008-0735-1","article-title":"Serum enzyme levels and influencing factors in three indigenous Ethiopian sheep breeds","volume":"17","author":"Tibbo","year":"2008","journal-title":"Comp Clin Path"},{"issue":"3","key":"10.1016\/j.jpedsurg.2021.09.021_bib0034","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tvjl.2006.01.013","article-title":"An aetiopathological study of chronic bronchopneumonia in lambs in Ireland","volume":"173","author":"Sheehan","year":"2007","journal-title":"Vet J"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0035","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13028-018-0409-1","article-title":"Bronchopneumonia in Swedish lambs: a study of pathological changes and bacteriological agents","volume":"60","author":"Lindstr\u00f6m","year":"2018","journal-title":"Acta Vet Scand"},{"issue":"5","key":"10.1016\/j.jpedsurg.2021.09.021_bib0036","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0195-5616(94)50109-8","article-title":"Management of otitis externa","volume":"24","author":"Rosychuk","year":"1994","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0037","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bdq.2017.10.001","article-title":"Amplification of nonspecific products in quantitative polymerase chain reactions (qPCR)","volume":"14","author":"Ruiz-Villalba","year":"2017","journal-title":"Biomol Detect Quantif"},{"issue":"6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0038","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jcyt.2017.03.003","article-title":"Manufacture and preparation of human placenta-derived mesenchymal stromal cells for local tissue delivery","volume":"19","author":"Lankford","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0039","article-title":"Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele","author":"Chen","year":"2017","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neuroscience.2012.12.038","article-title":"Neurorescue effects and stem properties of chorionic villi and amniotic progenitor cells","volume":"234","author":"Calzarossa","year":"2013","journal-title":"Neuroscience"},{"issue":"17","key":"10.1016\/j.jpedsurg.2021.09.021_bib0041","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s00018-019-03125-1","article-title":"Biological functions of mesenchymal stem cells and clinical implications","volume":"76","author":"Naji","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"19","key":"10.1016\/j.jpedsurg.2021.09.021_bib0042","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.0911647107","article-title":"Unique multipotent cells in adult human mesenchymal cell populations","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0043","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.lfs.2015.09.019","article-title":"Mesenchymal stem cells of different origin: comparative evaluation of proliferative capacity, telomere length and pluripotency marker expression","volume":"141","author":"Trivanovi\u0107","year":"2015","journal-title":"Life Sci"},{"issue":"Suppl 6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0044","first-page":"S753","article-title":"Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging","volume":"7","author":"Kooreman","year":"2010","journal-title":"J R Soc Interface"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0045","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13287-016-0363-7","article-title":"Mechanisms of mesenchymal stem\/stromal cell function","volume":"7","author":"Spees","year":"2016","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.jpedsurg.2021.09.021_bib0046","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/pd.5887","article-title":"Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis","volume":"41","author":"Kunpalin","year":"2021","journal-title":"Prenat Diagn"},{"issue":"6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0047","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.siny.2017.05.003","article-title":"Fetal stem cell and gene therapy","volume":"22","author":"Witt","year":"2017","journal-title":"Semin Fetal Neonatal Med"},{"issue":"4","key":"10.1016\/j.jpedsurg.2021.09.021_bib0048","first-page":"387","article-title":"In-utero stem cell transplantation: clinical use and therapeutic potential","volume":"63","author":"De Santis","year":"2011","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0049","doi-asserted-by":"crossref","first-page":"16020","DOI":"10.1038\/mtm.2016.20","article-title":"In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application","volume":"5","author":"Almeida-Porada","year":"2016","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0050","article-title":"Therapy for the treatment of sickle cell disease: taking advantage of the fetal immune system","volume":"8","author":"Cortabarria","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.jpedsurg.2021.09.021_bib0051","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/humrep\/den356","article-title":"Engraftment potential of human placenta-derived mesenchymal stem cells after in utero transplantation in rats","volume":"24","author":"Chen","year":"2009","journal-title":"Hum Reprod"},{"issue":"11","key":"10.1016\/j.jpedsurg.2021.09.021_bib0052","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/81395","article-title":"Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep","volume":"6","author":"Liechty","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0053","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1084\/jem.119.6.955","article-title":"Fetal response to antigenic stimulus. IV. Rejection of skin homografts by the fetal lamb","volume":"119","author":"Silverstein","year":"1964","journal-title":"J Exp Med"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0054","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bpobgyn.2015.08.014","article-title":"Placental stem cells","volume":"31","author":"Antoniadou","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fnins.2013.00194","article-title":"Stem cell therapy to protect and repair the developing brain: a review of mechanisms of action of cord blood and amnion epithelial derived cells","volume":"7","author":"Castillo-Melendez","year":"2013","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0056","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.placenta.2017.05.010","article-title":"Potential clinical applications of placental stem cells for use in fetal therapy of birth defects","volume":"59","author":"Vanover","year":"2017","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.jpedsurg.2021.09.021_bib0057","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jpedsurg.2017.03.027","article-title":"Donor mesenchymal stem cells home to maternal wounds after transamniotic stem cell therapy (TRASCET) in a rodent model","volume":"52","author":"Graham","year":"2017","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jpedsurg.2021.09.021_bib0058","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jss.2021.06.011","article-title":"Placental Mesenchymal Stromal Cells: Preclinical Safety Evaluation for Fetal Myelomeningocele Repair","volume":"267","author":"Jackson","year":"2021","journal-title":"J Surg Res"}],"container-title":["Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346821006400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022346821006400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:57:32Z","timestamp":1777388252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022346821006400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0022346821006400"],"URL":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2021.09.021","relation":{},"ISSN":["0022-3468"],"issn-type":[{"value":"0022-3468","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term safety evaluation of placental mesenchymal stromal cells for in utero repair of myelomeningocele in a novel ovine model","name":"articletitle","label":"Article Title"},{"value":"Journal of Pediatric Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpedsurg.2021.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}