{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:50:01Z","timestamp":1791377401117,"version":"4.3.2"},"reference-count":63,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jpet.2024.100050","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T03:29:03Z","timestamp":1732937343000},"page":"100050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in\u00a0vitro and in\u00a0vivo"],"prefix":"10.1016","volume":"392","author":[{"given":"Xi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-8460","authenticated-orcid":false,"given":"Bao Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpet.2024.100050_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1478-3231.2012.02755.x","article-title":"The nitric oxide pathway \u2013 evidence and mechanisms for protection against liver ischaemia reperfusion injury","volume":"32","author":"Abu-Amara","year":"2012","journal-title":"Liver Int"},{"key":"10.1016\/j.jpet.2024.100050_bib2","doi-asserted-by":"crossref","first-page":"9942","DOI":"10.3390\/ijms24129942","article-title":"Vitamin E analog Trolox attenuates MPTP-induced Parkinson's disease in mice, mitigating oxidative stress, neuroinflammation, and motor impairment","volume":"24","author":"Atiq","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jpet.2024.100050_bib3","first-page":"9050","article-title":"Finite representation of an infinite bulk system: solvent boundary potential for computer simulations","volume":"100","author":"Beglov","year":"1994","journal-title":"J\u00a0Chem Phys"},{"key":"10.1016\/j.jpet.2024.100050_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jpet.2024.100050_bib5","doi-asserted-by":"crossref","first-page":"17251","DOI":"10.1073\/pnas.1903029116","article-title":"The crystal structure of human microsomal triglyceride transfer protein","volume":"116","author":"Biterova","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpet.2024.100050_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102703","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","volume":"62","author":"Cheff","year":"2023","journal-title":"Redox Biol"},{"key":"10.1016\/j.jpet.2024.100050_bib7","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M115.680090","article-title":"Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis","volume":"290","author":"Chen","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jpet.2024.100050_bib8","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jpet.2024.100050_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2019.02.014","article-title":"Upregulated cyclin B1\/CDK1 mediates apoptosis following 2-methoxyestradiol-induced mitotic catastrophe: role of Bcl-XL phosphorylation","volume":"150","author":"Choi","year":"2019","journal-title":"Steroids"},{"key":"10.1016\/j.jpet.2024.100050_bib10","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1038\/s41598-020-62984-y","article-title":"4-hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage","volume":"10","author":"Choi","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpet.2024.100050_bib11","first-page":"10089","article-title":"Particle mesh Ewald: an N\u22c5log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J\u00a0Chem Phys"},{"key":"10.1016\/j.jpet.2024.100050_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155458","article-title":"Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2\/xCT\/GPX4 signaling pathway","volume":"126","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpet.2024.100050_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jpet.2024.100050_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jpet.2024.100050_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jpet.2024.100050_bib16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.taap.2014.09.002","article-title":"Lower susceptibility of female mice to acetaminophen hepatotoxicity: role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase","volume":"281","author":"Du","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jpet.2024.100050_bib17","first-page":"8577","article-title":"A\u00a0smooth particle mesh Ewald method","volume":"103","author":"Essmann","year":"1995","journal-title":"J\u00a0Chem Phys"},{"key":"10.1016\/j.jpet.2024.100050_bib18","first-page":"4613","article-title":"Constant pressure molecular dynamics simulation: the Langevin piston method","volume":"103","author":"Feller","year":"1995","journal-title":"J\u00a0Chem Phys"},{"key":"10.1016\/j.jpet.2024.100050_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0968-0004(94)90072-8","article-title":"Protein disulphide isomerase: building bridges in protein folding","volume":"19","author":"Freedman","year":"1994","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jpet.2024.100050_bib20","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jpet.2024.100050_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/mc.20458","article-title":"Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells","volume":"48","author":"Fukui","year":"2009","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jpet.2024.100050_bib22","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.neubiorev.2005.03.026","article-title":"Role of nitric oxide in brain regions related to defensive reactions","volume":"29","author":"Guimar\u00e3es","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jpet.2024.100050_bib23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nchembio.467","article-title":"Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins","volume":"6","author":"Hoffstrom","year":"2010","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jpet.2024.100050_bib24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00436-007-0784-4","article-title":"Identification and enzymatic activities of four protein disulfide isomerase (PDI) isoforms of Leishmania amazonensis","volume":"102","author":"Hong","year":"2008","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jpet.2024.100050_bib63","doi-asserted-by":"crossref","DOI":"10.3724\/abbs.2024165","article-title":"Mechanism of RSL3-induced ferroptotic cell death in HT22 cells: crucial role of protein disulfide isomerase","author":"Hou","year":"2024","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.jpet.2024.100050_bib25","first-page":"853","article-title":"Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells","volume":"55","author":"Hou","year":"2023","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.jpet.2024.100050_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nmeth.4067","article-title":"CHARMM36m: an improved force field for folded and intrinsically disordered proteins","volume":"14","author":"Huang","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jpet.2024.100050_bib27","first-page":"2090","article-title":"Langevin stabilization of molecular dynamics","volume":"114","author":"Izaguirre","year":"2001","journal-title":"J\u00a0Chem Phys"},{"key":"10.1016\/j.jpet.2024.100050_bib28","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1016\/j.apsb.2021.09.023","article-title":"Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls","volume":"11","author":"Jaeschke","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jpet.2024.100050_bib29","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jpet.2024.100050_bib30","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J\u00a0Comput Chem"},{"key":"10.1016\/j.jpet.2024.100050_bib31","first-page":"926","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J\u00a0Chem Phys"},{"key":"10.1016\/j.jpet.2024.100050_bib32","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1074\/jbc.RA119.011463","article-title":"An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo","volume":"295","author":"Koiwai","year":"2020","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jpet.2024.100050_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118561","article-title":"Estrogen receptor agonists protect against acetaminophen-induced hepatorenal toxicity in rats","volume":"263","author":"Koyuncuo\u011flu","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.jpet.2024.100050_bib34","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1210\/en.2003-0192","article-title":"Characterization of the oxidative metabolites of 17\u03b2-estradiol and estrone formed by 15 selectively expressed human cytochrome P450 isoforms","volume":"144","author":"Lee","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jpet.2024.100050_bib35","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1124\/jpet.300.3.838","article-title":"NADPH-dependent metabolism of estrone by human liver microsomes","volume":"300","author":"Lee","year":"2002","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jpet.2024.100050_bib36","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1111\/febs.14784","article-title":"Crystal structures of human 17\u03b2-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition","volume":"286","author":"Li","year":"2019","journal-title":"FEBS J"},{"key":"10.1016\/j.jpet.2024.100050_bib37","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1021\/acs.jctc.1c00302","article-title":"OPLS4: improving force field accuracy on challenging regimes of chemical space","volume":"17","author":"Lu","year":"2021","journal-title":"J\u00a0Chem Theory Comput"},{"key":"10.1016\/j.jpet.2024.100050_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-010715-103715","article-title":"The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies","volume":"56","author":"Martinez Molina","year":"2016","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jpet.2024.100050_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0163-7258(93)90057-K","article-title":"P450 enzymes of estrogen metabolism","volume":"57","author":"Martucci","year":"1993","journal-title":"Pharmacol Ther"},{"issue":"Pt 1","key":"10.1016\/j.jpet.2024.100050_bib40","first-page":"1","article-title":"Thioredoxin reductase","volume":"346","author":"Mustacich","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.jpet.2024.100050_bib41","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbrc.2016.06.066","article-title":"Protein disulfide isomerase mediates glutathione depletion-induced cytotoxicity","volume":"477","author":"Okada","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jpet.2024.100050_bib42","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J\u00a0Comput Chem"},{"key":"10.1016\/j.jpet.2024.100050_bib43","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/sj.onc.1201290","article-title":"Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells","volume":"15","author":"Qi","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.jpet.2024.100050_bib44","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1080\/15548627.2021.1911016","article-title":"Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells","volume":"17","author":"Qin","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jpet.2024.100050_bib45","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models","volume":"136","author":"Skouta","year":"2014","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.jpet.2024.100050_bib46","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jpet.2024.100050_bib47","doi-asserted-by":"crossref","first-page":"12472","DOI":"10.1073\/pnas.91.26.12472","article-title":"Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase","volume":"91","author":"Szab\u00f3","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpet.2024.100050_bib48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2005.10.044","article-title":"The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites","volume":"124","author":"Tian","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jpet.2024.100050_bib49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.canlet.2004.10.007","article-title":"Cytochrome P450-mediated metabolism of estrogens and its regulation in human","volume":"227","author":"Tsuchiya","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jpet.2024.100050_bib50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpet.2024.100050_bib51","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/bioinformatics\/bty816","article-title":"Large-scale prediction of binding affinity in protein-small ligand complexes: the PRODIGY-LIG web server","volume":"35","author":"Vangone","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpet.2024.100050_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","article-title":"CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J\u00a0Comput Chem"},{"key":"10.1016\/j.jpet.2024.100050_bib53","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1021\/acs.biochem.3c00261","article-title":"Strong protection by 4-hydroxyestrone against erastin-induced ferroptotic cell death in estrogen receptor-negative human breast cancer cells: evidence for protein disulfide isomerase as a mechanistic target for protection","volume":"63","author":"Wang","year":"2024","journal-title":"Biochemistry"},{"key":"10.1016\/j.jpet.2024.100050_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/mcb.00522-21","article-title":"Mechanism of erastin-induced ferroptosis in MDA-MB-231 human breast cancer cells: evidence for a critical role of protein disulfide isomerase","volume":"42","author":"Wang","year":"2022","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jpet.2024.100050_bib55","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tibs.2022.06.011","article-title":"Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum","volume":"48","author":"Wang","year":"2023","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jpet.2024.100050_bib56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2017.02.032","article-title":"Unique effect of 4-hydroxyestradiol and its methylation metabolites on lipid and cholesterol profiles in ovariectomized female rats","volume":"800","author":"Wang","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpet.2024.100050_bib57","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1570-9639(04)00063-9","article-title":"Protein disulfide isomerase","volume":"1699","author":"Wilkinson","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jpet.2024.100050_bib58","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41419-020-2334-2","article-title":"Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure","volume":"11","author":"Yamada","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jpet.2024.100050_bib59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jpet.2024.100050_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/19.1.1","article-title":"Functional role of estrogen metabolism in target cells: review and perspectives","volume":"19","author":"Zhu","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jpet.2024.100050_bib61","first-page":"2269","article-title":"Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?","volume":"58","author":"Zhu","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpet.2024.100050_bib62","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1210\/en.2006-0113","article-title":"Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: insights into the structural determinants favoring a differential subtype binding","volume":"147","author":"Zhu","year":"2006","journal-title":"Endocrinology"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524301995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524301995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T20:56:17Z","timestamp":1742244977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524301995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0022356524301995"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2024.100050","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in\u00a0vitro and in\u00a0vivo","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2024.100050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"100050"}}