{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:48:47Z","timestamp":1788922127722,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016455","name":"The University of Alabama at Birmingham Department of Psychology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jpet.2024.100531","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T01:12:50Z","timestamp":1735089170000},"page":"100531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baclofen and opioid interactions in mice could inform pain treatment methods"],"prefix":"10.1016","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-7627","authenticated-orcid":false,"given":"Stacie K.","family":"Totsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-1711","authenticated-orcid":false,"given":"Remy Y.","family":"Meir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Landis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4989-9697","authenticated-orcid":false,"given":"Robert E.","family":"Sorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpet.2024.100531_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fpsyt.2018.00464","article-title":"Baclofen in the treatment of patients with alcohol use disorder and other mental health disorders","volume":"9","author":"Agabio","year":"2018","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.jpet.2024.100531_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000347055","article-title":"Efficacy and tolerability of baclofen in substance use disorders: a systematic review","volume":"19","author":"Agabio","year":"2013","journal-title":"Eur Addict Res"},{"key":"10.1016\/j.jpet.2024.100531_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2710.2001.00325.x","article-title":"Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial","volume":"26","author":"Ahmadi-Abhari","year":"2001","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.jpet.2024.100531_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1046\/j.1365-2710.2000.00295.x","article-title":"Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal","volume":"25","author":"Akhondzadeh","year":"2000","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.jpet.2024.100531_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-244X-3-16","article-title":"Baclofen for maintenance treatment of opioid dependence: a randomized double-blind placebo-controlled clinical trial [ISRCTN32121581]","volume":"3","author":"Assadi","year":"2003","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jpet.2024.100531_bib6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0091-3057(84)80037-4","article-title":"Conditioned place preference with morphine: the effect of extinction training on the reinforcing CR","volume":"21","author":"Bardo","year":"1984","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jpet.2024.100531_bib7","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/0024-3205(81)90519-1","article-title":"Heroin reward is dependent on a dopaminergic substrate","volume":"29","author":"Bozarth","year":"1981","journal-title":"Life Sci"},{"key":"10.1016\/j.jpet.2024.100531_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s002130050056","article-title":"Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules","volume":"148","author":"Brebner","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jpet.2024.100531_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cpt.3248","article-title":"Comparative risk of injury with concurrent use of opioids and skeletal muscle relaxants","volume":"116","author":"Chen","year":"2024","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jpet.2024.100531_bib10","first-page":"58","article-title":"Ability of baclofen in reducing alcohol intake and withdrawal severity: I\u2014preclinical evidence","volume":"24","author":"Colombo","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jpet.2024.100531_bib11","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1377\/hlthaff.2016.0448","article-title":"Mandatory provider review and pain clinic laws reduce the amounts of opioids prescribed and overdose death rates","volume":"35","author":"Dowell","year":"2016","journal-title":"Health Aff (Millwood)"},{"key":"10.1016\/j.jpet.2024.100531_bib12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1212\/WNL.26.5.441","article-title":"An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions. A double-blind, cross-over study","volume":"26","author":"Duncan","year":"1976","journal-title":"Neurology"},{"key":"10.1016\/j.jpet.2024.100531_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/alcalc\/37.5.495","article-title":"Baclofen antagonizes intravenous self-administration of nicotine in mice and rats","volume":"37","author":"Fattore","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.jpet.2024.100531_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2020.108350","article-title":"The economic burden of opioid use disorder and fatal opioid overdose in the United States, 2017","volume":"218","author":"Florence","year":"2021","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.jpet.2024.100531_bib15","first-page":"715","article-title":"The economic costs of pain in the United States","volume":"13","author":"Gaskin","year":"2012","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.jpet.2024.100531_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0306-4522(95)00335-G","article-title":"Enhancement of morphine analgesia by the GABAB agonist baclofen","volume":"69","author":"Gordon","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpet.2024.100531_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbr.2009.10.013","article-title":"Baclofen enhances extinction of opiate conditioned place preference","volume":"207","author":"Heinrichs","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpet.2024.100531_bib18","first-page":"269","article-title":"Methodology for assessing agents that suppress methadone withdrawal: a study of baclofen","volume":"41","author":"Jaffe","year":"1982","journal-title":"NIDA Res Monogr"},{"key":"10.1016\/j.jpet.2024.100531_bib19","doi-asserted-by":"crossref","first-page":"e1432","DOI":"10.1212\/WNL.0000000000200904","article-title":"Comparative risk of opioid overdose with concomitant use of prescription opioids and skeletal muscle relaxants","volume":"99","author":"Khan","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jpet.2024.100531_bib20","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1523\/JNEUROSCI.12-07-02623.1992","article-title":"Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in\u00a0vivo microdialysis study","volume":"12","author":"Klitenick","year":"1992","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.jpet.2024.100531_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3344\/kjp.2019.32.2.69","article-title":"Opioid-induced constipation: a narrative review of therapeutic options in clinical management","volume":"32","author":"Lang-Illievich","year":"2019","journal-title":"Korean J Pain"},{"key":"10.1016\/j.jpet.2024.100531_bib22","first-page":"393","article-title":"Chronic intrathecal baclofen administration for control of severe spasticity","volume":"72","author":"Lazorthes","year":"1990","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.jpet.2024.100531_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0091-3057(91)90210-S","article-title":"Morphine-dopamine interaction: ventral tegmental morphine increases nucleus accumbens dopamine release","volume":"39","author":"Leone","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jpet.2024.100531_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0165-6147(96)01013-9","article-title":"GABA and its receptors in the spinal cord","volume":"17","author":"Malcangio","year":"1996","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jpet.2024.100531_bib25","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0896-6273(00)80110-5","article-title":"Under siege: the brain on opiates","volume":"16","author":"Nestler","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.jpet.2024.100531_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176768","article-title":"Baclofen prevents morphine rewarding effects and associated biochemical alterations in male and female mice","volume":"979","author":"Pedr\u00f3n","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpet.2024.100531_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0006-8993(80)90447-3","article-title":"The neurones of origin for the mesohabenular dopamine pathway","volume":"197","author":"Phillipson","year":"1980","journal-title":"Brain Res"},{"key":"10.1016\/j.jpet.2024.100531_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/01677063.2016.1180385","article-title":"Reward from bugs to bipeds: a comparative approach to understanding how reward circuits function","volume":"30","author":"Scaplen","year":"2016","journal-title":"J\u00a0Neurogenet"},{"key":"10.1016\/j.jpet.2024.100531_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0304-3959(92)90225-Z","article-title":"A further comment on testing for drug synergism","volume":"51","author":"Tallarida","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.jpet.2024.100531_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079239","article-title":"Effect of chronic pain on fentanyl self-administration in mice","volume":"8","author":"Wade","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jpet.2024.100531_bib30","first-page":"771","article-title":"Analysis of opioid-mediated analgesia in phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain","volume":"8","author":"Webster","year":"2015","journal-title":"J\u00a0Pain Res"},{"key":"10.1016\/j.jpet.2024.100531_bib31","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1124\/jpet.118.255844","article-title":"The effects of morphine, baclofen, and buspirone alone and in combination on schedule-controlled responding and hot plate antinociception in rats","volume":"370","author":"Wilkerson","year":"2019","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jpet.2024.100531_bib32","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/S0022-3565(24)35044-X","article-title":"Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release","volume":"290","author":"Xi","year":"1999","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jpet.2024.100531_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.forsciint.2024.112281","article-title":"Baclofen-related deaths in Australia 2000-2022","volume":"365","author":"Zahra","year":"2024","journal-title":"Forensic Sci Int"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524421800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524421800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T20:56:29Z","timestamp":1742244989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524421800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0022356524421800"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2024.100531","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baclofen and opioid interactions in mice could inform pain treatment methods","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2024.100531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100531"}}