{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:12:45Z","timestamp":1785035565993,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM127954"],"award-info":[{"award-number":["GM127954"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["CA222349"],"award-info":[{"award-number":["CA222349"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011594","name":"Penn State College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jpet.2025.103524","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T19:05:57Z","timestamp":1740769557000},"page":"103524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice"],"prefix":"10.1016","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-8124","authenticated-orcid":false,"given":"Kevin A.","family":"Fundora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-3573","authenticated-orcid":false,"given":"Kouta","family":"Hamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longgui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-9411","authenticated-orcid":false,"given":"Tatsuya","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2319-4912","authenticated-orcid":false,"given":"Xinwen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-2136","authenticated-orcid":false,"given":"Venugopal","family":"Vangala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-6155","authenticated-orcid":false,"given":"Fang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8004-4817","authenticated-orcid":false,"given":"Yoshinori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpet.2025.103524_bib1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2015.10.002","article-title":"Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis","volume":"28","author":"Anderson","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jpet.2025.103524_bib2","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1093\/emboj\/17.11.2982","article-title":"The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function","volume":"17","author":"Babst","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.jpet.2025.103524_bib3","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.molonc.2016.09.005","article-title":"VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal","volume":"10","author":"Bastola","year":"2016","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jpet.2025.103524_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-1119(02)01205-2","article-title":"Comparative sequence and expression analyses of four mammalian VPS4 genes","volume":"305","author":"Beyer","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.jpet.2025.103524_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1321655111","article-title":"Temporal and spatial organization of ESCRT protein recruitment during HIV-1 budding","volume":"111","author":"Bleck","year":"2014","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.jpet.2025.103524_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ceb.2020.06.002","article-title":"ESCRT puts its thumb on the nanoscale: fixing tiny holes in endolysosomes","volume":"65","author":"Bohannon","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41467-020-14284-2","article-title":"Human and mouse essentiality screens as a resource for disease gene discovery","volume":"11","author":"Cacheiro","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpet.2025.103524_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23415","article-title":"VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis","volume":"59","author":"Chen","year":"2021","journal-title":"Genesis"},{"key":"10.1016\/j.jpet.2025.103524_bib9","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA119.009432","article-title":"Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation","volume":"294","author":"Chen","year":"2019","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jpet.2025.103524_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/cmdc.201200520","article-title":"Structure\u2013activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase","volume":"8","author":"Chou","year":"2013","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jpet.2025.103524_bib11","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1073\/pnas.1015312108","article-title":"Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways","volume":"108","author":"Chou","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jpet.2025.103524_bib12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41594-021-00575-9","article-title":"A\u00a0chemical genetics approach to examine the functions of AAA proteins","volume":"28","author":"Cupido","year":"2021","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41589-019-0225-6","article-title":"Designing a chemical inhibitor for the AAA protein spastin using active site mutations","volume":"15","author":"Cupido","year":"2019","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1091\/mbc.e03-02-0097","article-title":"Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway","volume":"15","author":"Dalal","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jpet.2025.103524_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005749","article-title":"The mammalian orthologs of drosophila Lgd, CC2D1A and CC2D1B, function in the endocytic pathway, but their individual loss of function does not affect notch signalling","volume":"11","author":"Drusenheimer","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jpet.2025.103524_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/tra.12015","article-title":"The AAA ATPase VPS4\/SKD1 Regulates Endosomal Cholesterol Trafficking Independently of ESCRT-III","volume":"14","author":"Du","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.jpet.2025.103524_bib17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2017.03.020","article-title":"ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences","volume":"169","author":"Gong","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jpet.2025.103524_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115016","article-title":"Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain","volume":"43","author":"Hamamoto","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.jpet.2025.103524_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/15548627.2023.2258701","article-title":"ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis","volume":"20","author":"Hattori","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jpet.2025.103524_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41418-020-00610-0","article-title":"Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes","volume":"28","author":"Hattori","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jpet.2025.103524_bib21","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jpet.2025.103524_bib22","article-title":"Lysophagy protects against propagation of \u03b1-synuclein aggregation through ruptured lysosomal vesicles","volume":"121","author":"Kakuda","year":"2023","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.jpet.2025.103524_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.abb.2003.09.038","article-title":"CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the 3 CHMP4 isoforms","volume":"421","author":"Katoh","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jpet.2025.103524_bib24","doi-asserted-by":"crossref","first-page":"39104","DOI":"10.1074\/jbc.M301604200","article-title":"The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting\u2217","volume":"278","author":"Katoh","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jpet.2025.103524_bib25","doi-asserted-by":"crossref","first-page":"42951","DOI":"10.1021\/acsomega.3c06106","article-title":"1-Sulfonyl-3-amino-1H-1,2,4-triazoles as yellow fever virus inhibitors: synthesis and structure\u2013activity relationship","volume":"8","author":"Kazakova","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.jpet.2025.103524_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107905","article-title":"Small molecule enhancers of endosome-to-cytosol import augment anti-tumor immunity","volume":"32","author":"Kozik","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jpet.2025.103524_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/BJ20120662","article-title":"K11- and K48-linked ubiquitin chains interact with p97 during endoplasmic reticulum-associated degradation","volume":"459","author":"Locke","year":"2014","journal-title":"Biochem J"},{"key":"10.1016\/j.jpet.2025.103524_bib28","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1038\/emboj.2013.171","article-title":"Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury","volume":"32","author":"Maejima","year":"2013","journal-title":"EMBO J"},{"key":"10.1016\/j.jpet.2025.103524_bib29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nchembio.1313","article-title":"Covalent and allosteric inhibitors of the ATPase VCP\/p97 induce cancer cell death","volume":"9","author":"Magnaghi","year":"2013","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.cell.2017.07.005","article-title":"Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening","volume":"170","author":"McDonald","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jpet.2025.103524_bib31","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/emboj\/19.10.2181","article-title":"A\u00a0complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways","volume":"19","author":"Meyer","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.jpet.2025.103524_bib32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/15548627.2023.2267958","article-title":"Removal of hypersignaling endosomes by simaphagy","volume":"20","author":"Migliano","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jpet.2025.103524_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chom.2011.02.004","article-title":"ESCRT-III protein requirements for HIV-1 budding","volume":"9","author":"Morita","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jpet.2025.103524_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108493","article-title":"Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q","volume":"33","author":"Neggers","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jpet.2025.103524_bib35","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib36","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1038\/s41598-018-21491-x","article-title":"VPS4 is a dynamic component of the centrosome that regulates centrosome localization of \u03b3-tubulin, centriolar satellite stability and ciliogenesis","volume":"8","author":"Ott","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpet.2025.103524_bib37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.15252\/embj.201695148","article-title":"VCP\/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy","volume":"36","author":"Papadopoulos","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.jpet.2025.103524_bib38","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1462-5822.2009.01415.x","article-title":"Galectin-3, a marker for vacuole lysis by invasive pathogens","volume":"12","author":"Paz","year":"2010","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jpet.2025.103524_bib39","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/anie.201711429","article-title":"A\u00a0non-competitive inhibitor of VCP\/p97 and VPS4 reveals conserved allosteric circuits in type I and II AAA ATPases","volume":"57","author":"P\u00f6hler","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.jpet.2025.103524_bib40","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/MCB.22.2.626-634.2002","article-title":"AAA-ATPase p97\/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation","volume":"22","author":"Rabinovich","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib41","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899753","article-title":"ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival","volume":"37","author":"Radulovic","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.jpet.2025.103524_bib42","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.240333","article-title":"The ESCRTs\u2014converging on mechanism","volume":"133","author":"Remec Pavlin","year":"2020","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jpet.2025.103524_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004354","article-title":"Disruption of Vps4 and JNK function in drosophila causes tumour growth","volume":"4","author":"Rodahl","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jpet.2025.103524_bib44","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat Methods"},{"key":"10.1016\/j.jpet.2025.103524_bib45","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/jmbi.2001.4917","article-title":"Mammalian cells express 2 VPS4 proteins both of which are involved in intracellular protein trafficking","volume":"312","author":"Scheuring","year":"2001","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1083\/jcb.201404107","article-title":"pHuji, a pH-sensitive red fluorescent protein for imaging of exo- and endocytosis","volume":"207","author":"Shen","year":"2014","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib47","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nbt.3235","article-title":"Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains","volume":"33","author":"Shi","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jpet.2025.103524_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar5078","article-title":"Triggered recruitment of ESCRT machinery promotes endolysosomal repair","volume":"360","author":"Skowyra","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jpet.2025.103524_bib49","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910812","article-title":"Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer","volume":"12","author":"Szyma\u0144ska","year":"2020","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jpet.2025.103524_bib50","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1038\/s41467-018-05254-w","article-title":"An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpet.2025.103524_bib51","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1083\/jcb.201902170","article-title":"VPS37A directs ESCRT recruitment for phagophore closure","volume":"218","author":"Takahashi","year":"2019","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jpet.2025.103524_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110600","article-title":"A\u00a0super-ecliptic, pHluorin-mKate2, tandem fluorescent protein-tagged human LC3 for the monitoring of mammalian autophagy","volume":"9","author":"Tanida","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpet.2025.103524_bib53","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.devcel.2008.08.013","article-title":"Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation","volume":"15","author":"Teis","year":"2008","journal-title":"Developmental Cell"},{"key":"10.1016\/j.jpet.2025.103524_bib54","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3390\/biom13050737","article-title":"Molecular mechanisms driving and regulating the AAA+ ATPase VCP\/p97, an important therapeutic target for treating cancer, neurological and infectious diseases","volume":"13","author":"Valimehr","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jpet.2025.103524_bib55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nature20607","article-title":"Designed proteins induce the formation of nanocage-containing extracellular vesicles","volume":"540","author":"Votteler","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jpet.2025.103524_bib56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/hmg\/ddi426","article-title":"Inclusion body myopathy-associated mutations in p97\/VCP impair endoplasmic reticulum-associated degradation","volume":"15","author":"Weihl","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jpet.2025.103524_bib57","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/s41598-017-02456-y","article-title":"An episomal vector-based CRISPR\/Cas9 system for highly efficient gene knockout in human pluripotent stem cells","volume":"7","author":"Xie","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jpet.2025.103524_bib58","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1074\/jbc.M111.309104","article-title":"Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis","volume":"287","author":"Young","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jpet.2025.103524_bib59","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11046-015-9979-x","article-title":"The AAA ATPase Vps4 plays important roles in Candida albicans hyphal formation and is inhibited by DBeQ","volume":"181","author":"Zhang","year":"2016","journal-title":"Mycopathologia"},{"key":"10.1016\/j.jpet.2025.103524_bib60","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1080\/15548627.2019.1639301","article-title":"ESCRT-mediated phagophore sealing during mitophagy","volume":"16","author":"Zhen","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.jpet.2025.103524_bib61","doi-asserted-by":"crossref","first-page":"9480","DOI":"10.1021\/acs.jmedchem.5b01346","article-title":"Discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083)","volume":"58","author":"Zhou","year":"2015","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jpet.2025.103524_bib62","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.immuni.2012.12.007","article-title":"Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis","volume":"38","author":"Zou","year":"2013","journal-title":"Immunity"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525397375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525397375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:32:56Z","timestamp":1762209176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525397375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0022356525397375"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103524","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"103524"}}