{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:54:59Z","timestamp":1771667699647,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R37NS03958719"],"award-info":[{"award-number":["R37NS03958719"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["RO1HD102071"],"award-info":[{"award-number":["RO1HD102071"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011866","name":"University of Colorado Denver Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jpet.2025.103614","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T19:14:05Z","timestamp":1747941245000},"page":"103614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A multielectrode array reveals therapeutic potential of translocator protein ligands in a zebrafish model of Dravet syndrome"],"prefix":"10.1016","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0515-1873","authenticated-orcid":false,"given":"Lauryn","family":"Adair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5739-0444","authenticated-orcid":false,"given":"Rebecca","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Fulton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-6942","authenticated-orcid":false,"given":"Anna","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-0920","authenticated-orcid":false,"given":"Manisha","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jpet.2025.103614_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.yebeh.2012.06.016","article-title":"Epilepsy across the spectrum: promoting health and understanding. A summary of the Institute of Medicine report","volume":"25","author":"England","year":"2012","journal-title":"Epilepsy Behav"},{"issue":"1","key":"10.1016\/j.jpet.2025.103614_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac298","article-title":"Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase\/hypoxia-inducible factor-1\u03b1 hypoxia pathway","volume":"5","author":"Ksendzovsky","year":"2023","journal-title":"Brain Commun"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/humu.10217","article-title":"De novo SCN1A mutations are a major cause of severe myoclonic epilepsy of infancy","volume":"21","author":"Claes","year":"2003","journal-title":"Hum Mutat"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/jnr.10077","article-title":"Development of excitatory synapses in cultured neurons dissociated from the cortices of rat embryos and rat pups at birth","volume":"67","author":"Lin","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jpet.2025.103614_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.106948","article-title":"Metabolic correlates of cognitive impairment in mesial temporal lobe epilepsy","volume":"105","author":"Laurent","year":"2020","journal-title":"Epilepsy Behav"},{"issue":"5","key":"10.1016\/j.jpet.2025.103614_bib6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5698\/1535-7597.18.5.318","article-title":"A metabolic paradigm for epilepsy","volume":"18","author":"Patel","year":"2018","journal-title":"Epilepsy Curr"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41582-022-00651-8","article-title":"The metabolic basis of epilepsy","volume":"18","author":"Rho","year":"2022","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jpet.2025.103614_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/epi.18382","article-title":"Mitochondrial respiration defects in lymphoblast cell lines from patients with Dravet syndrome","author":"Figueroa","year":"2025","journal-title":"Epilepsia"},{"issue":"suppl 2","key":"10.1016\/j.jpet.2025.103614_bib9","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1186\/1471-2202-9-S2-S16","article-title":"Hypometabolism as a therapeutic target in Alzheimer\u2019s disease","volume":"9","author":"Costantini","year":"2008","journal-title":"BMC Neurosci"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib10","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neuroscience.2009.05.041","article-title":"In vivo mapping of temporospatial changes in glucose utilization in rat brain during epileptogenesis: an 18F-fluorodeoxyglucose\u2013small animal positron emission tomography study","volume":"162","author":"Guo","year":"2009","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.jpet.2025.103614_bib11","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s002590100499","article-title":"Temporal hypometabolism at the onset of cryptogenic temporal lobe epilepsy","volume":"28","author":"Matheja","year":"2001","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.jpet.2025.103614_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.eplepsyres.2014.10.014","article-title":"Efficacy and tolerability of the ketogenic diet in Dravet syndrome \u2013 comparison with various standard antiepileptic drug regimen","volume":"109","author":"Dressler","year":"2015","journal-title":"Epilepsy Res"},{"issue":"8","key":"10.1016\/j.jpet.2025.103614_bib13","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1177\/0883073813487599","article-title":"The ketogenic diet in Dravet syndrome","volume":"28","author":"Laux","year":"2013","journal-title":"J Child Neurol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s40263-018-0511-y","article-title":"Treatment strategies for Dravet syndrome","volume":"32","author":"Knupp","year":"2018","journal-title":"CNS Drugs"},{"issue":"suppl 2","key":"10.1016\/j.jpet.2025.103614_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2011.02993.x","article-title":"Severe myoclonic epilepsy in infancy (Dravet syndrome) 30 years later","volume":"52","author":"Dravet","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.jpet.2025.103614_bib16","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1038\/ncomms3410","article-title":"Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment","volume":"4","author":"Baraban","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jpet.2025.103614_bib17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fphar.2020.00464","article-title":"Phenotype-based screening of synthetic cannabinoids in a Dravet syndrome zebrafish model","volume":"11","author":"Griffin","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpet.2025.103614_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3389\/fphar.2018.00573","article-title":"Preclinical animal models for Dravet syndrome: seizure phenotypes, comorbidities and drug screening","volume":"9","author":"Griffin","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103614_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcz008","article-title":"Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome","volume":"1","author":"Griffin","year":"2019","journal-title":"Brain Commun"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib20","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0066-17.2017","article-title":"Behavioral comorbidities and drug treatments in a zebrafish scn1lab model of Dravet syndrome","volume":"4","author":"Grone","year":"2017","journal-title":"eNeuro"},{"issue":"2","key":"10.1016\/j.jpet.2025.103614_bib21","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0008-16.2016","article-title":"Altered glycolysis and mitochondrial respiration in a zebrafish model of Dravet syndrome","volume":"3","author":"Kumar","year":"2016","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.jpet.2025.103614_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab004","article-title":"Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome","volume":"3","author":"Banerji","year":"2021","journal-title":"Brain Commun"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0924-977X(02)00107-4","article-title":"In vivo imaging of neuroinflammation","volume":"12","author":"Cagnin","year":"2002","journal-title":"Eur Neuropsychopharmacol"},{"issue":"5630","key":"10.1016\/j.jpet.2025.103614_bib24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/269702a0","article-title":"High densities of benzodiazepine receptors in human cortical areas","volume":"269","author":"Braestrup","year":"1977","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jpet.2025.103614_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3181\/00379727-217-44215","article-title":"Structure and function of the peripheral-type benzodiazepine receptor in steroidogenic cells","volume":"217","author":"Papadopoulos","year":"1998","journal-title":"Proc Soc Exp Biol Med"},{"issue":"8","key":"10.1016\/j.jpet.2025.103614_bib26","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1073\/pnas.89.8.3170","article-title":"Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier","volume":"89","author":"McEnery","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.jpet.2025.103614_bib27","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbabio.2009.06.009","article-title":"Mitochondrial calcium and the permeability transition in cell death","volume":"1787","author":"Lemasters","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib28","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1038\/s41380-020-0745-1","article-title":"Neuronal activity increases translocator protein (TSPO) levels","volume":"26","author":"Notter","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jpet.2025.103614_bib29","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1038\/ncomms6452","article-title":"Positron emission tomography and functional characterization of a complete PBR\/TSPO knockout","volume":"5","author":"Banati","year":"2014","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jpet.2025.103614_bib30","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1210\/en.2015-1795","article-title":"Translocator protein (TSPO) affects mitochondrial fatty acid oxidation in steroidogenic cells","volume":"157","author":"Tu","year":"2016","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib31","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/brain\/aww017","article-title":"Early and protective microglial activation in Alzheimer\u2019s disease: a prospective study using 18F-DPA-714 PET imaging","volume":"139","author":"Hamelin","year":"2016","journal-title":"Brain"},{"issue":"13","key":"10.1016\/j.jpet.2025.103614_bib32","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/mds.21552","article-title":"Neuroinflammation in the pathophysiology of Parkinson\u2019s disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET","volume":"22","author":"Bartels","year":"2007","journal-title":"Mov Disord"},{"issue":"2-3","key":"10.1016\/j.jpet.2025.103614_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainresbull.2006.10.029","article-title":"Imaging microglial activation in Huntington\u2019s disease","volume":"72","author":"Tai","year":"2007","journal-title":"Brain Res Bull"},{"issue":"1","key":"10.1016\/j.jpet.2025.103614_bib34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41398-023-02630-z","article-title":"Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer\u2019s disease","volume":"13","author":"Pradhan","year":"2023","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jpet.2025.103614_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuropharm.2016.03.053","article-title":"Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of multiple sclerosis","volume":"108","author":"Ravikumar","year":"2016","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.jpet.2025.103614_bib36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/hup.757","article-title":"Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice","volume":"21","author":"Nguyen","year":"2006","journal-title":"Hum Psychopharmacol"},{"issue":"19","key":"10.1016\/j.jpet.2025.103614_bib37","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1523\/JNEUROSCI.2070-18.2019","article-title":"Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of parkinsonism","volume":"39","author":"Gong","year":"2019","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/laban0612-158","article-title":"Generation time of zebrafish (Danio rerio) and medakas (Oryzias latipes) housed in the same aquaculture facility","volume":"41","author":"Lawrence","year":"2012","journal-title":"Lab Anim (NY)"},{"issue":"3","key":"10.1016\/j.jpet.2025.103614_bib39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.neuroscience.2004.11.031","article-title":"Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression","volume":"131","author":"Baraban","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpet.2025.103614_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2021.804033","article-title":"DMSO concentrations up to 1% are safe to be used in the zebrafish embryo developmental toxicity assay","volume":"3","author":"Hoyberghs","year":"2021","journal-title":"Front Toxicol"},{"key":"10.1016\/j.jpet.2025.103614_bib41","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainresbull.2016.11.004","article-title":"Effects of dimethyl sulfoxide on the morphology and viability of primary cultured neurons and astrocytes","volume":"128","author":"Zhang","year":"2017","journal-title":"Brain Res Bull"},{"issue":"3","key":"10.1016\/j.jpet.2025.103614_bib42","first-page":"669","article-title":"Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome","volume":"140","author":"Griffin","year":"2017","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib43","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0068-15.2015","article-title":"Large-scale phenotype-based antiepileptic drug screening in a zebrafish model of Dravet syndrome","volume":"2","author":"Dinday","year":"2015","journal-title":"eNeuro"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/zeb.2020.1874","article-title":"Noninvasive multielectrode array for brain and spinal cord local field potential recordings from live zebrafish larvae","volume":"17","author":"Tomasello","year":"2020","journal-title":"Zebrafish"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156498","article-title":"Microarray noninvasive neuronal seizure recordings from intact larval zebrafish","volume":"11","author":"Meyer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jpet.2025.103614_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102895","article-title":"Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability","volume":"67","author":"Sri Hari","year":"2023","journal-title":"Redox Biol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib47","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jnr.490180407","article-title":"Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture","volume":"18","author":"Edmond","year":"1987","journal-title":"J Neurosci Res"},{"issue":"5","key":"10.1016\/j.jpet.2025.103614_bib48","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.neuro.2012.05.001","article-title":"Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set","volume":"33","author":"McConnell","year":"2012","journal-title":"Neurotoxicology"},{"issue":"3","key":"10.1016\/j.jpet.2025.103614_bib49","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0022-3565(24)29466-0","article-title":"Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABAA) receptors: mechanism and site of action","volume":"298","author":"Huang","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"10.1016\/j.jpet.2025.103614_bib50","doi-asserted-by":"crossref","DOI":"10.1172\/JCI168035","article-title":"Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors","volume":"133","author":"Drumm","year":"2023","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib51","article-title":"Culture of rat primary cortical cells for microelectrode array (MEA) recordings to screen for acute and developmental neurotoxicity","volume":"1","author":"Gerber","year":"2021","journal-title":"Curr Protoc"},{"issue":"1-2","key":"10.1016\/j.jpet.2025.103614_bib52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-0270(03)00186-9","article-title":"Cryopreserved rat cortical cells develop functional neuronal networks on microelectrode arrays","volume":"128","author":"Otto","year":"2003","journal-title":"J Neurosci Methods"},{"issue":"2","key":"10.1016\/j.jpet.2025.103614_bib53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nchembio.1136","article-title":"Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism","volume":"9","author":"Gut","year":"2013","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103614_bib54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0026-895X(25)10080-1","article-title":"Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control","volume":"35","author":"Hirsch","year":"1989","journal-title":"Mol Pharmacol"},{"issue":"2-3","key":"10.1016\/j.jpet.2025.103614_bib55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0014-2999(89)90843-1","article-title":"Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells","volume":"161","author":"Larcher","year":"1989","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103614_bib56","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3233\/JAD-190127","article-title":"TSPO ligands boost mitochondrial function and pregnenolone synthesis","volume":"72","author":"Lejri","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"10.1016\/j.jpet.2025.103614_bib57","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0028-3908(99)00253-1","article-title":"Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine","volume":"39","author":"Schlichter","year":"2000","journal-title":"Neuropharmacology"},{"issue":"5939","key":"10.1016\/j.jpet.2025.103614_bib58","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1175055","article-title":"Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects","volume":"325","author":"Rupprecht","year":"2009","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jpet.2025.103614_bib59","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.bjp.0705681","article-title":"Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand","volume":"142","author":"Kita","year":"2004","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.jpet.2025.103614_bib60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1503\/jpn.170201","article-title":"GABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study","volume":"44","author":"Da Silva","year":"2019","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.jpet.2025.103614_bib61","first-page":"139","article-title":"Pharmacological, electrophysiological, and neurochemical actions of the convulsant benzodiazepine Ro 5-4864 (4\u2032-chlordiazepam)","volume":"38","author":"Weissman","year":"1983","journal-title":"Adv Biochem Psychopharmacol"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib62","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/j.1471-4159.1983.tb00888.x","article-title":"Labelling of \u201cperipheral-type\u201d benzodiazepine binding sites in the rat brain by using [3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization","volume":"41","author":"Benavides","year":"1983","journal-title":"J Neurochem"},{"issue":"6","key":"10.1016\/j.jpet.2025.103614_bib63","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0026-895X(25)09864-5","article-title":"Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864","volume":"46","author":"Farges","year":"1994","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103614_bib64","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s11030-024-10963-0","article-title":"Current advances in the structure-activity relationship (SAR) analysis of the old\/new 18-kDa translocator protein ligands","volume":"29","author":"Singh","year":"2025","journal-title":"Mol Divers"},{"key":"10.1016\/j.jpet.2025.103614_bib65","first-page":"165","article-title":"Anxiety disorders and GABA neurotransmission: a disturbance of modulation","volume":"11","author":"Nuss","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.jpet.2025.103614_bib66","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2147\/NDT.S200568","article-title":"An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action","volume":"15","author":"Nuss","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"suppl 1","key":"10.1016\/j.jpet.2025.103614_bib67","first-page":"S36","article-title":"Anxiolytics targeting GABAA receptors: insights on etifoxine","volume":"19","author":"Poisbeau","year":"2018","journal-title":"World J Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.jpet.2025.103614_bib68","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2967\/jnumed.111.091694","article-title":"Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy","volume":"53","author":"Hirvonen","year":"2012","journal-title":"J Nucl Med"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525398277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525398277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:32:23Z","timestamp":1762209143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525398277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0022356525398277"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103614","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multielectrode array reveals therapeutic potential of translocator protein ligands in a zebrafish model of Dravet syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"103614"}}