{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:14:08Z","timestamp":1787022848583,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2025R108"],"award-info":[{"award-number":["PNURSP2025R108"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jpet.2025.103647","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:03:24Z","timestamp":1751421804000},"page":"103647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the therapeutic potential of aloenin-loaded nanogel for imiquimod-induced psoriasis-like skin conditions: In vitro and in vivo assessment"],"prefix":"10.1016","volume":"392","author":[{"given":"Sadaf Jamal","family":"Gilani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehssan","family":"Moglad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misbahuddin","family":"Rafeeq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Hamed","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-4023","authenticated-orcid":false,"given":"Sami I.","family":"Alzarea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Sayyed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Kazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jpet.2025.103647_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.967","article-title":"Curcumin alleviates imiquimod-induced psoriasis-like inflammation and regulates gut microbiota of mice","volume":"11","author":"Cai","year":"2023","journal-title":"Immun Inflamm Dis"},{"issue":"13","key":"10.1016\/j.jpet.2025.103647_bib2","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.3390\/ijms22137145","article-title":"Anoctamin1 induces hyperproliferation of HaCaT keratinocytes and triggers imiquimod-induced psoriasis-like skin injury in mice","volume":"22","author":"Choi","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jpet.2025.103647_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40659-020-00316-0","article-title":"Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice","volume":"53","author":"Gao","year":"2020","journal-title":"Biol Res"},{"key":"10.1016\/j.jpet.2025.103647_bib4","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.2147\/CCID.S418467","article-title":"Lipoxin A4 ameliorates imiquimod-induced psoriasis-like dermatitis via promoting the regression of inflammation","volume":"16","author":"Hu","year":"2023","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.jpet.2025.103647_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118596","article-title":"Anti-psoriatic potential of medicinal plants, Alstonia scholaris, Wrightia tinctoria, and Solanum xanthocarpum, using human HaCaT keratinocytes by multi-parametric analysis","volume":"334","author":"Ojha","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jpet.2025.103647_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2025.103173","article-title":"Herbal medicine for treating psoriasis: a systematic review","volume":"90","author":"Anheyer","year":"2025","journal-title":"Complement Ther Med"},{"issue":"2","key":"10.1016\/j.jpet.2025.103647_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.3002","article-title":"Lipase activity inhibited by aloenin A: glycoside from Aloe vera (L.) Burm. f.\u2014in vitro and molecular docking studies","volume":"36","author":"Deora","year":"2023","journal-title":"J Mol Recognit"},{"key":"10.1016\/j.jpet.2025.103647_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.5114\/ada.2021.108445","article-title":"Treatments in psoriasis: from standard pharmacotherapy to nanotechnology therapy","volume":"39","author":"Zhu","year":"2022","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1016\/j.jpet.2025.103647_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsadv.2023.100524","article-title":"Preparation, characterization, in-vitro and toxicological evaluation of carbopol based nanogels for solubility enhancement of Valsartan","volume":"18","author":"Suhail","year":"2023","journal-title":"Appl Surf Sci Adv"},{"issue":"4","key":"10.1016\/j.jpet.2025.103647_bib9","first-page":"231","article-title":"Formulation and evaluation of gel containing fluconazole microsponges","volume":"8","author":"Syed","year":"2020","journal-title":"Asian J Pharm Res Dev"},{"key":"10.1016\/j.jpet.2025.103647_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108160","article-title":"Losartan ointment attenuates imiquimod-induced psoriasis-like inflammation","volume":"100","author":"Shokrian Zeini","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"10.1016\/j.jpet.2025.103647_bib11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4155\/tde-2020-0076","article-title":"Formulation design and evaluation of aceclofenac nanogel for topical application","volume":"11","author":"Alam","year":"2020","journal-title":"Ther Deliv"},{"issue":"9","key":"10.1016\/j.jpet.2025.103647_bib12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1134\/S1061934820070047","article-title":"UV spectroscopic determination of aloin in Aloe vera (A. vera) samples based on chemometric data processing","volume":"75","author":"Burmistrova","year":"2020","journal-title":"J Anal Chem"},{"key":"10.1016\/j.jpet.2025.103647_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijbiomac.2017.10.112","article-title":"Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model","volume":"110","author":"Panonnummal","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jpet.2025.103647_bib14","article-title":"Hyperforin ameliorates imiquimod-induced psoriasis-like murine skin inflammation by modulating IL-17A-producing \u03b3\u03b4 T cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpet.2025.103647_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107754","article-title":"Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB\/c mice via down regulating NF-\u03baB and activation of Nrf2 signaling pathways","volume":"96","author":"Sangaraju","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103647_bib16","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/jcmm.17184","article-title":"Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis","volume":"26","author":"Xu","year":"2022","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.jpet.2025.103647_bib17","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/bph.15983","article-title":"Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A","volume":"180","author":"Zhang","year":"2023","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.jpet.2025.103647_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.5483\/BMBRep.2022-0169","article-title":"Alleviation of imiquimod-induced psoriasis-like symptoms in Ror\u03b1-deficient mouse skin","volume":"56","author":"Park","year":"2023","journal-title":"BMB Rep"},{"issue":"22","key":"10.1016\/j.jpet.2025.103647_bib19","doi-asserted-by":"crossref","first-page":"8560","DOI":"10.3390\/ijms21228560","article-title":"TLR2 deficiency exacerbates imiquimod-induced psoriasis-like skin inflammation through decrease in regulatory T cells and impaired IL-10 production","volume":"21","author":"Nakao","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jpet.2025.103647_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/ijp.IJP_591_20","article-title":"Natural product topical therapy in mitigating imiquimod-induced psoriasis-like skin inflammation-underscoring the anti-psoriatic potential of Nimbolide","volume":"53","author":"More","year":"2021","journal-title":"Indian J Pharmacol"},{"issue":"7","key":"10.1016\/j.jpet.2025.103647_bib21","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3390\/pharmaceutics14071489","article-title":"Towards the preparation of a hydrogel from lyophilisates of the Aloe arborescens aqueous extract","volume":"14","author":"Paw\u0142owicz","year":"2022","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.jpet.2025.103647_bib22","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3390\/cryst11091092","article-title":"Synthesis and characterization of antibacterial carbopol\/ZnO hybrid nanoparticles gel","volume":"11","author":"Ismail","year":"2021","journal-title":"Crystals"},{"key":"10.1016\/j.jpet.2025.103647_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174431","article-title":"Curcumin alleviates imiquimod-induced psoriasis in progranulin-knockout mice","volume":"909","author":"Zhou","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpet.2025.103647_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110696","article-title":"Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB\/c mice via suppression of inflammation response","volume":"131","author":"Zhou","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpet.2025.103647_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117922","article-title":"Amlexanox ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting Th17 cells and the NF-\u03baB signal pathway","volume":"184","author":"Wu","year":"2025","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.jpet.2025.103647_bib26","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s10787-023-01198-w","article-title":"Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8\/NF-\u03baB\/micro RNA-31, AKT\/mTOR\/P70S6K milieu, and Tregs\/Th17 balance","volume":"31","author":"Shahine","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jpet.2025.103647_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.913174","article-title":"A combination of linalool and linalyl acetate synergistically alleviates imiquimod-induced psoriasis-like skin inflammation in BALB\/c mice","volume":"13","author":"Rai","year":"2022","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103647_bib28","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3390\/molecules27041412","article-title":"Coptisine alleviates imiquimod-induced psoriasis-like skin lesions and anxiety-like behavior in mice","volume":"27","author":"Nguyen","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jpet.2025.103647_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.31083\/ph.2022.1970","article-title":"KdPT alleviates imiquimod-induced psoriasis-like skin lesion in mice via inhibiting proliferation and inflammation response","volume":"77","author":"Tang","year":"2022","journal-title":"Pharmazie"},{"issue":"7","key":"10.1016\/j.jpet.2025.103647_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.877","article-title":"Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice","volume":"11","author":"Wang","year":"2023","journal-title":"Immun Inflamm Dis"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525398605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525398605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:17:36Z","timestamp":1777943856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525398605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0022356525398605"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103647","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the therapeutic potential of aloenin-loaded nanogel for imiquimod-induced psoriasis-like skin conditions: In vitro and in vivo assessment","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103647"}}