{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:57:13Z","timestamp":1783198633486,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011807"],"award-info":[{"award-number":["2022A1515011807"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jpet.2025.103669","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T15:37:06Z","timestamp":1753803426000},"page":"103669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coated nanoparticles enhance immune efficacy of Helicobacter pylori outer membrane vesicles by activating Th1\/Th2\/Th17 responses"],"prefix":"10.1016","volume":"392","author":[{"given":"Songling","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpet.2025.103669_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-1302-3_1","article-title":"An overview of Helicobacter pylori infection","volume":"2283","author":"FitzGerald","year":"2021","journal-title":"Methods Mol Biol"},{"issue":"2","key":"10.1016\/j.jpet.2025.103669_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00001-18","article-title":"Helicobacter pylori biofilm formation and its potential role in pathogenesis","volume":"82","author":"Hathroubi","year":"2018","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/cells10010027","article-title":"Helicobacter pylori virulence factors-mechanisms of bacterial pathogenicity in the gastric microenvironment","volume":"10","author":"Baj","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10120-018-0867-1","article-title":"Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination","volume":"22","author":"Maleki Kakelar","year":"2019","journal-title":"Gastric Cancer"},{"issue":"Pt 3","key":"10.1016\/j.jpet.2025.103669_bib5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.semcancer.2021.09.014","article-title":"The interaction of Helicobacter pylori with cancer immunomodulatory stromal cells: new insight into gastric cancer pathogenesis","volume":"86","author":"Navashenaq","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"6715","key":"10.1016\/j.jpet.2025.103669_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/16495","article-title":"Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori","volume":"397","author":"Alm","year":"1999","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/hel.13048","article-title":"Clarifying varied Helicobacter pylori eradication therapies: a comprehensive review","volume":"29","author":"Wu","year":"2024","journal-title":"Helicobacter"},{"issue":"25","key":"10.1016\/j.jpet.2025.103669_bib8","first-page":"429","article-title":"Helicobacter pylori infection","volume":"115","author":"Fischbach","year":"2018","journal-title":"Dtsch Arztebl Int"},{"issue":"4","key":"10.1016\/j.jpet.2025.103669_bib9","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1111\/1541-4337.13181","article-title":"Antibiotic resistance mechanism and diagnosis of common foodborne pathogens based on genotypic and phenotypic biomarkers","volume":"22","author":"Liao","year":"2023","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"9","key":"10.1016\/j.jpet.2025.103669_bib10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41575-021-00449-x","article-title":"Helicobacter pylori infection and antibiotic resistance\u2014from biology to clinical implications","volume":"18","author":"Tshibangu-Kabamba","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"36","key":"10.1016\/j.jpet.2025.103669_bib11","doi-asserted-by":"crossref","first-page":"17118","DOI":"10.1039\/D4NR02323D","article-title":"A promising strategy to improve the stability and immunogenicity of killed but metabolically active vaccines: low-temperature preparation and coating of nanoparticles","volume":"16","author":"Zhao","year":"2024","journal-title":"Nanoscale"},{"issue":"2","key":"10.1016\/j.jpet.2025.103669_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1751-7915.2011.00284.x","article-title":"Nanoparticles for transcutaneous vaccination","volume":"5","author":"Hansen","year":"2012","journal-title":"Microb Biotechnol"},{"issue":"34","key":"10.1016\/j.jpet.2025.103669_bib13","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1039\/D3TB01375H","article-title":"Design and investigation of targeting agent orientation and density on nanoparticles for enhancing cellular uptake efficiency","volume":"11","author":"Fei","year":"2023","journal-title":"J Mater Chem B"},{"issue":"7","key":"10.1016\/j.jpet.2025.103669_bib14","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1039\/D4BM01399A","article-title":"Research progress of metal\u2013CpG composite nanoadjuvants in tumor immunotherapy","volume":"13","author":"Chen","year":"2025","journal-title":"Biomater Sci"},{"issue":"2","key":"10.1016\/j.jpet.2025.103669_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/eem2.12593","article-title":"The capture and catalytic conversion of CO by dendritic mesoporous silica-based nanoparticles","volume":"7","author":"Wang","year":"2024","journal-title":"Energy & Environ Materials"},{"key":"10.1016\/j.jpet.2025.103669_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101231","article-title":"Dendritic mesoporous organosilica nanoparticles (DMONs): chemical composition, structural architecture, and promising applications","volume":"39","author":"Wang","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.jpet.2025.103669_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jconrel.2020.04.031","article-title":"Bacterial outer membrane vesicles as a platform for biomedical applications: AN update","volume":"323","author":"Li","year":"2020","journal-title":"J Control Release"},{"issue":"4","key":"10.1016\/j.jpet.2025.103669_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/1040841X.2023.2212072","article-title":"Outer membrane proteins and vesicles as promising vaccine candidates against Vibrio spp. infections","volume":"50","author":"Singh","year":"2024","journal-title":"Crit Rev Microbiol"},{"issue":"10","key":"10.1016\/j.jpet.2025.103669_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrmicro3525","article-title":"Outer-membrane vesicles from gram-negative bacteria: biogenesis and functions","volume":"13","author":"Schwechheimer","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.micinf.2011.08.007","article-title":"Composition and function of Helicobacter pylori outer membrane vesicles","volume":"14","author":"Parker","year":"2012","journal-title":"Microbes Infect"},{"issue":"10","key":"10.1016\/j.jpet.2025.103669_bib21","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.7150\/ijbs.94156","article-title":"Helicobacter pylori outer membrane vesicles: biogenesis, composition, and biological functions","volume":"20","author":"Li","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"2","key":"10.1016\/j.jpet.2025.103669_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/21645515.2020.1780092","article-title":"Outer membrane vesicles: moving within the intricate labyrinth of assays that can predict risks of reactogenicity in humans","volume":"17","author":"Rossi","year":"2021","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41467-023-36101-2","article-title":"A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens","volume":"14","author":"Weyant","year":"2023","journal-title":"Nat Commun"},{"issue":"10102","key":"10.1016\/j.jpet.2025.103669_bib24","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(17)31449-6","article-title":"Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study","volume":"390","author":"Petousis-Harris","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jpet.2025.103669_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftz050","article-title":"Orally-administered outer-membrane vesicles from Helicobacter pylori reduce H. pylori infection via Th2-biased immune responses in mice","volume":"77","author":"Liu","year":"2019","journal-title":"Pathog Dis"},{"key":"10.1016\/j.jpet.2025.103669_bib26","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3389\/fmicb.2020.01340","article-title":"Outer membrane vesicles of Helicobacter pylori 7.13 as adjuvants promote protective efficacy against Helicobacter pylori infection","volume":"11","author":"Song","year":"2020","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/hel.13034","article-title":"Advances in Helicobacter pylori vaccine research: from candidate antigens to adjuvants\u2014a review","volume":"29","author":"Yunle","year":"2024","journal-title":"Helicobacter"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1523-5378.2005.00293.x","article-title":"Intranasal CpG-oligodeoxynucleotide is a potent adjuvant of vaccine against Helicobacter pylori, and T helper 1 type response and interferon-\u03b3 correlate with the protection","volume":"10","author":"Shi","year":"2005","journal-title":"Helicobacter"},{"key":"10.1016\/j.jpet.2025.103669_bib29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2147\/IJN.S350846","article-title":"Outer membrane vesicles coating nano-glycyrrhizic acid confers protection against Borderella bronchiseptica through Th1\/Th2\/Th17 responses","volume":"17","author":"Huang","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.jpet.2025.103669_bib30","article-title":"Nanoparticle reinforced bacterial outer-membrane vesicles effectively prevent fatal infection of carbapenem-resistant Klebsiella pneumoniae","volume":"24","author":"Wu","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jpet.2025.103669_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110612","article-title":"Enhancing effect of chitosan nanoparticles on the immune efficacy of Bordetella bronchiseptica outer membrane vesicles","volume":"122","author":"Li","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"10.1016\/j.jpet.2025.103669_bib32","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.vaccine.2016.01.028","article-title":"Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza a challenge in BALB\/c mice","volume":"34","author":"Rappazzo","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.jpet.2025.103669_bib33","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v2i0.20181","article-title":"Recombinant outer membrane vesicles carrying Chlamydia muridarum HtrA induce antibodies that neutralize chlamydial infection in vitro","volume":"2","author":"Bartolini","year":"2013","journal-title":"J Extracell Vesicles"},{"issue":"17","key":"10.1016\/j.jpet.2025.103669_bib34","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.vaccine.2015.03.010","article-title":"Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization","volume":"33","author":"Kuipers","year":"2015","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.jpet.2025.103669_bib35","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3390\/microorganisms8091328","article-title":"Helicobacter pylori-derived outer membrane vesicles (OMVs): role in bacterial pathogenesis?","volume":"8","author":"Jarzab","year":"2020","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.jpet.2025.103669_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijpharm.2017.11.054","article-title":"Mesoporous systems for poorly soluble drugs\u2014recent trends","volume":"536","author":"Riikonen","year":"2018","journal-title":"Int J Pharm"},{"issue":"33","key":"10.1016\/j.jpet.2025.103669_bib37","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1039\/C6TB01556E","article-title":"Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo","volume":"4","author":"Li","year":"2016","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.jpet.2025.103669_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejpb.2016.02.014","article-title":"Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity","volume":"102","author":"Rietscher","year":"2016","journal-title":"Eur J Pharm Biopharm"},{"issue":"10","key":"10.1016\/j.jpet.2025.103669_bib39","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.addr.2013.05.013","article-title":"Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant","volume":"65","author":"Hafner","year":"2013","journal-title":"Adv Drug Delivery Rev"},{"issue":"2","key":"10.1016\/j.jpet.2025.103669_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/anbr.202200130","article-title":"Outer membrane vesicle-coated nanoparticle vaccine protects against Acinetobacter baumannii pneumonia and sepsis","volume":"3","author":"Bjanes","year":"2023","journal-title":"Adv Nanobiomed Res"},{"issue":"2","key":"10.1016\/j.jpet.2025.103669_bib41","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1021\/nl504798g","article-title":"Modulating antibacterial immunity via bacterial membrane-coated nanoparticles","volume":"15","author":"Gao","year":"2015","journal-title":"Nano Lett"},{"issue":"3","key":"10.1016\/j.jpet.2025.103669_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.mucimm.2024.12.013","article-title":"Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections","volume":"18","author":"Zhao","year":"2025","journal-title":"Mucosal Immunol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525398824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525398824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:59Z","timestamp":1777943759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525398824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0022356525398824"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103669","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coated nanoparticles enhance immune efficacy of Helicobacter pylori outer membrane vesicles by activating Th1\/Th2\/Th17 responses","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103669"}}