{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:21:00Z","timestamp":1777494060725,"version":"3.51.4"},"reference-count":149,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016658","name":"National Plan on Drugs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["226776\/Z\/22\/Z"],"award-info":[{"award-number":["226776\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jpet.2025.103710","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T09:24:19Z","timestamp":1757755459000},"page":"103710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dependence of psychopharmacological drug effects on early social stress experience: An analysis aligned with the research domain criteria framework"],"prefix":"10.1016","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-6167","authenticated-orcid":false,"given":"Margarita","family":"Moreno-Montoya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-7402","authenticated-orcid":false,"given":"Elena","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-3660","authenticated-orcid":false,"given":"Jeffrey W.","family":"Dalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jpet.2025.103710_bib1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.amepre.2019.04.001","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the Adverse Childhood Experiences (ACE) study","volume":"56","author":"Felitti","year":"2019","journal-title":"Am J Prev Med"},{"issue":"12","key":"10.1016\/j.jpet.2025.103710_bib2","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s10802-023-01100-w","article-title":"A developmental psychopathology perspective on adverse childhood experiences (ACEs): introduction to the special issue","volume":"51","author":"Hawes","year":"2023","journal-title":"Res Child Adolesc Psychopathol"},{"issue":"8","key":"10.1016\/j.jpet.2025.103710_bib3","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1016\/S2468-2667(17)30118-4","article-title":"The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis","volume":"2","author":"Hughes","year":"2017","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jpet.2025.103710_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136037","article-title":"Hypothalamic-pituitary-adrenal axis dysfunction by early life stress","volume":"759","author":"Juruena","year":"2021","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jpet.2025.103710_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fncel.2017.00087","article-title":"Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure","volume":"11","author":"Van Bodegom","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fpsyt.2019.00118","article-title":"Developmental trajectories of early life stress and trauma: a narrative review on neurobiological aspects beyond stress system dysregulation","volume":"10","author":"Agorastos","year":"2019","journal-title":"Front Psychiatry"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41398-022-02092-9","article-title":"Early life adversity shapes neural circuit function during sensitive postnatal developmental periods","volume":"12","author":"Malave","year":"2022","journal-title":"Transl Psychiatry"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12916-020-01561-6","article-title":"Mechanisms linking childhood trauma exposure and psychopathology: a transdiagnostic model of risk and resilience","volume":"18","author":"McLaughlin","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.jpet.2025.103710_bib9","first-page":"1","article-title":"Assessing unpredictability in caregiver\u2013child relationships: insights from theoretical and empirical perspectives","author":"Ugarte","year":"2023","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.jpet.2025.103710_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pnpbp.2015.04.004","article-title":"Animal models of major depression and their clinical implications","volume":"64","author":"Cz\u00e9h","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00213-010-2096-0","article-title":"Early life stress paradigms in rodents: potential animal models of depression?","volume":"214","author":"Schmidt","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253406","article-title":"Effects of early life adversity on immediate early gene expression: systematic review and 3-level meta-analysis of rodent studies","volume":"17","author":"Schuler","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jpet.2025.103710_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/2398212820978049","article-title":"Early-life stress and inflammation: a systematic review of a key experimental approach in rodents","volume":"4","author":"Dutcher","year":"2020","journal-title":"Brain Neurosci Adv"},{"issue":"1\u20132","key":"10.1016\/j.jpet.2025.103710_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0149-7634(03)00010-1","article-title":"Early disruption of the mother-infant relationship: effects on brain plasticity and implications for psychopathology","volume":"27","author":"Cirulli","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2007.12.033","article-title":"Maternal separation during a specific postnatal time window prevents reinforcement of hippocampal long-term potentiation in adolescent rats","volume":"152","author":"Gruss","year":"2008","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/j.jpet.2025.103710_bib16","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.neubiorev.2005.04.012","article-title":"Early life genetic, epigenetic and environmental factors shaping emotionality in rodents","volume":"29","author":"Holmes","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0091-3057(99)00150-1","article-title":"The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats","volume":"64","author":"Lehmann","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"issue":"4\u20135","key":"10.1016\/j.jpet.2025.103710_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neubiorev.2005.03.011","article-title":"Long-term effects of early-life environmental manipulations in rodents and primates: potential animal models in depression research","volume":"29","author":"Pryce","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"10.1016\/j.jpet.2025.103710_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/10253890.2017.1343296","article-title":"Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential","volume":"20","author":"Walker","year":"2017","journal-title":"Stress"},{"issue":"209","key":"10.1016\/j.jpet.2025.103710_bib20","doi-asserted-by":"crossref","DOI":"10.3791\/66879","article-title":"Limited bedding and nesting as a model for early-life adversity in mice","volume":"2024","author":"Mroue-Ruiz","year":"2024","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jpet.2025.103710_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ynstr.2016.08.004","article-title":"Prenatal stressors in rodents: effects on behavior","volume":"6","author":"Weinstock","year":"2017","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.jpet.2025.103710_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neures.2023.11.005","article-title":"Early life stress and altered social behaviors: a perspective across species","volume":"211","author":"Parise","year":"2025","journal-title":"Neurosci Res"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.yfrne.2009.03.003","article-title":"Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: what can we learn from animal models?","volume":"30","author":"Veenema","year":"2009","journal-title":"Front Neuroendocrinol"},{"issue":"7","key":"10.1016\/j.jpet.2025.103710_bib24","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","article-title":"Research domain criteria (RDoC): toward a new classification framework for research on mental disorders","volume":"167","author":"Insel","year":"2010","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.31887\/DCNS.2012.14.1\/smorris","article-title":"Research domain criteria: cognitive systems, neural circuits, and dimensions of behavior","volume":"14","author":"Morris","year":"2012","journal-title":"Dial Clin Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fnmol.2019.00134","article-title":"Resilience and vulnerability to trauma: early life interventions modulate aversive memory reconsolidation in the dorsal hippocampus","volume":"12","author":"Couto-Pereira N de","year":"2019","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11064-013-1230-x","article-title":"Contextual fear conditioning in maternal separated rats: the amygdala as a site for alterations","volume":"39","author":"Diehl","year":"2014","journal-title":"Neurochem Res"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbr.2007.06.020","article-title":"Effects of brief and long maternal separations on the HPA axis activity and the performance of rats on context and tone fear conditioning","volume":"184","author":"Guijarro","year":"2007","journal-title":"Behav Brain Res"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainres.2006.03.009","article-title":"Early life stress impairs fear conditioning in adult male and female rats","volume":"1087","author":"Kosten","year":"2006","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1037\/bne0000248","article-title":"Early life stress impairs contextual threat expression in female, but not male, mice","volume":"132","author":"Manzano-Nieves","year":"2018","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbr.2014.03.022","article-title":"Female-dependent impaired fear memory of adult rats induced by maternal separation, and screening of possible related genes in the hippocampal CA1","volume":"267","author":"Sun","year":"2014","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00213-011-2209-4","article-title":"Infant maternal separation impairs adult cognitive performance in BALB\/cJ mice","volume":"216","author":"Wang","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpet.2025.103710_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2014.04.015","article-title":"Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats","volume":"269","author":"Xiong","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpet.2025.103710_bib34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbr.2015.10.034","article-title":"Maternal separation facilitates extinction of social fear in adult male mice","volume":"297","author":"Zoicas","year":"2016","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpet.2025.103710_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149268","article-title":"Impacts of linseed oil diet on anxiety and memory extinction after early life stress: a sex-specific analysis of mitochondrial dysfunction, astrocytic markers, and inflammation in the amygdala","volume":"1846","author":"Andressa Caetano","year":"2025","journal-title":"Brain Res"},{"key":"10.1016\/j.jpet.2025.103710_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbr.2014.01.040","article-title":"The effects of early-life adversity on fear memories in adolescent rats and their persistence into adulthood","volume":"264","author":"Chocyk","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpet.2025.103710_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2017.02.006","article-title":"Behavioral effects in adolescence and early adulthood in two length models of maternal separation in male rats","volume":"324","author":"Banqueri","year":"2017","journal-title":"Behav Brain Res"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib38","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1007\/s12035-024-04578-7","article-title":"Early-life stress influences the transcriptional activation of alpha-2A adrenergic receptor and associated protein kinase a signaling molecules in the frontal cortex of rats","volume":"62","author":"Ali","year":"2025","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbr.2012.11.014","article-title":"Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment","volume":"240","author":"Vivinetto","year":"2013","journal-title":"Behav Brain Res"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.psyneuen.2006.12.013","article-title":"Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats","volume":"32","author":"Aisa","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpet.2025.103710_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainresbull.2014.08.005","article-title":"Early deprivation reduced anxiety and enhanced memory in adult male rats","volume":"108","author":"Zhang","year":"2014","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jpet.2025.103710_bib42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.nlm.2016.09.015","article-title":"Impairment of decision making and disruption of synchrony between basolateral amygdala and anterior cingulate cortex in the maternally separated rat","volume":"136","author":"Cao","year":"2016","journal-title":"Neurobiol Learn Mem"},{"issue":"14","key":"10.1016\/j.jpet.2025.103710_bib43","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.7150\/ijbs.97723","article-title":"N-acetylcysteine alleviates depressive-like behaviors in adolescent EAAC1-\/- mice and early life stress model rats","volume":"20","author":"Kim","year":"2024","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jpet.2025.103710_bib44","doi-asserted-by":"crossref","DOI":"10.2174\/0118761429280572240311060851","article-title":"Paeoniflorin alleviates anxiety and visceral hypersensitivity via HPA axis and BDNF\/TrkB\/PLC\u03b31 pathway in maternal separation-induced IBS-like rats","volume":"17","author":"Liang","year":"2024","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.jpet.2025.103710_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114362","article-title":"Resistance exercise was safe for the pregnancy and offspring\u2019s development and partially protected rats against early life stress-induced effects","volume":"445","author":"Dos Santos","year":"2023","journal-title":"Behav Brain Res"},{"issue":"8","key":"10.1016\/j.jpet.2025.103710_bib46","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s00221-019-05567-2","article-title":"Effect of early maternal separation stress on attention, spatial learning and social interaction behaviour","volume":"237","author":"Kambali","year":"2019","journal-title":"Exp Brain Res"},{"issue":"5","key":"10.1016\/j.jpet.2025.103710_bib47","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00213-019-05252-w","article-title":"Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation","volume":"236","author":"Rincel","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"issue":"10","key":"10.1016\/j.jpet.2025.103710_bib48","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1210\/en.2008-0633","article-title":"A novel mouse model for acute and long-lasting consequences of early life stress","volume":"149","author":"Rice","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jpet.2025.103710_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41420-020-00308-9","article-title":"Early-life stress induces EAAC1 expression reduction and attention-deficit and depressive behaviors in adolescent rats","volume":"6","author":"Kim","year":"2020","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2010.04.054","article-title":"Long-term consequences of early maternal deprivation in serotonergic activity and HPA function in adult rat","volume":"480","author":"Rentesi","year":"2010","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib51","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.neuroscience.2008.05.011","article-title":"Effects of maternal separation on hypothalamic-pituitary-adrenal responses, cognition and vulnerability to stress in adult female rats","volume":"154","author":"Aisa","year":"2008","journal-title":"Neuroscience"},{"issue":"1-2","key":"10.1016\/j.jpet.2025.103710_bib52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2006.05.048","article-title":"Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress","volume":"404","author":"Cui","year":"2006","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.psyneuen.2015.04.015","article-title":"n-3 PUFAs have beneficial effects onanxiety and cognition in female rats: effects of early life stress","volume":"58","author":"Pusceddu","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"10.1016\/j.jpet.2025.103710_bib54","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/npp.2010.13","article-title":"Interactions between age, stress and insulin on cognition: implications for Alzheimer\u2019s disease","volume":"35","author":"Solas","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpet.2025.103710_bib55","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jpsychires.2021.04.008","article-title":"Environmental enrichment improves lifelong persistent behavioral and epigenetic changes induced by early-life stress","volume":"138","author":"Borba","year":"2021","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jpet.2025.103710_bib56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainresbull.2021.04.021","article-title":"Sex differences on the behavior and oxidative stress after ketamine treatment in adult rats subjected to early life stress","volume":"172","author":"Abelaira","year":"2021","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jpet.2025.103710_bib57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpsychires.2017.08.020","article-title":"Early life experience contributes to the developmental programming of depressive-like behaviour, neuroinflammation and oxidative stress","volume":"95","author":"R\u00e9us","year":"2017","journal-title":"J Psychiatr Res"},{"issue":"12","key":"10.1016\/j.jpet.2025.103710_bib58","doi-asserted-by":"crossref","first-page":"10182","DOI":"10.1007\/s12035-024-04198-1","article-title":"Hydroalcoholic extract of Centella asiatica and madecassic acid reverse depressive-like behaviors, inflammation and oxidative stress in adult rats submitted to stress in early life","volume":"61","author":"Bertollo","year":"2024","journal-title":"Mol Neurobiol"},{"issue":"9","key":"10.1016\/j.jpet.2025.103710_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.25377","article-title":"Activity-dependent synaptic plasticity in the medial prefrontal cortex of male rats underlies resilience-related behaviors to social adversity","volume":"102","author":"Montes-Rodr\u00edguez","year":"2024","journal-title":"J Neurosci Res"},{"issue":"B","key":"10.1016\/j.jpet.2025.103710_bib60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jchemneu.2016.02.004","article-title":"Stereological analyses of reward system nuclei in maternally deprived\/separated alcohol drinking rats","volume":"76","author":"Gondr\u00e9-Lewis","year":"2016","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.jpet.2025.103710_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12688\/wellcomeopenres.22276.1","article-title":"Analysis of hippocampal synaptic function in a rodent model of early life stress","volume":"9","author":"Wilkinson","year":"2024","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.jpet.2025.103710_bib62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ynstr.2018.01.002","article-title":"Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia","volume":"8","author":"Bolton","year":"2018","journal-title":"Neurobiol Stress"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nlm.2012.08.004","article-title":"Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex","volume":"98","author":"Baudin","year":"2012","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.jpet.2025.103710_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2023.100598","article-title":"Early social isolation differentially affects the glucocorticoid receptor system and alcohol-seeking behavior in male and female Marchigian Sardinian alcohol-preferring rats","volume":"28","author":"Benvenuti","year":"2024","journal-title":"Neurobiol Stress"},{"issue":"3537","key":"10.1016\/j.jpet.2025.103710_bib65","first-page":"143","article-title":"Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats","volume":"138","author":"Weeks","year":"1962","journal-title":"Science (1979)"},{"key":"10.1016\/j.jpet.2025.103710_bib66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fpsyt.2013.00055","article-title":"The effects of maternal separation on adult methamphetamine self-administration, extinction, reinstatement, and MeCP2 immunoreactivity in the nucleus accumbens","volume":"4","author":"Lewis","year":"2013","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.jpet.2025.103710_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2023.114107","article-title":"Prefrontal cortex neurons in adult rats exposed to early life stress fail to appropriately signal the consequences of motivated actions","volume":"263","author":"Bercum","year":"2023","journal-title":"Physiol Behav"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2004.10.018","article-title":"Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding","volume":"159","author":"Hellemans","year":"2005","journal-title":"Behav Brain Res"},{"issue":"9\u201310","key":"10.1016\/j.jpet.2025.103710_bib69","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00213-017-4579-8","article-title":"\u2018Waiting impulsivity\u2019 in isolation-reared and socially-reared rats: effects of amphetamine","volume":"234","author":"Liu","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib70","doi-asserted-by":"crossref","first-page":"80","DOI":"10.31083\/j.jin2204080","article-title":"Time-dependent effects of buspirone versus desipramine on the 5-choice serial reaction time task in rats reared in social isolation: implication of early life experience and motoric impulsivity","volume":"22","author":"Tung","year":"2023","journal-title":"J Integr Neurosci"},{"issue":"41","key":"10.1016\/j.jpet.2025.103710_bib71","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1523\/JNEUROSCI.2281-05.2005","article-title":"Mechanisms of late-onset cognitive decline after early-life stress","volume":"25","author":"Brunson","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib72","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainresbull.2017.05.014","article-title":"Fluvoxamine maleate effects on dopamine signaling in the prefrontal cortex of stressed Parkinsonian rats: implications for learning and memory","volume":"132","author":"Dall\u00e9","year":"2017","journal-title":"Brain Res Bull"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib73","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/hipo.22374","article-title":"Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice","volume":"25","author":"Naninck","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.jpet.2025.103710_bib74","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.nlm.2018.06.007","article-title":"Why are maternally separated females inflexible? Brain activity pattern of COx and c-Fos","volume":"155","author":"Banqueri","year":"2018","journal-title":"Neurobiol Learn Mem"},{"issue":"10","key":"10.1016\/j.jpet.2025.103710_bib75","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1046\/j.1528-1157.2002.14602.x","article-title":"Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures","volume":"43","author":"Huang","year":"2002","journal-title":"Epilepsia"},{"issue":"39","key":"10.1016\/j.jpet.2025.103710_bib76","doi-asserted-by":"crossref","first-page":"13005","DOI":"10.1523\/JNEUROSCI.1784-10.2010","article-title":"Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors","volume":"30","author":"Ivy","year":"2010","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12993-018-0142-y","article-title":"Sex differences in associations between maternal deprivation and alterations in hippocampal calcium-binding proteins and cognitive functions in rats","volume":"14","author":"Xu","year":"2018","journal-title":"Behav Brain Funct"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib78","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000356188","article-title":"Maternal separation induces alterations in reversal learning and brain-derived neurotrophic factor expression in adult rats","volume":"68","author":"Xue","year":"2013","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.jpet.2025.103710_bib79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fncel.2017.00132","article-title":"Overexpression of mineralocorticoid receptors in the mouse forebrain partly alleviates the effects of chronic early life stress on spatial memory, neurogenesis and synaptic function in the dentate gyrus","volume":"11","author":"Kanatsou","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib80","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1096\/fj.201600834R","article-title":"Early micronutrient supplementation protects against early stress-induced cognitive impairments","volume":"31","author":"Naninck","year":"2017","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib81","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbr.2010.05.017","article-title":"Maternal deprivation induces depressive-like behaviours only in female rats","volume":"213","author":"Mourlon","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpet.2025.103710_bib82","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fnagi.2018.00061","article-title":"Early-life stress does not aggravate spatial memory or the process of hippocampal neurogenesis in adult and middle-aged APP\/PS1 mice","volume":"10","author":"Hoeijmakers","year":"2018","journal-title":"Front Aging Neurosci"},{"issue":"12","key":"10.1016\/j.jpet.2025.103710_bib83","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/hipo.22661","article-title":"MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity","volume":"26","author":"Molet","year":"2016","journal-title":"Hippocampus"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib84","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1134\/S1819712418020095","article-title":"The Long-term effects of early postnatal stress on cognitive abilities and expression of genes of the glutamatergic system in mice","volume":"12","author":"Reshetnikov","year":"2018","journal-title":"Neurochem J"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib85","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/dev.21487","article-title":"Running during adolescence rescues a maternal separation-induced memory impairment in female mice: potential role of differential exon-specific BDNF expression","volume":"59","author":"Wearick-Silva","year":"2017","journal-title":"Dev Psychobiol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib86","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/10253890500404634","article-title":"Early maternal deprivation retards neurodevelopment in Wistar rats","volume":"8","author":"Ellenbroek","year":"2005","journal-title":"Stress"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib87","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1741-7015-11-126","article-title":"Toward the future of psychiatric diagnosis: the seven pillars of RDoC","volume":"11","author":"Cuthbert","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.jpet.2025.103710_bib88","series-title":"Definitions of the RDoC Domains and Constructs","year":"2011"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib89","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1037\/h0077609","article-title":"Naloxone and shock-elicited freezing in the rat","volume":"93","author":"Fanselow","year":"1979","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.jpet.2025.103710_bib90","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.conb.2018.02.010","article-title":"Learning rules for aversive associative memory formation","volume":"49","author":"Ozawa","year":"2018","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib91","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2466\/pr0.1967.21.1.221","article-title":"An improved one-trial passive avoidance learning situation","volume":"21","author":"Jarvik","year":"1967","journal-title":"Psychol Rep"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00504983","article-title":"Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of \u2018fear\u2019-motivated behaviour","volume":"327","author":"Handley","year":"1984","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jpet.2025.103710_bib93","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-8994-2_4","article-title":"The elevated plus maze test for measuring anxiety-like behavior in rodents","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"11","key":"10.1016\/j.jpet.2025.103710_bib94","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s00213-022-06275-6","article-title":"\u201cThe wrong tools for the right job\u201d: a critical meta-analysis of traditional tests to assess behavioural impacts of maternal separation","volume":"240","author":"Stupart","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpet.2025.103710_bib95","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnbeh.2015.00031","article-title":"Behavior in the elevated plus maze is differentially affected by testing conditions in rats under and over three weeks of age","volume":"9","author":"Albani","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib96","article-title":"Use of the open field maze to measure locomotor and anxiety-like behavior in mice","volume":"96","author":"Seibenhener","year":"2015","journal-title":"J Vis Exp"},{"issue":"5604","key":"10.1016\/j.jpet.2025.103710_bib97","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib98","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"issue":"9","key":"10.1016\/j.jpet.2025.103710_bib99","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biopsych.2009.10.018","article-title":"The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents","volume":"67","author":"Malkesman","year":"2010","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"issue":"10","key":"10.1016\/j.jpet.2025.103710_bib101","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/npp.2009.62","article-title":"Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task","volume":"34","author":"Zeeb","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib102","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1503\/jpn.140045","article-title":"Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats","volume":"40","author":"Barrus","year":"2015","journal-title":"J Psychiatry Neurosci"},{"issue":"11","key":"10.1016\/j.jpet.2025.103710_bib103","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1523\/JNEUROSCI.20-11-04320.2000","article-title":"Medial frontal cortex mediates perceptual attentional set shifting in the rat","volume":"20","author":"Birrell","year":"2000","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib104","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41398-022-01988-w","article-title":"Enduring disruption of reward and stress circuit activities by early-life adversity in male rats","volume":"12","author":"Levis","year":"2022","journal-title":"Transl Psychiatry"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s002130050121","article-title":"The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement","volume":"128","author":"Evenden","year":"1996","journal-title":"Psychopharmacology (Berl)"},{"issue":"3-4","key":"10.1016\/j.jpet.2025.103710_bib106","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","article-title":"The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry","volume":"163","author":"Robbins","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"issue":"9\u201310","key":"10.1016\/j.jpet.2025.103710_bib107","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00213-017-4555-3","article-title":"Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats","volume":"234","author":"Boutros","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib108","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib109","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1037\/0097-7403.2.2.97","article-title":"Remembrance of places passed: spatial memory in rats","volume":"2","author":"Olton","year":"1976","journal-title":"J Exp Psychol Anim Behav Process"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1101\/lm.41302","article-title":"Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts","volume":"9","author":"Mumby","year":"2002","journal-title":"Learn Mem"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib111","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1538\/expanim.21-0120","article-title":"Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory","volume":"71","author":"Othman","year":"2022","journal-title":"Exp Anim"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib112","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav Brain Res"},{"issue":"12","key":"10.1016\/j.jpet.2025.103710_bib113","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat Protoc"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib114","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0166-4328(85)90045-2","article-title":"Effects of lesions of prefrontal cortex and dorsomedial thalamus on delayed go\/no-go alternation in rats","volume":"17","author":"Sakurai","year":"1985","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1037\/0033-295X.87.2.175","article-title":"Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input","volume":"87","author":"Hoffman","year":"1980","journal-title":"Psychol Rev"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib116","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbr.2008.11.049","article-title":"Distinct forms of prepulse inhibition disruption distinguishable by the associated changes in prepulse-elicited reaction","volume":"204","author":"Yee","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.jpet.2025.103710_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173468","article-title":"Sex differences on the response to antidepressants and psychobiotics following early life stress in rats","volume":"220","author":"Carlessi","year":"2022","journal-title":"Pharmacol Biochem Behav"},{"issue":"11","key":"10.1016\/j.jpet.2025.103710_bib118","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/dneu.22283","article-title":"A single dose of S-ketamine induces long-term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation","volume":"75","author":"R\u00e9us","year":"2015","journal-title":"Dev Neurobiol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103710_bib119","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1007\/s12035-021-02718-x","article-title":"Combination of electroconvulsive stimulation with ketamine or escitalopram protects the brain against inflammation and oxidative stress induced by maternal deprivation and is critical for associated behaviors in male and female rats","volume":"59","author":"Abelaira","year":"2022","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.jpet.2025.103710_bib120","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1007\/s12035-022-02830-6","article-title":"Early life social stress causes sex- and region-dependent dopaminergic changes that are prevented by minocycline","volume":"59","author":"Catale","year":"2022","journal-title":"Mol Neurobiol"},{"issue":"1\u20133","key":"10.1016\/j.jpet.2025.103710_bib121","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2012.08.020","article-title":"Escitalopram improves memory deficits induced by maternal separation in the rat","volume":"695","author":"do Couto","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jpet.2025.103710_bib122","doi-asserted-by":"crossref","unstructured":"G\u0142ombik K, Stachowicz A, Trojan E, Olszanecki R, \u015alusarczyk J, Suski M, Chamera K, Budziszewska B, Laso\u0144 W, Basta-Kaim, A. Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria \u2013 A proteomic study in an animal model of depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017;78:51\u201360. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.05.014","DOI":"10.1016\/j.pnpbp.2017.05.014"},{"issue":"4","key":"10.1016\/j.jpet.2025.103710_bib123","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.neuroscience.2010.08.005","article-title":"Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression","volume":"170","author":"Desbonnet","year":"2010","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.jpet.2025.103710_bib124","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.biopsych.2011.08.005","article-title":"Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress","volume":"70","author":"Benekareddy","year":"2011","journal-title":"Biol Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.jpet.2025.103710_bib125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/FBP.0000000000000109","article-title":"Endocannabinoids and striatal function: implications for addiction-related behaviours","volume":"26","author":"Moreira","year":"2015","journal-title":"Behav Pharmacol"},{"issue":"7","key":"10.1016\/j.jpet.2025.103710_bib126","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/lm.041608.116","article-title":"Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood","volume":"23","author":"Alteba","year":"2016","journal-title":"Learn Mem"},{"key":"10.1016\/j.jpet.2025.103710_bib127","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.euroneuro.2020.08.005","article-title":"Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress","volume":"39","author":"Alteba","year":"2020","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jpet.2025.103710_bib128","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416101","article-title":"FAAH inhibition restores early life stress-induced alterations in PFC microRNAs associated with depressive-like behavior in male and female rats","volume":"23","author":"Portugalov","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jpet.2025.103710_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.105044","article-title":"Intranasal oxytocin administration facilitates the induction of long-term potentiation and promotes cognitive performance of maternally separated rats","volume":"123","author":"Joushi","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpet.2025.103710_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173318","article-title":"Environmental enrichment and intranasal oxytocin administration reverse maternal separation-induced impairments of prosocial choice behavior","volume":"213","author":"Joushi","year":"2022","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.jpet.2025.103710_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2024.107050","article-title":"Boosting decision-making in rat models of early-life adversity with environmental enrichment and intranasal oxytocin","volume":"165","author":"Joushi","year":"2024","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jpet.2025.103710_bib132","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1007\/s12035-021-02588-3","article-title":"Environmental enrichment rescues oxidative stress and behavioral impairments induced by maternal care deprivation: sex- and developmental-dependent differences","volume":"60","author":"R\u00e9us","year":"2023","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jpet.2025.103710_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111035","article-title":"Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress","volume":"396","author":"Xu","year":"2024","journal-title":"Chem Biol Interact"},{"issue":"10","key":"10.1016\/j.jpet.2025.103710_bib134","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/pcn.12902","article-title":"Rapid-acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective","volume":"73","author":"Hashimoto","year":"2019","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jpsychires.2016.12.002","article-title":"Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of rapamycin into prefrontal cortex","volume":"87","author":"Abelaira","year":"2017","journal-title":"J Psychiatr Res"},{"issue":"8","key":"10.1016\/j.jpet.2025.103710_bib136","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/02698811211026426","article-title":"Ketamine\u2019s effect on inflammation and kynurenine pathway in depression: a systematic review","volume":"35","author":"Kopra","year":"2021","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.jpet.2025.103710_bib137","article-title":"Neuroinflammation and glial cell activation in mental disorders","volume":"2","author":"Almeida","year":"2020","journal-title":"Brain Behav Immun Health"},{"issue":"7","key":"10.1016\/j.jpet.2025.103710_bib138","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/dneu.22846","article-title":"Effects of early-life stress and sex on blood\u2013brain barrier permeability and integrity in juvenile and adult rats","volume":"81","author":"Solarz","year":"2021","journal-title":"Dev Neurobiol"},{"issue":"8","key":"10.1016\/j.jpet.2025.103710_bib139","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1523\/JNEUROSCI.21-08-02580.2001","article-title":"Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia","volume":"21","author":"Tikka","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpet.2025.103710_bib140","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbi.2020.11.009","article-title":"Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation\/phagocytosis","volume":"91","author":"Bassett","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jpet.2025.103710_bib141","article-title":"Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid","volume":"161","author":"O\u2019Leary","year":"2020","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jpet.2025.103710_bib142","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.lfs.2018.08.050","article-title":"Serotonin receptors in depression and anxiety: Insights from animal studies","volume":"210","author":"\u017bmudzka","year":"2018","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.jpet.2025.103710_bib143","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.euroneuro.2016.12.005","article-title":"Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: new insight into the benefits of antidepressant drug treatment","volume":"27","author":"G\u0142ombik","year":"2017","journal-title":"Eur Neuropsychopharmacol"},{"issue":"24","key":"10.1016\/j.jpet.2025.103710_bib144","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416101","article-title":"FAAH inhibition restores early life stress-induced alterations in PFC microRNAs associated with depressive-like behavior in male and female rats","volume":"23","author":"Portugalov","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"20","key":"10.1016\/j.jpet.2025.103710_bib145","doi-asserted-by":"crossref","first-page":"21838","DOI":"10.1021\/acsomega.3c08934","article-title":"Activation of GPR55 ameliorates maternal separation-induced learning and memory deficits by augmenting 5-HT synthesis in the dorsal raphe nucleus of juvenile mice","volume":"9","author":"Sun","year":"2024","journal-title":"ACS Omega"},{"issue":"12","key":"10.1016\/j.jpet.2025.103710_bib146","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1007\/s12035-021-02588-3","article-title":"Environmental enrichment rescues oxidative stress and behavioral impairments induced by maternal care deprivation: sex- and developmental-dependent differences","volume":"60","author":"R\u00e9us","year":"2023","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103710_bib147","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2012.06526.x","article-title":"Myosin light chain kinase: pulling the strings of epithelial tight junction function","volume":"1258","author":"Cunningham","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jpet.2025.103710_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118616","article-title":"A review of the ethnopharmacology, phytochemistry, pharmacology, pharmacokinetics and quality control of Paeonia lactiflora Pall","volume":"335","author":"Ma","year":"2024","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"10.1016\/j.jpet.2025.103710_bib149","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/1521-1878(200009)22:9<836::AID-BIES9>3.0.CO;2-X","article-title":"Histone acetylation and an epigenetic code","volume":"22","author":"Turner","year":"2000","journal-title":"BioEssays"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:56:56Z","timestamp":1761850616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525402237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":149,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0022356525402237"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103710","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dependence of psychopharmacological drug effects on early social stress experience: An analysis aligned with the research domain criteria framework","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"103710"}}