{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:22:47Z","timestamp":1764058967680,"version":"3.45.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"publisher","award":["PBmb 340","DS675"],"award-info":[{"award-number":["PBmb 340","DS675"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jpet.2025.103727","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:53:40Z","timestamp":1758819220000},"page":"103727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological and toxicological profiling of JAMC-4\/108: targeted induction of apoptosis in human colorectal cancer cells"],"prefix":"10.1016","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-7252","authenticated-orcid":false,"given":"Roman","family":"Paduch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-6181","authenticated-orcid":false,"given":"Magdalena","family":"Mizerska-Kowalska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Dudzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliwia","family":"Kosz\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-600X","authenticated-orcid":false,"given":"Wirginia","family":"Kukula-Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-751X","authenticated-orcid":false,"given":"Anna","family":"Tab\u0119cka-\u0141onczy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariunzaya","family":"Batjargal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-0042","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"So\u0142ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jpet.2025.103727_bib1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/ijms26031313","article-title":"Colorectal cancer: current and future therapeutic approaches and related technologies addressing multidrug strategies against multiple level resistance mechanisms","volume":"26","author":"Puzzo","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","article-title":"Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","article-title":"Comprehensive review of targeted therapy for colorectal cancer","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jpet.2025.103727_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1570712","article-title":"Advancing targeted therapy for colorectal cancer: harnessing ligand-directed enzyme prodrug therapy for highly specific interventions","volume":"15","author":"Al-Jaber","year":"2025","journal-title":"Front Oncol"},{"key":"10.1016\/j.jpet.2025.103727_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113660","article-title":"Gurgem-7 toxicity assessment: regulation of cell survival or death by traditional Mongolian prescription","volume":"239","author":"Batjargal","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"issue":"3","key":"10.1016\/j.jpet.2025.103727_bib6","first-page":"345","article-title":"Mongolian medicine: history, development and existing problems","volume":"14","author":"Qu","year":"2022","journal-title":"Chin Herb Med"},{"issue":"3","key":"10.1016\/j.jpet.2025.103727_bib7","first-page":"343","article-title":"Traditional Mongolian medicine: past, present and future","volume":"14","author":"Bai","year":"2022","journal-title":"Chin Herb Med"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/0974-8520.100295","article-title":"Drug discovery from plant sources: an integrated approach","volume":"33","author":"Katiyar","year":"2012","journal-title":"Ayu"},{"issue":"9","key":"10.1016\/j.jpet.2025.103727_bib9","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1002\/ptr.8283","article-title":"Phytochemical-mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach","volume":"38","author":"Al Azzani","year":"2024","journal-title":"Phytother Res"},{"issue":"9","key":"10.1016\/j.jpet.2025.103727_bib10","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3390\/antiox9090822","article-title":"Influence of accelerated solvent extraction conditions on the LC-ESI-MS\/MS polyphenolic profile, triterpenoid content, and antioxidant and anti-lipoxygenase activity of Rhododendron luteum sweet leaves","volume":"9","author":"Olech","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.jpet.2025.103727_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/2008-322X.170349","article-title":"The effect of Lamium album extract on cultivated human corneal epithelial cells (10.014 pRSV-T)","volume":"10","author":"Paduch","year":"2015","journal-title":"J Ophthalmic Vis Res"},{"issue":"9\u201310","key":"10.1016\/j.jpet.2025.103727_bib12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10495-019-01557-5","article-title":"Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies","volume":"24","author":"Solek","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.jpet.2025.103727_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2022.01.011","article-title":"Cancer on-target: selective enhancement of 3-bromopyruvate action by an electromagnetic field in vitro","volume":"180","author":"So\u0142ek","year":"2022","journal-title":"Free Radic Biol Med"},{"issue":"21","key":"10.1016\/j.jpet.2025.103727_bib14","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.3390\/foods11213484","article-title":"Impact of thermal processing on the composition of secondary metabolites of ginger rhizome\u2014a review","volume":"11","author":"Zag\u00f3rska","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.jpet.2025.103727_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1067089","article-title":"Pharmacokinetics of active compounds of a Terminalia chebula Retz. ethanolic extract after oral administration rats using UPLC-MS\/MS","volume":"14","author":"Yao","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpet.2025.103727_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.902551","article-title":"Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations","volume":"13","author":"Y\u00fccel","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpet.2025.103727_bib17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.indcrop.2015.03.033","article-title":"Chromatographic analysis, antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds","volume":"70","author":"Nile","year":"2015","journal-title":"Ind Crops Prod"},{"key":"10.1016\/j.jpet.2025.103727_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.semcancer.2019.08.009","article-title":"Ginger and its active compounds in cancer therapy: from folk uses to nano-therapeutic applications","volume":"69","author":"Mahomoodally","year":"2021","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"10.1016\/j.jpet.2025.103727_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202201098","article-title":"Cytotoxic activity of herbal medicines as assessed in vitro: a review","volume":"20","author":"Gavanji","year":"2023","journal-title":"Chem Biodivers"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/628073","article-title":"Cytotoxic and apoptotic effects of different extracts of Artemisia turanica Krasch. on K562 and HL-60 cell lines","volume":"2013","author":"Tayarani-Najaran","year":"2013","journal-title":"Sci World J"},{"key":"10.1016\/j.jpet.2025.103727_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jep.2015.01.040","article-title":"In vitro cytotoxic and pro-apoptotic effects of water extracts of Tulbaghia violacea leaves and bulbs","volume":"164","author":"Saibu","year":"2015","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"10.1016\/j.jpet.2025.103727_bib22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.prp.2017.01.006","article-title":"Hepatoprotective Mongolian prescription II enhances the antitumor effects of chemotherapeutics in hepatocellular carcinoma xenografts","volume":"213","author":"Nanda","year":"2017","journal-title":"Pathol Res Pract"},{"issue":"4","key":"10.1016\/j.jpet.2025.103727_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231466","article-title":"DaHuangWan targets EGF signaling to inhibit the proliferation of hepatoma cells","volume":"15","author":"Si","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib24","article-title":"Treatment of liver cancer: role of the traditional Mongolian medicine","volume":"2022","author":"Bao","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jpet.2025.103727_bib25","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2147\/JIR.S275595","article-title":"Reactive oxygen species: drivers of physiological and pathological processes","volume":"13","author":"Checa","year":"2020","journal-title":"J Inflamm Res"},{"issue":"8","key":"10.1016\/j.jpet.2025.103727_bib26","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2174\/138945012802009044","article-title":"Pro-oxidant natural products as anticancer agents","volume":"13","author":"Martin-Cordero","year":"2012","journal-title":"Curr Drug Targets"},{"issue":"51","key":"10.1016\/j.jpet.2025.103727_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5564\/mjc.v25i51.2934","article-title":"Cytotoxicity screening of 114 Mongolian plant extracts on liver, colon, breast, and cervix cancer cell lines","volume":"25","author":"Oidovsambuu","year":"2024","journal-title":"Mongolian J Chem"},{"issue":"2","key":"10.1016\/j.jpet.2025.103727_bib28","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3390\/ijms24021691","article-title":"Modulation of cell death pathways for cellular protection and anti-tumoral activity: the role of Thymus spp. extracts and their bioactive molecules","volume":"24","author":"Martins-Gomes","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jpet.2025.103727_bib29","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.3390\/molecules26102990","article-title":"Rhododendron molle G. Don extract induces apoptosis and inhibits migration in human colorectal cancer cells and potential anticancer components analysis","volume":"26","author":"Zong","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jpet.2025.103727_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116312","article-title":"Mechanism of the Mongolian medicine Eerdun Wurile basic formula in improving postoperative cognitive dysfunction by inhibiting apoptosis through the SIRT1\/p53 signaling pathway","volume":"309","author":"Li","year":"2023","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103727_bib31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.18632\/aging.100934","article-title":"Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies","volume":"8","author":"Pistritto","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"10.1016\/j.jpet.2025.103727_bib32","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jpet.2025.103727_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1416781","article-title":"Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species","volume":"15","author":"Qi","year":"2024","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103727_bib34","first-page":"170","article-title":"Cytotoxicity and preliminary analysis of the pro-apoptotic and cell cycle arrest effects of lantana ukambensis against colorectal cancer cells","volume":"11","author":"Sawadogo","year":"2020","journal-title":"Int J Appl Biol Pharm"},{"key":"10.1016\/j.jpet.2025.103727_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3868354","article-title":"The role of herbal bioactive components in mitochondria function and cancer therapy","volume":"2019","author":"Tao","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jpet.2025.103727_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/873210","article-title":"Natural product nitric oxide chemistry: new activity of old medicines","volume":"2012","author":"Jiang","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000732","article-title":"Decreased risk of colorectal cancer among patients with type 2 diabetes receiving Chinese herbal medicine: a population-based cohort study","volume":"8","author":"Jhang","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"5","key":"10.1016\/j.jpet.2025.103727_bib38","first-page":"314","article-title":"Aerial parts of Peucedanum chenur have anti-cancer properties through the induction of apoptosis and inhibition of invasion in human colorectal cancer cells","volume":"24","author":"Yadegari","year":"2020","journal-title":"Iran Biomed J"},{"key":"10.1016\/j.jpet.2025.103727_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.crbiot.2024.100217","article-title":"Anti-melanoma efficacy of traditional multi-herbal extracts from Mongolian ethnomedicine on B16F10 murine cells","volume":"7","author":"Dauletkhan","year":"2024","journal-title":"Curr Res Biotechnol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103727_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7956503","article-title":"Understanding the multitarget pharmacological mechanism of the traditional mongolian common herb pair GuangZao-RouDouKou acting on coronary heart disease based on a bioinformatics approach","volume":"2018","author":"Lu","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jpet.2025.103727_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155600","article-title":"Natural products and derivatives for breast cancer treatment: From drug discovery to molecular mechanism","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpet.2025.103727_bib42","first-page":"229","article-title":"Herbal therapies for cancer treatment: a review of phytotherapeutic efficacy","volume":"18","author":"Jen\u010da","year":"2024","journal-title":"Biologics"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:17:47Z","timestamp":1764058667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525402407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0022356525402407"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103727","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological and toxicological profiling of JAMC-4\/108: targeted induction of apoptosis in human colorectal cancer cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103727"}}