{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:58:28Z","timestamp":1789073908697,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jpet.2025.103731","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T02:11:10Z","timestamp":1758939070000},"page":"103731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sinomenine alleviates cancer-induced bone pain by promoting p65 ubiquitination and modulating microglial polarization"],"prefix":"10.1016","volume":"392","author":[{"given":"Xueqin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jpet.2025.103731_bib1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.20892\/j.issn.2095-3941.2022.0231","article-title":"Current cancer burden in China: epidemiology, etiology, and prevention","volume":"19","author":"Maomao","year":"2022","journal-title":"Cancer Biol Med"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"11","key":"10.1016\/j.jpet.2025.103731_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12032-021-01587-7","article-title":"Cancer induced bone pain: current management and future perspectives","volume":"38","author":"Kapoor","year":"2021","journal-title":"Med Oncol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103731_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/cancers15030591","article-title":"Update on prevalence of pain in patients with cancer 2022: a systematic literature review and meta-analysis","volume":"15","author":"Snijders","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1172\/JCI134708","article-title":"Medications for opioid use disorders: clinical and pharmacological considerations","volume":"130","author":"Volkow","year":"2020","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.jpet.2025.103731_bib6","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1177\/0003134820952834","article-title":"Are NSAIDs safe? Assessing the risk-benefit profile of nonsteroidal anti-inflammatory drug use in postoperative pain management","volume":"87","author":"Chang","year":"2021","journal-title":"Am Surg"},{"issue":"6","key":"10.1016\/j.jpet.2025.103731_bib7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s12264-023-01126-6","article-title":"Peripheral Mechanism of Cancer-Induced Bone Pain","volume":"40","author":"Yang","year":"2024","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.jpet.2025.103731_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jare.2021.06.006","article-title":"Neurophysiological mechanisms of cancer-induced bone pain","volume":"35","author":"Zheng","year":"2022","journal-title":"J Adv Res"},{"issue":"2","key":"10.1016\/j.jpet.2025.103731_bib9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jpet.2025.103731_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114570","article-title":"The dual role of microglia in neuropathic pain after spinal cord injury: detrimental and protective effects","volume":"370","author":"Sun","year":"2023","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jpet.2025.103731_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102160","article-title":"Modulating the polarization phenotype of microglia\u2014a valuable strategy for central nervous system diseases","volume":"93","author":"Long","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jpet.2025.103731_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112912","article-title":"Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK\/PGC-1\u03b1 signaling axis","volume":"149","author":"Ge","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpet.2025.103731_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211060962","article-title":"P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models","volume":"18","author":"Wu","year":"2022","journal-title":"Mol Pain"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ptr.8039","article-title":"Stigmasterol regulates microglial M1\/M2 polarization via the TLR4\/NF-\u03baB pathway to alleviate neuropathic pain","volume":"38","author":"Si","year":"2024","journal-title":"Phytother Res"},{"issue":"9","key":"10.1016\/j.jpet.2025.103731_bib15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-\u03baB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jpet.2025.103731_bib16","article-title":"Post-translational modifications of p65: state of the art","volume":"12","author":"Sun","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.jpet.2025.103731_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41418-021-00862-4","article-title":"Ubiquitination of NF-\u03baB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance","volume":"29","author":"Ren","year":"2022","journal-title":"Cell Death Differ"},{"issue":"5","key":"10.1016\/j.jpet.2025.103731_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.864","article-title":"RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma","volume":"11","author":"Zeng","year":"2023","journal-title":"Immun Inflamm Dis"},{"issue":"34","key":"10.1016\/j.jpet.2025.103731_bib19","article-title":"Rictor ameliorates acute antibody-mediated rejection following kidney transplantation by suppressing macrophage M1 polarization through p65-NLRP3 axis","volume":"12","author":"Ni","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jpet.2025.103731_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101932","article-title":"Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-\u03baB signaling pathway in vascular endothelial cells after traumatic spinal cord injury","volume":"41","author":"Ge","year":"2021","journal-title":"Redox Biol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103731_bib21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1302\/2046-3758.144.BJR-2024-0327.R1","article-title":"Carpaine ameliorates synovial inflammation by promoting p65 degradation and inhibiting the NF-\u03baB signalling pathway","volume":"14","author":"Zhang","year":"2025","journal-title":"Bone Joint Res"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12906-020-02978-5","article-title":"Methodological and reporting quality evaluation of meta-analyses on the Chinese herbal preparation Zheng Qing Feng Tong Ning for the treatment of rheumatoid arthritis","volume":"20","author":"Liang","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.jpet.2025.103731_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105711","article-title":"Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo","volume":"122","author":"Duan","year":"2022","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.jpet.2025.103731_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1876862","article-title":"Analgesic mechanism of sinomenine against chronic pain","volume":"2020","author":"Jiang","year":"2020","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.jpet.2025.103731_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1041006","article-title":"Sinomenine regulates immune cell subsets: potential neuro-immune intervene for precise treatment of chronic pain","volume":"10","author":"Lai","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103731_bib26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/jdi.13938","article-title":"Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol-requiring enzyme 1 alpha-X-box binding protein 1 pathway by downregulating prostaglandin-endoperoxide synthase 2","volume":"14","author":"Chen","year":"2023","journal-title":"J Diabetes Investig"},{"issue":"5","key":"10.1016\/j.jpet.2025.103731_bib27","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/brainsci13050716","article-title":"Sinomenine protects against early brain injury by inhibiting microglial inflammatory response via Nrf2-dependent pathway after subarachnoid hemorrhage","volume":"13","author":"Fu","year":"2023","journal-title":"Brain Sci"},{"key":"10.1016\/j.jpet.2025.103731_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918793232","article-title":"Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2\/STAT3 and neuronal CAMKII\/CREB cascades in rat models","volume":"14","author":"Chen","year":"2018","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpet.2025.103731_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116190","article-title":"Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4\/NF-\u03baB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer\u2019s disease mice","volume":"171","author":"Ni","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpet.2025.103731_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2016.00286","article-title":"The Walker 256 breast cancer cell-induced bone pain model in rats","volume":"7","author":"Shenoy","year":"2016","journal-title":"Front Pharmacol"},{"issue":"10","key":"10.1016\/j.jpet.2025.103731_bib31","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1097\/j.pain.0000000000000248","article-title":"Enhanced binding capability of nuclear factor-\u03baB with demethylated P2X3 receptor gene contributes to cancer pain in rats","volume":"156","author":"Zhou","year":"2015","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.jpet.2025.103731_bib32","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1097\/j.pain.0000000000001962","article-title":"Microglial annexin A3 downregulation alleviates bone cancer-induced pain through inhibiting the Hif-1\u03b1\/vascular endothelial growth factor signaling pathway","volume":"161","author":"Zhang","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.jpet.2025.103731_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/1744806920909993","article-title":"Scorpion alleviates bone cancer pain through inhibition of bone destruction and glia activation","volume":"16","author":"Yu","year":"2020","journal-title":"Mol Pain"},{"key":"10.1016\/j.jpet.2025.103731_bib34","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918824250","article-title":"Upregulation of bone morphogenetic protein 2 (Bmp2) in dorsal root ganglion in a rat model of bone cancer pain","volume":"15","author":"Wang","year":"2019","journal-title":"Mol Pain"},{"issue":"9","key":"10.1016\/j.jpet.2025.103731_bib35","first-page":"1349","article-title":"Upregulation of spinal miR-155-5p contributes to mechanical hyperalgesia by promoting inflammatory activation of microglia in bone cancer pain rats","volume":"12","author":"Jian","year":"2022","journal-title":"Life (Basel)"},{"issue":"4","key":"10.1016\/j.jpet.2025.103731_bib36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1007\/s12031-019-01455-0","article-title":"A novel mechanism of BAM8-22 inhibiting microglia activation: represses CX3CR1 expression via upregulating miR-184","volume":"70","author":"Wang","year":"2020","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.jpet.2025.103731_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jneuroim.2016.08.010","article-title":"Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage","volume":"299","author":"Shi","year":"2016","journal-title":"J Neuroimmunol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00540-018-2579-4","article-title":"Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J Anesth"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12974-023-02904-9","article-title":"PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4","volume":"20","author":"Bi","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jpet.2025.103731_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.716469","article-title":"NF-\u03baB: at the borders of autoimmunity and inflammation","volume":"12","author":"Barnabei","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpet.2025.103731_bib41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fphar.2020.00525","article-title":"Chanling gao attenuates bone cancer pain in rats by the IKK\u03b2\/NF-\u03baB signaling pathway","volume":"11","author":"Yang","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpet.2025.103731_bib42","article-title":"Prevalence and severity of pain in cancer patients in Germany","volume":"2","author":"Broemer","year":"2021","journal-title":"Front Pain Res (Lausanne)"},{"issue":"12","key":"10.1016\/j.jpet.2025.103731_bib43","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/jbmr.3618","article-title":"Understanding the bone in cancer metastasis","volume":"33","author":"Fornetti","year":"2018","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jpet.2025.103731_bib44","article-title":"Neuroinflammation in HIV-related neuropathic pain","volume":"12","author":"Lu","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jpet.2025.103731_bib45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2020.11.030","article-title":"Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice","volume":"92","author":"Yi","year":"2021","journal-title":"Brain Behav Immun"},{"issue":"3","key":"10.1016\/j.jpet.2025.103731_bib46","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10787-023-01216-x","article-title":"Microglia polarization in nociplastic pain: mechanisms and perspectives","volume":"31","author":"Atta","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"2","key":"10.1016\/j.jpet.2025.103731_bib47","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.pain.2013.10.008","article-title":"Cancer pain is not necessarily correlated with spinal overexpression of reactive glia markers","volume":"155","author":"Ducourneau","year":"2014","journal-title":"Pain"},{"issue":"10","key":"10.1016\/j.jpet.2025.103731_bib48","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.3390\/cancers12102740","article-title":"Modulation of rat cancer-induced bone pain is independent of spinal microglia activity","volume":"12","author":"Diaz-delCastillo","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"Pt A","key":"10.1016\/j.jpet.2025.103731_bib49","article-title":"The effect of immunotherapy PD-1 blockade on acute bone cancer pain: Insights from transcriptomic and microbiomic profiling","volume":"142","author":"Ding","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10.1016\/j.jpet.2025.103731_bib50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1213\/ANE.0000000000006824","article-title":"Microglia promote inhibitory synapse phagocytosis in the spinal cord dorsal horn and modulate pain-like behaviors in a murine cancer-induced bone pain model","volume":"139","author":"Zhang","year":"2024","journal-title":"Anesth Analg"},{"issue":"1180","key":"10.1016\/j.jpet.2025.103731_bib51","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/postmj\/qgad102","article-title":"Aitongping patch could alleviate cancer pain via suppressing microglia activation and modulating the miR-150-5p\/CXCL12 signaling","volume":"100","author":"Chen","year":"2024","journal-title":"Postgrad Med J"},{"issue":"8","key":"10.1016\/j.jpet.2025.103731_bib52","first-page":"E1199","article-title":"P2X7 receptor-induced bone cancer pain by regulating microglial activity via NLRP3\/IL-1beta signaling","volume":"25","author":"Wu","year":"2022","journal-title":"Pain Physician"},{"issue":"22","key":"10.1016\/j.jpet.2025.103731_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70214","article-title":"Sinomenine ameliorated microglial activation and neuropathic pain after chronic constriction injury via TGF-\u03b21\/ALK5\/Smad3 signalling pathway","volume":"28","author":"Ling","year":"2024","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jpet.2025.103731_bib54","article-title":"Microglial polarization in TBI: signaling pathways and influencing pharmaceuticals","volume":"14","author":"Li","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jpet.2025.103731_bib55","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jconrel.2020.04.036","article-title":"Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury","volume":"323","author":"Sharma","year":"2020","journal-title":"J Control Release"},{"issue":"7","key":"10.1016\/j.jpet.2025.103731_bib56","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1523\/JNEUROSCI.2082-22.2022","article-title":"FUS Contributes to nerve injury-induced nociceptive hypersensitivity by activating NF-\u03baB pathway in primary sensory Neurons","volume":"43","author":"Han","year":"2023","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.jpet.2025.103731_bib57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s10565-024-09900-6","article-title":"TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN\/NF-kB signaling pathway","volume":"40","author":"Zhao","year":"2024","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.jpet.2025.103731_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154291","article-title":"Study on inhibition of Britannin on triple-negative breast carcinoma through degrading ZEB1 proteins","volume":"104","author":"Lu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpet.2025.103731_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115833","article-title":"Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing Notch1 degradation and downregulating key vasculogenic genes","volume":"217","author":"Qi","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jpet.2025.103731_bib60","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2016.01.011","article-title":"Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy","volume":"92","author":"Qin","year":"2016","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.jpet.2025.103731_bib61","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s43018-019-0021-y","article-title":"MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination","volume":"1","author":"Cong","year":"2020","journal-title":"Nat Cancer"},{"issue":"9","key":"10.1016\/j.jpet.2025.103731_bib62","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.7150\/thno.49819","article-title":"SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma","volume":"11","author":"Lin","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jpet.2025.103731_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118855","article-title":"Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2\/STAT3\/SOCS1 pathway in streptozotocin-induced diabetic rats","volume":"265","author":"Zhu","year":"2021","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.jpet.2025.103731_bib64","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/08923973.2020.1732407","article-title":"Sinomenine alleviates lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages","volume":"42","author":"Yin","year":"2020","journal-title":"Immunopharmacol Immunotoxicol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:19:14Z","timestamp":1764058754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525402444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0022356525402444"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103731","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sinomenine alleviates cancer-induced bone pain by promoting p65 ubiquitination and modulating microglial polarization","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103731"}}