{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:26:02Z","timestamp":1772130362789,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jpet.2025.103761","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:58:30Z","timestamp":1761353910000},"page":"103761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuation of the discriminative stimulus and reinforcing effects of positive GABAA modulators after Shisa7 knockdown in rats"],"prefix":"10.1016","volume":"392","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5946-7797","authenticated-orcid":false,"given":"Tamara M.","family":"Morris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley S.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5277-1226","authenticated-orcid":false,"given":"Sarah M.","family":"Melton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-4768","authenticated-orcid":false,"given":"Aslan","family":"Abdurrahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-034X","authenticated-orcid":false,"given":"Ashok","family":"Aiyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Winsauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1124\/pr.109.002063","article-title":"Regulation of GABA(A) receptor subunit expression by pharmacological agents","volume":"62","author":"Uusi-Oukari","year":"2010","journal-title":"Pharmacol Rev"},{"issue":"Pt A","key":"10.1016\/j.jpet.2025.103761_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuropharm.2018.01.036","article-title":"GABA(A) receptor: positive and negative allosteric modulators","volume":"136","author":"Olsen","year":"2018","journal-title":"Neuropharmacology"},{"issue":"6462","key":"10.1016\/j.jpet.2025.103761_bib3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.aax5719","article-title":"Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions","volume":"366","author":"Han","year":"2019","journal-title":"Science"},{"issue":"6755","key":"10.1016\/j.jpet.2025.103761_bib4","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","article-title":"Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes","volume":"401","author":"Rudolph","year":"1999","journal-title":"Nature"},{"issue":"5489","key":"10.1016\/j.jpet.2025.103761_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety","volume":"290","author":"Low","year":"2000","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jpet.2025.103761_bib6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/75761","article-title":"Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype","volume":"3","author":"McKernan","year":"2000","journal-title":"Nat Neurosci"},{"issue":"8","key":"10.1016\/j.jpet.2025.103761_bib7","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1523\/JNEUROSCI.17-08-02728.1997","article-title":"Stoichiometry and assembly of a recombinant GABAA receptor subtype","volume":"17","author":"Tretter","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.jpet.2025.103761_bib8","article-title":"GABA(A) receptor subtypes and benzodiazepine use, misuse, and abuse","volume":"13","author":"Engin","year":"2022","journal-title":"Front Psychiatry"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1073\/pnas.0405621102","article-title":"Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates","volume":"102","author":"Rowlett","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib10","article-title":"Intravenous delivery of a dicer substrate siRNA to the central nervous system via rabies virus glycoprotein","volume":"7","author":"Henderson","year":"2024","journal-title":"J Mol Biol Methods"},{"issue":"2","key":"10.1016\/j.jpet.2025.103761_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00213-002-1037-y","article-title":"Role of GABAA\/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys","volume":"161","author":"Lelas","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s002130000615","article-title":"Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs","volume":"154","author":"Lelas","year":"2001","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.jpet.2025.103761_bib13","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/acer.14000","article-title":"GABA(A) receptor subtypes and the abuse-related effects of Ethanol in Rhesus monkeys: experiments with selective positive allosteric modulators","volume":"43","author":"Berro","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"issue":"2\u20133","key":"10.1016\/j.jpet.2025.103761_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.addr.2007.03.009","article-title":"Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications","volume":"59","author":"Kumar","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"10.1016\/j.jpet.2025.103761_bib15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0165-6147(92)90059-F","article-title":"Drugs of abuse: behavioural principles, methods and terms","volume":"13","author":"Stolerman","year":"1992","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jpet.2025.103761_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/164_2017_80","article-title":"GABA(A) receptor subtype mechanisms and the abuse-related effects of ethanol: genetic and pharmacological evidence","volume":"248","author":"Chandler","year":"2018","journal-title":"Handb Exp Pharmacol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103761_bib17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.alcohol.2010.08.020","article-title":"Effects of 7-keto dehydroepiandrosterone on voluntary ethanol intake in male rats","volume":"45","author":"Worrel","year":"2011","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103761_bib18","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.pbb.2006.11.013","article-title":"Effects of gamma-hydroxybutyric acid and flunitrazepam on ethanol intake in male rats","volume":"85","author":"Leonard","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"10.1016\/j.jpet.2025.103761_bib19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1530-0277.2011.01622.x","article-title":"GABA(A) receptor modulation during adolescence alters adult ethanol intake and preference in rats","volume":"36","author":"Hulin","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00213-018-5110-6","article-title":"Effects of cocaine on the discriminative stimulus and reinforcing effects of mephedrone in male rats","volume":"236","author":"Erwin","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.pbb.2012.06.008","article-title":"Ovarian hormones and chronic administration during adolescence modify the discriminative stimulus effects of delta-9-tetrahydrocannabinol (delta(9)-THC) in adult female rats","volume":"102","author":"Winsauer","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"10.1016\/j.jpet.2025.103761_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s002130050531","article-title":"Generalization of a restraint-induced discriminative stimulus to cocaine in rats","volume":"135","author":"Mantsch","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"issue":"2\u20133 Spec Issue","key":"10.1016\/j.jpet.2025.103761_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/FBP.0000000000000225","article-title":"Cocaine-like discriminative stimulus effects of phendimetrazine and phenmetrazine in rats","volume":"27","author":"Bauer","year":"2016","journal-title":"Behav Pharmacol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103761_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0091-3057(91)90081-C","article-title":"Discriminative stimulus properties of triadimefon: comparison with methylphenidate","volume":"40","author":"Perkins","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF02253729","article-title":"Rats become acutely tolerant to cathine after amphetamine or cathinone administration","volume":"101","author":"Schechter","year":"1990","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpet.2025.103761_bib26","series-title":"Henderson AS Effects of GABAA allosteric modulators on learning in rats after Shisa7 knockdown [dissertation]","year":"2024"},{"issue":"1\u20132","key":"10.1016\/j.jpet.2025.103761_bib27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejphar.2011.06.054","article-title":"Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem","volume":"668","author":"Vinkers","year":"2011","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00213-002-1275-z","article-title":"Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)\/alpha1 receptors","volume":"165","author":"Rowlett","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/jpet.106.106161","article-title":"Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol","volume":"319","author":"Werner","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.jpet.2025.103761_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0091-3057(99)00075-1","article-title":"Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures","volume":"64","author":"Grant","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0741-8329(98)00035-4","article-title":"Discriminative stimulus effects of ethanol: neuropharmacological characterization","volume":"17","author":"Kostowski","year":"1999","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.jpet.2025.103761_bib32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0091-3057(97)00034-8","article-title":"Discriminative stimulus properties of ethanol in the rat: differential effects of selective and nonselective benzodiazepine receptor agonists","volume":"58","author":"Bienkowski","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"issue":"4 And 5","key":"10.1016\/j.jpet.2025.103761_bib33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00008877-199408000-00006","article-title":"Discrimination of ethanol and of diazepam: differential cross-tolerance","volume":"5","author":"Lytle","year":"1994","journal-title":"Behav Pharmacol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib34","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0022-3565(24)36923-X","article-title":"Selectivity in the generalization profile in baboons trained to discriminate lorazepam: benzodiazepines, barbiturates and other sedative\/anxiolytics","volume":"282","author":"Ator","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0022-3565(25)21952-8","article-title":"Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect","volume":"227","author":"Shannon","year":"1983","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00008877-199206000-00006","article-title":"Discriminative stimulus effects of alprazolam and diazepam: generalization to benzodiazepines, antidepressants and buspirone","volume":"3","author":"Wettstein","year":"1992","journal-title":"Behav Pharmacol"},{"issue":"2","key":"10.1016\/j.jpet.2025.103761_bib37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s002130050036","article-title":"Discriminative stimulus properties of alprazolam","volume":"148","author":"Gommans","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jpet.2025.103761_bib38","series-title":"Pharmacologic analysis of drug-receptor interaction","author":"Kenakin","year":"1997"},{"issue":"7740","key":"10.1016\/j.jpet.2025.103761_bib39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41586-018-0832-5","article-title":"GABA(A) receptor signalling mechanisms revealed by structural pharmacology","volume":"565","author":"Masiulis","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jpet.2025.103761_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.alcohol.2018.05.003","article-title":"Effects of noncontingent ethanol, DHEA, and pregnanolone administration on ethanol self-administration in outbred female rats","volume":"75","author":"Erwin","year":"2019","journal-title":"Alcohol"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00180836","article-title":"Effects of training dose on discrimination and cross-generalization of chlordiazepoxide, pentobarbital and ethanol in the rat","volume":"88","author":"De Vry","year":"1986","journal-title":"Psychopharmacology (Berl)"},{"issue":"4 and 5","key":"10.1016\/j.jpet.2025.103761_bib42","first-page":"441","article-title":"Ethanol drug discrimination in rats: substitution with GABA agonists and NMDA antagonists","volume":"5","author":"Shelton","year":"1994","journal-title":"Behav Pharmacol"},{"issue":"8","key":"10.1016\/j.jpet.2025.103761_bib43","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bcp.2004.07.023","article-title":"Gamma-aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions","volume":"68","author":"Boehm","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pbb.2008.03.006","article-title":"GABA(A) receptors and alcohol","volume":"90","author":"Lobo","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"10.1016\/j.jpet.2025.103761_bib45","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1124\/jpet.104.080275","article-title":"Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys","volume":"313","author":"Platt","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"10.1016\/j.jpet.2025.103761_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108899","article-title":"Activity- and sleep-dependent regulation of tonic inhibition by Shisa7","volume":"34","author":"Wu","year":"2021","journal-title":"Cell Rep"},{"issue":"12","key":"10.1016\/j.jpet.2025.103761_bib47","first-page":"1708","article-title":"GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol","volume":"25","author":"Mihalek","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"10.1016\/j.jpet.2025.103761_bib48","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1523\/JNEUROSCI.3199-08.2009","article-title":"Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol","volume":"29","author":"Rewal","year":"2009","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib49","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1124\/jpet.103.049478","article-title":"GABAA receptor alpha 1 and beta 2 subunit null mutant mice: behavioral responses to ethanol","volume":"305","author":"Blednov","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.jpet.2025.103761_bib50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/sj.npp.1301097","article-title":"Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice","volume":"32","author":"June","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpet.2025.103761_bib51","doi-asserted-by":"crossref","unstructured":"Ruedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM. Modulation of alpha5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcohol Clin Exp Res. 37(4):624\u2013634. https:\/\/doi.org\/10.1111\/acer.12018.","DOI":"10.1111\/acer.12018"},{"issue":"3","key":"10.1016\/j.jpet.2025.103761_bib52","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0376-8716(00)00145-9","article-title":"Effects of alprazolam, caffeine, and zolpidem in humans trained to discriminate triazolam from placebo","volume":"61","author":"Smith","year":"2001","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"10.1016\/j.jpet.2025.103761_bib53","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/acer.12320","article-title":"Little evidence of a role for the alpha1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking","volume":"38","author":"Sawyer","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"issue":"12","key":"10.1016\/j.jpet.2025.103761_bib56","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1038\/s41386-022-01334-0","article-title":"Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors","volume":"47","author":"Wu","year":"2022","journal-title":"Neuropsychopharmacology"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356525402742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:48:55Z","timestamp":1772128135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356525402742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0022356525402742"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103761","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attenuation of the discriminative stimulus and reinforcing effects of positive GABAA modulators after Shisa7 knockdown in rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2025.103761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103761"}}