{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:35:33Z","timestamp":1787924133627,"version":"build-2784847793"},"reference-count":79,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health Atlanta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jpet.2026.104983","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:17:38Z","timestamp":1783603058000},"page":"104983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model"],"prefix":"10.1016","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-2563","authenticated-orcid":false,"given":"Jill A.","family":"Poole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob L.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-8596","authenticated-orcid":false,"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-2238","authenticated-orcid":false,"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Gleason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver W.","family":"Schanze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1142-7790","authenticated-orcid":false,"given":"Aaron D.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-9184","authenticated-orcid":false,"given":"John D.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8783-7576","authenticated-orcid":false,"given":"Deanna","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7779-9213","authenticated-orcid":false,"given":"Michael","family":"Lush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-8980","authenticated-orcid":false,"given":"Han-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-1680","authenticated-orcid":false,"given":"E. Suzanne","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpet.2026.104983_bib1","series-title":"Kelley and Firestein\u2019s Textbook of Rheumatology","first-page":"1167","article-title":"Chapter 70 \u2013 Clinical features of rheumatoid arthritis","author":"Erickson","year":"2017"},{"issue":"135","key":"10.1016\/j.jpet.2026.104983_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/09059180.00008014","article-title":"Rheumatoid arthritis-associated lung disease","volume":"24","author":"Shaw","year":"2015","journal-title":"Eur Respir Revi"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/rccm.201004-0622OC","article-title":"Rheumatoid arthritis-interstitial lung disease-associated mortality","volume":"183","author":"Olson","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1016\/j.jpet.2026.104983_bib4","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/rheumatology\/keu165","article-title":"Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics--a large multicentre UK study","volume":"53","author":"Kelly","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jpet.2026.104983_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111330","article-title":"Expansion of distinct peripheral blood myeloid cell subpopulations in patients with rheumatoid arthritis-associated interstitial lung disease","volume":"127","author":"Poole","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"10.1016\/j.jpet.2026.104983_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103900","article-title":"Unmet needs and emerging pharmacotherapies for autoimmune connective tissue disease-associated interstitial lung diseases","volume":"24","author":"Kondoh","year":"2025","journal-title":"Autoimmun Rev"},{"issue":"22","key":"10.1016\/j.jpet.2026.104983_bib7","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1056\/NEJMoa2503643","article-title":"Nerandomilast in patients with progressive pulmonary fibrosis","volume":"392","author":"Maher","year":"2025","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jpet.2026.104983_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/acr2.11535","article-title":"Peripheral blood biomarkers for rheumatoid arthritis-associated interstitial lung disease: a systematic review","volume":"5","author":"Van Kalsbeek","year":"2023","journal-title":"ACR Open Rheumatol"},{"issue":"4","key":"10.1016\/j.jpet.2026.104983_bib9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.rdc.2022.06.002","article-title":"Inhalant and additional mucosal-related environmental risks for rheumatoid arthritis","volume":"48","author":"Luedders","year":"2022","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2174\/1874312901711010088","article-title":"Is male rheumatoid arthritis an occupational disease? A review","volume":"11","author":"Murphy","year":"2017","journal-title":"Open Rheumatol J"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/15459624.2017.1403610","article-title":"Personal exposure of dairy workers to dust, endotoxin, muramic acid, ergosterol, and ammonia on large-scale dairies in the high plains western United States","volume":"15","author":"Davidson","year":"2018","journal-title":"J Occup Environ Hyg"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1378\/chest.115.3.829","article-title":"Bacterial endotoxin is an active component of cigarette smoke","volume":"115","author":"Hasday","year":"1999","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/oemed-2024-109604","article-title":"Occupational exposure to respirable and inhalable dust and its components in a Nicaraguan sugarcane plantation","volume":"82","author":"d\u2019Errico","year":"2025","journal-title":"Occup Environ Med"},{"issue":"12","key":"10.1016\/j.jpet.2026.104983_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11882-022-01051-0","article-title":"A clinician\u2019s guide to occupational exposures in the military","volume":"22","author":"Van De Graaff","year":"2022","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chest.2024.12.037","article-title":"Characterization of occupational endotoxin-related small airway disease with longitudinal paired inspiratory\/expiratory CT scans","volume":"168","author":"Sun","year":"2025","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.jpet.2026.104983_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/pai.13784","article-title":"The influence of urban exposures and residence on childhood asthma","volume":"33","author":"Grant","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib17","doi-asserted-by":"crossref","first-page":"L239","DOI":"10.1152\/ajplung.00221.2023","article-title":"Combined repetitive inhalant endotoxin and collagen-induced arthritis drive inflammatory lung disease and arthritis severity in a testosterone-dependent manner","volume":"326","author":"Poole","year":"2024","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jpet.2026.104983_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108069","article-title":"The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease","volume":"100","author":"Mikuls","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12931-022-02085-8","article-title":"Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice","volume":"23","author":"Poole","year":"2022","journal-title":"Respir Res"},{"issue":"9","key":"10.1016\/j.jpet.2026.104983_bib20","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/jbmr.3745","article-title":"Combined collagen-induced arthritis and organic dust-induced airway inflammation to model inflammatory lung disease in rheumatoid arthritis","volume":"34","author":"Poole","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"167","key":"10.1016\/j.jpet.2026.104983_bib21","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0144-2022","article-title":"Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD","volume":"32","author":"Calderon","year":"2023","journal-title":"Eur Respir Rev"},{"issue":"5","key":"10.1016\/j.jpet.2026.104983_bib22","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.chest.2021.06.058","article-title":"IL-33 depletion in COVID-19 lungs","volume":"160","author":"Gaurav","year":"2021","journal-title":"Chest"},{"issue":"19","key":"10.1016\/j.jpet.2026.104983_bib23","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302405RR","article-title":"The soluble factor milieu in idiopathic pulmonary fibrosis dysregulates epithelial differentiation","volume":"38","author":"Kortekaas","year":"2024","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib24","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.123.002050","article-title":"Therapeutic targeting of full-length interleukin-33 protein levels with cell-permeable decoy peptides attenuates fibrosis in the bleomycin model in vivo","volume":"392","author":"Atamas","year":"2025","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12931-023-02334-4","article-title":"The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis","volume":"24","author":"Stephenson","year":"2023","journal-title":"Respir Res"},{"issue":"6","key":"10.1016\/j.jpet.2026.104983_bib26","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.jaci.2014.05.011","article-title":"IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice","volume":"134","author":"Li","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpet.2026.104983_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110264","article-title":"The immunomodulatory of interleukin-33 in rheumatoid arthritis: a systematic review","volume":"265","author":"Liu","year":"2024","journal-title":"Clin Immunol"},{"issue":"10","key":"10.1016\/j.jpet.2026.104983_bib28","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1177\/0271678X18772998","article-title":"A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model","volume":"39","author":"Thom","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib29","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.bbrc.2009.12.107","article-title":"Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation","volume":"391","author":"Ali","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41467-019-13853-4","article-title":"GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis","volume":"11","author":"Regan-Komito","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jpet.2026.104983_bib31","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.immuni.2020.03.006","article-title":"Interleukin-33 signaling controls the development of iron-recycling macrophages","volume":"52","author":"Lu","year":"2020","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jpet.2026.104983_bib32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1165\/rcmb.2013-0178OC","article-title":"Organic dust, lipopolysaccharide, and peptidoglycan inhalant exposures result in bone loss\/disease","volume":"49","author":"Dusad","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12026-013-8479-7","article-title":"Induction of bone loss in DBA\/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant","volume":"58","author":"Dusad","year":"2014","journal-title":"Immunol Res"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12931-024-02804-3","article-title":"Targeting transitioning lung monocytes\/macrophages as treatment strategies in lung disease related to environmental exposures","volume":"25","author":"Schwab","year":"2024","journal-title":"Respir Res"},{"key":"10.1016\/j.jpet.2026.104983_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1432334","article-title":"Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures","volume":"15","author":"Schwab","year":"2024","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.jpet.2026.104983_bib36","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-024-01826-9","article-title":"Coordinated chemokine expression defines macrophage subsets across tissues","volume":"25","author":"Li","year":"2024","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.jpet.2026.104983_bib37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1165\/rcmb.2023-0402OC","article-title":"Extracellular vesicle ASC: a novel mediator for lung-brain axis in preterm brain injury","volume":"71","author":"Starke","year":"2024","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jpet.2026.104983_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2025.104916","article-title":"Bacteriophage derived dsRNA induces polarized activation of alveolar macrophages from Balb\/c and C57Bl\/6 mice in vitro in sex- and age-dependent manner","volume":"408","author":"Dovhyi","year":"2025","journal-title":"Cell Immunol"},{"issue":"9","key":"10.1016\/j.jpet.2026.104983_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106392","article-title":"The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection","volume":"9","author":"Tantawy","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpet.2026.104983_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ni.3320","article-title":"Tissue biology perspective on macrophages","volume":"17","author":"Okabe","year":"2026","journal-title":"Nat Immunol"},{"issue":"21","key":"10.1016\/j.jpet.2026.104983_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112920","article-title":"Absence of CCR2 promotes proliferation of alveolar macrophages that control lung inflammation in acute respiratory distress syndrome in mice","volume":"23","author":"Oliveira","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib42","doi-asserted-by":"crossref","DOI":"10.1080\/1547691X.2022.2148782","article-title":"Effect of epithelial-specific MyD88 signaling pathway on airway inflammatory response to organic dust exposure","volume":"20","author":"Johnson","year":"2023","journal-title":"J Immunotoxicol"},{"issue":"2","key":"10.1016\/j.jpet.2026.104983_bib43","doi-asserted-by":"crossref","first-page":"L334","DOI":"10.1152\/ajplung.00206.2018","article-title":"MyD88 controls airway epithelial Muc5ac expression during TLR activation conditions from agricultural organic dust exposure","volume":"316","author":"Dickinson","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib44","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150004","article-title":"SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion","volume":"35","author":"Ren","year":"2015","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jpet.2026.104983_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1557583","article-title":"Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis","volume":"16","author":"Poole","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpet.2026.104983_bib46","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-61779-513-8_17","article-title":"Assessment of intracellular mucin content in vivo","volume":"842","author":"Piccotti","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"9","key":"10.1016\/j.jpet.2026.104983_bib47","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/art.40900","article-title":"Malondialdehyde-acetaldehyde adducts and antibody responses in rheumatoid arthritis-associated interstitial lung disease","volume":"71","author":"England","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"1\u20132","key":"10.1016\/j.jpet.2026.104983_bib48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"issue":"4","key":"10.1016\/j.jpet.2026.104983_bib49","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1183\/09031936.00091307","article-title":"Penh is not a measure of airway resistance","volume":"30","author":"Lundblad","year":"2007","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.jpet.2026.104983_bib50","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1152\/japplphysiol.00080.2002","article-title":"A reevaluation of the validity of unrestrained plethysmography in mice","volume":"93","author":"Lundblad","year":"2002","journal-title":"J Appl Physiol (1985)"},{"issue":"23","key":"10.1016\/j.jpet.2026.104983_bib51","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1801562","article-title":"MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease","volume":"379","author":"Juge","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jpet.2026.104983_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2022.152098","article-title":"Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease","volume":"57","author":"Wheeler","year":"2022","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.jpet.2026.104983_bib53","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1164\/rccm.202109-2087LE","article-title":"Prospective identification of subclinical interstitial lung disease in a rheumatoid arthritis cohort is associated with the MUC5B promoter variant","volume":"205","author":"Matson","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib54","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BOR.0000000000001007","article-title":"Updates on interstitial lung disease and other selected extra-articular manifestations of rheumatoid arthritis","volume":"36","author":"Myasoedova","year":"2024","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jpet.2026.104983_bib55","first-page":"1","article-title":"Genetic underpinning of idiopathic pulmonary fibrosis: the role of mucin","volume":"25","author":"Fotook Kiaei","year":"2025","journal-title":"Expert Rev Respir Med"},{"issue":"12","key":"10.1016\/j.jpet.2026.104983_bib56","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1080\/02770903.2021.2020815","article-title":"Interleukin (IL)-33 immunobiology in asthma and airway inflammatory diseases","volume":"59","author":"Gaurav","year":"2022","journal-title":"J Asthma"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib57","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12931-021-01705-z","article-title":"Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice","volume":"22","author":"Morichika","year":"2021","journal-title":"Respir Res"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/toxsci\/kfad061","article-title":"IL33-mediated NPM1 promotes fibroblast-to-myofibroblast transition via ERK\/AP-1 signaling in silica-induced pulmonary fibrosis","volume":"195","author":"Wang","year":"2023","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jpet.2026.104983_bib59","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3389\/fimmu.2018.01476","article-title":"The IL-33 receptor ST2 regulates pulmonary inflammation and fibrosis to bleomycin","volume":"9","author":"Fanny","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpet.2026.104983_bib60","article-title":"Adoptive transfer of IL-33-stimulated macrophages into bleomycin-induced mouse models to study their effect on idiopathic pulmonary fibrosis in vivo","volume":"195","author":"Zhai","year":"2023","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jpet.2026.104983_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2022.104657","article-title":"Full-length IL-33 augments pulmonary fibrosis in an ST2- and Th2-independent, non-transcriptomic fashion","volume":"383","author":"Luzina","year":"2023","journal-title":"Cell Immunol"},{"issue":"9","key":"10.1016\/j.jpet.2026.104983_bib62","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1164\/rccm.200805-666OC","article-title":"Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1\/ST2-IL-33 pathway","volume":"179","author":"Kearley","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/mi.2017.32","article-title":"Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection","volume":"11","author":"Robinson","year":"2018","journal-title":"Mucosal Immunol"},{"issue":"8","key":"10.1016\/j.jpet.2026.104983_bib64","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1084\/jem.20162152","article-title":"Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span","volume":"214","author":"Misharin","year":"2017","journal-title":"J Exp Med"},{"issue":"82","key":"10.1016\/j.jpet.2026.104983_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add8945","article-title":"Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation","volume":"8","author":"Fabre","year":"2023","journal-title":"Sci Immunol"},{"issue":"564","key":"10.1016\/j.jpet.2026.104983_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao3469","article-title":"Cadherin-11-mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-\u03b2","volume":"12","author":"Lodyga","year":"2019","journal-title":"Sci Signal"},{"key":"10.1016\/j.jpet.2026.104983_bib67","doi-asserted-by":"crossref","first-page":"10953","DOI":"10.2147\/JIR.S530754","article-title":"Role of interleukin-6 in rheumatoid arthritis-associated interstitial lung disease: focus on the JAK\/STAT pathway and macrophage polarization","volume":"18","author":"Yu","year":"2025","journal-title":"J Inflamm Res"},{"issue":"12","key":"10.1016\/j.jpet.2026.104983_bib68","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1002\/art.20659","article-title":"Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody","volume":"50","author":"Mikuls","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.jpet.2026.104983_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035296","article-title":"Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis","volume":"7","author":"Sokolove","year":"2012","journal-title":"PLoS One"},{"issue":"SI","key":"10.1016\/j.jpet.2026.104983_bib70","doi-asserted-by":"crossref","first-page":"SI47","DOI":"10.1093\/rheumatology\/keae615","article-title":"MUC5B promoter variant and survival in rheumatoid arthritis-associated interstitial lung disease","volume":"64","author":"Klein","year":"2025","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"10.1016\/j.jpet.2026.104983_bib71","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/art.43149","article-title":"Peripheral biomarker signatures in rheumatoid arthritis-associated interstitial lung disease","volume":"77","author":"Wheeler","year":"2025","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jpet.2026.104983_bib72","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/985301","article-title":"Increased IL-33 in synovial fluid and paired serum is associated with disease activity and autoantibodies in rheumatoid arthritis","volume":"2013","author":"Tang","year":"2013","journal-title":"Clin Dev Immunol"},{"issue":"5","key":"10.1016\/j.jpet.2026.104983_bib73","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.4049\/jimmunol.1502124","article-title":"In vivo expansion of activated Foxp3+ regulatory T cells and establishment of a type 2 immune response upon IL-33 treatment protect against experimental arthritis","volume":"197","author":"Biton","year":"2016","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jpet.2026.104983_bib74","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cyto.2014.05.007","article-title":"Immune-mediated experimental arthritis in IL-33 deficient mice","volume":"69","author":"Talabot-Ayer","year":"2014","journal-title":"Cytokine"},{"issue":"31","key":"10.1016\/j.jpet.2026.104983_bib75","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1073\/pnas.0801898105","article-title":"IL-33 exacerbates antigen-induced arthritis by activating mast cells","volume":"105","author":"Xu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jpet.2026.104983_bib76","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4297354","article-title":"Blocking interleukin-33 alleviates the joint inflammation and inhibits the development of collagen-induced arthritis in mice","volume":"2020","author":"Li","year":"2020","journal-title":"J Immunol Res"},{"issue":"7","key":"10.1016\/j.jpet.2026.104983_bib77","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1093\/rheumatology\/kead535","article-title":"Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis","volume":"63","author":"Poole","year":"2024","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"10.1016\/j.jpet.2026.104983_bib78","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/cpt.3147","article-title":"A randomized phase I study of the anti-interleukin-33 antibody tozorakimab in healthy adults and patients with chronic obstructive pulmonary disease","volume":"115","author":"Reid","year":"2024","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.jpet.2026.104983_bib79","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.jaci.2019.08.039","article-title":"IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation","volume":"144","author":"Allinne","year":"2019","journal-title":"J Allergy Clin Immunol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356526011833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356526011833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:15:40Z","timestamp":1787922940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356526011833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":79,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0022356526011833"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2026.104983","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2026.104983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics.","name":"copyright","label":"Copyright"}],"article-number":"104983"}}