{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:10:21Z","timestamp":1790701821021,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471833"],"award-info":[{"award-number":["81471833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20230807112007014"],"award-info":[{"award-number":["JCYJ20230807112007014"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jpet.2026.105009","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:30:12Z","timestamp":1786721412000},"page":"105009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial proteomic signatures of postcardiac arrest brain injury reveal potential therapeutic targets"],"prefix":"10.1016","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1063-2046","authenticated-orcid":false,"given":"Yankang","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-7354","authenticated-orcid":false,"given":"Xianfei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10307","key":"10.1016\/j.jpet.2026.105009_bib1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(21)00953-3","article-title":"Brain injury after cardiac arrest","volume":"398","author":"Perkins","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jpet.2026.105009_bib2","first-page":"e158","article-title":"Improving outcomes after post-cardiac arrest brain injury: a scientific statement from the International Liaison Committee on Resuscitation","volume":"150","author":"Perkins","year":"2024","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s13054-023-04745-7","article-title":"Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest","volume":"27","author":"Wider","year":"2023","journal-title":"Crit Care"},{"issue":"12","key":"10.1016\/j.jpet.2026.105009_bib4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00134-021-06548-2","article-title":"Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis","volume":"47","author":"Sandroni","year":"2021","journal-title":"Intensive Care Med"},{"issue":"16","key":"10.1016\/j.jpet.2026.105009_bib5","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJMoa2208687","article-title":"Blood-pressure targets in comatose survivors of cardiac arrest","volume":"387","author":"Kjaergaard","year":"2022","journal-title":"N Engl J Med"},{"issue":"22","key":"10.1016\/j.jpet.2026.105009_bib6","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1093\/eurheartj\/ehz120","article-title":"Early goal-directed haemodynamic optimization of cerebral oxygenation in comatose survivors after cardiac arrest: the Neuroprotect post-cardiac arrest trial","volume":"40","author":"Ameloot","year":"2019","journal-title":"Eur Heart J"},{"issue":"12","key":"10.1016\/j.jpet.2026.105009_bib7","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1007\/s00134-018-5453-9","article-title":"Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial","volume":"44","author":"Jakkula","year":"2018","journal-title":"Intensive Care Med"},{"issue":"7","key":"10.1016\/j.jpet.2026.105009_bib8","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/s00134-025-08012-x","article-title":"Clinical heterogeneity and phenotyping of post cardiac arrest brain injury: one size may not fit all","volume":"51","author":"Sekhon","year":"2025","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib9","first-page":"32","article-title":"Mitochondrial quality control in human health and disease","volume":"11","author":"Liu","year":"2024","journal-title":"Mil Med Res"},{"issue":"5","key":"10.1016\/j.jpet.2026.105009_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MOT.0000000000001015","article-title":"Mitochondria and ischemia reperfusion injury","volume":"27","author":"Panconesi","year":"2022","journal-title":"Curr Opin Organ Transpl"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib11","first-page":"1","article-title":"Roles of mitochondrial quality control in the pathogenesis of atherosclerosis","volume":"10","author":"Alsalman","year":"2025","journal-title":"Cardiovasc Innov Appl"},{"key":"10.1016\/j.jpet.2026.105009_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.resplu.2025.100993","article-title":"Proteomics identify pathogenesis and novel biomarkers for monitoring and early prognostication of brain injury after cardiac arrest: a randomized animal study","volume":"24","author":"Yao","year":"2025","journal-title":"Resusc Plus"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41580-023-00650-7","article-title":"Mitochondrial proteome research: the road ahead","volume":"25","author":"Baker","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.jpet.2026.105009_bib14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/biom10030396","article-title":"Hypothalamic NAD+-sirtuin axis: function and regulation","volume":"10","author":"Roh","year":"2020","journal-title":"Biomolecules"},{"issue":"29","key":"10.1016\/j.jpet.2026.105009_bib15","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1080\/10408398.2022.2070722","article-title":"Molecular and cellular regulatory roles of sirtuin protein","volume":"63","author":"Pande","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"2","key":"10.1016\/j.jpet.2026.105009_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10522-025-10207-0","article-title":"Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging","volume":"26","author":"Gupta","year":"2025","journal-title":"Biogerontology"},{"issue":"10","key":"10.1016\/j.jpet.2026.105009_bib17","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1111\/ejn.16167","article-title":"Role of SIRT1 in sepsis-induced encephalopathy: molecular targets for future therapies","volume":"58","author":"Shehata","year":"2023","journal-title":"Eur J Neurosci"},{"issue":"3","key":"10.1016\/j.jpet.2026.105009_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70118","article-title":"SIRT1 alleviates mitochondrial fission and necroptosis in cerebral ischemia\/reperfusion injury via SIRT1-RIP1 signaling pathway","volume":"6","author":"Wei","year":"2025","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41419-025-07834-3","article-title":"Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD(+)\/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration","volume":"16","author":"Chai","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jpet.2026.105009_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111743","article-title":"Cerebral and myocardial mitochondrial injury differ in a rat model of cardiac arrest and cardiopulmonary resuscitation","volume":"140","author":"Ji","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"6630","key":"10.1016\/j.jpet.2026.105009_bib21","first-page":"351","article-title":"Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides","volume":"379","author":"Bridges","year":"2023","journal-title":"Science (1979)"},{"issue":"2","key":"10.1016\/j.jpet.2026.105009_bib22","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4103\/NRR.NRR-D-24-01269","article-title":"Blood-brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model: single-cell RNA sequencing analysis","volume":"21","author":"Jiang","year":"2026","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jpet.2026.105009_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114599","article-title":"Mechanistic correlation between mitochondrial permeability transition pores and mitochondrial ATP dependent potassium channels in ischemia reperfusion","volume":"162","author":"Behera","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jpet.2026.105009_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2025.101382","article-title":"Ischemia-reperfusion injury: a roadmap to precision therapies","volume":"104","author":"Li","year":"2025","journal-title":"Mol Aspects Med"},{"issue":"12","key":"10.1016\/j.jpet.2026.105009_bib25","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat Rev Drug Discov"},{"issue":"8006","key":"10.1016\/j.jpet.2026.105009_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-024-07167-9","article-title":"Mitochondrial complex I activity in microglia sustains neuroinflammation","volume":"628","author":"Peruzzotti-Jametti","year":"2024","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jpet.2026.105009_bib27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41580-024-00730-2","article-title":"Fundamentals of redox regulation in biology","volume":"25","author":"Sies","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"10.1016\/j.jpet.2026.105009_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nrm3440","article-title":"Endoplasmic reticulum-mitochondria contacts: function of the junction","volume":"13","author":"Rowland","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cmet.2024.10.007","article-title":"Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome","volume":"37","author":"Li","year":"2025","journal-title":"Cell Metab"},{"issue":"12","key":"10.1016\/j.jpet.2026.105009_bib30","doi-asserted-by":"crossref","first-page":"15916","DOI":"10.1007\/s12035-025-05257-x","article-title":"Deficiency of PLA2G6 induces ferroptosis in dopaminergic neurons and contributes to Parkinson's disease pathogenesis via disruption of PRDX6\/FTH1\/GPX4 axis","volume":"62","author":"Li","year":"2025","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jpet.2026.105009_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111099","article-title":"Ceramides and mitochondrial homeostasis","volume":"117","author":"Ding","year":"2024","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib32","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41419-025-08114-w","article-title":"Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm","volume":"16","author":"Wang","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jpet.2026.105009_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2025.111566","article-title":"Mitochondrial metabolic reprogramming of microglia in neuroinflammation: implications for major depressive disorder","volume":"143","author":"Wang","year":"2025","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.jpet.2026.105009_bib34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","article-title":"A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer's disease","volume":"30","author":"Baik","year":"2019","journal-title":"Cell Metab"},{"issue":"7170","key":"10.1016\/j.jpet.2026.105009_bib35","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jpet.2026.105009_bib36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fnmol.2017.00443","article-title":"SIRT1\/PGC-1\u03b1 signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats","volume":"10","author":"Zhou","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"28","key":"10.1016\/j.jpet.2026.105009_bib37","first-page":"4447","article-title":"SRT1720, an activator of silent information regulator 1, alleviates acute traumatic brain injury ina rat model","volume":"28","author":"Qian","year":"2024","journal-title":"Chin J Tissue Eng Res"},{"issue":"3","key":"10.1016\/j.jpet.2026.105009_bib38","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cmet.2012.01.015","article-title":"Mitochondrial complex I plays an essential role in human respirasome assembly","volume":"15","author":"Moreno-Lastres","year":"2012","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.jpet.2026.105009_bib39","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cmet.2020.02.017","article-title":"Serine catabolism feeds NADH when respiration is impaired","volume":"31","author":"Yang","year":"2020","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.jpet.2026.105009_bib40","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200121R","article-title":"Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit","volume":"36","author":"Shoaib","year":"2022","journal-title":"FASEB J"},{"issue":"Pt 4","key":"10.1016\/j.jpet.2026.105009_bib41","article-title":"Role of sirtuins in cerebral ischemia-reperfusion injury: mechanisms and therapeutic potential","volume":"310","author":"Li","year":"2025","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"10.1016\/j.jpet.2026.105009_bib42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apsb.2024.10.010","article-title":"Akkermansia muciniphila-derived acetate activates the hepatic AMPK\/SIRT1\/PGC-1\u03b1 axis to alleviate ferroptosis in metabolic-associated fatty liver disease","volume":"15","author":"Zhuge","year":"2025","journal-title":"Acta Pharm Sin B"},{"issue":"6500","key":"10.1016\/j.jpet.2026.105009_bib43","article-title":"Human CNS barrier-forming organoids with cerebrospinal fluid production","volume":"369","author":"Pellegrini","year":"2020","journal-title":"Science (1979)"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356526012097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356526012097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:45:47Z","timestamp":1790700347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356526012097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0022356526012097"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2026.105009","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial proteomic signatures of postcardiac arrest brain injury reveal potential therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2026.105009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105009"}}