{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:37:05Z","timestamp":1793266625396,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jpet.2026.105020","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:33:38Z","timestamp":1787700818000},"page":"105020","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model"],"prefix":"10.1016","volume":"393","author":[{"given":"Kamonpan","family":"Fongsodsri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasarat","family":"Somkaew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornanong","family":"Aramwit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onrapak","family":"Reamtong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tipparat","family":"Thiangtrongjit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapanee","family":"Kanjanapruthipong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watcharamat","family":"Muangkaew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Passanesh","family":"Sukphopetch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-2996","authenticated-orcid":false,"given":"Sumate","family":"Ampawong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/pharmaceutics17010056","article-title":"Pathophysiology and treatment of psoriasis: from clinical practice to basic research","volume":"17","author":"Gao","year":"2025","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.jpet.2026.105020_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.7861\/clinmed.2021-0257","article-title":"Psoriasis: a brief overview","volume":"21","author":"Raharja","year":"2021","journal-title":"Clin Med"},{"key":"10.1016\/j.jpet.2026.105020_bib3","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.2147\/IJN.S508995","article-title":"Investigating the therapeutic potential of sericin nanofibers and rice-encapsulated nanosericin for psoriasis: mechanistic insights from a 3D skin model","volume":"20","author":"Sukphopetch","year":"2025","journal-title":"Int J Nanomedicine"},{"issue":"4","key":"10.1016\/j.jpet.2026.105020_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00403-024-02846-z","article-title":"Global burden and future trends in psoriasis epidemiology: insights from the global burden of disease study 2019 and predictions to 2030","volume":"316","author":"Wang","year":"2024","journal-title":"Arch Dermatol Res"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/09546634.2020.1729335","article-title":"Long-term topical management of psoriasis: the road ahead","volume":"33","author":"Segaert","year":"2022","journal-title":"J Dermatolog Treat"},{"issue":"22","key":"10.1016\/j.jpet.2026.105020_bib6","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.7150\/thno.45488","article-title":"Extracellular vesicles in inflammatory skin disorders: from pathophysiology to treatment","volume":"10","author":"Shao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jpet.2026.105020_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntm.2024.100048","article-title":"Exosomes for skin treatment: therapeutic and cosmetic applications","volume":"3","author":"Sreeraj","year":"2024","journal-title":"Nano TransMed"},{"issue":"6","key":"10.1016\/j.jpet.2026.105020_bib8","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1096\/fj.201802090RR","article-title":"Neutrophil exosomes enhance the skin autoinflammation in generalized pustular psoriasis via activating keratinocytes","volume":"33","author":"Shao","year":"2019","journal-title":"FASEB J"},{"issue":"12","key":"10.1016\/j.jpet.2026.105020_bib9","doi-asserted-by":"crossref","first-page":"13241","DOI":"10.1096\/fj.201900642R","article-title":"Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis","volume":"33","author":"Jiang","year":"2019","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.jpet.2026.105020_bib10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jid.2020.07.009","article-title":"Small extracellular vesicles containing miR-381-3p from keratinocytes promote T helper type 1 and T helper type 17 polarization in psoriasis","volume":"141","author":"Jiang","year":"2021","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.blre.2012.12.002","article-title":"Extracellular vesicles in physiological and pathological conditions","volume":"27","author":"Yuana","year":"2013","journal-title":"Blood Rev"},{"issue":"4","key":"10.1016\/j.jpet.2026.105020_bib12","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI81135","article-title":"The biology and function of exosomes in cancer","volume":"126","author":"Kalluri","year":"2016","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1703244","article-title":"Inhibiting extracellular vesicles formation and release: a review of EV inhibitors","volume":"9","author":"Catalano","year":"2019","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"10.1016\/j.jpet.2026.105020_bib14","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3390\/ijms18051007","article-title":"Chloramidine\/bisindolylmaleimide-I-mediated inhibition of exosome and microvesicle release and enhanced efficacy of cancer chemotherapy","volume":"18","author":"Kosgodage","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jpet.2026.105020_bib15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.7150\/thno.89180","article-title":"Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles","volume":"14","author":"Jiang","year":"2024","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.jpet.2026.105020_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrm1356","article-title":"Working out the strength and flexibility of desmosomes","volume":"5","author":"Getsios","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jpet.2026.105020_bib17","article-title":"Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model","volume":"9","author":"Radine","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"44","key":"10.1016\/j.jpet.2026.105020_bib18","doi-asserted-by":"crossref","first-page":"27132","DOI":"10.1073\/pnas.2004563117","article-title":"Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography","volume":"117","author":"Sikora","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"D1","key":"10.1016\/j.jpet.2026.105020_bib19","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.jpet.2026.105020_bib20","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/labinvest.3780309","article-title":"Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disorders","volume":"81","author":"Allen","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.jpet.2026.105020_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2022.151904","article-title":"Electron microscopy reveals that phospholipase C and Ca2+ signaling regulate keratin filament uncoupling from desmosomes in Pemphigus","volume":"241","author":"Egu","year":"2022","journal-title":"Ann Anat"},{"issue":"10","key":"10.1016\/j.jpet.2026.105020_bib22","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/infdis\/jis244","article-title":"Staphylococcus aureus activation of caspase 1\/calpain signaling mediates invasion through human keratinocytes","volume":"205","author":"Soong","year":"2012","journal-title":"J Infect Dis"},{"issue":"11","key":"10.1016\/j.jpet.2026.105020_bib23","doi-asserted-by":"crossref","first-page":"21433","DOI":"10.3390\/ijms151121433","article-title":"Epidermal growth factor receptor transactivation is required for mitogen-activated protein kinase activation by muscarinic acetylcholine receptors in HaCaT keratinocytes","volume":"15","author":"Ockenga","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"21","key":"10.1016\/j.jpet.2026.105020_bib24","doi-asserted-by":"crossref","first-page":"14925","DOI":"10.1074\/jbc.M113.527127","article-title":"Adducin is required for desmosomal cohesion in keratinocytes","volume":"289","author":"R\u00f6tzer","year":"2014","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.jpet.2026.105020_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/all.15582","article-title":"RAB25 coordinates filaggrin-containing keratohyalin granule maturation and affects atopic dermatitis severity","volume":"78","author":"Jeong","year":"2023","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.jpet.2026.105020_bib26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/cdd.2017.5","article-title":"A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation","volume":"24","author":"Palazzo","year":"2017","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39218-y","article-title":"Sericin coated thin polymeric films reduce keratinocyte proliferation via the mTOR pathway and epidermal inflammation through IL17 signaling in psoriasis rat model","volume":"13","author":"Aramwit","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/ijms24010145","article-title":"Sericin-based poly(vinyl) alcohol relieves plaque and epidermal lesions in psoriasis; a chance for dressing development in a specific area","volume":"24","author":"Tuentam","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13568-023-01592-1","article-title":"Efficient strategy to isolate exosomes using anti-CD63 antibodies conjugated to gold nanoparticles","volume":"13","author":"Panwar","year":"2023","journal-title":"AMB Express"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/ijms25010167","article-title":"Mechanistic investigation of WWOX function in NF-kB-induced skin inflammation in psoriasis","volume":"25","author":"Shin","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jpet.2026.105020_bib31","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3390\/genes11101155","article-title":"Transcriptome profiling analyses in psoriasis: a dynamic contribution of keratinocytes to the pathogenesis","volume":"11","author":"Rioux","year":"2020","journal-title":"Genes (Basel)"},{"issue":"4","key":"10.1016\/j.jpet.2026.105020_bib32","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.jaci.2018.08.042","article-title":"Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1\u03b1 release","volume":"143","author":"Archer","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jpet.2026.105020_bib33","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3389\/fimmu.2018.01549","article-title":"The interplay between keratinocytes and immune cells in the pathogenesis of psoriasis","volume":"9","author":"Albanesi","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jpet.2026.105020_bib34","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3389\/fimmu.2020.01176","article-title":"The dichotomous responses driven by \u03b2-defensins","volume":"11","author":"Shelley","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib35","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicles"},{"issue":"5","key":"10.1016\/j.jpet.2026.105020_bib36","article-title":"Possible role of endoplasmatic reticulum stress in psoriasis vulgaris","volume":"8","author":"Prans","year":"2017","journal-title":"J Clin Exp Dermatol Res"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2008.12.004","article-title":"Endoplasmic reticulum stress plays a central role in development of leptin resistance","volume":"9","author":"Ozcan","year":"2009","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.jpet.2026.105020_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045078","article-title":"ER stress activates NF-\u03baB by integrating functions of basal IKK activity, IRE1 and PERK","volume":"7","author":"Tam","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib39","article-title":"Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential","volume":"2012","author":"Basseri","year":"2012","journal-title":"Biochem Res Int"},{"issue":"2","key":"10.1016\/j.jpet.2026.105020_bib40","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s44319-023-00027-z","article-title":"UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation","volume":"25","author":"Ahlstedt","year":"2024","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jpet.2026.105020_bib41","article-title":"Advances in the potential roles of Cullin-RING ligases in regulating autoimmune diseases","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jpet.2026.105020_bib42","article-title":"Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement","volume":"132","author":"Jalal","year":"2019","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jpet.2026.105020_bib43","article-title":"miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling","volume":"13","author":"Li","year":"2025","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"10.1016\/j.jpet.2026.105020_bib44","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000208168","article-title":"Differential effects of ceramide on cell viability and extracellular matrix remodeling in keratinocytes and fibroblasts","volume":"22","author":"Philips","year":"2009","journal-title":"Skin Pharmacol Physiol"},{"issue":"24","key":"10.1016\/j.jpet.2026.105020_bib45","doi-asserted-by":"crossref","first-page":"20973","DOI":"10.1074\/jbc.M101707200","article-title":"Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment","volume":"276","author":"Masumi","year":"2001","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.jpet.2026.105020_bib46","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1210\/en.2012-1510","article-title":"TNF-\u03b1 up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism","volume":"153","author":"Gan","year":"2012","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.jpet.2026.105020_bib47","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2011.11.056","article-title":"Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.jpet.2026.105020_bib48","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a015297","article-title":"Desmosomes: regulators of cellular signaling and adhesion in epidermal health and disease","volume":"4","author":"Johnson","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jpet.2026.105020_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.745670","article-title":"Desmosomes as signaling hubs in the regulation of cell behavior","volume":"9","author":"M\u00fcller","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.jpet.2026.105020_bib50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/excr.1997.3890","article-title":"The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C","volume":"239","author":"Denning","year":"1998","journal-title":"Exp Cell Res"},{"issue":"17","key":"10.1016\/j.jpet.2026.105020_bib51","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.3390\/ijms21176127","article-title":"Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases","volume":"21","author":"Ghemrawi","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.jpet.2026.105020_bib52","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1089\/ars.2009.2485","article-title":"Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders","volume":"11","author":"Wang","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"8","key":"10.1016\/j.jpet.2026.105020_bib53","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1038\/jid.2010.108","article-title":"PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents","volume":"130","author":"Adhikary","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"5","key":"10.1016\/j.jpet.2026.105020_bib54","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.4049\/jimmunol.171.5.2703","article-title":"Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways","volume":"171","author":"Cataisson","year":"2003","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.jpet.2026.105020_bib55","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.cellsig.2007.05.014","article-title":"Protein kinase C as a stress sensor","volume":"19","author":"Barnett","year":"2007","journal-title":"Cell Signal"},{"issue":"5","key":"10.1016\/j.jpet.2026.105020_bib56","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/kjm2.12034","article-title":"Silencing KRT16 inhibits keratinocyte proliferation and VEGF secretion in psoriasis via inhibition of ERK signaling pathway","volume":"35","author":"Chen","year":"2019","journal-title":"Kaohsiung J Med Sci"},{"issue":"7","key":"10.1016\/j.jpet.2026.105020_bib57","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jid.2023.12.023","article-title":"GRP78 downregulation in keratinocytes promotes skin inflammation through the recruitment and activation of CCR6+ IL-17A-producing \u03b3\u03b4 T cells","volume":"144","author":"Zhao","year":"2024","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.jpet.2026.105020_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.cstres.2026.100163","article-title":"Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes","volume":"31","author":"Zhang","year":"2026","journal-title":"Cell Stress Chaperones"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356526012206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356526012206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:17:51Z","timestamp":1793265471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356526012206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0022356526012206"],"URL":"https:\/\/doi.org\/10.1016\/j.jpet.2026.105020","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpet.2026.105020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105020"}}