{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:06:40Z","timestamp":1788890800627,"version":"build-2803163510"},"reference-count":18,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["JKP2011008"],"award-info":[{"award-number":["JKP2011008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013088","name":"Qing Lan Project","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"crossref","award":["NCET-10-0816"],"award-info":[{"award-number":["NCET-10-0816"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.jpha.2013.03.001","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:32:15Z","timestamp":1363739535000},"page":"387-393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques"],"prefix":"10.1016","volume":"3","author":[{"given":"Mo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ting","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Dong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Jun","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2013.03.001_bib1","first-page":"109","article-title":"A recent overview on in vitro and in vivo immunological activities of methisoprinol","volume":"10","author":"Morin","year":"1982","journal-title":"Allergol. Immunopath."},{"issue":"12","key":"10.1016\/j.jpha.2013.03.001_bib2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/088307380301801201","article-title":"Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study","volume":"18","author":"Gascon","year":"2003","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.jpha.2013.03.001_bib3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1258\/0956462961917960","article-title":"Efficacy of inosine pranobex oral therapy in subclinical human papillomavirus infection of the vulva: a randomized double-blinded placebo controlled study","volume":"7","author":"Tay","year":"1996","journal-title":"Int. J. STD AIDS"},{"key":"10.1016\/j.jpha.2013.03.001_bib4","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1471-0528.2006.01041.x","article-title":"Oral inosiplex in the treatment of cervical condylomata acuminata: a randomized placebo-controlled trial","volume":"113","author":"Georgala","year":"2006","journal-title":"BJOG"},{"issue":"Suppl. 1","key":"10.1016\/j.jpha.2013.03.001_bib5","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/0192-0561(91)90120-V","article-title":"Inosine pranobex in the treatment of HIV infection: a review","volume":"13","author":"Simone","year":"1991","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.jpha.2013.03.001_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/ard.49.5.293","article-title":"Randomised, double blind, placebo controlled trial of inosine pranobex in rheumatoid arthritis","volume":"49","author":"Brzeski","year":"1990","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jpha.2013.03.001_bib7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2340\/00015555-0138","article-title":"Inosiplex for treatment of alopecia areata: a randomized placebo-controlled study","volume":"86","author":"Georgala","year":"2006","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jpha.2013.03.001_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0090-9556(25)07717-7","article-title":"Inosiplex: metabolism and excretion of the dimethylaminoisopropanol and p-acetamidobenzoic acid components in rhesus monkeys","volume":"12","author":"Streeter","year":"1984","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jpha.2013.03.001_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jchromb.2007.04.013","article-title":"An HPLC method for determination of inosine and hypoxanthine in human plasma from healthy volunteers and patients presenting with potential acute cardiac ischemia","volume":"854","author":"Farthing","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpha.2013.03.001_bib10","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.elecom.2006.07.013","article-title":"A novel electrochemical sensing system for inosine and its application for inosine determination in pharmaceuticals and human serum","volume":"8","author":"Liu","year":"2006","journal-title":"Electrochem. Commun."},{"key":"10.1016\/j.jpha.2013.03.001_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-4347(00)81931-3","article-title":"Direct and simultaneous high-performance liquid chromatographic assay for the determination of p-aminobenzoic acid and its conjugates in human urine","volume":"426","author":"Chan","year":"1998","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.jpha.2013.03.001_bib12","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jpba.2006.10.021","article-title":"Simultaneous determination of p-aminobenzoic acid and its metabolites in the urine of volunteers, treated with p-aminobenzoic acid sunscreen formulation","volume":"12","author":"Wang","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jpha.2013.03.001_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpha.2012.10.006","article-title":"Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC\u2013MS\/MS: method development, validation and application to pharmacokinetics","volume":"3","author":"Li","year":"2013","journal-title":"J. Pharm. Anal."},{"issue":"1","key":"10.1016\/j.jpha.2013.03.001_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpha.2012.09.002","article-title":"Simultaneous determination of atorvastatin, metformin and glimepiride in human plasma by LC\u2013MS\/MS and its application to a human pharmacokinetic study","volume":"3","author":"Polagani","year":"2013","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2013.03.001_bib15","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1023\/A:1007669411738","article-title":"Bioanalytical method validation\u2014a revisit with a decade of progress","volume":"17","author":"Shah","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jpha.2013.03.001_bib16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.scient.2011.12.016","article-title":"Determination of para-aminobenzoic acid (PABA) in B-complex tablets using the multivariate curve resolution- alternating least squares (MCR\u2013ALS) method","volume":"19","author":"Mirzaei","year":"2012","journal-title":"Sci. Iran. C"},{"key":"10.1016\/j.jpha.2013.03.001_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0378-4347(84)80099-7","article-title":"Rapid and sensitive determination of acetylsalicylic acid and its metabolites using reversed-phase high-performance liquid chromatography","volume":"310","author":"O'kruk","year":"1984","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpha.2013.03.001_bib18","first-page":"738","article-title":"Pharmacokinetics of inosiplex tablets in healthy Chinese volunteers","volume":"10","author":"Que","year":"2010","journal-title":"Chin. J. New. Drugs Clin. Rem."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177913000282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177913000282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:27:21Z","timestamp":1761859641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177913000282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S2095177913000282"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2013.03.001","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2013.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}