{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:53:06Z","timestamp":1768553586679,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.jpha.2016.12.002","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T14:02:56Z","timestamp":1483106576000},"page":"123-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Anti-atherosclerotic activity of root bark of Premna integrifolia Linn. in high fat diet induced atherosclerosis model rats"],"prefix":"10.1016","volume":"7","author":[{"given":"Chitra","family":"Subramani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arivukkodi","family":"Rajakkannu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunadevi","family":"Rathinam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudesh","family":"Gaidhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilavarasan","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhiman Vaidya","family":"Kartar Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2016.12.002_bib1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/01.CIR.0000020190.45892.75","article-title":"AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update: consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases","volume":"106","author":"Pearson","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jpha.2016.12.002_bib2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jpha.2016.12.002_bib3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nature05487","article-title":"Mechanisms linking obesity with cardiovascular disease","volume":"444","author":"Van Gaal","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jpha.2016.12.002_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ajcn\/17.5.281","article-title":"Quantitative effects of dietary fat on serum cholesterol in man","volume":"17","author":"Hegsted","year":"1965","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jpha.2016.12.002_bib5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/01.ATV.0000201071.49029.17","article-title":"Diet and murine atherosclerosis","volume":"26","author":"Getz","year":"2006","journal-title":"Aterio. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jpha.2016.12.002_bib6","first-page":"271","article-title":"Hypolipidemic activity of P. integrifolia in rats","volume":"62","author":"Khanna","year":"1991","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jpha.2016.12.002_bib7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-8741(02)00144-7","article-title":"Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats","volume":"84","author":"Kar","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2016.12.002_bib8","first-page":"903","article-title":"The effect of Premna integrifolia Linn. (Verbenaceae) on blood glucose in streptozotocin induced type 1 and type 2 diabetic rats","volume":"56","author":"Alamgir","year":"2001","journal-title":"Pharmazie"},{"key":"10.1016\/j.jpha.2016.12.002_bib9","first-page":"295","article-title":"Premnazole, an isooxazole alkaloid of Premna integrifolia and Gmelina arborea with anti-inflammatory activity","volume":"63","author":"Barik","year":"1992","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jpha.2016.12.002_bib10","first-page":"130","article-title":"Preliminary study of anti-inflammatory and anti-arthritic activity","volume":"12","author":"Rathore","year":"1997","journal-title":"Rheumatism"},{"key":"10.1016\/j.jpha.2016.12.002_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3923\/ijp.2007.352.356","article-title":"Evaluation of immune-modulatory activity of Clerodendrum phlomidis and Premna integrifolia root","volume":"3","author":"Gokani","year":"2007","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.jpha.2016.12.002_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/0975-7406.116825","article-title":"Anti-obesity activity of chloroform-ethanol extract of Premna integrifolia in mice fed with cafeteria diet","volume":"5","author":"Mali","year":"2013","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"10.1016\/j.jpha.2016.12.002_bib13","first-page":"1430","article-title":"Assessment of analgesic and anti-bacterial activity of Premna integrifolia Linn. (family:Verbenaceae) leaves","volume":"2","author":"Karmakar","year":"2011","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib14","first-page":"293","article-title":"In-vitro antioxidant activity of Premna integrifolia Linn. roots","volume":"5","author":"Jain","year":"2013","journal-title":"Res. J. Pharmacol. Pharmacodyn."},{"key":"10.1016\/j.jpha.2016.12.002_bib15","first-page":"29","article-title":"Antioxidant and anti-diabetic activities of the methanolic extract of Premna integrifolia bark","volume":"8","author":"Majumder","year":"2014","journal-title":"Adv. Biol. Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jep.2007.01.026","article-title":"Antiparasitic activity of some New Caledonian medicinal plants","volume":"112","author":"Desrivot","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2016.12.002_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3329\/jsr.v1i1.1046","article-title":"Evaluation of hepatoprotective and in-vitro cytotoxic activity of leaves of Premna serratifolia Linn","volume":"1","author":"Vadivu","year":"2009","journal-title":"J. Sci. Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/2229-5186.129339","article-title":"Beneficial effect of extracts of Premna integrifolia root on human leucocytes and erythrocytes against hydrogen peroxide induced oxidative damage","volume":"5","author":"Mali","year":"2014","journal-title":"Chron. Young Sci."},{"key":"10.1016\/j.jpha.2016.12.002_bib19","series-title":"A compendium of 500 species","first-page":"348","author":"Anonymous, Indian Medicinal Plants","year":"1997"},{"key":"10.1016\/j.jpha.2016.12.002_bib20","unstructured":"Anonymous, The Ayurvedic Pharmacopoeia of India, Part-I, Vol. III, Ist Ed. Department of ISM and Homeopathy, Ministry of Health and Family Welfare, Government of India, Delhi, 2001, 3\u20134."},{"key":"10.1016\/j.jpha.2016.12.002_bib21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/BF01945508","article-title":"A simple method for rapid production of atherosclerosis in rats","volume":"29","author":"Altman","year":"1973","journal-title":"Experientia"},{"key":"10.1016\/j.jpha.2016.12.002_bib22","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/clinchem\/21.10.1523","article-title":"Indirect assessment of hydroxylmethylglutaryl-CoA reductase (NADPH) activity in liver","volume":"21","author":"Rao","year":"1975","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jpha.2016.12.002_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0009-8981(80)90192-8","article-title":"Modified assay for determination of hydroxyproline in a tissue hydrolyzate","volume":"104","author":"Edwards","year":"1980","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jpha.2016.12.002_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpha.2016.12.002_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-2275(20)35381-5","article-title":"A sensitive method for the determination of free fatty acids in plasma","volume":"22","author":"Horn","year":"1981","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0022-2275(20)41609-8","article-title":"A more sensitive and stable colorimetric determination of free fatty acids in blood","volume":"18","author":"Itaya","year":"1977","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacl.2010.02.005","article-title":"Atherogenic index of plasma (log10 (triglyceride\/high density lipoprotein cholesterol) predicts high blood pressure, diabetes, and vascular events","volume":"4","author":"Onat","year":"2010","journal-title":"J. Clin. Lipidol."},{"key":"10.1016\/j.jpha.2016.12.002_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4103\/0973-8258.122068","article-title":"Effect of aqueous enriched fraction of Premna integrifolia root against cafeteria diet induced obesity in Swiss albino mice","volume":"7","author":"Mali","year":"2013","journal-title":"Int. J. Green. Pharm."},{"key":"10.1016\/j.jpha.2016.12.002_bib29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11745-012-3753-3","article-title":"Lipid lowering and antioxidant effect of miglitol in triton treated hyperlipidemic and high fat diet induced obese rats","volume":"48","author":"Shrivastava","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.jpha.2016.12.002_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.alcohol.2006.12.006","article-title":"Combined effects of high-fat diet and ethanol induce oxidative stress in rat liver","volume":"40","author":"Demori","year":"2006","journal-title":"Alcohol"},{"key":"10.1016\/j.jpha.2016.12.002_bib31","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00047.2003","article-title":"Role of oxidative modifications in atherosclerosis","volume":"84","author":"Stocker","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jpha.2016.12.002_bib32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2174\/1566524023362177","article-title":"Oxidation of low-density lipoprotein in atherosclerosis from basic biochemistry to clinical studies","volume":"2","author":"Albertini","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jpha.2016.12.002_bib33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.autrev.2008.04.018","article-title":"Oxidation of LDL and its clinical implication","volume":"7","author":"Matsuura","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jpha.2016.12.002_bib34","first-page":"211","article-title":"Comparative evaluation of hypolipidimic activity of some marketed herbal formulations in triton induced hyperlipidemic rats","volume":"3","author":"Kanungo","year":"2007","journal-title":"Pharmacol. Online"},{"key":"10.1016\/j.jpha.2016.12.002_bib35","first-page":"F4","article-title":"The role of HDL-cholesterol in preventing atherosclerotic disease","volume":"7","author":"Barter","year":"2005","journal-title":"Eur. Soc. Cardiol."},{"key":"10.1016\/j.jpha.2016.12.002_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jpha.2016.12.002_bib37","first-page":"855","article-title":"Mini review experimental atherosclerosis: a historical overview","volume":"70","author":"Mohammed","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.jpha.2016.12.002_bib38","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.2215\/CJN.09121010","article-title":"Atorvastatin and low-density lipoprotein cholesterol in type 2 diabetes mellitus patients on hemodialysis","volume":"6","author":"Marz","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jpha.2016.12.002_bib39","first-page":"233","article-title":"Assessment of lipid lowering effect of Sida rhomboidea. Roxb. methanolic extract in experimentally induced hyper lipidemia","volume":"3","author":"Patel","year":"2009","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.jpha.2016.12.002_bib40","first-page":"238","article-title":"Evaluation of protective effect of Cleome viscosa extract on diet induced atherosclerosis in diabetic rats","volume":"6","author":"Faheemuddin","year":"2013","journal-title":"J. Chem. Pharm. Sci."},{"key":"10.1016\/j.jpha.2016.12.002_bib41","first-page":"86","article-title":"Evaluation of the antihyperlipidemic, cardioprotective activity of a polyherbal formulation","volume":"2","author":"Pamidiboina","year":"2010","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jpha.2016.12.002_bib42","first-page":"149","article-title":"Effects of diet-induced hypercholesterolemia on the lipid profile and some enzyme activities in female Wistar rats","volume":"4","author":"Otunola","year":"2010","journal-title":"Afr. J. Biochem. Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib43","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/S0021-9258(18)99653-5","article-title":"Rat liver lactate dehydrogenase.\u00a0Amino-termin and acetylation status","volume":"241","author":"Stegink","year":"1966","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpha.2016.12.002_bib44","first-page":"419","article-title":"Captopril ameliorates myocardial and hematological toxicities induced by adriamycin","volume":"45","author":"Al-Shabanah","year":"1998","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.jpha.2016.12.002_bib45","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/exmp.1995.1021","article-title":"Propolis protects against doxorubicin-induced myocardiopathy in rats","volume":"62","author":"Chopra","year":"1995","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.jpha.2016.12.002_bib46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/bmb\/ldm014","article-title":"Creatine kinase monitoring in sport medicine","volume":"81\u201382","author":"Brancacci","year":"2007","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.jpha.2016.12.002_bib47","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0022-2275(20)41379-3","article-title":"The discovery and development of HMG-CoA reductase inhibitors","volume":"33","author":"Endo","year":"1992","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpha.2016.12.002_bib48","first-page":"62","article-title":"Anti-hyperlipidemic effect of acacia honey (desi kikar) in cholesterol-diet induced hyperlipidemia in rats","volume":"27","author":"Adnan","year":"2011","journal-title":"Biomedica"},{"key":"10.1016\/j.jpha.2016.12.002_bib49","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/0168-8278(91)90002-S","article-title":"Poly 4-hydroxylase and its role in collagen synthesis","volume":"13","author":"Pihlajaniemi","year":"1991","journal-title":"J. Hepatol."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177916301253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177916301253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:29:24Z","timestamp":1761859764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177916301253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S2095177916301253"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2016.12.002","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-atherosclerotic activity of root bark of Premna integrifolia Linn. in high fat diet induced atherosclerosis model rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2016.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}