{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:12:42Z","timestamp":1787249562032,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jpha.2021.02.005","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T11:22:15Z","timestamp":1615116135000},"page":"164-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass\/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis"],"prefix":"10.1016","volume":"12","author":[{"given":"Surajit","family":"Mistry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasish","family":"Burman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilendu Jyoti","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Chanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2021.02.005_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2009.06.012","article-title":"Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin","volume":"139","author":"Xie","year":"2009","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.jpha.2021.02.005_bib2","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3389\/fmicb.2019.01626","article-title":"Antibiotic-loaded polymethylmethacrylate beads and spacers in treatment of orthopedic infections and the role of biofilm formation","volume":"10","author":"van Vugt","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jpha.2021.02.005_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.addr.2007.03.011","article-title":"Ceramics composites as and scaffolds for drug delivery in tissue engineering","volume":"59","author":"Habraken","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2021.02.005_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40204-019-0116-7","article-title":"Manipulation of the degradation behavior of calcium sulfate by the addition of bioglass","volume":"8","author":"Hsu","year":"2019","journal-title":"Prog. Biomater."},{"key":"10.1016\/j.jpha.2021.02.005_bib5","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.biomaterials.2005.11.025","article-title":"45S5 Bioglass-derived glass ceramic scaffolds for bone tissue engineering","volume":"27","author":"Chen","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2021.02.005_bib6","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1016\/j.biomaterials.2010.04.005","article-title":"Teicoplanin-loaded borate bioactive glass implants for treating chronic bone infection in a rabbit tibia osteomyelitis model","volume":"31","author":"Zhang","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2021.02.005_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12034-018-1558-6","article-title":"In\u00a0vitro bioactivity evaluation of \u03b1-calcium sulphate hemihydrate and bioactive glass composites for their potential use in bone regeneration","volume":"41","author":"Zheng","year":"2018","journal-title":"Bull. Mater. Sci."},{"key":"10.1016\/j.jpha.2021.02.005_bib8","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/polb.22259","article-title":"Biomedical applications of biodegradable polymers","volume":"49","author":"Ulery","year":"2011","journal-title":"J.\u00a0Polym. Sci. B Polym. Phys."},{"key":"10.1016\/j.jpha.2021.02.005_bib9","first-page":"289","article-title":"The effect of poly(lactic-co-glycolic acid) (PLGA) coating on the mechanical, biodegradable, bioactive properties and drug release of porous calcium silicate scaffolds","volume":"22","author":"Zhao","year":"2012","journal-title":"Biomed. Mater. Eng."},{"key":"10.1016\/j.jpha.2021.02.005_bib10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jor.21531","article-title":"Microbiological and pharmacological tests on new antibiotic-loaded PMMA-based composites for the treatment of osteomyelitis","volume":"30","author":"Giavaresi","year":"2012","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.jpha.2021.02.005_bib11","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/jor.23722","article-title":"Antibiotic elution from acrylic bone cement loaded with high doses of tobramycin and vancomycin","volume":"36","author":"Slane","year":"2018","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.jpha.2021.02.005_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/AAC.03676-14","article-title":"Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections","volume":"59","author":"Howlin","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jpha.2021.02.005_bib13","article-title":"A novel injectable borate bioactive glass cement as an antibiotic delivery vehicle for treating osteomyelitis","volume":"9","author":"Ding","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpha.2021.02.005_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jbm.b.31009","article-title":"In vivo response of porous hydroxyapatite and beta-tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds","volume":"86","author":"Ghosh","year":"2008","journal-title":"J.\u00a0Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jpha.2021.02.005_bib15","first-page":"19449","article-title":"A\u00a0novel injectable and degradable calcium phosphate\/calcium sulfate bone cement","volume":"10","author":"Zhou","year":"2011","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.jpha.2021.02.005_bib16","first-page":"247","article-title":"Simple high performance liquid chromatography method for determination of norfloxacin in plasma and application in bioequivalence study","volume":"4","author":"Loh","year":"2012","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jpha.2021.02.005_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","article-title":"Methods for in\u00a0vitro evaluating antimicrobial activity: a review","volume":"6","author":"Balouiri","year":"2016","journal-title":"J.\u00a0Pharm. Anal."},{"key":"10.1016\/j.jpha.2021.02.005_bib18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3109\/03639045.2010.528427","article-title":"Local drug delivery system for the treatment of osteomyelitis: in vitro evaluation","volume":"37","author":"Soundrapandian","year":"2011","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jpha.2021.02.005_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4236\/jbnb.2017.81003","article-title":"Preparation of high percentage \u03b1-calcium sulfate hemihydrate via a hydrothermal method","volume":"8","author":"Fu","year":"2017","journal-title":"J.\u00a0Biomaterials Nanobiotechnol."},{"key":"10.1016\/j.jpha.2021.02.005_bib20","first-page":"197","article-title":"\u03b1-Hemihydrate gypsum from flue gas desulphurization gypsum","volume":"19","author":"Le\u0161kevi\u010dien\u0117","year":"2013","journal-title":"Mater. Sci-Medzg."},{"key":"10.1016\/j.jpha.2021.02.005_bib21","first-page":"170","article-title":"Modification of FGD gypsum in hydrothermal mixed salt solution","volume":"18","author":"Wu","year":"2006","journal-title":"J.\u00a0Environ. Sci. (China)"},{"key":"10.1016\/j.jpha.2021.02.005_bib22","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1151-2916.1991.tb07132.x","article-title":"Bioceramics: from concept to clinic","volume":"74","author":"Hench","year":"1991","journal-title":"J.\u00a0Am. Ceram. Soc."},{"key":"10.1016\/j.jpha.2021.02.005_bib23","doi-asserted-by":"crossref","first-page":"70197","DOI":"10.1039\/C6RA07819B","article-title":"Biological behavior of bioactive glasses and their composites","volume":"6","author":"Zahid","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpha.2021.02.005_bib24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1551-2916.2012.05100.x","article-title":"Low temperature sintering of innovative bioactive glasses","volume":"95","author":"Bellucci","year":"2012","journal-title":"J.\u00a0Am. Ceram. Soc."},{"key":"10.1016\/j.jpha.2021.02.005_bib25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.micromeso.2008.08.046","article-title":"Comparison of the in\u00a0vitro bioactivity and drug release property of mesoporous bioactive glasses (MBGs) and bioactive glasses (BGs) scaffolds","volume":"118","author":"Zhu","year":"2009","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.jpha.2021.02.005_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/jfb4040209","article-title":"Self-setting calcium orthophosphate formulations","volume":"4","author":"Dorozhkin","year":"2013","journal-title":"J.\u00a0Funct. Biomater."},{"key":"10.1016\/j.jpha.2021.02.005_bib27","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.3390\/ma3073867","article-title":"Bioactive glass and glass-ceramic scaffolds for bone tissue engineering","volume":"3","author":"Gerhardt","year":"2010","journal-title":"Materials"},{"key":"10.1016\/j.jpha.2021.02.005_bib28","article-title":"A\u00a0review of calcium phosphate cements and acrylic bone cements as injectable materials for bone repair and implant fixation","volume":"17","author":"Yousefi","year":"2019","journal-title":"J.\u00a0Appl. Biomater. Funct. Mater."},{"key":"10.1016\/j.jpha.2021.02.005_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jconrel.2008.05.020","article-title":"Antibiotic-eluting medical devices for various applications","volume":"130","author":"Zilbermann","year":"2008","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.jpha.2021.02.005_bib30","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.msec.2017.04.099","article-title":"Scaffold composed of porous vancomycin-loaded poly(lactide-co-glycolide) microspheres: a controlled-release drug delivery system with shape-memory effect","volume":"78","author":"Du","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jpha.2021.02.005_bib31","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/jbm.a.31545","article-title":"In situ SAXRD study of sol\u2013gel induced well-ordered mesoporous bioglasses for drug delivery","volume":"85","author":"Zhao","year":"2008","journal-title":"J.\u00a0Biomed. Mater. Res. A"},{"key":"10.1016\/j.jpha.2021.02.005_bib32","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/S0266-3538(03)00275-6","article-title":"Bioresorbable and bioactive polymer\/bioglass\u00ae composites with tailored pore structure for tissue engineering applications","volume":"63","author":"Boccaccini","year":"2003","journal-title":"Compos. Sci. Technol."},{"key":"10.1016\/j.jpha.2021.02.005_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jbm.b.30223","article-title":"Degradation and drug release of phosphate glass\/polycaprolactone biological composites for hard-tissue regeneration","volume":"75","author":"Kim","year":"2005","journal-title":"J.\u00a0Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jpha.2021.02.005_bib34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/BLO.0b013e31811ff866","article-title":"Antibiotics for local delivery systems cause skeletal cell toxicity in\u00a0vitro","volume":"462","author":"Antoci","year":"2007","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jpha.2021.02.005_bib35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/ma11020326","article-title":"Recent evidence on bioactive glass antimicrobial and antibiofilm activity: a mini-review","volume":"11","author":"Drago","year":"2018","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.jpha.2021.02.005_bib36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/01.ASW.0000407647.12832.6c","article-title":"Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets","volume":"24","author":"Gauland","year":"2011","journal-title":"Adv. Skin Wound Care"},{"key":"10.1016\/j.jpha.2021.02.005_bib37","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.actbio.2008.02.027","article-title":"Modeling vancomycin release kinetics from microporous calcium phosphate ceramics comparing static and dynamic immersion conditions","volume":"4","author":"Gbureck","year":"2008","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2021.02.005_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1517\/17425241003602259","article-title":"Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems","volume":"7","author":"Fu","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jpha.2021.02.005_bib39","doi-asserted-by":"crossref","first-page":"415S","DOI":"10.1093\/jn\/138.2.415S","article-title":"Extracellular pH regulates bone cell function","volume":"138","author":"Arnett","year":"2008","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.jpha.2021.02.005_bib40","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1021\/la104876w","article-title":"Interfacial pH: a critical factor for osteoporotic bone regeneration","volume":"27","author":"Shen","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.jpha.2021.02.005_bib41","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.actbio.2007.05.003","article-title":"Self-setting properties and in\u00a0vitro bioactivity of calcium sulfate hemihydrate-tricalcium silicate composite bone cements","volume":"3","author":"Huan","year":"2007","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2021.02.005_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1302\/2058-5241.1.000017","article-title":"Chronic osteomyelitis: what the surgeon needs to know","volume":"1","author":"Panteli","year":"2017","journal-title":"Effort Open Rev."},{"key":"10.1016\/j.jpha.2021.02.005_bib43","first-page":"604","article-title":"Drug delivery to brain and bone marrow: a review","volume":"3","author":"Saikia","year":"2016","journal-title":"Eur. J. Biomed. Pharmaceut. Sci."},{"key":"10.1016\/j.jpha.2021.02.005_bib44","first-page":"584","article-title":"Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis","volume":"5","author":"Zhu","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jpha.2021.02.005_bib45","doi-asserted-by":"crossref","first-page":"119617","DOI":"10.1016\/j.biomaterials.2019.119617","article-title":"Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation","volume":"230","author":"Cui","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2021.02.005_bib46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2019.03.020","article-title":"Electrospun polymer micro\/nanofibers as pharmaceutical repositories for healthcare","volume":"302","author":"Feng","year":"2019","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.jpha.2021.02.005_bib47","doi-asserted-by":"crossref","first-page":"1700527","DOI":"10.1002\/advs.201700527","article-title":"Antibacterial hydrogels","volume":"5","author":"Li","year":"2018","journal-title":"Adv. Sci."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177921000204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177921000204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:32:35Z","timestamp":1761859955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177921000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S2095177921000204"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2021.02.005","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass\/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2021.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}