{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:44:30Z","timestamp":1788903870464,"version":"build-2803163510"},"reference-count":182,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jpha.2023.07.008","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T12:05:54Z","timestamp":1689595554000},"page":"1235-1251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Stage-specific treatment of colorectal cancer: A microRNA-nanocomposite approach"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-2098","authenticated-orcid":false,"given":"Adewale Oluwaseun","family":"Fadaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3533-9279","authenticated-orcid":false,"given":"Taiwo","family":"Akinsoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-886X","authenticated-orcid":false,"given":"Ashwil","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abram Madimabe","family":"Madiehe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervin","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Keyster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucky Mashudu","family":"Sikhwivhilu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-5388","authenticated-orcid":false,"given":"Nicole Remaliah Samantha","family":"Sibuyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2023.07.008_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cll.2018.02.008","article-title":"Molecular diagnostics in colorectal carcinoma: Advances and applications for 2018","volume":"38","author":"Bhalla","year":"2018","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.jpha.2023.07.008_bib2","first-page":"200","article-title":"The molecular biology of colorectal carcinoma and its implications: A review","volume":"9","author":"Harrison","year":"2011","journal-title":"Surg."},{"key":"10.1016\/j.jpha.2023.07.008_bib3","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jpha.2023.07.008_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113336","article-title":"The role of oxidative stress and its counteractive utility in colorectal cancer (CRC)","volume":"12","author":"Basak","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.jpha.2023.07.008_bib5","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.3748\/wjg.v21.i7.2191","article-title":"Semaphorin 4D and hypoxia-inducible factor-1\u03b1 overexpression is related to prognosis in colorectal carcinoma","volume":"21","author":"Wang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jpha.2023.07.008_bib6","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1111\/cas.13352","article-title":"Long non-coding RNAs and prostate cancer","volume":"108","author":"Misawa","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib7","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","article-title":"microRNA","volume":"141","author":"Lu","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jpha.2023.07.008_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"microRNA therapeutics: Towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jpha.2023.07.008_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1139\/bcb-2018-0034","article-title":"SAV1, regulated by microRNA-21, suppresses tumor growth in colorectal cancer","volume":"97","author":"Jiang","year":"2019","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.jpha.2023.07.008_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/genes9110531","article-title":"Nucleotide modifications decrease innate immune response induced by synthetic analogs of snRNAs and snoRNAs","volume":"9","author":"Stepanov","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.jpha.2023.07.008_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s41544-019-0039-4","article-title":"Biogenesis and function of extracellular miRNAs","volume":"1","author":"Zhao","year":"2019","journal-title":"ExRNA"},{"key":"10.1016\/j.jpha.2023.07.008_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/10717544.2014.882469","article-title":"A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery","volume":"22","author":"Paliwal","year":"2015","journal-title":"Drug Deliv"},{"key":"10.1016\/j.jpha.2023.07.008_bib13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molcel.2016.09.027","article-title":"Impact of microRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression","volume":"64","author":"Denzler","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jpha.2023.07.008_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s41544-019-0024-y","article-title":"Recent progress in microRNA-based delivery systems for the treatment of human disease","volume":"1","author":"Fu","year":"2019","journal-title":"ExRNA"},{"key":"10.1016\/j.jpha.2023.07.008_bib15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.addr.2014.05.009","article-title":"In vivo delivery of miRNAs for cancer therapy: Challenges and strategies","volume":"81","author":"Chen","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2023.07.008_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijpharm.2018.05.045","article-title":"Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA\/siRNA for cancer therapy","volume":"546","author":"Li","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpha.2023.07.008_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.addr.2019.07.010","article-title":"Nanocarrier-based systems for targeted and site specific therapeutic delivery","volume":"144","author":"Majumder","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2023.07.008_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nano.2009.04.008","article-title":"Colloidal nanocarriers: A review on formulation technology, types and applications toward targeted drug delivery","volume":"6","author":"Mishra","year":"2010","journal-title":"Nanomed."},{"key":"10.1016\/j.jpha.2023.07.008_bib19","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1021\/accountsmr.2c00147","article-title":"Self-adaptive nanomaterials for rational drug delivery in cancer therapy","volume":"3","author":"Yang","year":"2022","journal-title":"Acc. Mater. Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.apsb.2022.10.019","article-title":"Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis","volume":"13","author":"Zhao","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpha.2023.07.008_bib21","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.4155\/fmc.14.116","article-title":"miRNA-based therapies: Strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents","volume":"6","author":"Baumann","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jpha.2023.07.008_bib22","article-title":"The role of microRNAs in human cancer","volume":"1","author":"Peng","year":"2016","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jpha.2023.07.008_bib23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1158\/1940-6207.CAPR-11-0358","article-title":"Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling","volume":"5","author":"Lu","year":"2012","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2490-12-14","article-title":"miR-21 may acts as an oncomir by targeting RECK, a matrix metalloproteinase regulator, in prostate cancer","volume":"12","author":"Reis","year":"2012","journal-title":"BMC Urol"},{"key":"10.1016\/j.jpha.2023.07.008_bib25","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/pros.22499","article-title":"Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer","volume":"72","author":"Shen","year":"2012","journal-title":"Prostate"},{"key":"10.1016\/j.jpha.2023.07.008_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-019-5839-2","article-title":"miR-23b and miR-27b are oncogenic microRNAs in breast cancer: Evidence from a CRISPR\/Cas9 deletion study","volume":"19","author":"Hannafon","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib27","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/carcin\/bgu130","article-title":"Exosome-derived miRNAs and ovarian carcinoma progression","volume":"35","author":"Vaksman","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jpha.2023.07.008_bib28","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/ijc.29516","article-title":"Reciprocal repression between TUSC7 and miR-23b in gastric cancer","volume":"137","author":"Qi","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib29","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3892\/or.2014.3012","article-title":"A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo","volume":"31","author":"Chen","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jpha.2023.07.008_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejca.2016.11.004","article-title":"The roles of oncogenic miRNAs and their therapeutic importance in breast cancer","volume":"72","author":"O\u2019Bryan","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"microRNAs as oncogenes and tumor suppressors","volume":"302","author":"Zhang","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jpha.2023.07.008_bib32","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.18632\/oncotarget.27811","article-title":"microRNA-based regulation of Aurora A kinase in breast cancer","volume":"11","author":"Fadaka","year":"2020","journal-title":"Oncotarget"},{"key":"10.1016\/j.jpha.2023.07.008_bib33","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1073\/pnas.1708264114","article-title":"microRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia","volume":"114","author":"Rassenti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpha.2023.07.008_bib34","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.18632\/oncotarget.6223","article-title":"MEF2 transcription factors: Developmental regulators and emerging cancer genes","volume":"7","author":"Pon","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jpha.2023.07.008_bib35","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.21037\/jgo-20-418","article-title":"miR-133a-5p suppresses gastric cancer through TCF4 down-regulation","volume":"12","author":"He","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.jpha.2023.07.008_bib36","article-title":"microRNA-34 family: A potential tumor suppressor and therapeutic candidate in cancer","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib37","article-title":"Biomarkers for stratification in colorectal cancer: microRNAs","volume":"26","author":"Fadaka","year":"2019","journal-title":"Cancer Contr."},{"key":"10.1016\/j.jpha.2023.07.008_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-018-0631-y","article-title":"Effect of dietary components on miRNA and colorectal carcinogenesis","volume":"18","author":"Fadaka","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jpha.2023.07.008_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205190","article-title":"Functional prediction of candidate microRNAs for CRC management using in silico approach","volume":"20","author":"Fadaka","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib40","doi-asserted-by":"crossref","DOI":"10.1177\/1010428319883721","article-title":"In silico identification of microRNAs as candidate colorectal cancer biomarkers","volume":"41","author":"Fadaka","year":"2019","journal-title":"Tumor Biol."},{"key":"10.1016\/j.jpha.2023.07.008_bib41","doi-asserted-by":"crossref","DOI":"10.1177\/1010428320933512","article-title":"Genomic profiling of microRNA target genes in colorectal cancer","volume":"42","author":"Fadaka","year":"2020","journal-title":"Tumor Biol"},{"key":"10.1016\/j.jpha.2023.07.008_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194899","article-title":"microRNA assisted gene regulation in colorectal cancer","volume":"20","author":"Fadaka","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1208\/s12248-009-9145-9","article-title":"Therapeutic microRNA strategies in human cancer","volume":"11","author":"Li","year":"2009","journal-title":"AAPS J"},{"key":"10.1016\/j.jpha.2023.07.008_bib44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/PPO.0b013e318258b78f","article-title":"The role of microRNAs in colorectal cancer","volume":"18","author":"Schetter","year":"2012","journal-title":"Cancer J"},{"key":"10.1016\/j.jpha.2023.07.008_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nrclinonc.2011.157","article-title":"Has the new TNM classification for colorectal cancer improved care?","volume":"9","author":"Nagtegaal","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jpha.2023.07.008_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111099","article-title":"The role of miRNAs in colorectal cancer progression and chemoradiotherapy","volume":"134","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpha.2023.07.008_bib47","doi-asserted-by":"crossref","first-page":"9913","DOI":"10.1007\/s11033-020-05949-8","article-title":"miR-196: Emerging of a new potential therapeutic target and biomarker in colorectal cancer","volume":"47","author":"Pourdavoud","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jpha.2023.07.008_bib48","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.7150\/thno.37621","article-title":"The c-Myc\/miR-27b-3p\/ATG10 regulatory axis regulates chemoresistance in colorectal cancer","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2023.07.008_bib49","first-page":"882","article-title":"Reduced accumulation of specific microRNAs in colorectal neoplasia","volume":"1","author":"Michael","year":"2003","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib50","first-page":"409","article-title":"Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy","volume":"39","author":"Drebber","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jpha.2023.07.008_bib51","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2014.03.006","article-title":"microRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer","volume":"25","author":"Valeri","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jpha.2023.07.008_bib52","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/path.4309","article-title":"microRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2","volume":"232","author":"Liao","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.jpha.2023.07.008_bib53","first-page":"939","article-title":"The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers, Genes Chromosom.","volume":"47","author":"Guo","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib54","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2005.01.014","article-title":"RAS is regulated by the let-7 microRNA family","volume":"120","author":"Johnson","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jpha.2023.07.008_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2015.5","article-title":"Concurrent targeting of KRAS and AKT by miR-4689 is a novel treatment against mutant KRAS colorectal cancer","volume":"4","author":"Hiraki","year":"2015","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jpha.2023.07.008_bib56","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.18632\/oncotarget.1614","article-title":"microRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression","volume":"5","author":"Fang","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.jpha.2023.07.008_bib57","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-12-30","article-title":"microRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells","volume":"12","author":"Wu","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib58","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1136\/gutjnl-2011-301846","article-title":"microRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis","volume":"62","author":"Hur","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jpha.2023.07.008_bib59","article-title":"microRNAs as regulator of signaling networks in metastatic colon cancer","volume":"2015","author":"Wang","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.jpha.2023.07.008_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7879","article-title":"miR-1269 promotes metastasis and forms a positive feedback loop with TGF-1269","volume":"6","author":"Bu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2023.07.008_bib61","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/path.4097","article-title":"Loss of miR-101 expression promotes Wnt\/\u03b2-catenin signalling pathway activation and malignancy in colon cancer cells","volume":"229","author":"Strillacci","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.jpha.2023.07.008_bib62","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jpha.2023.07.008_bib63","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/bjc.2012.365","article-title":"The prognostic importance of miR-21 in stage II colon cancer: A population-based study","volume":"107","author":"Kjaer-Frifeldt","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib64","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/bjc.2014.652","article-title":"Changes in circulating microRNA-126 during treatment with chemotherapy and bevacizumab predicts treatment response in patients with metastatic colorectal cancer","volume":"112","author":"Hansen","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib65","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1158\/0008-5472.CAN-18-3880","article-title":"Long noncoding RNA MIR17HG promotes colorectal cancer progression via miR-17-5p","volume":"79","author":"Xu","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpha.2023.07.008_bib66","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-021-03102-y","article-title":"miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jpha.2023.07.008_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153603","article-title":"Apigenin inhibits the growth of colorectal cancer through down-regulation of E2F1\/3 by miRNA-215-5p","volume":"89","author":"Cheng","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2023.07.008_bib68","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1158\/1541-7786.MCR-11-0342","article-title":"miRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation","volume":"10","author":"Reid","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib69","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/nm.4424","article-title":"lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt\/\u03b2-catenin signaling","volume":"23","author":"Lu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpha.2023.07.008_bib70","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fgene.2019.00478","article-title":"The potential for microRNA therapeutics and clinical research","volume":"10","author":"Hanna","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.jpha.2023.07.008_bib71","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/17512433.2019.1567326","article-title":"Patisiran for the treatment of hereditary transthyretin-mediated amyloidosis","volume":"12","author":"Yang","year":"2019","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"10.1016\/j.jpha.2023.07.008_bib72","author":"Businesswire"},{"key":"10.1016\/j.jpha.2023.07.008_bib73","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/17460441.2020.1765770","article-title":"Challenges identifying efficacious miRNA therapeutics for cancer","volume":"15","author":"Segal","year":"2020","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.jpha.2023.07.008_bib74","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/15476286.2018.1445959","article-title":"Anti-miRNA oligonucleotides: A comprehensive guide for design","volume":"15","author":"Lima","year":"2018","journal-title":"RNA Biol."},{"key":"10.1016\/j.jpha.2023.07.008_bib75","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.2147\/IJN.S146315","article-title":"Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors","volume":"12","author":"Din","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jpha.2023.07.008_bib76","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.addr.2007.04.008","article-title":"Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles","volume":"59","author":"Wong","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2023.07.008_bib77","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11051-020-04959-8","article-title":"Application of nano-based systems for drug delivery and targeting: A review","volume":"22","author":"Maghsoudnia","year":"2020","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib78","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-med-040210-162544","article-title":"Nanoparticle delivery of cancer drugs","volume":"63","author":"Wang","year":"2012","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.jpha.2023.07.008_bib79","series-title":"Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy","first-page":"79","article-title":"Ligand-functionalized nanocarrier-based active drugs targeting for liver cancer therapy","author":"Shah","year":"2019"},{"key":"10.1016\/j.jpha.2023.07.008_bib80","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0975-7406.130965","article-title":"Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues","volume":"6","author":"Madaan","year":"2014","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib81","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ijpharm.2018.07.030","article-title":"Dendrimers: A versatile nanocarrier for drug delivery and targeting","volume":"548","author":"Sherje","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpha.2023.07.008_bib82","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.progpolymsci.2013.07.005","article-title":"Dendrimer as nanocarrier for drug delivery","volume":"39","author":"Kesharwani","year":"2014","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23061419","article-title":"Polyamidoamine dendrimers for enhanced solubility of small molecules and other desirable properties for site specific delivery: Insights from experimental and computational studies","volume":"23","author":"Shadrack","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2023.07.008_bib84","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ymthe.2019.02.012","article-title":"Delivering the messenger: Advances in technologies for therapeutic mRNA delivery","volume":"27","author":"Kowalski","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jpha.2023.07.008_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201900282","article-title":"PAMAM dendrimer-based nanodevices for nuclear medicine applications","volume":"20","author":"Xiao","year":"2020","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jpha.2023.07.008_bib86","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12272-018-1008-4","article-title":"Recent progress in dendrimer-based nanomedicine development","volume":"41","author":"Kim","year":"2018","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib87","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1021\/acs.biomac.5b00979","article-title":"Recent advances in dendrimer research for cardiovascular diseases","volume":"16","author":"Yu","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jpha.2023.07.008_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2018.06.005","article-title":"Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review","volume":"15","author":"Hossen","year":"2018","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib89","doi-asserted-by":"crossref","DOI":"10.1177\/1533033819879902","article-title":"Organic nanoparticles as drug delivery systems and their potential role in the treatment of chronic myeloid leukemia","volume":"18","author":"Hussein Kamareddine","year":"2019","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.jpha.2023.07.008_bib90","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jconrel.2007.06.012","article-title":"Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy","volume":"122","author":"Lai","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2023.07.008_bib91","doi-asserted-by":"crossref","first-page":"70870","DOI":"10.1039\/C6RA15716E","article-title":"Chondroitin sulfate-functionalized polyamidoamine-mediated miR-34a delivery for inhibiting the proliferation and migration of pancreatic cancer","volume":"6","author":"Duan","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpha.2023.07.008_bib92","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3892\/or.2013.2283","article-title":"Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells","volume":"29","author":"Liu","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jpha.2023.07.008_bib93","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1039\/C1NJ20408D","article-title":"Dendrimers as non-viral vectors for siRNA delivery","volume":"36","author":"Liu","year":"2012","journal-title":"New J. Chem."},{"key":"10.1016\/j.jpha.2023.07.008_bib94","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jconrel.2009.06.019","article-title":"Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery","volume":"140","author":"Taratula","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2023.07.008_bib95","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/156720111793663642","article-title":"Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes","volume":"8","author":"Taratula","year":"2011","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.jpha.2023.07.008_bib96","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/10611860500418881","article-title":"Polypropylenimine dendrimer-induced gene expression changes: The effect of complexation with DNA, dendrimer generation and cell type","volume":"13","author":"Omidi","year":"2005","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jpha.2023.07.008_bib97","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.addr.2016.08.006","article-title":"Self-assembling peptide-based building blocks in medical applications","volume":"110-111","author":"Acar","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2023.07.008_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.00127","article-title":"Nanoscale self-assembly for therapeutic delivery","volume":"8","author":"Yadav","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jpha.2023.07.008_bib99","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.7150\/thno.31854","article-title":"Supramolecular assemblies of peptides or nucleopeptides for gene delivery","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2023.07.008_bib100","series-title":"Chapter 8 Nonviral gene therapy: Peptiplexes. M. Filice, J. Ruiz-Cabello, Nucleic Acid Nanotheranostics:","first-page":"247","author":"Tomich","year":"2019"},{"key":"10.1016\/j.jpha.2023.07.008_bib101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2018.07.001","article-title":"PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy","volume":"285","author":"Osman","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2023.07.008_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00080","article-title":"Advantages and limitations of current imaging techniques for characterizing liposome morphology","volume":"9","author":"Robson","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2023.07.008_bib103","first-page":"381","article-title":"Application of liposomes in medicine and drug delivery, Artif. Cells Nanomed","volume":"44","author":"Daraee","year":"2016","journal-title":"Biotechnol"},{"key":"10.1016\/j.jpha.2023.07.008_bib104","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.bjc.6603345","article-title":"Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer","volume":"95","author":"White","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1023\/A:1011199028318","article-title":"Phase I-II study of pegylated liposomal cisplatin (SPI-077\u2122) in patients with inoperable head and neck cancer","volume":"12","author":"Harrington","year":"2001","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jpha.2023.07.008_bib106","first-page":"541","article-title":"Phase II study of liposomal cisplatin (SPI-77) in platinum-sensitive recurrences of ovarian cancer","volume":"30","author":"Seetharamu","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib107","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics9020012","article-title":"Liposomal formulations in clinical use: An updated review","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpha.2023.07.008_bib108","doi-asserted-by":"crossref","first-page":"11669","DOI":"10.1021\/acsomega.1c00992","article-title":"Liposomal delivery of microRNA-7 targeting EGFR to inhibit the growth, invasion, and migration of ovarian cancer","volume":"6","author":"Cui","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.jpha.2023.07.008_bib109","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2014.00077","article-title":"Multifunctional polymeric micelles for delivery of drugs and siRNA","volume":"5","author":"Jhaveri","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2023.07.008_bib110","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1208\/s12249-014-0113-z","article-title":"Polymeric micelles: Nanocarriers for cancer-targeted drug delivery","volume":"15","author":"Zhang","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpha.2023.07.008_bib111","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.addr.2012.08.003","article-title":"Immunomicelles for advancing personalized therapy","volume":"64","author":"Sawant","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2023.07.008_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.115574","article-title":"Design and development of polymeric micelles as nanocarriers for anti-cancer Ribociclib drug","volume":"329","author":"Fei","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jpha.2023.07.008_bib113","first-page":"637","article-title":"Polymeric micelles as mighty nanocarriers for cancer gene therapy: A review, Cancer Chemother.","volume":"79","author":"Marzbali","year":"2017","journal-title":"Pharmacol."},{"key":"10.1016\/j.jpha.2023.07.008_bib114","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1021\/nn300942b","article-title":"Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection","volume":"6","author":"Christie","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpha.2023.07.008_bib115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-021-03632-w","article-title":"Multifunctional gold nanoparticles for improved diagnostic and therapeutic applications: A review","volume":"16","author":"Sibuyi","year":"2021","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.jpha.2023.07.008_bib116","article-title":"Biological applications of silica-based nanoparticles","volume":"8","author":"da Silva Bruckmann","year":"2022","journal-title":"Magnetochemistry"},{"key":"10.1016\/j.jpha.2023.07.008_bib117","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12274-008-8018-3","article-title":"Bioconjugated silica nanoparticles: Development and applications","volume":"1","author":"Wang","year":"2008","journal-title":"Nano Res"},{"key":"10.1016\/j.jpha.2023.07.008_bib118","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/aic.15976","article-title":"Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers","volume":"64","author":"Fan","year":"2018","journal-title":"AlChE. J."},{"key":"10.1016\/j.jpha.2023.07.008_bib119","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/smll.200902355","article-title":"Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors","volume":"6","author":"Rosenholm","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.jpha.2023.07.008_bib120","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020380","article-title":"Plant extract-synthesized silver nanoparticles for application in dental therapy","volume":"14","author":"Ahmed","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpha.2023.07.008_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031799","article-title":"Broad spectrum anti-bacterial activity and non-selective toxicity of gum Arabic silver nanoparticles","volume":"23","author":"Fadaka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib122","first-page":"32","article-title":"Inorganic nano-carriers based smart drug delivery systems for tumor therapy","volume":"1","author":"Shi","year":"2020","journal-title":"Smart Mater. Med."},{"key":"10.1016\/j.jpha.2023.07.008_bib123","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1021\/acs.chemrev.5b00482","article-title":"Cu and Cu-based nanoparticles: Synthesis and applications in catalysis","volume":"116","author":"Gawande","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jpha.2023.07.008_bib124","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1016\/j.biomaterials.2014.04.029","article-title":"Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI","volume":"35","author":"Cheng","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib125","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s42247-021-00335-x","article-title":"Review on metal nanoparticles as nanocarriers: Current challenges and perspectives in drug delivery systems","volume":"5","author":"Chandrakala","year":"2022","journal-title":"Emergent Mater"},{"key":"10.1016\/j.jpha.2023.07.008_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13111795","article-title":"Nanotechnology-based delivery systems for antimicrobial peptides","volume":"13","author":"Fadaka","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpha.2023.07.008_bib127","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50424-5","article-title":"Impact of conjugation strategies for targeting of antibodies in gold nanoparticles for ultrasensitive detection of 17\u03b2-estradiol","volume":"9","author":"Oliveira","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpha.2023.07.008_bib128","article-title":"Attaching DNA to gold nanoparticles with a protein Corona","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.jpha.2023.07.008_bib129","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/ac202749p","article-title":"microRNA conjugated gold nanoparticles and cell transfection","volume":"84","author":"Crew","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2023.07.008_bib130","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-08185-1","article-title":"miR-206 conjugated gold nanoparticle based targeted therapy in breast cancer cells","volume":"12","author":"Chaudhari","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpha.2023.07.008_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120212","article-title":"Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice","volume":"256","author":"Liu","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib132","doi-asserted-by":"crossref","DOI":"10.1186\/s40580-019-0193-2","article-title":"Current trends and challenges in cancer management and therapy using designer nanomaterials","volume":"6","author":"Navya","year":"2019","journal-title":"Nano Converg."},{"key":"10.1016\/j.jpha.2023.07.008_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104796","article-title":"Secondary toxic effect of graphene oxide and graphene quantum dots alters the expression of miR-21 and miR-29a in human cell lines","volume":"65","author":"Hashemi","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jpha.2023.07.008_bib134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/IJN.S144155","article-title":"Biophysical and biological contributions of polyamine-coated carbon nanotubes and bidimensional buckypapers in the delivery of miRNAs to human cells","volume":"13","author":"Celluzzi","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpha.2023.07.008_bib135","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1021\/ja053962k","article-title":"Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing","volume":"127","author":"Kam","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2023.07.008_bib136","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.carbon.2018.09.019","article-title":"Graphene-based Nano-Carrier modifications for gene delivery applications","volume":"140","author":"Imani","year":"2018","journal-title":"Carbon"},{"key":"10.1016\/j.jpha.2023.07.008_bib137","doi-asserted-by":"crossref","DOI":"10.3390\/nano9020139","article-title":"Differential cytotoxicity of different sizes of graphene oxide nanoparticles in Leydig (TM3) and Sertoli (TM4) cells","volume":"9","author":"Gurunathan","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib138","doi-asserted-by":"crossref","first-page":"17704","DOI":"10.1039\/C7RA01029J","article-title":"Graphene quantum dots: Effect of size, composition and curvature on their assembly","volume":"7","author":"Elvati","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpha.2023.07.008_bib139","series-title":"Integrated mRNA and microRNA transcriptomic analysis reveals the common and individual responses of zebrafish embryos exposed to four types of graphene quantum dots (GQDs), Research Square","author":"Deng","year":"2021"},{"key":"10.1016\/j.jpha.2023.07.008_bib140","doi-asserted-by":"crossref","first-page":"9014","DOI":"10.1021\/acsami.6b02662","article-title":"Imaging dendrimer-grafted graphene oxide mediated anti-miR-21 delivery with an activatable luciferase reporter","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2023.07.008_bib141","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.nano.2018.05.016","article-title":"Multifunctional core-shell nanoplatforms (gold@graphene oxide) with mediated NIR thermal therapy to promote miRNA delivery","volume":"14","author":"Assali","year":"2018","journal-title":"Nanomed."},{"key":"10.1016\/j.jpha.2023.07.008_bib142","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jcis.2018.01.073","article-title":"Design and evaluation of galactosylated chitosan\/graphene oxide nanoparticles as a drug delivery system","volume":"516","author":"Wang","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib143","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.msec.2017.05.054","article-title":"A colon targeted drug delivery system based on alginate modificated graphene oxide for colorectal liver metastasis","volume":"79","author":"Zhang","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jpha.2023.07.008_bib144","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26195804","article-title":"microRNA delivery by graphene-based complexes into glioblastoma cells","volume":"26","author":"Kutwin","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2023.07.008_bib145","article-title":"Functionalization and optimization\u2013strategy of graphene oxide-based nanomaterials for gene and drug delivery","volume":"12","author":"Han","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jpha.2023.07.008_bib146","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1039\/C2CC38417E","article-title":"Near-infrared light-responsive graphene oxide composite multilayer capsules: A novel route for remote controlled drug delivery","volume":"49","author":"Kurapati","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jpha.2023.07.008_bib147","doi-asserted-by":"crossref","DOI":"10.3390\/nano8070484","article-title":"Graphene oxide\/ZnS: Mn nanocomposite functionalized with folic acid as a nontoxic and effective theranostic platform for breast cancer treatment","volume":"8","author":"Diaz-Diestra","year":"2018","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib148","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.617097","article-title":"Controllable synthesis of biocompatible fluorescent carbon dots from cellulose hydrogel for the specific detection of Hg2+","volume":"9","author":"Huang","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jpha.2023.07.008_bib149","doi-asserted-by":"crossref","DOI":"10.3390\/nano11123419","article-title":"Carbon dots: Synthesis, properties and applications","volume":"11","author":"Cui","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.optmat.2020.110796","article-title":"Hydrothermal synthesis of bright blue-emitting carbon dots for bioimaging and fluorescent determination of baicalein","volume":"113","author":"Luo","year":"2021","journal-title":"Opt. Mater."},{"key":"10.1016\/j.jpha.2023.07.008_bib151","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01274-3","article-title":"Carbon dots hybrid for dual fluorescent detection of microRNA-21 integrated bioimaging of MCF-7 using a microfluidic platform","volume":"20","author":"Mohammadi","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.jpha.2023.07.008_bib152","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.2147\/IJN.S304873","article-title":"Highly efficient microRNA delivery using functionalized carbon dots for enhanced conversion of fibroblasts to cardiomyocytes","volume":"16","author":"Yang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpha.2023.07.008_bib153","series-title":"Carbon Dots in Biology","first-page":"283","article-title":"Chapter 13 Carbon dots in drug delivery","author":"Sibuyi","year":"2023"},{"key":"10.1016\/j.jpha.2023.07.008_bib154","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/nn900918w","article-title":"Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs","volume":"3","author":"Xia","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpha.2023.07.008_bib155","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.2147\/IJN.S120611","article-title":"Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery","volume":"11","author":"Prabhakar","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpha.2023.07.008_bib156","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1021\/am5082793","article-title":"Hybrid lipid-capped mesoporous silica for stimuli-responsive drug release and overcoming multidrug resistance","volume":"7","author":"Han","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2023.07.008_bib157","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.7150\/thno.52076","article-title":"Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts","volume":"11","author":"Xu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2023.07.008_bib158","doi-asserted-by":"crossref","first-page":"24392","DOI":"10.1021\/acsami.8b06642","article-title":"Polyamino acid layer-by-layer (LbL) constructed silica-supported mesoporous titania nanocarriers for stimuli-responsive delivery of microRNA 708 and paclitaxel for combined chemotherapy","volume":"10","author":"Gupta","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2023.07.008_bib159","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1166\/jbn.2020.2960","article-title":"Enhanced suppression of disulfide cross-linking micelles nanocarriers loaded miR-145 delivering system via down-regulation of MYC and FSCN1 in colon cancer cells","volume":"16","author":"Zhai","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jpha.2023.07.008_bib160","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.biomaterials.2019.04.028","article-title":"Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer","volume":"210","author":"Chan","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib161","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-020-01545-9","article-title":"Polyamines and related signaling pathways in cancer","volume":"20","author":"Li","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jpha.2023.07.008_bib162","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2016.12.017","article-title":"Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy","volume":"246","author":"Xie","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2023.07.008_bib163","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jconrel.2015.02.018","article-title":"Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer","volume":"203","author":"Wang","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2023.07.008_bib164","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/gt.2016.60","article-title":"Cationic microRNA-delivering nanocarriers for efficient treatment of colon carcinoma in xenograft model","volume":"23","author":"Liang","year":"2016","journal-title":"Gene Ther."},{"key":"10.1016\/j.jpha.2023.07.008_bib165","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1166\/jbn.2016.2253","article-title":"PEG-poly(amino acid)s\/MicroRNA complex nanoparticles effectively arrest the growth and metastasis of colorectal cancer","volume":"12","author":"Wang","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jpha.2023.07.008_bib166","article-title":"Metal-organic framework nanocarriers for drug delivery in biomedical applications","volume":"12","author":"Sun","year":"2020","journal-title":"Nanomicro Lett."},{"key":"10.1016\/j.jpha.2023.07.008_bib167","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900406","article-title":"Light-induced redox-responsive smart drug delivery system by using selenium-containing Polymer@MOF shell\/core nanocomposite","volume":"8","author":"Luo","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.jpha.2023.07.008_bib168","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1021\/acsami.0c21006","article-title":"Dual roles of metal\u2013organic frameworks as nanocarriers for miRNA delivery and adjuvants for chemodynamic therapy","volume":"13","author":"Zhao","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2023.07.008_bib169","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1021\/acsabm.9b01189","article-title":"Multiplexed microRNA detection using metal\u2013organic framework for signal output","volume":"3","author":"Peng","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.jpha.2023.07.008_bib170","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1021\/acsnano.2c04886","article-title":"Delivery of miRNAs through metal\u2013organic framework nanoparticles for assisting neural stem cell therapy for ischemic stroke","volume":"16","author":"Yang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpha.2023.07.008_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131676","article-title":"DNA-functionalized metal-organic framework ratiometric nanoprobe for microRNA detection and imaging in live cells","volume":"361","author":"Han","year":"2022","journal-title":"Sens. Actuat. B"},{"key":"10.1016\/j.jpha.2023.07.008_bib172","doi-asserted-by":"crossref","first-page":"34910","DOI":"10.1039\/D2RA04959G","article-title":"Metal-organic frameworks-based biosensor for microRNA detection in prostate cancer cell lines","volume":"12","author":"Najafabadi","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpha.2023.07.008_bib173","doi-asserted-by":"crossref","DOI":"10.3390\/nano12020277","article-title":"Biomedical applications of metal-organic frameworks for disease diagnosis and drug delivery: A review","volume":"12","author":"Al Sharabati","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib174","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcis.2016.11.015","article-title":"Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate","volume":"488","author":"Pujara","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.2010.05842.x","article-title":"Bioavailability of resveratrol","volume":"1215","author":"Walle","year":"2011","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.jpha.2023.07.008_bib176","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1021\/jf9042858","article-title":"Involvement of breast cancer resistance protein (BCRP1\/ABCG2) in the bioavailability and tissue distribution of trans-Resveratrol in knockout mice","volume":"58","author":"Alfaras","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpha.2023.07.008_bib177","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/PPO.0b013e3181ddc5bf","article-title":"Stage II and stage III colon cancer","volume":"16","author":"Rousseau","year":"2010","journal-title":"Cancer J"},{"key":"10.1016\/j.jpha.2023.07.008_bib178","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1021\/acssuschemeng.7b01903","article-title":"Lignin nanoparticle as a novel green carrier for the efficient delivery of resveratrol","volume":"5","author":"Dai","year":"2017","journal-title":"ACS Sustainable Chem. Eng."},{"key":"10.1016\/j.jpha.2023.07.008_bib179","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1016\/j.biomaterials.2012.06.019","article-title":"Star-shape copolymer of lysine-linked di-tocopherol polyethylene glycol 2000 succinate for doxorubicin delivery with reversal of multidrug resistance","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2023.07.008_bib180","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2010.06.023","article-title":"Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor","volume":"147","author":"Iqbal","year":"2010","journal-title":"J. Control Release"},{"key":"10.1016\/j.jpha.2023.07.008_bib181","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1054\/bjoc.2000.1559","article-title":"Selective cancer cell killing by \u03b1-tocopheryl succinate","volume":"84","author":"Neuzil","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jpha.2023.07.008_bib182","article-title":"Polymer-mediated gene therapy: Recent advances and merging of delivery techniques","volume":"12","author":"Salameh","year":"2020","journal-title":"Wiley Interdiscip. Rev."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177923001478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177923001478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:35:40Z","timestamp":1761860140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177923001478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":182,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2095177923001478"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2023.07.008","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stage-specific treatment of colorectal cancer: A microRNA-nanocomposite approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2023.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}]}}