{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:14:56Z","timestamp":1777907696670,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M653967"],"award-info":[{"award-number":["2019M653967"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M693946"],"award-info":[{"award-number":["2021M693946"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972052"],"award-info":[{"award-number":["81972052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201537"],"award-info":[{"award-number":["82201537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902213"],"award-info":[{"award-number":["81902213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730065"],"award-info":[{"award-number":["81730065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122043"],"award-info":[{"award-number":["82122043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jpha.2023.08.006","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T21:43:25Z","timestamp":1691703805000},"page":"86-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52"],"prefix":"10.1016","volume":"14","author":[{"given":"Shengyou","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-0150","authenticated-orcid":false,"given":"Liangliang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuojing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-0591","authenticated-orcid":false,"given":"Jinghui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2023.08.006_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pneurobio.2015.09.006","article-title":"The regulatory roles of non-coding RNAs in nerve injury and regeneration","volume":"134","author":"Yu","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jpha.2023.08.006_bib2","first-page":"49","article-title":"Peripheral neuropathy: Clinical and electrophysiological considerations, Neuroimaging","volume":"24","author":"Chung","year":"2014","journal-title":"Clin. N. Am."},{"key":"10.1016\/j.jpha.2023.08.006_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-023-01767-9","article-title":"Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration","volume":"21","author":"Huang","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.jpha.2023.08.006_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jnutbio.2017.04.006","article-title":"Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL\/6J mice","volume":"46","author":"Chen","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jpha.2023.08.006_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10238-015-0364-3","article-title":"Human adipose-derived stem cells stimulate neuroregeneration","volume":"16","author":"Masgutov","year":"2016","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jpha.2023.08.006_bib6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jpha.2022.06.001","article-title":"18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1\/2 in activated HSCs","volume":"12","author":"Zhang","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2023.08.006_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jpha.2023.08.006_bib8","article-title":"Ferroptosis in life: To be or not to be, Biomed","volume":"159","author":"Xu","year":"2023","journal-title":"Pharmacother."},{"key":"10.1016\/j.jpha.2023.08.006_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuro.2018.04.012","article-title":"Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure","volume":"67","author":"Tang","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jpha.2023.08.006_bib10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/mp.2016.196","article-title":"Glutathione peroxidase 4: A new player in neurodegeneration?","volume":"22","author":"Cardoso","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpha.2023.08.006_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/glia.22451","article-title":"Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury","volume":"61","author":"Shi","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.jpha.2023.08.006_bib12","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.jpain.2022.07.010","article-title":"MAO-B inhibitor, KDS2010, alleviates spinal nerve ligation-induced neuropathic pain in rats through competitively blocking the BDNF\/TrkB\/NR2B signaling","volume":"23","author":"Ph\u1ea1m","year":"2022","journal-title":"J. Pain"},{"key":"10.1016\/j.jpha.2023.08.006_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12516","article-title":"3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration","volume":"65","author":"Qian","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jpha.2023.08.006_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106971","article-title":"Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2\/ARE pathway in ischemia\/reperfusion rats","volume":"32","author":"Gao","year":"2023","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.jpha.2023.08.006_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158583","article-title":"Human multipotent mesenchymal stromal cell-derived extracellular vesicles enhance neuroregeneration in a rat model of sciatic nerve crush injury","volume":"23","author":"Demyanenko","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2023.08.006_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2016.10.015","article-title":"Single injection of a novel nerve growth factor coacervate improves structural and functional regeneration after sciatic nerve injury in adult rats","volume":"288","author":"Li","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jpha.2023.08.006_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00083","article-title":"Superparamagnetic iron oxide nanoparticle-mediated forces enhance the migration of schwann cells across the astrocyte-schwann cell boundary in vitro","volume":"11","author":"Huang","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jpha.2023.08.006_bib18","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.7150\/thno.44912","article-title":"Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p","volume":"10","author":"Xia","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2023.08.006_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jpha.2023.08.006_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00222","article-title":"Silencing of A20 aggravates neuronal death and inflammation after traumatic brain injury: A potential trigger of necroptosis","volume":"12","author":"Bao","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jpha.2023.08.006_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121755","article-title":"Sequential oxygen supply system promotes peripheral nerve regeneration by enhancing Schwann cells survival and angiogenesis","volume":"289","author":"Ma","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2023.08.006_bib22","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1111\/jog.14968","article-title":"Protective effect and potential mechanism of Schwann cell-derived exosomes on mechanical damage of rat dorsal root ganglion cells","volume":"47","author":"Huang","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.jpha.2023.08.006_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41556-018-0039-x","article-title":"Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons","volume":"20","author":"Hervera","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jpha.2023.08.006_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jpha.2023.08.006_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jpha.2023.08.006_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/hep.29117","article-title":"Characterization of ferroptosis in murine models of hemochromatosis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jpha.2023.08.006_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105698","article-title":"Macrophage ferroportin serves as a therapeutic target against bacteria-induced acute lung injury by promoting barrier restoration","volume":"25","author":"Wang","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.jpha.2023.08.006_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134870","article-title":"The synthetic pyrethroid deltamethrin impairs zebrafish (Danio rerio) swim bladder development","volume":"701","author":"Wu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2023.08.006_bib29","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41589-018-0072-x","article-title":"Scavenging of superoxide by a membrane-bound superoxide oxidase","volume":"14","author":"Lundgren","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jpha.2023.08.006_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.660072","article-title":"Cox4i2 triggers an increase in reactive oxygen species, leading to ferroptosis and apoptosis in HHV7 infected schwann cells","volume":"8","author":"Chang","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jpha.2023.08.006_bib31","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41593-021-00862-0","article-title":"Genome-wide CRISPRi\/a screens in human neurons link lysosomal failure to ferroptosis","volume":"24","author":"Tian","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jpha.2023.08.006_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8253742","article-title":"RXR\u03b1 blocks nerve regeneration after spinal cord injury by targeting p66shc","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jpha.2023.08.006_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuropharm.2018.07.001","article-title":"Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress","volume":"139","author":"Caillaud","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpha.2023.08.006_bib34","article-title":"Iron exposure and the cellular mechanisms linked to neuron degeneration in adult mice","volume":"8","author":"Li","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jpha.2023.08.006_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104693","article-title":"Sevoflurane anesthesia during pregnancy in mice induces cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis","volume":"135","author":"Zuo","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jpha.2023.08.006_bib36","doi-asserted-by":"crossref","first-page":"15686","DOI":"10.1074\/jbc.RA119.010227","article-title":"Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels","volume":"294","author":"Nishito","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpha.2023.08.006_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73456","article-title":"Aging is associated with increased brain iron through cortex-derived hepcidin expression","volume":"11","author":"Sato","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.jpha.2023.08.006_bib38","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1016\/j.celrep.2018.05.013","article-title":"Ubiquitin-dependent degradation of mitochondrial proteins regulates energy metabolism","volume":"23","author":"Lavie","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jpha.2023.08.006_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233770","article-title":"UBA52 is crucial in HSP90 ubiquitylation and neurodegenerative signaling during early phase of Parkinson\u2019s disease","volume":"11","author":"Tiwari","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jpha.2023.08.006_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114367","article-title":"Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury","volume":"363","author":"Quan","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jpha.2023.08.006_bib41","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1179\/1743132812Y.0000000070","article-title":"Inhibition of p38 MAPK reduces loss of primary sensory neurons after nerve transection","volume":"34","author":"Agthong","year":"2012","journal-title":"Neurol. Res."},{"key":"10.1016\/j.jpha.2023.08.006_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neulet.2016.02.006","article-title":"Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla","volume":"617","author":"Leong","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jpha.2023.08.006_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpha.2022.09.003","article-title":"Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor","volume":"13","author":"Mu","year":"2023","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpha.2023.08.006_bib44","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jpha.2023.08.006_bib45","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."}],"updated-by":[{"DOI":"10.1016\/j.jpha.2025.101324","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000}}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209517792300196X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209517792300196X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:35:33Z","timestamp":1761860133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209517792300196X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S209517792300196X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2023.08.006","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2023.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}]}}