{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:42:39Z","timestamp":1791549759115,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jpha.2024.100973","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T18:08:43Z","timestamp":1711649323000},"page":"100973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia"],"prefix":"10.1016","volume":"14","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-8283","authenticated-orcid":false,"given":"Jinpeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeper","family":"Abliz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2024.100973_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13604","article-title":"Insomnia disorder: State of the science and challenges for the future","volume":"31","author":"Riemann","year":"2022","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.jpha.2024.100973_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.106001","article-title":"Study on the potential mechanism, therapeutic drugs and prescriptions of insomnia based on bioinformatics and molecular docking","volume":"149","author":"Huang","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.jpha.2024.100973_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2020.00527","article-title":"The prevalence of insomnia subtypes in relation to demographic characteristics, anxiety, depression, alcohol consumption and use of hypnotics","volume":"11","author":"Bjor\u00f8y","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.jpha.2024.100973_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/sleep\/31.4.473","article-title":"Prevalence, course, and comorbidity of insomnia and depression in young adults","volume":"31","author":"Buysse","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.jpha.2024.100973_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jad.2022.10.047","article-title":"Chain mediating effect of insomnia, depression, and anxiety on the relationship between nightmares and cognitive deficits in adolescents","volume":"322","author":"Zhang","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jpha.2024.100973_bib6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrd2464","article-title":"Emerging anti-insomnia drugs: Tackling sleeplessness and the quality of wake time","volume":"7","author":"Wafford","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jpha.2024.100973_bib7","doi-asserted-by":"crossref","DOI":"10.52965\/001c.24927","article-title":"Zolpidem: Efficacy and side effects for insomnia","volume":"9","author":"Edinoff","year":"2021","journal-title":"Health Psychol. Res."},{"key":"10.1016\/j.jpha.2024.100973_bib8","series-title":"Pharmacopoeia of the Peoples Republic of China","first-page":"163","author":"Commission","year":"2020"},{"key":"10.1016\/j.jpha.2024.100973_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154483","article-title":"Therapeutic potential of Polygala saponins in neurological diseases","volume":"108","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2024.100973_bib10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3109\/13880200903280042","article-title":"Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice","volume":"48","author":"Yao","year":"2010","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpha.2024.100973_bib11","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.phymed.2016.10.015","article-title":"Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice","volume":"23","author":"Cao","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2024.100973_bib12","article-title":"The neuritogenic and neuroprotective potential of senegenin against A\u03b2-induced neurotoxicity in PC 12 cells","volume":"16","author":"Jesky","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.jpha.2024.100973_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112417","article-title":"A review on the phytopharmacological studies of the genus Polygala","volume":"249","author":"Lacaille-Dubois","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2024.100973_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pnpbp.2014.02.013","article-title":"The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity","volume":"53","author":"Jin","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jpha.2024.100973_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114281","article-title":"Direct infusion-tandem mass spectrometry combining with data mining strategies enables rapid chemome characterization of medicinal plants: A case study of Polygala tenuifolia","volume":"204","author":"Li","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpha.2024.100973_bib16","first-page":"5744","article-title":"Research progress on Polygalae Radix","volume":"46","author":"Liu","year":"2021","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jpha.2024.100973_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2021.102939","article-title":"Pharmacometabolomics-guided clozapine therapy in treatment resistant schizophrenia: Preliminary exploration of future too near","volume":"67","author":"Grover","year":"2022","journal-title":"Asian J. Psychiatry"},{"key":"10.1016\/j.jpha.2024.100973_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107824","article-title":"Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds","volume":"224","author":"Wang","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jpha.2024.100973_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123418","article-title":"Comprehensive quantitative method for neurotransmitters to study the activity of a sedative-hypnotic candidate using microdialysis and LC \u00d7 LC-MS\/MS","volume":"245","author":"Chen","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.jpha.2024.100973_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154177","article-title":"Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology","volume":"102","author":"Shao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpha.2024.100973_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.869972","article-title":"Integrated serum pharmacochemistry and network pharmacology approach to explore the effective components and potential mechanisms of menispermi rhizoma against myocardial ischemia","volume":"10","author":"Wei","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.jpha.2024.100973_bib22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.bios.2017.11.069","article-title":"Conducting polymer-based electrochemical biosensors for neurotransmitters: A review","volume":"102","author":"Moon","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpha.2024.100973_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23115954","article-title":"Neurotransmitters-key factors in neurological and neurodegenerative disorders of the central nervous system","volume":"23","author":"Teleanu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2024.100973_bib24","article-title":"A sensitive and wide coverage ambient mass spectrometry imaging method for functional metabolites based molecular histology","volume":"5","author":"He","year":"2018","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.jpha.2024.100973_bib25","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1021\/acs.analchem.1c00467","article-title":"Mapping metabolic networks in the brain by ambient mass spectrometry imaging and metabolomics","volume":"93","author":"Pang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpha.2024.100973_bib26","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1016\/j.apsb.2022.03.018","article-title":"A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient mass spectrometry imaging","volume":"12","author":"Liu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpha.2024.100973_bib27","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.apsb.2022.11.011","article-title":"Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets","volume":"13","author":"Jin","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpha.2024.100973_bib28","first-page":"119","article-title":"Separation and identification of the hypnotic active ingredients of Polygala tenuifolia Willd","volume":"34","author":"Chen","year":"2018","journal-title":"Food Mach"},{"key":"10.1016\/j.jpha.2024.100973_bib29","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/07420520500395094","article-title":"Diazepam affects both level and amplitude of rat locomotor activity rhythm but has no effect on core body temperature","volume":"22","author":"Djeridane","year":"2005","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.jpha.2024.100973_bib30","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/bmc.3076","article-title":"Simultaneous analysis of polygala acid, senegenin and 3,6'-disinapoylsucrose in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration","volume":"28","author":"Lin","year":"2014","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpha.2024.100973_bib31","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/13880209.2020.1818790","article-title":"UHPLC-MS\/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma","volume":"58","author":"Zhao","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpha.2024.100973_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4155\/bio-2016-0078","article-title":"Systematic evaluation of serum and plasma collection on the endogenous metabolome","volume":"9","author":"Zhou","year":"2017","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jpha.2024.100973_bib33","first-page":"434","article-title":"Sedative and hypnotic effects and transcriptome analysis of Polygala tenuifolia in aged insomnia rats, Chin","volume":"26","author":"Ren","year":"2020","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.jpha.2024.100973_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.neubiorev.2016.04.018","article-title":"The brain norepinephrine system, stress and cardiovascular vulnerability","volume":"74","author":"Wood","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jpha.2024.100973_bib35","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/01.HYP.27.3.449","article-title":"Localization of alpha 2A- and alpha 2B-adrenergic receptor subtypes in brain","volume":"27","author":"Tavares","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.jpha.2024.100973_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb0556","article-title":"Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons","volume":"369","author":"Peng","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jpha.2024.100973_bib37","first-page":"321","article-title":"Adenosine and sleep, Sleep Med","volume":"6","author":"Porkka-Heiskanen","year":"2002","journal-title":"Rev."},{"key":"10.1016\/j.jpha.2024.100973_bib38","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsab017","article-title":"Molecular resolution of a behavioral paradox: Sleep and arousal are regulated by distinct acetylcholine receptors in different neuronal types in Drosophila","volume":"44","author":"Dai","year":"2021","journal-title":"Sleep"},{"key":"10.1016\/j.jpha.2024.100973_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature19773","article-title":"Circuit-based interrogation of sleep control","volume":"538","author":"Weber","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jpha.2024.100973_bib40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbr.2011.01.017","article-title":"The cholinergic system, EEG and sleep","volume":"221","author":"Platt","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jpha.2024.100973_bib41","first-page":"65","article-title":"Histamine in the regulation of wakefulness, Sleep Med","volume":"15","author":"Thakkar","year":"2011","journal-title":"Rev."},{"key":"10.1016\/j.jpha.2024.100973_bib42","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41592-019-0551-3","article-title":"Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging","volume":"16","author":"Shariatgorji","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jpha.2024.100973_bib43","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1038\/s41596-021-00538-w","article-title":"Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging","volume":"16","author":"Shariatgorji","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jpha.2024.100973_bib44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-079X.2004.00196.x","article-title":"The human pineal gland and melatonin in aging and Alzheimer\u2019s disease","volume":"38","author":"Wu","year":"2005","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jpha.2024.100973_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.826193","article-title":"Evidence that substantia nigra pars compacta dopaminergic neurons are selectively vulnerable to oxidative stress because they are highly metabolically active","volume":"16","author":"Ni","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jpha.2024.100973_bib46","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/13880209.2020.1812674","article-title":"Lilium davidii extract alleviates p-chlorophenylalanine-induced insomnia in rats through modification of the hypothalamic-related neurotransmitters, melatonin and homeostasis of the hypothalamic-pituitary-adrenal axis","volume":"58","author":"Si","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpha.2024.100973_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115868","article-title":"Lavender essential oil fractions alleviate sleep disorders induced by the combination of anxiety and caffeine in mice","volume":"302","author":"Xu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2024.100973_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23092375","article-title":"Targeted neurotransmitters profiling identifies metabolic signatures in rat brain by LC-MS\/MS: Application in insomnia, depression and Alzheimer\u2019s disease","volume":"23","author":"Xu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2024.100973_bib49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0024-3205(75)90501-9","article-title":"New concepts on the mechanism of action of benzodiazepines","volume":"17","author":"Costa","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/j.jpha.2024.100973_bib50","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1755-5949.2010.00197.x","article-title":"Melatonin receptor agonists: New options for insomnia and depression treatment","volume":"17","author":"Spadoni","year":"2011","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jpha.2024.100973_bib51","first-page":"263","article-title":"Review of the histamine system and\u00a0the\u00a0clinical effects of H1 antagonists: Basis for a new model for understanding the effects of insomnia medications, Sleep Med.","volume":"17","author":"Krystal","year":"2013","journal-title":"Rev."},{"key":"10.1016\/j.jpha.2024.100973_bib52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/S1516-44462011000100017","article-title":"Sedative antidepressants and insomnia","volume":"33","author":"Santos Moraes","year":"2011","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.jpha.2024.100973_bib53","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0277-9536(91)90216-Y","article-title":"Adverse effects of benzodiazepines","volume":"33","author":"Gudex","year":"1991","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.jpha.2024.100973_bib54","article-title":"Preclinical safety of the root extract of Polygala tenuifolia willdenow in sprague-dawley rats and beagle dogs, Evid. Based Complementary","volume":"2014","author":"Shin","year":"2014","journal-title":"Altern. Med."},{"key":"10.1016\/j.jpha.2024.100973_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/187152707779940835","article-title":"Effects of psychiatric medications on sleep and sleep disorders","volume":"6","author":"DeMartinis","year":"2007","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jpha.2024.100973_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/da.1043","article-title":"Depression, sleep physiology, and antidepressant drugs","volume":"14","author":"Winokur","year":"2001","journal-title":"Depress. Anxiety"}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177924000704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177924000704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T22:10:42Z","timestamp":1723500642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177924000704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2095177924000704"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2024.100973","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2024.100973","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"100973"}}