{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:35:37Z","timestamp":1783589737937,"version":"3.55.0"},"reference-count":130,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jpha.2024.101131","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T17:22:11Z","timestamp":1730136131000},"page":"101131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The biological roles of exosome-encapsulated traditional Chinese medicine monomers in neuronal disorders"],"prefix":"10.1016","volume":"15","author":[{"given":"Chen","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2024.101131_bib1","first-page":"259","article-title":"Philosophical basis of original thinking in Chinese medicine","volume":"47","author":"Wang","year":"2017","journal-title":"Zhonghua Yi Shi Za Zhi"},{"key":"10.1016\/j.jpha.2024.101131_bib2","series-title":"P U. Unschuld. Ii. the meaning of the title Huang di Nei Jing su Wen. Huang Di Nei Jing Su Wen","year":"2019"},{"key":"10.1016\/j.jpha.2024.101131_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.healthpol.2008.09.003","article-title":"Traditional Chinese medicine in the Chinese health care system","volume":"90","author":"Xu","year":"2009","journal-title":"Health Pol."},{"key":"10.1016\/j.jpha.2024.101131_bib4","article-title":"Ferroptosis: A new mechanism of traditional Chinese medicine for treating ulcerative colitis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2024.101131_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0165-6147(98)01276-0","article-title":"Stroke therapy in traditional Chinese medicine (TCM): Prospects for drug discovery and development","volume":"20","author":"Gong","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jpha.2024.101131_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jep.2016.06.052","article-title":"Botanical drugs in ayurveda and traditional Chinese medicine","volume":"194","author":"Jaiswal","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2024.101131_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460377","article-title":"Recent advances of modern sample preparation techniques for traditional Chinese medicines","volume":"1606","author":"Jin","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpha.2024.101131_bib8","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2147\/DDDT.S417465","article-title":"An exosome-based therapeutic strategy targeting neuroinflammation in Alzheimer's disease with berberine and palmatine","volume":"17","author":"Zhao","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jpha.2024.101131_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2021.03.018","article-title":"Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy","volume":"126","author":"Gao","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpha.2024.101131_bib10","article-title":"Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease","volume":"8","author":"Iyaswamy","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jpha.2024.101131_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ph15010083","article-title":"Extracellular vesicle delivery of neferine for the attenuation of neurodegenerative disease proteins and motor deficit in an Alzheimer's disease mouse model","volume":"15","author":"Tang","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jpha.2024.101131_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112123","article-title":"Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway","volume":"126","author":"Huang","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jpha.2024.101131_bib13","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1039\/C9NR01255A","article-title":"Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT\/GSK-3\u03b2 pathway","volume":"11","author":"Wang","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.jpha.2024.101131_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10561-022-10008-6","article-title":"Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson's disease mouse model","volume":"24","author":"Mobahat","year":"2023","journal-title":"Cell Tissue Bank."},{"key":"10.1016\/j.jpha.2024.101131_bib15","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/acsnano.1c08473","article-title":"Intranasal administration of self-oriented nanocarriers based on therapeutic exosomes for synergistic treatment of Parkinson's disease","volume":"16","author":"Peng","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpha.2024.101131_bib16","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/mt.2011.164","article-title":"Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain","volume":"19","author":"Zhuang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jpha.2024.101131_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111314","article-title":"Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis","volume":"117","author":"He","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jpha.2024.101131_bib18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.biocel.2016.09.002","article-title":"Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury","volume":"79","author":"Kalani","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jpha.2024.101131_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy","volume":"150","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2024.101131_bib20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biomaterials.2018.06.029","article-title":"NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo","volume":"178","author":"Jia","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2024.101131_bib21","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1021\/acs.jafc.0c07658","article-title":"Enhanced neuroprotective effects of epicatechin gallate encapsulated by bovine milk-derived exosomes against Parkinson's disease through antiapoptosis and antimitophagy","volume":"69","author":"Luo","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpha.2024.101131_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jconrel.2022.12.026","article-title":"Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia","volume":"353","author":"Zheng","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jpha.2024.101131_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-00879-4","article-title":"Surface-modified engineered exosomes attenuated cerebral ischemia\/reperfusion injury by targeting the delivery of quercetin towards impaired neurons","volume":"19","author":"Guo","year":"2021","journal-title":"J. Nanobiotechnology."},{"key":"10.1016\/j.jpha.2024.101131_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112505","article-title":"Tumor-derived exosomes reversing TMZ resistance by synergistic drug delivery for glioma-targeting treatment","volume":"215","author":"Wang","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jpha.2024.101131_bib25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jconrel.2023.11.033","article-title":"Targeted delivery of hybrid nanovesicles for enhanced brain penetration to achieve synergistic therapy of glioma","volume":"365","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2024.101131_bib26","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"New opportunities and challenges of natural products research: When target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpha.2024.101131_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1220862","article-title":"Role of traditional Chinese medicine monomers in cerebral ischemia\/reperfusion injury: A review of the mechanism","volume":"14","author":"Zheng","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2024.101131_bib28","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/10717544.2019.1660732","article-title":"Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine","volume":"26","author":"Zhang","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jpha.2024.101131_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcdf.2013.01.001","article-title":"Current development of polysaccharides from Ganoderma: Isolation, structure and bioactivities","volume":"1","author":"Nie","year":"2013","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"10.1016\/j.jpha.2024.101131_bib30","doi-asserted-by":"crossref","first-page":"18974","DOI":"10.1039\/D1RA01365C","article-title":"Polysaccharide from rubescens: Extraction, optimization, characterization and antioxidant activities","volume":"11","author":"Cheng","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpha.2024.101131_bib31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijbiomac.2016.03.058","article-title":"Polysaccharide extraction from Sphallerocarpus gracilis roots by response surface methodology","volume":"88","author":"Ma","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpha.2024.101131_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2023.106395","article-title":"Ultrasound-assisted extraction and analysis of maidenhairtree polysaccharides","volume":"95","author":"Wang","year":"2023","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jpha.2024.101131_bib33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.carbpol.2013.09.099","article-title":"Optimization of enzyme-assisted extraction and characterization of polysaccharides from Hericium erinaceus","volume":"101","author":"Zhu","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpha.2024.101131_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.renene.2016.05.011","article-title":"Hydrolysis of pretreated rice straw by an enzyme cocktail comprising acidic xylanase from Aspergillus sp. for bioethanol production","volume":"98","author":"Thomas","year":"2016","journal-title":"Renew. Energy"},{"key":"10.1016\/j.jpha.2024.101131_bib35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.carbpol.2013.06.036","article-title":"Enzyme assisted extraction of polysaccharides from the fruit of Cornus officinalis","volume":"98","author":"You","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpha.2024.101131_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.carbpol.2015.11.016","article-title":"Ultrasound extraction of polysaccharides from mulberry leaves and their effect on enhancing antioxidant activity","volume":"137","author":"Zhang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpha.2024.101131_bib37","article-title":"Applications and prospects of ultrasound-assisted extraction in Chinese herbal medicine","volume":"1","author":"Sun","year":"2019","journal-title":"Open Access J. Biomed. Sci."},{"key":"10.1016\/j.jpha.2024.101131_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300712","article-title":"Comparison of different extraction methods of active ingredients of Chinese medicine and natural products","volume":"47","author":"Li","year":"2024","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jpha.2024.101131_bib39","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.ultsonch.2012.03.003","article-title":"Ultrasound-assisted extraction of three bufadienolides from Chinese medicine ChanSu","volume":"19","author":"Sun","year":"2012","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.jpha.2024.101131_bib40","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/cbdd.13794","article-title":"Extraction, separation, modification, structural characterization, and antioxidant activity of plant polysaccharides","volume":"96","author":"Huang","year":"2020","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jpha.2024.101131_bib41","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jep.2016.05.054","article-title":"Semi-bionic extraction of compound turmeric protects against dextran sulfate sodium-induced acute enteritis in rats","volume":"190","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2024.101131_bib42","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1002\/tox.24145","article-title":"Supercritical CO2 fluid extract from Stellariae Radix ameliorates 2, 4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation","volume":"39","author":"Wu","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jpha.2024.101131_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25173847","article-title":"Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials","volume":"25","author":"Uwineza","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2024.101131_bib44","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1039\/C6CS00061D","article-title":"Molecular imprinting: Perspectives and applications","volume":"45","author":"Chen","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jpha.2024.101131_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28010301","article-title":"Applications of molecular imprinting technology in the study of traditional Chinese medicine","volume":"28","author":"Zhang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jpha.2024.101131_bib46","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1360\/N972018-00964","article-title":"Advanced preparation technologies and strategies for molecularly imprinted materials","volume":"64","author":"Wang","year":"2019","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.jpha.2024.101131_bib47","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/jssc.200800134","article-title":"Traditional Chinese medicine and separation science","volume":"31","author":"Liu","year":"2008","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jpha.2024.101131_bib48","article-title":"Exosome processing and characterization approaches for research and technology development","volume":"9","author":"Lai","year":"2022","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.jpha.2024.101131_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jpha.2024.101131_bib50","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: From biogenesis to uptake and intracellular signalling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jpha.2024.101131_bib51","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2024.101131_bib52","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.2147\/IJN.S264498","article-title":"Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jpha.2024.101131_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jpha.2024.101131_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.865245","article-title":"Emerging innovations on exosome-based onco-therapeutics","volume":"13","author":"Dai","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpha.2024.101131_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13329","article-title":"The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next","volume":"85","author":"Song","year":"2021","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jpha.2024.101131_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrm.2015.15","article-title":"The regulation and functions of the nuclear RNA exosome complex","volume":"17","author":"Kilchert","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jpha.2024.101131_bib57","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jpha.2024.101131_bib58","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jconrel.2020.10.020","article-title":"Challenges in the development and establishment of exosome-based drug delivery systems","volume":"329","author":"Wang","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2024.101131_bib59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12257-015-0781-x","article-title":"Influence of storage condition on exosome recovery","volume":"21","author":"Lee","year":"2016","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"10.1016\/j.jpha.2024.101131_bib60","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jpha.2024.101131_bib61","doi-asserted-by":"crossref","DOI":"10.1208\/s12248-018-0211-z","article-title":"Therapeutic potential of engineered extracellular vesicles","volume":"20","author":"Mentkowski","year":"2018","journal-title":"AAPS J."},{"key":"10.1016\/j.jpha.2024.101131_bib62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/acsnano.6b07607","article-title":"re-engineering extracellular vesicles as smart nanoscale therapeutics","volume":"11","author":"Armstrong","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpha.2024.101131_bib63","doi-asserted-by":"crossref","first-page":"27441","DOI":"10.1021\/acsami.7b06464","article-title":"Chemically edited exosomes with dual ligand purified by microfluidic device for active targeted drug delivery to tumor cells","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jpha.2024.101131_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2023.108647","article-title":"Recent progresses of exosome\u2013liposome fusions in drug delivery","volume":"35","author":"Zheng","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2024.101131_bib65","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1021\/jacs.7b00319","article-title":"Molecular recognition-based DNA nanoassemblies on the surfaces of nanosized exosomes","volume":"139","author":"Wan","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpha.2024.101131_bib66","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v5.31053","article-title":"Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting","volume":"5","author":"Kooijmans","year":"2016","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jpha.2024.101131_bib67","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.cclet.2021.11.050","article-title":"Exosome based miRNA delivery strategy for disease treatment","volume":"33","author":"Fang","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2024.101131_bib68","doi-asserted-by":"crossref","unstructured":"C. Th\u00e9ry, S. Amigorena, G. Raposo, et al., Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Curr. Protoc. Cell Bio. 2006. https:\/\/doi.org\/10.1002\/0471143030.cb0322s30.","DOI":"10.1002\/0471143030.cb0322s30"},{"key":"10.1016\/j.jpha.2024.101131_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.201800021","article-title":"Methods and technologies for exosome isolation and characterization","volume":"2","author":"Zhang","year":"2018","journal-title":"Small Methods"},{"key":"10.1016\/j.jpha.2024.101131_bib70","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1586\/epr.09.17","article-title":"Exosomes: Proteomic insights and diagnostic potential","volume":"6","author":"Simpson","year":"2009","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.jpha.2024.101131_bib71","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1158\/0008-5472.CAN-17-0994","article-title":"The biology of cancer exosomes: Insights and new perspectives","volume":"77","author":"Ruivo","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.jpha.2024.101131_bib72","article-title":"Review on strategies and technologies for exosome isolation and purification","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jpha.2024.101131_bib73","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ygyno.2011.04.035","article-title":"Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage","volume":"122","author":"Rupp","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.jpha.2024.101131_bib74","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00216-022-04174-5","article-title":"A review on comparative studies addressing exosome isolation methods from body fluids","volume":"415","author":"Martins","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpha.2024.101131_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-41800-2","article-title":"Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications","volume":"9","author":"Patel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpha.2024.101131_bib76","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3343\/alm.2020.40.3.253","article-title":"Isolation of small extracellular vesicles from human serum using a combination of ultracentrifugation with polymer-based precipitation","volume":"40","author":"Ryu","year":"2020","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.jpha.2024.101131_bib77","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-6728-5_7","article-title":"A protocol for isolation and proteomic characterization of distinct extracellular vesicle subtypes by sequential centrifugal ultrafiltration","volume":"1545","author":"Xu","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jpha.2024.101131_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/cells7120273","article-title":"Tangential flow filtration for highly efficient concentration of extracellular vesicles from large volumes of fluid","volume":"7","author":"Busatto","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.jpha.2024.101131_bib79","first-page":"115","article-title":"Principles and problems of exosome isolation from biological fluids","volume":"16","author":"Yakubovich","year":"2022","journal-title":"Biochem. (Mosc) Suppl. Ser. A Membr. Cell Biol"},{"key":"10.1016\/j.jpha.2024.101131_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/srep33641","article-title":"Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles' characteristics compared to precipitating agents","volume":"6","author":"G\u00e1mez-Valero","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpha.2024.101131_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145686","article-title":"Isolation of exosomes from blood plasma: Qualitative and quantitative comparison of ultracentrifugation and size exclusion chromatography methods","volume":"10","author":"Baranyai","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jpha.2024.101131_bib82","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1007\/s00216-022-04253-7","article-title":"Current status and outlook of advances in exosome isolation","volume":"414","author":"Liu","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpha.2024.101131_bib83","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-4939-2550-6_15","article-title":"A protocol for exosome isolation and characterization: Evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods","volume":"1295","author":"Greening","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jpha.2024.101131_bib84","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1039\/C7LC00592J","article-title":"Microfluidics for exosome isolation and analysis: Enabling liquid biopsy for personalized medicine","volume":"17","author":"Contreras-Naranjo","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.jpha.2024.101131_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119491","article-title":"Nanomaterial-based blood-brain-barrier (BBB) crossing strategies","volume":"224","author":"Xie","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2024.101131_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.118549","article-title":"The application of exosomes and Exosome-nanoparticle in treating brain disorders","volume":"350","author":"Salarpour","year":"2022","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jpha.2024.101131_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.07.011","article-title":"Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain","volume":"142","author":"Yuan","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2024.101131_bib88","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12195-016-0458-3","article-title":"Elucidation of exosome migration across the blood-brain barrier model in vitro","volume":"9","author":"Chen","year":"2016","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.jpha.2024.101131_bib89","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymthe.2020.11.030","article-title":"Plant exosome-like nanovesicles: Emerging therapeutics and drug delivery nanoplatforms","volume":"29","author":"Dad","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jpha.2024.101131_bib90","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.biocel.2012.06.018","article-title":"Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection","volume":"44","author":"Rana","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jpha.2024.101131_bib91","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.2147\/IJN.S370784","article-title":"Extracellular vesicles: The next generation theranostic nanomedicine for inflammatory bowel disease","volume":"17","author":"Li","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jpha.2024.101131_bib92","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/10717544.2020.1748758","article-title":"Prospects and challenges of extracellular vesicle-based drug delivery system: Considering cell source","volume":"27","author":"Meng","year":"2020","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jpha.2024.101131_bib93","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-021-01312-y","article-title":"Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis","volume":"20","author":"Li","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jpha.2024.101131_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2020.100261","article-title":"Exosome engineering: Current progress in cargo loading and targeted delivery","volume":"20","author":"Fu","year":"2020","journal-title":"NanoImpact"},{"key":"10.1016\/j.jpha.2024.101131_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12051883","article-title":"The potential roles of exosomes carrying APP and tau cleavage products in Alzheimer's disease","volume":"12","author":"Zhao","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jpha.2024.101131_bib96","doi-asserted-by":"crossref","first-page":"107508","DOI":"10.1016\/j.cclet.2022.05.022","article-title":"Exosome-based drug delivery systems in cancer therapy","volume":"34","author":"Wang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpha.2024.101131_bib97","article-title":"Low-intensity ultrasound radiation increases exosome yield for efficient drug delivery","volume":"57","author":"Zhao","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpha.2024.101131_bib98","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.addr.2012.07.001","article-title":"Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery","volume":"65","author":"Yeo","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpha.2024.101131_bib99","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.jpha.2024.101131_bib100","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00417-018-4097-3","article-title":"Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes","volume":"256","author":"Zhang","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jpha.2024.101131_bib101","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1021\/acs.molpharmaceut.8b00901","article-title":"Exosome as a novel shuttle for delivery of therapeutics across biological barriers","volume":"16","author":"Das","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpha.2024.101131_bib102","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-019-0418-3","article-title":"Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a","volume":"17","author":"Ma","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jpha.2024.101131_bib103","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biomaterials.2019.01.016","article-title":"Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion","volume":"197","author":"Mathew","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2024.101131_bib104","doi-asserted-by":"crossref","first-page":"6214","DOI":"10.2174\/1381612821666151027153410","article-title":"Synthetic and biological vesicular nano-carriers designed for gene delivery","volume":"21","author":"Soltani","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jpha.2024.101131_bib105","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jpha.2024.101131_bib106","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1093\/brain\/awab099","article-title":"Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease","volume":"144","author":"Spina","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.jpha.2024.101131_bib107","first-page":"156","article-title":"Antidementia drug therapy of Alzheimer's dementia: Status 2018 and outlook","volume":"144","author":"Hausner","year":"2019","journal-title":"Dtsch. Med. Wochenschr."},{"key":"10.1016\/j.jpha.2024.101131_bib108","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/med.21434","article-title":"Drugs in clinical trials for Alzheimer's disease: The major trends","volume":"37","author":"Bachurin","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jpha.2024.101131_bib109","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.biopha.2017.05.124","article-title":"A review on phytoconstituents and biological activities of cuscuta species","volume":"92","author":"Ahmad","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpha.2024.101131_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101321","article-title":"The emerging role of exosomes in Alzheimer's disease","volume":"68","author":"Zhang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jpha.2024.101131_bib111","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1142\/S0192415X17500902","article-title":"Curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1\/GSK-3\u03b2 in N2a\/APP695swe cells and APP\/PS1 double transgenic Alzheimer's disease mice","volume":"45","author":"Sun","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jpha.2024.101131_bib112","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.2147\/IJN.S208332","article-title":"Curcumin-loaded nanoparticles: A novel therapeutic strategy in treatment of central nervous system disorders","volume":"14","author":"Yavarpour-Bali","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jpha.2024.101131_bib113","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jpha.2024.101131_bib114","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s40266-018-0599-2","article-title":"Adjunctive therapies in Parkinson's disease: How to choose the best treatment strategy approach","volume":"35","author":"Fabbri","year":"2018","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jpha.2024.101131_bib115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1474-4422(12)70264-8","article-title":"Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): A randomised controlled trial","volume":"12","author":"Odekerken","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jpha.2024.101131_bib116","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.887407","article-title":"Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson's disease","volume":"12","author":"Cui","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jpha.2024.101131_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.749192","article-title":"Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpha.2024.101131_bib118","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/WCO.0000000000000319","article-title":"Multiple sclerosis: Genetics, biomarkers, treatments","volume":"29","author":"Axisa","year":"2016","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.jpha.2024.101131_bib119","article-title":"Exosomes and biomaterials: In search of a new therapeutic strategy for multiple sclerosis","volume":"12","author":"Ojeda-Hern\u00e1ndez","year":"2022","journal-title":"Life (Basel)"},{"key":"10.1016\/j.jpha.2024.101131_bib120","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-6-11","article-title":"Pathophysiology, treatment, and animal and cellular models of human ischemic stroke","volume":"6","author":"Woodruff","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jpha.2024.101131_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107918","article-title":"A novel biscoumarin compound ameliorates cerebral ischemia reperfusion-induced mitochondrial oxidative injury via Nrf2\/Keap1\/ARE signaling","volume":"167","author":"Wang","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jpha.2024.101131_bib122","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresbull.2018.11.006","article-title":"New progress in the approaches for blood-brain barrier protection in acute ischemic stroke","volume":"144","author":"Li","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jpha.2024.101131_bib123","first-page":"275","article-title":"Functionalized exosome-loaded ginsenoside Rg1 for the treatment of ischemic stroke","volume":"39","author":"Luo","year":"2023","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"10.1016\/j.jpha.2024.101131_bib124","doi-asserted-by":"crossref","DOI":"10.3390\/ph13100319","article-title":"Exosomes in gliomas: Biogenesis, isolation, and preliminary applications in nanomedicine","volume":"13","author":"Romano","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jpha.2024.101131_bib125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910899","article-title":"Exosomes and brain metastases: A review on their role and potential applications","volume":"22","author":"Oliveira","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2024.101131_bib126","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-023-02006-x","article-title":"Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood-brain-barrier penetration and tumor microenvironment modulation","volume":"21","author":"Kim","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.jpha.2024.101131_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.144692","article-title":"Ginsenoside Rg3-engineered exosomes as effective delivery platform for potentiated chemotherapy and photoimmunotherapy of glioblastoma","volume":"471","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jpha.2024.101131_bib128","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1007\/s12035-023-03365-0","article-title":"Exosomes: Promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy","volume":"60","author":"Khatami","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jpha.2024.101131_bib129","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jconrel.2015.07.030","article-title":"Using exosomes, naturally-equipped nanocarriers, for drug delivery","volume":"219","author":"Batrakova","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpha.2024.101131_bib130","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/acs.langmuir.1c00687","article-title":"Insight into the exosomal membrane: From viewpoints of membrane fluidity and polarity","volume":"37","author":"Suga","year":"2021","journal-title":"Langmuir"}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177924002284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177924002284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:19:38Z","timestamp":1750317578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177924002284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":130,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2095177924002284"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2024.101131","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The biological roles of exosome-encapsulated traditional Chinese medicine monomers in neuronal disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2024.101131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101131"}}