{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:23:21Z","timestamp":1791822201687,"version":"4.3.4"},"reference-count":89,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jpha.2024.101148","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:42:16Z","timestamp":1731573736000},"page":"101148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exploring the potential protective role of anthocyanins in mitigating micro\/nanoplastic-induced reproductive toxicity: A steroid receptor perspective"],"prefix":"10.1016","volume":"15","author":[{"given":"Jiaojiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-2020","authenticated-orcid":false,"given":"Fuqiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjukka","family":"Kolehmainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-2631","authenticated-orcid":false,"given":"Iman","family":"Zarei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2024.101148_bib1","doi-asserted-by":"crossref","first-page":"36046","DOI":"10.1007\/s11356-018-3508-7","article-title":"Occurrence, sources, human health impacts and mitigation of microplastic pollution","volume":"25","author":"Karbalaei","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib2","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1021\/acs.est.9b02942","article-title":"The plastic cycle: A novel and holistic paradigm for the anthropocene","volume":"53","author":"Bank","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jpha.2024.101148_bib3","first-page":"1","article-title":"Degradation of micro- and nano-plastics by photocatalytic methods","volume":"3","author":"Bratovcic","year":"2019","journal-title":"J. Nanosci. Nanotechnol. Appl."},{"key":"10.1016\/j.jpha.2024.101148_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.marpolbul.2019.01.032","article-title":"Potential interaction between plastic litter and green turtle Chelonia mydas during nesting in an extremely polluted beach","volume":"140","author":"G\u00fcndo\u011fdu","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.jpha.2024.101148_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11869-022-01272-2","article-title":"Atmospheric micro (nano) plastics: Future growing concerns for human health","volume":"16","author":"Bhat","year":"2023","journal-title":"Air Qual. Atmos. Health"},{"key":"10.1016\/j.jpha.2024.101148_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.toxlet.2020.01.008","article-title":"Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation","volume":"324","author":"Park","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jpha.2024.101148_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167471","article-title":"Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans","volume":"906","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2024.101148_bib8","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1002\/tox.23923","article-title":"Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis","volume":"38","author":"Cai","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153059","article-title":"Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice","volume":"465","author":"Wei","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.jpha.2024.101148_bib10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s10029-020-02186-7","article-title":"Could polypropylene mesh impair male reproductive organs? Experimental study with different methods of implantation","volume":"24","author":"Damous","year":"2020","journal-title":"Hernia"},{"key":"10.1016\/j.jpha.2024.101148_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134317","article-title":"Long-term exposure of the Mediterranean mussels, Mytilus galloprovincialis to polyethylene terephthalate microfibers: Implication for reproductive and neurotoxic effects","volume":"299","author":"Choi","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.jpha.2024.101148_bib12","doi-asserted-by":"crossref","first-page":"13483","DOI":"10.1007\/s11356-022-23013-9","article-title":"Ingestion and impacts of water-borne polypropylene microplastics on Daphnia similis","volume":"30","author":"Jeyavani","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib13","first-page":"257","article-title":"Protective effect of vitamin E on sperm quality and in vitro fertilizing potential and testosterone concentration in polyvinyl chloride treated male rats","volume":"11","author":"Sadeghi","year":"2020","journal-title":"Vet. Res. Forum"},{"key":"10.1016\/j.jpha.2024.101148_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ani13071132","article-title":"Impact of microplastics and nanoplastics on livestock health: An emerging risk for reproductive efficiency","volume":"13","author":"Urli","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.jpha.2024.101148_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.748912","article-title":"Microplastics and their impact on reproduction-can we learn from the C. elegans model?","volume":"4","author":"Jewett","year":"2022","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116524","article-title":"Canidin-3-glucoside prevents nano-plastics induced toxicity via activating autophagy and promoting discharge","volume":"274","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jpha.2024.101148_bib17","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1039\/D1FO02983E","article-title":"Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jpha.2024.101148_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/s12870-022-03699-2","article-title":"Accumulation and regulation of anthocyanins in white and purple Tibetan Hulless Barley (Hordeum vulgare L. var. nudum Hook. f.) revealed by combined de novo transcriptomics and metabolomics","volume":"22","author":"Yao","year":"2022","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.jpha.2024.101148_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tifs.2017.07.015","article-title":"Anthocyanins as promising molecules and dietary bioactive components against diabetes \u2013 A review of recent advances","volume":"68","author":"Gowd","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.jpha.2024.101148_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00394-005-0557-8","article-title":"Stability and biotransformation of various dietary anthocyanins in vitro","volume":"45","author":"Fleschhut","year":"2006","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib21","article-title":"Anthocyanins: Factors affecting their stability and degradation","volume":"10","author":"Enaru","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jpha.2024.101148_bib22","series-title":"Bioavailability of anthocyanins. Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes","first-page":"2465","author":"Faria","year":"2013"},{"key":"10.1016\/j.jpha.2024.101148_bib23","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/ptr.5642","article-title":"Chemistry, pharmacology and health benefits of anthocyanins","volume":"30","author":"Smeriglio","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jpha.2024.101148_bib24","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/acs.jafc.5b05031","article-title":"Enzymatic acylation of anthocyanin isolated from black rice with methyl aromatic acid ester as donor: Stability of the acylated derivatives","volume":"64","author":"Yan","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpha.2024.101148_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/09637486.2018.1506753","article-title":"Structure-stability relationship of anthocyanins under cell culture condition","volume":"70","author":"Zhang","year":"2019","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib26","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1007\/s00253-022-11835-z","article-title":"Biosynthesis and regulation of anthocyanin pathway genes","volume":"106","author":"Sunil","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jpha.2024.101148_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1361779","article-title":"Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits","volume":"61","author":"Khoo","year":"2017","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.jpha.2024.101148_bib28","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/jhn.12647","article-title":"Usual dietary anthocyanin intake, sources and their association with blood pressure in a representative sample of Australian adults","volume":"32","author":"Igwe","year":"2019","journal-title":"J. Hum. Nutr. Diet."},{"key":"10.1016\/j.jpha.2024.101148_bib29","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1021\/jf060300l","article-title":"Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption","volume":"54","author":"Wu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpha.2024.101148_bib30","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1017\/S000711451100239X","article-title":"Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort","volume":"106","author":"Zamora-Ros","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib31","article-title":"Anticancer effects of lingonberry and bilberry on digestive tract cancers","volume":"10","author":"Onali","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jpha.2024.101148_bib32","author":"Valsta"},{"key":"10.1016\/j.jpha.2024.101148_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9080665","article-title":"Antioxidant capacity of anthocyanins and other vegetal pigments","volume":"9","author":"Tena","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jpha.2024.101148_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/09637486.2016.1146235","article-title":"Anti-obesity effects of artificial planting blueberry (Vaccinium ashei) anthocyanin in high-fat diet-treated mice","volume":"67","author":"Wu","year":"2016","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib35","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1080\/10408398.2021.1913092","article-title":"Anthocyanin supplement as a dietary strategy in cancer prevention and management: A comprehensive review","volume":"62","author":"Chen","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib36","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1080\/10408398.2023.2187212","article-title":"Anthocyanins-gut microbiota-health axis: A review","volume":"64","author":"Liang","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070690","article-title":"Dietary effects of anthocyanins in human health: A comprehensive review","volume":"14","author":"Gon\u00e7alves","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jpha.2024.101148_bib38","doi-asserted-by":"crossref","first-page":"11327","DOI":"10.1080\/10408398.2022.2090893","article-title":"The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration","volume":"63","author":"Hu","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jpha.2024.101148_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134332","article-title":"3-MCPD as contaminant in processed foods: State of knowledge and remaining challenges","volume":"403","author":"Eisenreich","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.jpha.2024.101148_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110767","article-title":"Effects of cyanidin-3-O-glucoside on 3-chloro-1,2-propanediol induced intestinal microbiota dysbiosis in rats","volume":"133","author":"Chen","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib41","doi-asserted-by":"crossref","first-page":"12675","DOI":"10.1021\/acs.jafc.8b04229","article-title":"Cyanidin-3-O-glucoside at low doses protected against 3-chloro-1, 2-propanediol induced testis injury and improved spermatogenesis in male rats","volume":"66","author":"Jiang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpha.2024.101148_bib42","doi-asserted-by":"crossref","DOI":"10.1177\/15579883221096549","article-title":"Microplastics may be a significant cause of male infertility","volume":"16","author":"Zhang","year":"2022","journal-title":"Am. J. Mens Health"},{"key":"10.1016\/j.jpha.2024.101148_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165922","article-title":"Raman Microspectroscopy evidence of microplastics in human Semen","volume":"901","author":"Montano","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2024.101148_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162713","article-title":"Detection and characterization of microplastics in the human testis and Semen","volume":"877","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2024.101148_bib45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfae060","article-title":"Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis","volume":"200","author":"Hu","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jpha.2024.101148_bib46","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s10311-024-01752-0","article-title":"Occurrence, toxicity and removal of polystyrene microplastics and nanoplastics in human sperm","volume":"22","author":"Chen","year":"2024","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.jpha.2024.101148_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2024.101148_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib50","first-page":"1025","article-title":"Evidence on invasion of blood, adipose tissues, nervous system and reproductive system of mice after a single oral exposure: Nanoplastics versus microplastics","volume":"35","author":"Yang","year":"2022","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.jpha.2024.101148_bib51","doi-asserted-by":"crossref","DOI":"10.1007\/s12665-022-10614-3","article-title":"Cadmium chemical fractions in sediments: Effect of grain size, pH, organic acids, and inorganic ions","volume":"81","author":"Wang","year":"2022","journal-title":"Environ. Earth Sci."},{"key":"10.1016\/j.jpha.2024.101148_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124644","article-title":"Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)","volume":"406","author":"Deng","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2024.101148_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113966","article-title":"Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK\/eIF2\u03b1 signaling pathway","volume":"243","author":"Feng","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jpha.2024.101148_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152665","article-title":"Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats","volume":"449","author":"An","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.jpha.2024.101148_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155825","article-title":"Oxidative stress mediated by the TLR4\/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice","volume":"838","author":"Wu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpha.2024.101148_bib56","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1289\/ehp.1409271","article-title":"Bidirectional transfer study of polystyrene nanoparticles across the placental barrier in an ex vivo human placental perfusion model","volume":"123","author":"Grafmueller","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jpha.2024.101148_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135527","article-title":"Placental and fetal enrichment of microplastics from disposable paper cups: Implications for metabolic and reproductive health during pregnancy","volume":"478","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2024.101148_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139138","article-title":"Effects of micro(nano)plastics on the reproductive system: A review","volume":"336","author":"Song","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.jpha.2024.101148_bib59","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.reprotox.2021.10.002","article-title":"Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice","volume":"106","author":"Hu","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120404","article-title":"The emerging risk of microplastics and nanoplastics on the microstructure and function of reproductive organs in mammals: A systematic review of preclinical evidence","volume":"295","author":"Marcelino","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jpha.2024.101148_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.901798","article-title":"Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways","volume":"4","author":"Dubey","year":"2022","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib62","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-022-00473-y","article-title":"Consequences of nano and microplastic exposure in rodent models: The known and unknown","volume":"19","author":"da Silva Brito","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib63","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpha.2024.101148_bib64","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jpha.2024.101148_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jpha.2024.101148_bib66","doi-asserted-by":"crossref","first-page":"47921","DOI":"10.1007\/s11356-021-13911-9","article-title":"Polystyrene microplastics induce blood-testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats","volume":"28","author":"Li","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2024.101148_bib68","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107220","article-title":"Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles","volume":"163","author":"Zhou","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119789","article-title":"Microplastics-perturbed gut microbiota triggered the testicular disorder in male mice: Via fecal microbiota transplantation","volume":"309","author":"Wen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jpha.2024.101148_bib71","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1002\/tox.23611","article-title":"Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS\/MAPK\/HIF1\u03b1 pathway","volume":"37","author":"Wang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jpha.2024.101148_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/caspase-1 signaling pathway in rats","volume":"212","author":"Hou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jpha.2024.101148_bib73","doi-asserted-by":"crossref","first-page":"34594","DOI":"10.1007\/s11356-021-18218-3","article-title":"Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat","volume":"29","author":"Haddadi","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jpha.2024.101148_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/nu14050984","article-title":"Cyanidin-3-O-glucoside supplement improves sperm quality and spermatogenesis in a mice model of ulcerative colitis","volume":"14","author":"Xiao","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jpha.2024.101148_bib75","article-title":"Anthocyanins prevent AAPH-induced steroidogenesis disorder in leydig cells by counteracting oxidative stress and StAR abnormal expression in a structure-dependent manner","volume":"12","author":"Hu","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jpha.2024.101148_bib76","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/humupd\/dmu058","article-title":"The effects of dietary polyphenols on reproductive health and early development","volume":"21","author":"Ly","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jpha.2024.101148_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127571","article-title":"Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice","volume":"425","author":"Yang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jpha.2024.101148_bib78","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/reveh-2019-0016","article-title":"Cadmium toxicity: Effects on human reproduction and fertility","volume":"34","author":"Kumar","year":"2019","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.jpha.2024.101148_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109250","article-title":"Estrogenic flavonoids and their molecular mechanisms of action","volume":"114","author":"Kiyama","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jpha.2024.101148_bib80","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1002\/mnfr.201500479","article-title":"Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha","volume":"59","author":"Nanashima","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jpha.2024.101148_bib81","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-319-56895-9_6","article-title":"Estrogen receptors in cell membranes: Regulation and signaling","volume":"227","author":"Saczko","year":"2017","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"10.1016\/j.jpha.2024.101148_bib82","doi-asserted-by":"crossref","first-page":"172","DOI":"10.15296\/ijwhr.2023.8005","article-title":"Effect of anthocyanin on the ovarian damage and oxidative stress markers in adult female rat after torsion\/detorsion","volume":"11","author":"Teymoori","year":"2023","journal-title":"Int. J. Women\u2019s Health Reprod. Sci."},{"key":"10.1016\/j.jpha.2024.101148_bib83","author":"Zhang"},{"key":"10.1016\/j.jpha.2024.101148_bib84","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqz033","article-title":"Oviductal retention of embryos in female mice lacking estrogen receptor \u03b1 in the isthmus and the uterus","volume":"161","author":"Herrera","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.jpha.2024.101148_bib85","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1530\/JME-15-0254","article-title":"What\u2019s new in estrogen receptor action in the female reproductive tract","volume":"56","author":"Hewitt","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.jpha.2024.101148_bib86","first-page":"503","article-title":"Estrogens receptors-new players in spermatogenesis, Iran","volume":"6","author":"Saraswat","year":"2016","journal-title":"J. Appl. Anim. Sci."},{"key":"10.1016\/j.jpha.2024.101148_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2018.04.001","article-title":"A comparative review on estrogen receptors in the reproductive male tract of non mammalian vertebrates","volume":"134","author":"Verderame","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.jpha.2024.101148_bib88","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1095\/biolreprod.110.087353","article-title":"Estrogen, efferent ductules, and the epididymis","volume":"84","author":"Joseph","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jpha.2024.101148_bib89","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1095\/biolreprod.109.080366","article-title":"Epididymal hypo-osmolality induces abnormal sperm morphology and function in the estrogen receptor alpha knockout mouse","volume":"82","author":"Joseph","year":"2010","journal-title":"Biol. Reprod."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177924002454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177924002454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T17:11:53Z","timestamp":1741021913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177924002454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2095177924002454"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2024.101148","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the potential protective role of anthocyanins in mitigating micro\/nanoplastic-induced reproductive toxicity: A steroid receptor perspective","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2024.101148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101148"}}