{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:45:45Z","timestamp":1790595945470,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170844"],"award-info":[{"award-number":["82170844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270613"],"award-info":[{"award-number":["82270613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Analysis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jpha.2025.101333","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T11:09:59Z","timestamp":1747048199000},"page":"101333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Naringenin boosts Parkin-mediated mitophagy via estrogen receptor alpha to maintain mitochondrial quality control and heal diabetic foot ulcer"],"prefix":"10.1016","volume":"15","author":[{"given":"Xin-Meng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-Jiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ying","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Qing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Cherng","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-6262","authenticated-orcid":false,"given":"Yuan-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpha.2025.101333_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s13098-024-01507-5","article-title":"Association between sarcopenia and the foot-ankle function in type 2 diabetic foot ulcer","volume":"16","author":"An","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.jpha.2025.101333_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global epidemiology of diabetic foot ulceration: A systematic review and meta-analysis","volume":"49","author":"Zhang","year":"2017","journal-title":"Ann. Med."},{"key":"10.1016\/j.jpha.2025.101333_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114662","article-title":"The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing","volume":"282","author":"Zhou","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpha.2025.101333_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s13047-020-00383-2","article-title":"Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer","volume":"13","author":"Armstrong","year":"2020","journal-title":"J. Foot Ankle Res."},{"key":"10.1016\/j.jpha.2025.101333_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008143.pub3","article-title":"Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus","author":"Hemmingsen","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jpha.2025.101333_bib6","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.2337\/dc17-1683","article-title":"Association of hemoglobin A1c and wound healing in diabetic foot ulcers","volume":"41","author":"Fesseha","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpha.2025.101333_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23407","article-title":"Mitochondrial dysfunction and oxidative stress in diabetic wound","volume":"37","author":"Jiang","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jpha.2025.101333_bib8","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00041.2021","article-title":"Mitochondrial quality control in health and in Parkinson's disease","volume":"102","author":"Eldeeb","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jpha.2025.101333_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-03660-5","article-title":"Mitochondrial quality control protects photoreceptors against oxidative stress in the H2O2-induced models of retinal degeneration diseases","volume":"12","author":"Zhou","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpha.2025.101333_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165756","article-title":"The impact of mitochondrial quality control by Sirtuins on the treatment of type 2 diabetes and diabetic kidney disease","volume":"1866","author":"Xu","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jpha.2025.101333_bib11","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.7150\/ijbs.75402","article-title":"Mitochondrial quality control in diabetic cardiomyopathy: From molecular mechanisms to therapeutic strategies","volume":"18","author":"Cai","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jpha.2025.101333_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177100","article-title":"Taxifolin attenuates hepatic ischemia-reperfusion injury by enhancing PINK1\/Parkin-mediated mitophagy","volume":"985","author":"Zhang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpha.2025.101333_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/foods13132137","article-title":"Korean red ginseng improves oxidative stress-induced hepatic insulin resistance via enhancing mitophagy","volume":"13","author":"Rustamov","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jpha.2025.101333_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.883057","article-title":"Erythropoietin mitigates diabetic nephropathy by restoring PINK1\/parkin-mediated mitophagy","volume":"13","author":"Yi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpha.2025.101333_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13975","article-title":"l-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways","volume":"238","author":"Li","year":"2023","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.jpha.2025.101333_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/biom9030099","article-title":"Antidiabetic properties of naringenin: A citrus fruit polyphenol","volume":"9","author":"Den Hartogh","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jpha.2025.101333_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/advances\/nmaa106","article-title":"A comprehensive systematic review of the effects of naringenin, a citrus-derived flavonoid, on risk factors for nonalcoholic fatty liver disease","volume":"12","author":"Naeini","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jpha.2025.101333_bib18","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/ptr.6781","article-title":"Naringenin, a flavanone with antiviral and anti-inflammatory effects: A promising treatment strategy against COVID-19","volume":"34","author":"Tutunchi","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.jpha.2025.101333_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.lfs.2018.07.017","article-title":"Combating oxidative stress disorders with citrus flavonoid: Naringenin","volume":"208","author":"Zaidun","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jpha.2025.101333_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.946766","article-title":"Naringenin ameliorates myocardial injury in STZ-induced diabetic mice by reducing oxidative stress, inflammation and apoptosis via regulating the Nrf2 and NF-\u03baB signaling pathways","volume":"9","author":"He","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jpha.2025.101333_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101161","article-title":"Flavonoid naringenin attenuates oxidative stress, apoptosis and improves neurotrophic effects in the diabetic rat retina","volume":"9","author":"Al-Dosari","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jpha.2025.101333_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.fct.2019.04.008","article-title":"Food flavonoid ligand structure\/estrogen receptor-\u03b1 affinity relationships \u2013 toxicity or food functionality?","volume":"129","author":"Ye","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jpha.2025.101333_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1039\/C4FO00300D","article-title":"Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes: Implications on Sorghum-derived phytoestrogens","volume":"6","author":"Yang","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.jpha.2025.101333_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415809","article-title":"Mechanism underlying naringenin hypocholesterolemic effects: Involvement of estrogen receptor \u03b1 subtype","volume":"23","author":"Pallottini","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpha.2025.101333_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/wrr.12263","article-title":"A cohort study of diabetic patients and diabetic foot ulceration patients in China","volume":"23","author":"Jiang","year":"2015","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.jpha.2025.101333_bib26","doi-asserted-by":"crossref","first-page":"127S","DOI":"10.1016\/j.jvs.2018.04.069","article-title":"The effect of estrogen on diabetic wound healing is mediated through increasing the function of various bone marrow-derived progenitor cells","volume":"68","author":"Zhuge","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.jpha.2025.101333_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113207","article-title":"Dual effects of bisphenol A on wound healing, involvement of estrogen receptor \u03b2","volume":"231","author":"Wen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jpha.2025.101333_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1039913","article-title":"Estrogen receptor \u03b1 regulates phenotypic switching and proliferation of vascular smooth muscle cells through the NRF1-OMI-mitophagy signaling pathway under simulated microgravity","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jpha.2025.101333_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7150\/thno.29766","article-title":"Engineering bioactive self-healing antibacterial exosomes hydrogel for promoting chronic diabetic wound healing and complete skin regeneration","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jpha.2025.101333_bib30","article-title":"Adenosine accelerates the healing of diabetic ischemic ulcers by improving autophagy of endothelial progenitor cells grown on a biomaterial","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpha.2025.101333_bib31","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jvs.2016.03.407","article-title":"Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis","volume":"65","author":"Zhou","year":"2017","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.jpha.2025.101333_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02288-8","article-title":"Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds","volume":"12","author":"Yan","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jpha.2025.101333_bib33","article-title":"Programmed microalgae-gel promotes chronic wound healing in diabetes","volume":"15","author":"Kang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2025.101333_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-44968-y","article-title":"Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing","volume":"15","author":"Pranantyo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpha.2025.101333_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-020-01680-0","article-title":"Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db\/db mice","volume":"11","author":"De Gregorio","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jpha.2025.101333_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1084\/jem.187.3.297","article-title":"Role of nerve growth factor in cutaneous wound healing: Accelerating effects in normal and healing-impaired diabetic mice","volume":"187","author":"Matsuda","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jpha.2025.101333_bib37","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1016\/S0142-9612(03)00220-5","article-title":"Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db\/db mice","volume":"24","author":"Obara","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jpha.2025.101333_bib38","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20132063","article-title":"12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor","volume":"211","author":"Liu","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jpha.2025.101333_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137752","article-title":"Bioadhesive supramolecular polymer\/hyaluronic acid hydrogel with sustained release of zinc ions and dexamethasone for diabetic wound healing","volume":"286","author":"Yang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpha.2025.101333_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122900","article-title":"Structural analysis and accelerating wound healing function of a novel galactosylated glycosaminoglycan from the snail Helix lucorum","volume":"348","author":"Li","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpha.2025.101333_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2024.11.027","article-title":"Pluripotent polysaccharide coordinated hydrogels remodel inflammation, neovascularization and reepithelization for efficient diabetic wound prohealing","volume":"377","author":"Zhang","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jpha.2025.101333_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305852","article-title":"Human fibroblast-derived matrix hydrogel accelerates regenerative wound remodeling through the interactions with macrophages","volume":"11","author":"Savitri","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jpha.2025.101333_bib43","doi-asserted-by":"crossref","first-page":"E105","DOI":"10.1152\/ajpendo.00042.2016","article-title":"Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice","volume":"311","author":"Costa","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jpha.2025.101333_bib44","doi-asserted-by":"crossref","first-page":"H1924","DOI":"10.1152\/ajpheart.00368.2011","article-title":"Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes","volume":"301","author":"Lee","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jpha.2025.101333_bib45","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/omi.12167","article-title":"Caveolin-1 serves as a negative effector in senescent human gingival fibroblasts during Fusobacterium nucleatum infection","volume":"32","author":"Ahn","year":"2017","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.jpha.2025.101333_bib46","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.ymthe.2019.07.016","article-title":"Pharmacological and genetic inhibition of caveolin-1 promotes epithelialization and wound closure","volume":"27","author":"Jozic","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jpha.2025.101333_bib47","doi-asserted-by":"crossref","first-page":"D552","DOI":"10.1093\/nar\/gkh029","article-title":"GenePaint.org: An atlas of gene expression patterns in the mouse embryo","volume":"32","author":"Visel","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jpha.2025.101333_bib48","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1371\/journal.pgen.0030178","article-title":"Regulatory pathway analysis by high-throughput in situ hybridization","volume":"3","author":"Visel","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jpha.2025.101333_bib49","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14703","article-title":"SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy","volume":"30","author":"Yang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jpha.2025.101333_bib50","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.bbadis.2018.04.009","article-title":"Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy","volume":"1865","author":"Wang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jpha.2025.101333_bib51","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12192-022-01273-1","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorates myocardial ischemia-reperfusion injury by enhancing PINK1\/Parkin-mediated mitophagy in type 2 diabetic rats","volume":"27","author":"Ji","year":"2022","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jpha.2025.101333_bib52","first-page":"269","article-title":"Acid-responsive CST@NPs enhanced diabetic wound healing through rescuing mitochondrial dysfunction","volume":"44","author":"Zhang","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jpha.2025.101333_bib53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10571-017-0519-8","article-title":"Protective role of naringenin against A\u03b225-35-caused damage via ER and PI3K\/Akt-mediated pathways, Cell","volume":"38","author":"Zhang","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jpha.2025.101333_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176115","article-title":"Naringenin protects pancreatic \u03b2 cells in diabetic rat through activation of estrogen receptor \u03b2","volume":"960","author":"Lin","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpha.2025.101333_bib55","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1038\/jid.2014.175","article-title":"Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair","volume":"134","author":"Campbell","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jpha.2025.101333_bib56","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.freeradbiomed.2018.11.003","article-title":"17\u03b2-Estradiol protects mesenchymal stem cells against high glucose-induced mitochondrial oxidants production via Nrf2\/Sirt3\/MnSOD signaling","volume":"130","author":"Oh","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jpha.2025.101333_bib57","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1074\/jbc.M117.805069","article-title":"Estrogen receptor \u03b1 protects pancreatic \u03b2-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress","volume":"293","author":"Zhou","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpha.2025.101333_bib58","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/sj.ejcn.1602543","article-title":"Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects","volume":"61","author":"Kanaze","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.jpha.2025.101333_bib59","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/dom.13868","article-title":"Safety and pharmacokinetics of naringenin: A randomized, controlled, single-ascending-dose clinical trial","volume":"22","author":"Rebello","year":"2020","journal-title":"Diabetes Obes. Metabol."}],"container-title":["Journal of Pharmaceutical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177925001509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095177925001509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:17:05Z","timestamp":1777623425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095177925001509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2095177925001509"],"URL":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101333","relation":{},"ISSN":["2095-1779"],"issn-type":[{"value":"2095-1779","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naringenin boosts Parkin-mediated mitophagy via estrogen receptor alpha to maintain mitochondrial quality control and heal diabetic foot ulcer","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpha.2025.101333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Xi\u2019an Jiaotong University.","name":"copyright","label":"Copyright"}],"article-number":"101333"}}